#=GF ID   Holin_9
#=GF AC   PF16936.9
#=GF DE   Putative holin
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   HMMER:F7P6L2-TCDB
#=GF GA   25.30 25.30;
#=GF TC   75.20 75.10;
#=GF NC   25.20 25.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR031614;
#=GF DR   TC; 1.E.3;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of putative holins from Actinobacteria with
#=GF CC   three TM regions.
#=GF SQ   70
#=GS A0A5N5VDG4_MYCPH/14-91   AC A0A5N5VDG4.1
#=GS A0A1Z4ED20_9MYCO/14-91   AC A0A1Z4ED20.1
#=GS A0A1E3S7Y1_MYCIE/1-78    AC A0A1E3S7Y1.1
#=GS A0A0J6WC10_MYCCU/1-78    AC A0A0J6WC10.1
#=GS A0A132SFF9_9MYCO/1-78    AC A0A132SFF9.1
#=GS A0A0I9TX53_9MYCO/14-91   AC A0A0I9TX53.1
#=GS I4BDN2_MYCCN/24-101      AC I4BDN2.1
#=GS A0A4R8R442_9MYCO/14-91   AC A0A4R8R442.1
#=GS A0A1A0PM26_9MYCO/14-91   AC A0A1A0PM26.1
#=GS A0A7I7S181_9MYCO/14-91   AC A0A7I7S181.1
#=GS G7CHL8_MYCT3/1-78        AC G7CHL8.1
#=GS A0A7G1INZ5_MYCKA/1-78    AC A0A7G1INZ5.1
#=GS X7ZVI8_MYCXE/1-51        AC X7ZVI8.1
#=GS F5Z0Q7_MYCSD/14-91       AC F5Z0Q7.1
#=GS A0A0N9XLS6_MYCFO/14-91   AC A0A0N9XLS6.1
#=GS X8FL97_MYCUL/1-66        AC X8FL97.1
#=GS A0A2A7NGK2_MYCAG/1-78    AC A0A2A7NGK2.1
#=GS A0A1A3PQJ6_9MYCO/14-91   AC A0A1A3PQJ6.1
#=GS A0A557XWE3_9MYCO/14-91   AC A0A557XWE3.1
#=GS A0A1X2DI12_9MYCO/14-91   AC A0A1X2DI12.1
#=GS A0A7I7YW42_9MYCO/14-91   AC A0A7I7YW42.1
#=GS A0A1A1YJY7_9MYCO/14-91   AC A0A1A1YJY7.1
#=GS A0A1X0DC75_MYCHE/14-91   AC A0A1X0DC75.1
#=GS A0A1E8Q2P4_9MYCO/14-91   AC A0A1E8Q2P4.1
#=GS A0A7I7NQ53_9MYCO/14-91   AC A0A7I7NQ53.1
#=GS A0A1X1RNA7_MYCCE/6-83    AC A0A1X1RNA7.1
#=GS K5BH45_MYCHD/14-91       AC K5BH45.1
#=GS A0A1X1RD32_MYCFA/14-91   AC A0A1X1RD32.1
#=GS X8B8M5_MYCAV/14-91       AC X8B8M5.1
#=GS A0A7I9XTV5_9MYCO/14-91   AC A0A7I9XTV5.1
#=GS A0A0M2JSP9_9MYCO/14-91   AC A0A0M2JSP9.1
#=GS A0A1A0TN87_9MYCO/14-91   AC A0A1A0TN87.1
#=GS A0A1X1SWG0_9MYCO/14-91   AC A0A1X1SWG0.1
#=GS A0A7I7Y2B5_9MYCO/1-78    AC A0A7I7Y2B5.1
#=GS A0A1A3N160_MYCAS/1-78    AC A0A1A3N160.1
#=GS A0A498QLZ4_9MYCO/22-99   AC A0A498QLZ4.1
