#=GF ID   ICEA
#=GF AC   PF05315.15
#=GF DE   ICEA Protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_2792 (release 7.7)
#=GF GA   24.00 24.00;
#=GF TC   24.00 25.40;
#=GF NC   23.60 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0263
#=GF RN   [1]
#=GF RM   11843964
#=GF RT   Distribution of distinct vacA, cagA and iceA alleles in
#=GF RT   Helicobacter pylori in Hong Kong. 
#=GF RA   Wong BC, Yin Y, Berg DE, Xia HH, Zhang JZ, Wang WH, Wong WM,
#=GF RA   Huang XR, Tang VS, Lam SK; 
#=GF RL   Helicobacter 2001;6:317-324.
#=GF DR   INTERPRO; IPR007979;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several ICEA proteins from Helicobacter
#=GF CC   pylori. Helicobacter pylori infection causes gastritis and
#=GF CC   peptic ulcer disease, and is classified as a definite carcinogen
#=GF CC   of gastric cancer. ICEA1 is  speculated to be associated with
#=GF CC   peptic ulcer disease [1].
#=GF SQ   27
#=GS A0A498G252_9EURY/157-290  AC A0A498G252.1
#=GS A0A1T4PXJ0_9SPIR/5-223    AC A0A1T4PXJ0.1
#=GS A0A6L5WFV5_9PROT/5-222    AC A0A6L5WFV5.1
#=GS R5DUR5_9FIRM/6-202        AC R5DUR5.1
#=GS V8CK27_9HELI/5-136        AC V8CK27.1
#=GS R4TG48_9PHYC/5-209        AC R4TG48.1
#=GS A0A1H6I921_9EURY/170-304  AC A0A1H6I921.1
#=GS A0A4V2V0J2_9FIRM/49-217   AC A0A4V2V0J2.1
#=GS A0A1W6LLN7_9BACT/54-222   AC A0A1W6LLN7.1
#=GS A0A0N9R0S0_CEV01/2-208    AC A0A0N9R0S0.1
#=GS A0A6A9SZ99_9EURY/254-384  AC A0A6A9SZ99.1
#=GS H5VFN0_HELBI/1-216        AC H5VFN0.1
#=GS G8DDT3_9PHYC/5-209        AC G8DDT3.1
#=GS A0A076F840_9PROT/6-223    AC A0A076F840.1
#=GS I7H4A2_9HELI/1-100        AC I7H4A2.1
#=GS J9R1X7_RIEAN/2-219        AC J9R1X7.1
#=GS A0A1H5X5W6_9EURY/162-295  AC A0A1H5X5W6.1
#=GS A0A7H9CF51_9PROT/2-223    AC A0A7H9CF51.1
#=GS A0A4R2NCL6_9PAST/2-223    AC A0A4R2NCL6.1
#=GS A0A4R1N352_9FIRM/73-215   AC A0A4R1N352.1
#=GS O25810_HELPY/1-157        AC O25810.1
#=GS A0A1H3E3H3_9EURY/161-295  AC A0A1H3E3H3.1
#=GS R6MU15_9FIRM/8-207        AC R6MU15.1
#=GS A0A1V3J3E1_9PAST/5-226    AC A0A1V3J3E1.1
#=GS A0A7J9SJW4_9EURY/163-294  AC A0A7J9SJW4.1
#=GS Q7VHB6_HELHP/4-221        AC Q7VHB6.1
#=GS F2NRE4_TRES6/98-300       AC F2NRE4.1
A0A498G252_9EURY/157-290             ............................................................................................fptqqsitrqd--------------------------------..------------------------------.-----------------M..P..DSFKRRVRDLYDHRDA----FDGSSPSTTLEVDHRv....pEV..R....W..DE.SESfdyeSMSDEDV..R.E.H.FQILSRKHNLLKSRKCEACVESGKRPTFFEID...-...---YYYEGGE.EY.........D..ED..VGCVGCGWYNPHEWRA---------....-....-....-....-------alqae......
