#=GF ID IL4_i_Ig
#=GF AC PF18258.5
#=GF DE Interleukin-4 inducing immunoglobulin-binding domain
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF05279
#=GF GA 26.30 26.30;
#=GF TC 26.30 26.60;
#=GF NC 26.20 26.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0333
#=GF RN [1]
#=GF RM 21516468
#=GF RT 1H, 13C and 15N chemical shift assignments of IPSEDeltaNLS.
#=GF RA Meyer NH, Schramm G, Sattler M;
#=GF RL Biomol NMR Assign. 2011;5:225-227.
#=GF DR INTERPRO; IPR041305;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in Interleukin-4 inducing protein alpha-1
#=GF CC (IPSE/alpha-1) present in Schistosoma mansoni, a parasite of
#=GF CC humans. IPSE/alpha-1 triggers the release of IL-4 from basophils
#=GF CC in the liver which is a major site of egg deposition during S.
#=GF CC mansoni infection. This domain adopts a beta gamma-crystallin
#=GF CC fold that is stabilized by three disulfide bonds within the
#=GF CC domain (23/26, 59/93, and 111/121). The domain is involved in
#=GF CC immunoglobulin binding [1].
#=GF SQ 53
#=GS A0A183N0L3_9TREM/50-100 AC A0A183N0L3.1
#=GS A0A3Q0KS90_SCHMA/50-136 AC A0A3Q0KS90.1
#=GS A0A183KXD7_9TREM/432-484 AC A0A183KXD7.1
#=GS A0A4Z2DHU3_SCHJA/55-143 AC A0A4Z2DHU3.1
#=GS A0A183W2W3_TRIRE/178-266 AC A0A183W2W3.1
#=GS A0A183W2W3_TRIRE/51-132 AC A0A183W2W3.1
#=GS A0A430Q119_SCHBO/53-141 AC A0A430Q119.1
#=GS A0A2H1CHU6_FASHE/60-148 AC A0A2H1CHU6.1
#=GS A0A4Z2DH90_SCHJA/68-156 AC A0A4Z2DH90.1
#=GS A0A4S2M4D4_OPIFE/51-138 AC A0A4S2M4D4.1
#=GS A0A430QC65_SCHBO/26-113 AC A0A430QC65.1
#=GS A0A430PZ92_SCHBO/4-72 AC A0A430PZ92.1
#=GS A0A430QC56_SCHBO/26-113 AC A0A430QC56.1
#=GS A0A8J4WGB9_9TREM/55-142 AC A0A8J4WGB9.1
#=GS A0A504YDT4_FASGI/60-148 AC A0A504YDT4.1
#=GS A0A183N4I9_9TREM/230-318 AC A0A183N4I9.1
#=GS A0A5K4F8A9_SCHMA/26-113 AC A0A5K4F8A9.1
#=GS Q869D4_SCHMA/26-113 AC Q869D4.1
#=GS A0A075AJ90_9TREM/132-227 AC A0A075AJ90.1
#=GS A0A5J4NI30_9TREM/56-143 AC A0A5J4NI30.1
#=GS A0A183N4I9_9TREM/52-140 AC A0A183N4I9.1
#=GS A0A183VVT0_TRIRE/52-140 AC A0A183VVT0.1
#=GS A0A7M3QS57_SPIER/46-134 AC A0A7M3QS57.1
#=GS A0A183VUM9_TRIRE/74-162 AC A0A183VUM9.1
#=GS A0A5K4F9J2_SCHMA/52-140 AC A0A5K4F9J2.1