#=GS A0A2R5HBD5_9MYCO/14-91   AC A0A2R5HBD5.1
#=GS A0A1A2GJ57_9MYCO/14-91   AC A0A1A2GJ57.1
#=GS A0A5A7X264_9MYCO/14-91   AC A0A5A7X264.1
#=GS A0A378TD08_9MYCO/14-91   AC A0A378TD08.1
#=GS A0A1E3RZE3_9MYCO/14-91   AC A0A1E3RZE3.1
#=GS I0RD03_MYCXE/14-91       AC I0RD03.1
#=GS X7Y8M8_MYCKA/1-78        AC X7Y8M8.1
#=GS A0A6N4WGN4_9MYCO/1-78    AC A0A6N4WGN4.1
#=GS A0A1X0GYB4_9MYCO/14-91   AC A0A1X0GYB4.1
#=GS A0A5S9PXS6_MYCVN/14-91   AC A0A5S9PXS6.1
#=GS A0A3S4RQB8_MYCCI/1-78    AC A0A3S4RQB8.1
#=GS A0A1N3N7D6_9MYCO/14-91   AC A0A1N3N7D6.1
#=GS A0A1A3C5J4_9MYCO/14-91   AC A0A1A3C5J4.1
#=GS A0A7I7SQ61_9MYCO/22-99   AC A0A7I7SQ61.1
#=GS A0A0Q2QF50_MYCGO/1-78    AC A0A0Q2QF50.1
#=GS A0A7I7K436_9MYCO/14-91   AC A0A7I7K436.1
#=GS A0A1X0DBB7_9MYCO/14-91   AC A0A1X0DBB7.1
#=GS A0A4Y9MI29_9MYCO/1-78    AC A0A4Y9MI29.1
#=GS A0A1X2BK51_9MYCO/14-90   AC A0A1X2BK51.1
#=GS B2HQS2_MYCMM/14-91       AC B2HQS2.1
#=GS A0A7I7SEH3_9MYCO/36-113  AC A0A7I7SEH3.1
#=GS Q73SW9_MYCPA/14-91       AC Q73SW9.1
#=GS A0A0G3IIK8_9MYCO/14-91   AC A0A0G3IIK8.1
#=GS A0A1X1RCT4_MYCBE/1-77    AC A0A1X1RCT4.1
#=GS A0A2G5PHM1_9MYCO/14-91   AC A0A2G5PHM1.1
#=GS A0A7I7MS64_9MYCO/14-91   AC A0A7I7MS64.1
#=GS A0A1A0MBN0_9MYCO/1-78    AC A0A1A0MBN0.1
#=GS I2AJT1_9MYCO/1-78        AC I2AJT1.1
#=GS A0A2S8KFD2_9MYCO/38-115  AC A0A2S8KFD2.1
#=GS O53745_MYCTU/1-78        AC O53745.3
#=GS A1T380_MYCVP/32-109      AC A1T380.1
#=GS A0A1S1NP91_9MYCO/14-91   AC A0A1S1NP91.1
#=GS A0A1X2LZR0_9MYCO/1-78    AC A0A1X2LZR0.1
#=GS A0A1X1SWV1_9MYCO/14-94   AC A0A1X1SWV1.1
A0A5N5VDG4_MYCPH/14-91              .LLVGTAVGLILGVATSVLVDAAIRPDVV...VGLVVGVPSILGILTILLSGRRWATTVGAFLLAVAPGWFGVLVAVEAVS-h.
A0A1Z4ED20_9MYCO/14-91              .MLIGIAVGLLAGVAGTLVMHARVRPDII...IALVAGLPSILGLLVILFSGRRWVTMVGAFILALTPGWLGVLVAIQVTSG..
A0A1E3S7Y1_MYCIE/1-78               .MLVGIAVGQLAGVAMSLLVHARMRPDVV...IALVVGIPTVIGLAAILLSGRRWVTMLGAFVLALAPGWLGVLVAVQVVS-h.
A0A0J6WC10_MYCCU/1-78               .MIVGVALGMMGALLAAVEITAPVRPDVV...IALVVGIPGVLGTLTILMSGRRWVTALGALVLAVGPGWFGALAALQVATG..