A0A1T4PXJ0_9SPIR/5-223               .......................................................................................................TQIELFLELAKPDENGVSRWVAKTEFVGKYSD..LMFQNGWSWGRGDGALAKRFILERF---PE.YGAIEKVRTAGLKTDCSF..S..QNIRSDIKNFYKDKNCVMLGVHGTSVNTRIEIDHK......DG..R....K..ND.MRV....SDMATQK..L.E.D.FQPLCKAANDVKRQICKNCKATDKRWDAKNLL...G...NPYSFYKGDE.NY.........T..EE..LGCIGCYQYDPVEYRKESVKKLVKE....AsentT....E....FIMKKLY...........
A0A6L5WFV5_9PROT/5-222               .......................................................................................................TKTELFLELAKPNKDGISRWVKVSEFVKKYKD..LALGNGGSWCRKSSSLAKKYIVEFDKTITK.GNTIDRIRLNGFNTEIYF..N..QHIRSDIKAYYKNKNCVMLGINGNSENTKIEIDHK......DG..R....K..ND.WRV....SSAKTQN..L.K.D.FQPLCKAANDAKRQICKKCKETNKRWDAKIYI...G...NPYSFYDGDE.EY.........D..EK..LGCVGCYQFDPVEYRIACVKKISKE....A....S....E....FIMKKLY...........
R5DUR5_9FIRM/6-202                   .......................................................................................................TKIELFEELAGIDENGFSRWVSVDEFVGEYQG..LQLLNGAGWSRDDGPFGRKYIVERDKTRTP.GNRTDAIRTVGFNNGD-Y..S..QHIRADIKRQIQSQRCVILGTS------NPEVDHK......NG..M....K..NE.DRV....MRNEDQK..L.S.D.FQPLSKAANDAKRQFCKECIRTGIRYDAKKL-...G...YPMSYYKGDArHN.........G..EE..NACEGCFWYDPLEFRKH--------....-....-....-....-------lkek.......
V8CK27_9HELI/5-136                   .......................................................................................................TKIDLFLELAKPDEMGFSRWVGVGEFVGACRT..LQLGNGGSWCKASSTLAKKHIIEFDKSRTS.GNAIDAIRLQGFNPHQSF..N..QAIRKDIKDFYKSQKCVMLGVCGKSENTHIEIDHK......DG..Q....Q..TR.---....-------..-.-.-.--------------------------------...-...----------.--.........-..--..-------------------------....-....-....-....-------knqqgarygk.
R4TG48_9PHYC/5-209                   .................................................................................................kkhqai------ENLFKPNAEGISEWIT-RETIGADEE..LNWGNNGVTRGGVLYHYDKYIWEFGRANDKpSGKILKIRLNGLNPEKAL..NlkRPIREDIHKYHKNMGCVARGST-----SDLRTDHK......ND..L....Y..ND.LRV....LNMKTQT..F.D.D.FQCLCNHCNLQKRQVSKKTVELGKRYSATNIP...MlsiFGVDFTQGDE.TY.........D..KDdiNAMVGTYWYDPVAF-----------....-....-....-....-------mtylks.....
A0A1H6I921_9EURY/170-304             ......................................................trqempepfkkrvrelydgrdafdlstpggtpevdhrkprirwdepedf--------------------------------..------------------------------.------------------..-..-----------------------------------......--..-....-..--.DYE....SMSDAAV..R.E.H.FQILSGKHNLLKSRKCERCVETGERPPFLGIE...-...---FYYEGGR.EY.........E..DD..VGCSGCGWYNPHRWREAVTDRLER-....-....-....-....-------aaacd......
A0A4V2V0J2_9FIRM/49-217              ............................................................dkdekdnwfnkihcencdqttvhrklrsleindgtkarsgipg--------------------------------..------------------------------.------------------..-..-KLAKKIKEYYG---CIDAYSLRKEVPTKLEIDHR......KPqvR....W.dND.EDI....NDVNMSNgvIeE.R.FMLLTRENNLLKSRKCEKCNQTGERQTGYNID...-...---FFYMGTK.VY.........E..EH..IGCEGCFWFNPDKWRE-AINNIV--....-....-....-....-------kdyr.......