#=GS A0A183JKX8_9TREM/1-34 AC A0A183JKX8.1
#=GS A0A183N9E7_9TREM/104-192 AC A0A183N9E7.1
#=GS G7Y5K7_CLOSI/53-140 AC G7Y5K7.1
#=GS A0A430PZC5_SCHBO/26-113 AC A0A430PZC5.1
#=GS A0A8E0S0D0_9TREM/62-150 AC A0A8E0S0D0.1
#=GS A0A5K4F959_SCHMA/26-113 AC A0A5K4F959.1
#=GS A0A183VT84_TRIRE/60-137 AC A0A183VT84.1
#=GS A0A183MPV7_9TREM/6-85 AC A0A183MPV7.1
#=GS A0A183SMB8_SCHSO/51-139 AC A0A183SMB8.1
#=GS A0A430Q6U3_SCHBO/52-104 AC A0A430Q6U3.1
#=GS A0A183N5C3_9TREM/46-133 AC A0A183N5C3.1
#=GS A0A4V3SF46_OPIFE/53-140 AC A0A4V3SF46.1
#=GS A0A5K4FBF3_SCHMA/26-112 AC A0A5K4FBF3.1
#=GS A0A430Q137_SCHBO/50-100 AC A0A430Q137.1
#=GS A0A183KG39_9TREM/53-141 AC A0A183KG39.1
#=GS A0A183N5C2_9TREM/46-133 AC A0A183N5C2.1
#=GS A0A4Z2DH26_SCHJA/31-119 AC A0A4Z2DH26.1
#=GS G7Y7S5_CLOSI/51-138 AC G7Y7S5.1
#=GS A0A430PZB9_SCHBO/46-108 AC A0A430PZB9.1
#=GS A0A654GYQ2_9CEST/46-134 AC A0A654GYQ2.1
#=GS A0A3P7MX97_DIBLA/7-49 AC A0A3P7MX97.1
#=GS A0A4Z2DH36_SCHJA/51-139 AC A0A4Z2DH36.1
#=GS A0A183P5X1_9TREM/53-141 AC A0A183P5X1.1
#=GS A0A074ZCD1_9TREM/96-183 AC A0A074ZCD1.1
#=GS A0A183KX25_9TREM/2-41 AC A0A183KX25.1
#=GS A0A183N0L0_9TREM/19-63 AC A0A183N0L0.1
#=GS A0A183N9E4_9TREM/1-39 AC A0A183N9E4.1
#=GS A0A5K4F0S5_SCHMA/26-113 AC A0A5K4F0S5.1
A0A183N0L3_9TREM/50-100 ..............CLRLFASLFGRYYWVDFCDSNSYIDPYFMYYTNMICSHRS--Y.LMTR.YWIVY--........--------------..---------------------s....................
A0A3Q0KS90_SCHMA/50-136 ..............CVRLYAPFFGRYYWTDVCDSNSYITPYFMWYTNTICAHRS--Y.LFTR.YWIVYMR........HGFLGQHIILTPGV..CIRNLRQHGIWSVGSILKCT-k....................
A0A183KXD7_9TREM/432-484 ..............CVRLYMEPNQLGDWFDICDSNELLSSTCVWRTKSICTPGNTNP.FRKT.YWLIYE-........--------------..---------------------.....................
A0A4Z2DHU3_SCHJA/55-143 ..............CLRMYSEISQTGYWFDICDSNEALSPYLMMTTQSICAPSNVWY.RTPR.YWLGYQQ........PYFTGSYILLGPGQ..CVANVRTYGIVSIGSILQCQQ.....................
A0A183W2W3_TRIRE/178-266 ..............CLRLYSEANRRGYWSDMCDSNEALSPLQVWNTRSLCSPGYQLH.GRSS.YWLIYEQ........PHFTGPYILLGPDR..CVDNVYKYKLISISSILTCTQ.....................
A0A183W2W3_TRIRE/51-132 ..............CLRLFTEQSQDGDWFDICDSNELLSSLFIWKIQSACAPASGSS.GKQR.YWLLYDQ........MILTHMLLIVL---..---------------------tgfavstlqtainttek....