A0A132SFF9_9MYCO/1-78               .MIIGVALGMMAALIAAVEITATIRPDVA...IGLVLGVPGIVGMSMILFSGKQWVTAIGAMVLAIGPGCFGALTAIQVASG..
A0A0I9TX53_9MYCO/14-91              .LLIGSAVGLLTGVACTVLVHQRIRPDVV...IALVVGIPSVTGLPLILFSGRRWVTTLGAFILALAPGWFGVLVAIEVAS-r.
I4BDN2_MYCCN/24-101                 .MIVGVAIGMVAGIAATVQVSATVRPDVV...IALVVGVPSVIGMLTILASGRRWVTALGAMILAIGPGWFGALAAIQVASG..
A0A4R8R442_9MYCO/14-91              .MLLGIAVGLGAGMSSVLVAHQSVRPDLV...IGLIVAVPSLIGFLILIASTRKWMTAVAAFILAIAPGWFGILAAIQVIQG..
A0A1A0PM26_9MYCO/14-91              .MLVGTAVGLVAGIAATKLVSTPVRPDVV...VALVVGVPSVFGMAMILLSHRRWMTALGAFVLAVAPGWFAALATVQVVHG..
A0A7I7S181_9MYCO/14-91              .MLIGVAVGFMAGIAATMVVTAPVRPDVV...IGLVVAVPSTIGLLLVLCSGRRWITTFGVFVLSVAPGWLGVLVAMQAVS-l.
G7CHL8_MYCT3/1-78                   .MLVGTAVGMIGAVAATLLVTATIRPDIV...IALVVGVPSALGMLMIISSTQRWMTALGAFILAIAPGWLGVLVLIEVVN-s.
A0A7G1INZ5_MYCKA/1-78               .MLVGNAVGLLAGVAGTVLVHTPLRPDIV...IALVVAIPSVLGLAIILFSGRRWVTTLGAFILALAPGWFGVLVAIEVATG..
X7ZVI8_MYCXE/1-51                   m----------------------------...IALVVGVPSALGLLLILLSRHRWVTALGAFLLALAPGWFGLLVAIQVG--an
F5Z0Q7_MYCSD/14-91                  .MLVGATAGVLAGIGATLLVTAPLRPDVV...IALVLVAPTVAGLVLVFASSRRWVTGLGAFLLALGLGWFGVLAAIQAVSG..
A0A0N9XLS6_MYCFO/14-91              .MSVGVAVGLLAGIATSLLVTATVRPDVV...IALVLGVPGVLGTLLVLLSGRRWVTTLGTFALAIAPGWFGALAIIQVAS-h.
X8FL97_MYCUL/1-66                   .------------MGSSILVHTRVRPDLV...IALVVGIPSVIGMLVILFSGRRWVTVLGAFILALAPGWLGVLVAIQVAS-h.
A0A2A7NGK2_MYCAG/1-78               .MLVGAAIGFIAATAATVVVSATVRPDVV...IALVVGVPSALGMVMVLLSHRRWMTALGASVVAVAPGWFGALVAFQAVHG..
A0A1A3PQJ6_9MYCO/14-91              .MLLGVAAGLLGGTAALTVEHARMRPDIA...IALVVGFPSAVGLLVVLLARRRWLTALGAFILALAPGWFGVLALVEVVT-r.
A0A557XWE3_9MYCO/14-91              .MLLGCAAGLLAGVAFTSVARAGTRPDVA...IALVVGIPALTGLLTILFSGRRWVTTLGAFVLGLGPGWFGVLVALRVACG..
A0A1X2DI12_9MYCO/14-91              .MLVGNAVGALAGVAATVLVHARVRPDVV...IALVVGIPSVIGLLVILLSGRRWVTTVGAFILALAPGWLGVLVAIQVVSG..
A0A7I7YW42_9MYCO/14-91              .MLIGSAVGFLAAVAFVVLFHARLRPELV...IALVLGLPSVIGLTTILFSGRRWVTTAGAFVLAVAPGWFGALLALQVTS-r.