A0A1W6LLN7_9BACT/54-222              ..................................................................kgnfykrmycasceaqtfhrklksleilevnkarygi--------------------------------..------------------------------.------------------..R..SKLAKRIKQLYNFEEAVLLRRL---SERELEIDHK......FP..QvrwaK..NE.ECF....DEYSDEE..L.K.DnFILLSRSNNLWKSRHCENCLKTGKRGHFPGIK...-...--Y-WYKGGE.EWk......gkTenDP..AGCIGCFWYNPYKWRESLQKLIDK-....-....-....-....-------ss.........
A0A0N9R0S0_CEV01/2-208               ......................................................................................................s-KRQAINELFKPNQDGISEWIN-KDIIREFRNgiLDWCNNGVFRHGVFQGDNRYIWEKDPLKG-.--KIQMIRTVGFSSEHLYghE..RPIRDDIRKFHESNPCVA---CGEIHN--IIIDHK......ND..L....Y..ND.ERV....LNKTTQT..F.D.D.FQPLCNSCNLKKRQICKKTKETGERYSATNIPilaV...FGIDFIEGSK.QF.........NinDK..NAMVGTYWYDPVRFT----------....-....-....-....-------nfikivlks..
A0A6A9SZ99_9EURY/254-384             ................................................................................................kpitrqn--------------------------------..------------------------------.-----------------M..P..NSFKQRVRDLYDHRDA----FDGSSPSTTLEVDHRv....pEV..Rw.eqS..EDfDYE....SMSDDDI..E.E.H.FQILSRKHNLLKSRKCEQCVETGKRPQFMQID...-...---FYYEGDE.NY.........D..DQ..TGCEGCGWYNPHEWRD---------....-....-....-....-------alqaql.....
H5VFN0_HELBI/1-216                   ......................................................................................................m---DLFLELAQPNTDGFSRWVSVSEFSGKYQE..LQLGNGGSWLRPSSSLAKKYKIEVDKSQSS.GNSIDRIRLVGFNTEIVF..N..QNIRQDIKDFYKNQRCVMLGVCGKSENTKIEIDHK......DG..R....K..ND.LRV....ADVSSQR..L.E.D.FQSLCKAANDIKRQICKTCKETNLRWNAKNIA...G...NPYAFYAGDE.HH.........T..DE..LGCVGCYQYDPVAYCQECVKKIAKE....A....S....E....YIYHKIY...........
G8DDT3_9PHYC/5-209                   .................................................................................................kkhqai------ENLFKPNAEGISEWIT-RETIGADEE..LNWGNNGVTRGGVLYHYDKYIWEFGRANDKpSGKILKIRLNGLNPEKAL..NlkRPIREDIHKYHKNMGCVARGST-----SDLRTDHK......ND..L....Y..ND.LRV....LNMKTQT..F.D.D.FQCLCNHCNLQKRQVSKKTVELGKRYSATNIP...MlsiFGVDFTQGDE.TY.........D..KDdiNAMVGTYWYDPVAF-----------....-....-....-....-------mtylks.....
A0A076F840_9PROT/6-223               .......................................................................................................TKMELFLKLANPDKNGVSRWVYVSEFKDEYEN..LKFGNGGSWCRANSSLAKKYKIEFDKSKSS.GNSIDAIRLIGFNNDKIF..N..QNIRTDIKDFYKSKNCVMLGVCGNSENTKIEIDHK......DG..R....K..ID.DRI....SDTKTQK..L.E.D.FQPLCKAANDIKRQICKKCKETNIRWSAKNIL...G...NPYDFYLGDE.KY.........S..DK..FGCVGCYQYDPVKYRKECVKKISQE....V....S....Q....NIMEKLY...........