A0A430Q119_SCHBO/53-141 ..............CLRLYSEINQNGYWSDICDSNELLSPYLMMTTQSICAPANVWY.KTPR.YWLAYQQ........PYYSGSYILLKPGQ..CVKNVRAYGLLSIGSILQCAQ.....................
A0A2H1CHU6_FASHE/60-148 ..............CLRLYSQKRFAGAWSDMCDSNELLSHFNIFHTKSVCAPKDNFW.QKKR.YWLLFEE........PSFRGKYIMLPEQE..CVRNLPRSGLTTVGSVLVCN-v....................
A0A4Z2DH90_SCHJA/68-156 ..............CLRLYSGPNRVGDWFDICDSNELLSSMYVWRTRSLCAAGSALS.HMQT.YWLIYER........PHFRGPYLLLGPTR..CINDVNQYKLLATTSVLMCTE.....................
A0A4S2M4D4_OPIFE/51-138 ..............CLRLYTQRKFHGSWSDMCSSNEVLLVQSIFNTRSVCAPQEKWP.DSNT.YWLLFER........PYFIGSYVMLAPND..CVRNLQ-SSLSTVGSVLRCT-s....................
A0A430QC65_SCHBO/26-113 ..............CLRLYDGKYKSGSYSEVYKSVGSLSPP--WIPGSVCVPLIHNStGQPP.YWRIYED........VNYSGANTAVGHGA..CIDDFMKSGLRRISSIQKCV-y....................
A0A430PZ92_SCHBO/4-72 ......svgslspp-----------------------------WIPGSVCVPLIHNStGQPP.YWRIYED........VNYSGANTAVGHGA..CIDDFMKSGLRRISSIQKCV-y....................
A0A430QC56_SCHBO/26-113 ..............CLRLYDGKYKSGSYSEVYKSVGSLSPP--WIPGSVCVPLIHNStGQPP.YWRIYED........VNYSGANTAVGHGA..CIDDFMKSGLRRISSIQKCV-y....................
A0A8J4WGB9_9TREM/55-142 ..............CLRLYAESRFQGSWSDFCSSNELLRFDTMFNTQSVCAPKDQWW.DKKR.YWLLFEQ........PQFHGPYIILSEKD..CIRHLPRV-LRTVGSVLKCVQ.....................
A0A504YDT4_FASGI/60-148 ..............CLRLYSQKRFAGAWSDMCSSNELLSHFNIFHTKSVCAPKDNFW.QKKR.YWLLFEE........PSFRGKYIMLPEQE..CVRNLPRSGLTTVGSVLVCN-v....................
A0A183N4I9_9TREM/230-318 ..............CVRLYMEPNQLGDWFDICDSNELLSSTFVWRTRSICTPGNTNS.FKKT.YWLIYER........SHFAGPYILLGHSK..CIDDINQYKLLATMSILICVE.....................
A0A5K4F8A9_SCHMA/26-113 ..............CLQLYDETYERGSYIEVYKSVGSLSPP--WTAGSVCVPFVNDT.KRERpYWYLFDN........VNYTGRITGLGHGT..CIDDFTKSGFKGISSIKRCIQ.....................
Q869D4_SCHMA/26-113 ..............CLQLYDETYERGSYIEVYKSVGSLSPP--WTPGSVCVPFVNDT.KRERpYWYLFDN........VNYTGRITGLGHGT..CIDDFTKSGFKGISSIKRCIQ.....................
A0A075AJ90_9TREM/132-227 ..............CPRLYTDRGFRGQWSDVCSSNEYPLYEVIFNTNSVCVPSGQWW.NQQT.VWILFEQsfhfstrePQFEGSYVVLSAGD..CIRGLKRF-LNTVGSVLKCT-a....................
A0A5J4NI30_9TREM/56-143 ..............CLRLYAESRFQGSWSDICSSNELLRFDGMFNTHSVCAPKDQWW.DKKR.YWLLFEQ........PHFHGPYVILSEKD..CIRHLPRV-LRTVGSVLKCVQ.....................