A0A1A1YJY7_9MYCO/14-91              .MLVGLAVGQIAGIASTLLVKAAIRPDIV...VALVIAVPSMIGMLTILLSGRRWLTALGAFVLAIAPGWFSVLVTIQVVHG..
A0A1X0DC75_MYCHE/14-91              .MLIGCAAGLLAGVAFTVVVHARVRPDVV...IALVVGIPTVTGLLTILFSGRRWVTVLGAFILSLAPGWFGVLVAIQVASG..
A0A1E8Q2P4_9MYCO/14-91              .MLTGVAVGLLAGIASMLVVTATVRPDLV...IAAVVGVPSVVGLLLVLLSHRRWLTTAGVFVLSIAPGWFGALAAVQAVSG..
A0A7I7NQ53_9MYCO/14-91              .MLVGNAVGLLVGVGATVLVHERLRPDVV...MALVVGIPSVVGLLVILFSGRRWVTMLGAFILALAPGWFGVLVAIQVASG..
A0A1X1RNA7_MYCCE/6-83               .MLIGAAVGVLAGTAATLLVSARIRPDVV...IALVVGLPSAAGLLLILMSRRRWVTALGAFTLAVAPGWFGVLALIEVMT-p.
K5BH45_MYCHD/14-91                  .LLLGTAVGLIVGIGVRLAIDVELRPDVV...IALVVGVPGGLGLLTVLCSNTRWATAFGAFLLAVAPGWFGVLVAIQAVQG..
A0A1X1RD32_MYCFA/14-91              .MLLGLAAGVLAGVLGAVLVESPVRPDLV...MGLVLGVPSVLGVLTVLVAGRRWVTATGAFLVSVAPGWFAVLVLAQVVNG..
X8B8M5_MYCAV/14-91                  .MLIGSAVGLLAGVAFTVAVHARVRPDLA...VAAVVGIPSVIGLALILFSGRRWVTTLGAFVLAVAPGWFGVLVALRVTAG..
A0A7I9XTV5_9MYCO/14-91              .MLVGTAAGLVAGVAATLLVHARIRPDIV...IALVVGVPTAIGLVLLVFSRRRWVTALGAFAVAVAPGWFGVLVAIQVVF-g.
A0A0M2JSP9_9MYCO/14-91              .MLVGVTLGMAGALLAAGEITTALKPAAV...IALAVGIPSVLGTLVILLSGRRWTTAVGALVVAIGPGCLGALTALQVAAG..
A0A1A0TN87_9MYCO/14-91              .MLVGAAVGLLAAVTATMLITASVRPDAV...IALVVGVPGALGLLLILVSGRRWMTALGAFVLAIGPGWLGTLALIEVVRG..
A0A1X1SWG0_9MYCO/14-91              .MLVGAAVGLVAAVTSTLLITATVRPDIV...IGLVVGVPSMAGVLMILCSGRRWVTTLGASVLAIAPGWLGALALIEVVNG..
A0A7I7Y2B5_9MYCO/1-78               .MLIGAAAGVVLGVAVTLLVHASMRPDAA...IAVVLGAPTILGMALIMTSGRRWVTALGAFVAAIAPGWFAALVLIQVVHG..
A0A1A3N160_MYCAS/1-78               .MLVGSALGQLLGVATNLLVHTRMRPDVA...VALVVGIPSVIGLSLIVFAGRRWVTMLGAAILALAPGWLGMLVALRVVNG..
A0A498QLZ4_9MYCO/22-99              .LLVGNAVGLLAGVAGTVLVHTPIRPDLV...IALVVAIPSVLGLAIILFSGRRWVTTLGAFILALAPGWFGVLVAIEVASG..
A0A2R5HBD5_9MYCO/14-91              .MLIGTAVGLLAGVALTVVVHTRVRPDIV...IALVVGLPSVIGLLTILFSGRRWVTMLGAFILAMSPGWFGVLVGIEVTAG..
A0A1A2GJ57_9MYCO/14-91              .MLIGCAAGFLAGVAFTVLVHARMHPDVV...IALVVGVPTVTGLLTTLFSGRRWITALGAFVLSLGPGWFGVLVALQVASG..