I7H4A2_9HELI/1-100                   .......................................................................................................--------------------------------..MQLGNGRSWCRASSSLAKTYIVELDKSLTS.SSAIDAIRLQGFNPQKAF..N..QAIRKDIKDFYKSQKCVMLGVCGKSENTTIEIDHK......DE..Q....Q..T-.---....-------..-.-.-.--------------------------------...-...----------.--.........-..--..-------------------------....-....-....-....-------rknqqgarcgk
J9R1X7_RIEAN/2-219                   .......................................................................................................TKTELFLELAKPDSNGVSRWVSVNEFIGKYKA..LQLGNGGSWCRASSSLAKTYTIEFDKTKTR.GNSIDAIRLTGFNNSNTF..N..QSIRKEIKDFYKNKNCVMLGINGNSINTKIEIDHK......DG..R....K..DN.DRV....SNIKTQR..L.E.D.FQPLSKAANDAKRQICKRCKETNLRWNAKNLK...G...NPYSFYEGDE.HY.........T..QE..LGCVGCYQFDPVEYRKSSVIKISKE....V....T....D....NILKKLY...........
A0A1H5X5W6_9EURY/162-295             ..........................................................................................ptqksitrqempa--------------------------------..------------------------------.------------------..-..-SFKRRVRDLYGGRDA----FDGSSPSTTLEVDHRv....pEV..RweesE..NY.DYE....SMSDEEV..R.E.H.FQILTRTHNLLKSRKCEACVESGERPPFMQIE...-...---YYYEGGQ.KY.........E..EE..VGCVGCGWYNPHEWRAS--------....-....-....-....-------lqael......
A0A7H9CF51_9PROT/2-223               .......................................................................................................SKMELFLKLAEPDDNGVSRWVESSEFVGDYKD..LALGNGGSWCRANSTLAKRYIVEFDKSLTS.GNSIDAIRLNGFNQAQTF..N..QAIRKDIKEFYKDKKCVMLGVNGNSENTKIEIDHK......DG..R....K..DD.WRV....SNQSTQK..L.E.D.FQPLCKAANDIKRQICKNCKETNKRWSARNIL...G...NPYDFYAGDE.KY.........T..KE..LGCVGCYQYDPVEYRKQSVKRISKE....A....SencvD....FIMNKLY...........
A0A4R2NCL6_9PAST/2-223               .......................................................................................................SKMKLFLKLCSPDNNGVSRWVSVDEFIGEYEG..LKLGNGGSWCRASSSLAKKYIIEFDKSRTK.SNAIDAVRLNGFNQQPSF..S..QNIRQDIREYYKNKNCVMLGVNGKSENTKIEIDHK......DG..R....K..NN.QRI....SNIQTQK..L.E.D.FQPLSKAANDVKRQICKKCKETGKRWNAKNIL...G...NPYAFYLGDE.NY.........S..EQ..LGCLGCYQYDPVEYRKVIVRRITEE....A....S....QntveFIFNKLY...........
A0A4R1N352_9FIRM/73-215              .....................................................................................klksldridvtktrsgip--------------------------------..------------------------------.------------------..-..SKLAKRIKEHYNYIDAYSL---RKEAATRLEIDHR......EP..Qv.rwKhnED.TND....VNMSEEA..I.EkK.FMLLTRENNLLKSRKCEKCAETGMRPIGYNID...-...---FYYKGNG.YY.........D..EQ..IGCQGCFWYNPDKWREA--------....-....-....-....-------ineqlks....
O25810_HELPY/1-157                   .......................................................................................................--------------------------------..---------------------MEFDKGQTL.GNFIDRIRLNGYNTECVF..N..QSICQDIKNHYKQQCCAMCGVRGNSENTQIEVDHK......DG..R....K..DD.SRV....SDLSTQA..F.D.D.FQALCKACNDKKRQICKKCKETGYRFDARKIP...G...NHYSFYEGEA.EY.........D..--..-GCVGCYQYDPIQYRKTCNDRIYNE....-....-....-....-------gyqkg......