A0A183N4I9_9TREM/52-140 ..............CMRLFSFYKNKDYWIDLCDSNPSLSPFLKKYTRAVCSPRSTRF.DNIK.YWVLYSQ........EMFRGRYILVQPDT..CISVIRRGGLRSVGSIMKCL-x....................
A0A183VVT0_TRIRE/52-140 ..............CLRIYSEAFRNGFWSDFCNSNELLSPFQIWTTLSMCAPQNVWY.KQSR.YWVAYEQ........PGFLGSYLFLKPGE..CINNVRQYGLKSIASIVECVQ.....................
A0A7M3QS57_SPIER/46-134 ..............CLRLYQQRWKTGDWADFCNSNELLPNCFFWNTGSACAPPQQWW.QRQT.YWLLFEG........PFFNGRYALLQAGE..CRQDLRRMGLQTVGSVLICE-l....................
A0A183VUM9_TRIRE/74-162 ..............CLRLYSEVNRRGYWSDMCDSNEALSPLQVWSTGSLCTPGYQLH.GRSS.YWLIYEY........NNFRGRYLLLSPDM..CIYNVHRYGIRTTSSILKCVQ.....................
A0A5K4F9J2_SCHMA/52-140 ..............CVRLYTGPNELGDWFDICDSNELLSSMFVWRAQSMCTSGNTNP.IRTI.YWLIYER........SHFTGPYILLGPSR..CIDDIRQYKFLATTSILICVE.....................
A0A183JKX8_9TREM/1-34 .............m-------------------------------------------.----.-------........--FRGRYILVQPHT..CVTVIRRGGLRSVGSIMKCL-t....................
A0A183N9E7_9TREM/104-192 ..............CVRLYMEPNQLGDWFDICDSNELLSSTFVWRTRSICTPGNTNS.FKKT.YWLIYER........SHFAGPYILLGHSK..CIDDINQYKLLATMSILICVE.....................
G7Y5K7_CLOSI/53-140 ..............CPRLYTDRGFRGQWSDMCSSNEYPLYEVIFNTESVCVPSGQWW.NRQT.VWILFEE........PQFEGSYIVFSAGD..CVRGLKRF-LNTVGSILKCT-a....................
A0A430PZC5_SCHBO/26-113 ..............CLRLYDGKYKSGSYSEVYKSVGSLSPP--WIPGSVCVPLIHNStGQPP.YWRIYED........VNYSGANTAVGHGA..CIDDFMKSGLRRISSIQKCV-y....................
A0A8E0S0D0_9TREM/62-150 ..............CLRLYSEKRFAGAWSDLCNSNELLAHFNIFHTESVCAPKDNFW.QKKR.YWLLFTE........PSFRGKYIMLSEQE..CVRNLDRTGMTTVGSVLICN-v....................
A0A5K4F959_SCHMA/26-113 ..............CLQLYDETYERGSYIEVYKSVGSLSPP--WTPGSVCVPFVNDT.KRERpYWYLFDN........VNYTGRITGLGHGT..CIDDFTKSGFEGISSIKRCIQ.....................
A0A183VT84_TRIRE/60-137 ..............CLRLYSEINLRGSWYDMCDSNEAISRKQAWNTRSACSPEM---.----.VW----R........PEFYGRYLLLSPGQ..CIYNIPQYGLKRVSSIVKCTQ.....................
A0A183MPV7_9TREM/6-85 risvahdipyrgnp-----------------------ISMHVCLSSVIQCSHEHQHW.ETQT.HTSVILQ........EMFRGRYIPVQPDT..CISVIRRGGLRSVGSIMKCL-t....................
A0A183SMB8_SCHSO/51-139 ..............CLRLYQQRWKTGDWADFCNSNELLPSCFFWNSGSACAPPQQWW.QRQT.YWLLFEG........PFFNGRYALLQAGE..CKQDLRRMGLQSVGSVLICEQ.....................