A0A5A7X264_9MYCO/14-91              .MLVGVAAGFLAGIGSTLVVTASIRPDVV...IAVVVGVPSAIGMLLILFSGRRWITTFGAFVLALAPGWFGALVAMQVVSG..
A0A378TD08_9MYCO/14-91              .MVVGSAVGVIIGVLTTVFVHISMRPDAA...IALVLAGPTLLGLVLILTAGSRWVTVWGTFLLAIAPSWFGVLVLTQVVQ-h.
A0A1E3RZE3_9MYCO/14-91              .MLVGAAVGVIIGIAASLLVTATIRPDIV...IGLVVGVPSVIGMLTILLSGRRWVTTVGAFVLALAPAWLGTLVAIQVVNG..
I0RD03_MYCXE/14-91                  .MLAGTATGLLAAAAATVSVHTRVRPDVV...IALVVGVPSALGLLLILLSRHRWVTALGAFILALAPGWFGLLVAIQVG--an
X7Y8M8_MYCKA/1-78                   .MLVGNAVGLLAGVAGTVLVHTPIRPDLV...IALVVGIPSVLGLAIILFSGRRWVTTLGAFILALAPGWFGVLAAIQVASG..
A0A6N4WGN4_9MYCO/1-78               .MLVGCVTGLIAAVVTTVLVKAPIRPDLV...VALVIGVPGAIGMLTILLSGRRWLTTVGAFILAMAPGWLATLVLIQVVSG..
A0A1X0GYB4_9MYCO/14-91              .LLIGTAVGLLLGIGLTLLVSAKIRPDVA...IALVVGVPGAIGMLTILFSRARWVTAVGAFVLAIAPGWFGVLVAIQSVNG..
A0A5S9PXS6_MYCVN/14-91              .MIVGVAVGMMAAVAATVEVTATVRPDIV...IAVVIGVPAIVGLLTILFSSRRWVTALGALVLAVGPGWFGALAAIQVASG..
A0A3S4RQB8_MYCCI/1-78               .MLIGAAVGVVLGVLATLQVQASLRPDAV...IALVLGVPTVLGLLFILTASRRWMTVVGAFTLAIAPGWFAVLVLIQVVHG..
A0A1N3N7D6_9MYCO/14-91              .MLLGIAVGLGAGMSSVLVAHESVRPDLV...IGLIVAIPSLIGFLILIASTRKWMTAVAAFILAIAPGWFGILAAIQVIQG..
A0A1A3C5J4_9MYCO/14-91              .LLVGAAVGLILGIASTLVIHAGLRPDVV...IALVVGIPGSVGMLTILLSGRRWVTTLGAFVLAIAPGWFGVLVAIEVVHG..
A0A7I7SQ61_9MYCO/22-99              .LLVGTATGLIAAVAATVLVKTPVRPDLV...VGLVVAVPSVIGMLLILFSRRRWITTAGAFILAMAPGWLGALVLVQVVSS..
A0A0Q2QF50_MYCGO/1-78               .MLVGSAVGQLLAVASSLLIHARIRPDIA...IALVVGIPAVVGLSVILFSGRRWVTMLGAAILALGPGWLGMLVALQVVS-h.
A0A7I7K436_9MYCO/14-91              .MIVGVAIGMIGAIAAAVEITATVRPDIV...IALVVGIPGVIGLITILVSKRRWVTAVGAMILAIGPGWFGALTAIQVATG..
A0A1X0DBB7_9MYCO/14-91              .MLVGVAVGILCAVLASLLVHAPVRADLV...VALVLGVPTGLGVLTLLVSGRRWVTAAGAFLLSIAPGWFAVLALIQVTHG..
A0A4Y9MI29_9MYCO/1-78               .MLVGAAVGLIAAVTATLLITASVRPDIT...IALVTGVPGALGLLMILTSGRRWVTTAGAFTLAIAPGWLGALALIEVVNG..
