#=GF ID   HlyD_D4
#=GF AC   PF16572.9
#=GF DE   Long alpha hairpin domain of cation efflux system protein, CusB
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_3ooc
#=GF GA   26.40 26.40;
#=GF TC   26.40 26.40;
#=GF NC   26.30 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0105
#=GF RN   [1]
#=GF RM   19695261
#=GF RT   Crystal structure of the membrane fusion protein CusB from
#=GF RT   Escherichia coli.
#=GF RA   Su CC, Yang F, Long F, Reyon D, Routh MD, Kuo DW, Mokhtari AK,
#=GF RA   Van Ornam JD, Rabe KL, Hoy JA, Lee YJ, Rajashankar KR, Yu EW;
#=GF RL   J Mol Biol. 2009;393:342-355.
#=GF DR   INTERPRO; IPR032328;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   HlyD_D4 is the long alpha-hairpin domain in the centre of CusB
#=GF CC   or HlyD proteins. CusB and HlyD proteins are membrane fusion
#=GF CC   proteins of the CusCFBA copper efflux system in E.coli and
#=GF CC   related bacteria. Efflux systems of this
#=GF CC   resistance-nodulation-division group - RND - have been developed
#=GF CC   to excrete poisonous metal ions, and in E.coli the only one that
#=GF CC   deals with silver and copper is the CusA transporter. The
#=GF CC   transporter CusA works in conjunction with a periplasmic
#=GF CC   component that is a membrane fusion protein, eg CusB, and an
#=GF CC   outer-membrane channel component CusC in a CusABC complex driven
#=GF CC   by import of protons. HlyD_D4 is thought to interact with the
#=GF CC   alpha-helical tunnels of the corresponding outer-membrane
#=GF CC   channels, ie the periplasmic domain of CusC [1].
#=GF SQ   6
#=GS Q3SJ80_THIDA/161-214   AC Q3SJ80.1
#=GS CUSB_ECOLI/150-204     AC P77239.1
#=GS A0A2P1PR01_9GAMM/1-41  AC A0A2P1PR01.1
#=GS W9T854_9PSED/157-209   AC W9T854.1
#=GS A1VVV7_POLNA/192-248   AC A1VVV7.1
#=GS A4VL99_PSEU5/156-209   AC A4VL99.1
Q3SJ80_THIDA/161-214              ......IAELLVPEWAAVQQE..YL.A....L...KAL.............GD...-...P...S.....LE..GAARE...RMRLSGMPESLIRDVAARGKI.........
CUSB_ECOLI/150-204                ......LLDLTIPDWVEAQSE..YL.L....L...RET.............GG...T...A...T.....QT..EGILE...RLRLAGMPEADIRRLIATQKI.........
A0A2P1PR01_9GAMM/1-41             ......---------------..-M.A....L...RRTq...........sSG...L...A...E.....VR..DAARQ...RLGLLGMSEAQIRAVEH----akla.....
W9T854_9PSED/157-209              ......LVDLLIPEWVAVQEE..FL.A....V...RRI.............GE...-...P...A.....LL..DAARQ...RLRLAGMPAETIRQLERS---ag.......
A1VVV7_POLNA/192-248              ......LLDLYVPEWVAAQEE..FL.A....V...KRMq...........gSD...L...A...S.....LV..DGARQ...RMRLAGMSDEQIRQVEASGKS.........
A4VL99_PSEU5/156-209              ......LADLLIPEWAAAQEE..YL.A....L...RRA.............GD...-...A...A.....LL..DAARQ...RLRLAGMPASTISRLERSGKI.........
#=GC seq_cons                     ......LhDLhlPEWsAsQpE..aL.A....L...RRh.............G-.......A...u.....Lh..DAARQ...RLRLAGMP-upIRplEtotK..........
//