A0A1H3E3H3_9EURY/161-295             .............................................................................................ptqqsitrqd--------------------------------..------------------------------.-----------------M..P..DSFKRRVRDLYDHRDA----FDGSSPSTTLEVDHRv....pEV..R....W..EE.SESfdyeSMTDEEV..T.E.H.FQILSRKHNLLKSRKCESCVETGTRPPFMQIE...-...---YYYEGDE.TY.........D..ED..LGCVGCGWYNPHEWRAS--------....-....-....-....-------lqaeld.....
R6MU15_9FIRM/8-207                   .....................................................................................................tk--PFLFEKLASPDENGVSRWVSKSEFVGKYAD..LMFQNGASWCRKESSIAKKYIVEFDKSQTP.GNGVDRIRLNGFRKEDDWigG..QSIRSDIKNYYKQKRCVILGTS------NPEVDHK......NG..W....K..ND.SNA....MNTATQK..L.G.D.FQPLSKAANDAKRQFCKECRRTGKRYDAKKL-...G...YPVSFYYGDE.NH.........N.eSE..DGCIGCFWYDPIEFRKHL-------....-....-....-....-------sfk........
A0A1V3J3E1_9PAST/5-226               .......................................................................................................TKMQLFLELANPDSNGFSRWVDSAEFSGKYEV..LKLGNGGSWCRASSQLAKQYIIELDKTKTK.GNSIDAIRLVGFNQRKTF..N..QNIRQDIKNHYKNKRCVMLGVNGNSENTKIEIDHK......DG..R....K..ND.HRV....SNIETQK..L.E.D.FQPLCKAANDIKRQICKSCKETNKRWDAKNIL...G...NPYSFYKGDE.NY.........T..QE..LGCVGCYQYDPVQYRKSCVKRISNEaskhA....T....N....FILNKLY...........
A0A7J9SJW4_9EURY/163-294             ...............................................................................................gqsvtrqg--------------------------------..------------------------------.-----------------M..P..DSFKRRVRDLYDHRDA----FDGSSPSTTLEVDHRvpeirwDS..S....E..DF.DYE....SMTDEEV..R.E.H.FQILTRSHNLLKSRKCESCVENDERPPFL---...G...IEY-YYEGDA.AY.........D..DS..LGCVGCGWYNPHEWRAS--------....-....-....-....-------lhael......
Q7VHB6_HELHP/4-221                   .......................................................................................................SKIEIFLELAKPDKNGISRWVSVSEFIGEYKA..LALGNGGSWCRASSTLAKKYILEFDKSKSA.GNAIDAIRLKGFNTQKTF..N..QAIRKDIKDFYKNQNCVMLGICGKSENTKIEIDHK......DG..R....K..ND.LRI....SNQQTQK..L.E.D.FQPLCKAANDVKRQICKVCRETNKRWSAKNIK...G...NPYAFYQGDE.NY.........T..QE..LGCVGCYQYDPVAYRKESARKIAKE....A....A....D....FITQKLY...........
F2NRE4_TRES6/98-300                  ltedfeykcvncqlpnnpnwarriqdlkefgytiatklseycphcnkntthlimlpikrggitgyetwsselrtrivsllksydvfeakttkkegllpdhkfs--------------------------------..------------------------------.------------------..-..------------------------------EIRWN......DE..T....K..RE.TLE....NLTDKEI..L.R.D.FQLLSNQRNQQKREICRNCYQTGKRG---TIY...G...IPF-FYEGTE.NWdssipkngkS..AE..KGCIGCAWYDIERWRQELIKKL---....-....-....-....-------k..........
#=GC seq_cons                        ..............................................................................................................................................................hEh....s.....h.hlRh.Ghp.t..h..s..psI+p-I+caYcpppCVhhthsGpS.sTplElDHK......-s..p....c..s-.pch....sphpspt..h.-.D.FQ.Ls+tsN.hKpphCcpChETscRhsuhpI....h.....h.aYpG-E.pY.........s..cc..hGClGCa.YsPhcaRpt.............................................
//