A0A1X2BK51_9MYCO/14-90              .MLVGAAVGLLAGVGFTL-AHAGIGPEFA...LALVVGVPSVTGVLTILFSGRRWVTMLGAFVLALAPGWLGVLAALQVASG..
B2HQS2_MYCMM/14-91                  .MLVGGAVGQLAGVGSSILVHTRVRPDLV...IALVVGIPSVIGMLVILFSGRRWVTVLGAFILALAPGWLGVLVAIQVAS-h.
A0A7I7SEH3_9MYCO/36-113             .MLVGVAVGIVAAIGASLLIDARVRPDVV...IAVVLGVPTVLGLATMLFAGRRWLTAAGAFVVAIAPGWFATLAAIEVVSS..
Q73SW9_MYCPA/14-91                  .MLIGSAVGLLAGVAFTVAVQAHVRPDLA...IAAVVGIPSVIGLALILFSGRRWVTTLGAFVLAVAPGWFGVLVALRVTAG..
A0A0G3IIK8_9MYCO/14-91              .LLVGTVTGLIAAVVATLLVKTPIRPDLV...VGLVVAVPSVIGMLLILFSGRRWITTVGAFILAMAPGWLGALVLVQVVSS..
A0A1X1RCT4_MYCBE/1-77               .MLIGAAVGLLAGVGCT-AVHVRVRPELA...IALVAGIPTVTGLVAILFSGRRWVTMVGAFVLALAPGWFGVLIAARVASG..
A0A2G5PHM1_9MYCO/14-91              .MLVGVTVGILCGVLGMLLVTTPIRPDLA...MGLVLGVPSGIGILAVLVSGRRWVTGAGAFLLSVAPGWFAVMVLAQVVHG..
A0A7I7MS64_9MYCO/14-91              .MLVGSAVGQLAGVASSALIHVRIRPDIV...IALVVGIPSVIGLSVILFSGRRWVTALGACILAVAPGWFGVLVALRVVAG..
A0A1A0MBN0_9MYCO/1-78               .MLTGVALGQLAAVASTLLVHTRVRPDVV...IALVVGIPSVIGLLVILLSGRRWVTMVGAFILALAPGWFGALVAIQVVSG..
I2AJT1_9MYCO/1-78                   .MLIGSAVGALACVAYTVVVHASVRPDIA...IASVVGIPSVVGLTMILFSGRRWVTALGAFILAAAPGWFGVLVALRVTAG..
A0A2S8KFD2_9MYCO/38-115             .MLVGTAAGLLGGIAAMKLVDATVRPDFV...IALVVGVPSIFGMVLILFSHRAWMTALGAFVLAIAPAWFGALAVIQVVHG..
O53745_MYCTU/1-78                   .MLVGNAIGLLAGVACSVLVHARIRPDIV...IAMVVGIPSAIGLLVILFSGRRWVTMLGAFILALAPGWFGVLVAIQVASS..
A1T380_MYCVP/32-109                 .MIIGVALGMMAALLAAVEITATIRPDLA...IGLVIGVPSIVGMLTILFSNRRWMTAVGAMVLAIGPGWFGALTAIQVATG..
A0A1S1NP91_9MYCO/14-91              .MLLGAAVGMLAGIAVTVLVQRPVRPDVV...IGLVVGIPTALGLLLVLVSGRRWVTALGAFVLALSPGWFGALAAIEVVRG..
A0A1X2LZR0_9MYCO/1-78               .MLVGNAIGLLAGVACTVLVHARIRPDIV...IAMVVGIPGAIGLLVILFSGRRWVTMLGAFILALAPGWFGVLVAIQVASS..
A0A1X1SWV1_9MYCO/14-94              .MLIGGAVGLLAGVASVVSLHGQIRSDLVapaIAAAVGIPSVIGVVAILLSGRRWVTMLGAFLLALAPGWLGVLIALRVVSG..
#=GC seq_cons                       .MLlGsAVGllAGVAuTllVcAplRPDlV...IALVVGlPSllGlLhILhSGRRWVTsLGAFlLAlAPGWFGlLVAIQVssG..
//