A0A430Q6U3_SCHBO/52-104 ..............CMRLYSFYKNRDYWIDLCDSNPSLSPFLKKYTRAVCSPRSTRL.HNIK.YWVVY--........--------------..---------------------s....................
A0A183N5C3_9TREM/46-133 ..............CLRLYDGTYESGPYTEVYKSVGSLSPP--WIPGSVCVPLIHDSkGQPP.YWRIYEG........VNYSGANTAIGHGS..CIDDFKKSGLRRISSIQKCV-y....................
A0A4V3SF46_OPIFE/53-140 ..............CPRLYTDRGFRGQWSDMCSSNEYPLYEVIFNTNSICVPSGQWW.NQQT.VWILFEE........PQFEGSYVVLSPGD..CIRGLKRF-LNTVGSILKCA-a....................
A0A5K4FBF3_SCHMA/26-112 ..............CLQLYDETYERGSYIEVYKSVGSLSPP--WTPGSVCVPLNDTK.RERP.YWYLFDN........VNYTGRITGLGHGT..CIDDFTKSGFKGISSIKRCIQ.....................
A0A430Q137_SCHBO/50-100 ..............CLRLFAPLLGRYYWVDFCDSNSYIDPYFMYHTNMICSHRS--F.LTTR.YWIVY--........--------------..---------------------s....................
A0A183KG39_9TREM/53-141 ..............CLRLYSEINQNGYWSDICDSNELLSPYLMMTTQSICAPANVWY.KTPR.YWLAYQQ........PYYSGSYILLKPGQ..CVKNVRAYGLLSIGSILQCAQ.....................
A0A183N5C2_9TREM/46-133 ..............CLRLYDGTYESGPYTEVYKSVGSLSPP--WIPGSVCVPLIHDSkGQPP.YWRIYEG........VNYSGANTAIGHGS..CIDDFKKSGLRRISSIQKCV-y....................
A0A4Z2DH26_SCHJA/31-119 ..............CLRLFSRYNFHDYWSDMCDSNRLPSPFIMSYTREVCSHSVNEY.SNRK.YWIVYSY........SNFRGRYILVPPGR..CITSIRRYGIYRVGSIMKCI-l....................
G7Y7S5_CLOSI/51-138 ..............CLRLYTQRKFQGTWSDICSSNEVLLVQSIFNTRSVCAPQGKWP.DSNN.YWLLFER........PYFIGSYVMLAPND..CVRKLQ-SSLSTVGSVLKCT-s....................
A0A430PZB9_SCHBO/46-108 ..............CLRLYDGTYENGSYTDVYKSVGLLSPP--WIPGSVCVPLIHDSkGQPP.YWRLYEY........V-------------..---------------------srsnhfndy............
A0A654GYQ2_9CEST/46-134 ..............CLRIYQQRWKTGDWADFCNSNELLPSCFFWNSGSVCAPPQQWW.QRQT.YWLLFEG........PFFNGRYALLQAGE..CRQDLRRMGLQTVGSVLICE-l....................
A0A3P7MX97_DIBLA/7-49 ........ssdfcc-------------------------------------------.----.-----RG........PFFTGRYALLQTGE..CKQDLRRMGLQSVGSILICE-r....................
A0A4Z2DH36_SCHJA/51-139 ..............CIRLYSIYQTQYFWTDICDSNRMISPLFRWYTRSVCSPPSSIL.GNRV.YWILYSQ........FNFHGSYIIIPPGI..CSQDIRRYGLFSISSILRCI-r....................
A0A183P5X1_9TREM/53-141 ..............CLRLYSEINQNGYWSDICDSNELLSPYLMMTTQSICAPANVWY.KTPR.YWLAYQQ........PYYSGSYILLKPGQ..CVKNVRAYGLLSIGSILQCAQ.....................
A0A074ZCD1_9TREM/96-183 ..............CLRLYTQRKFQGSWSDICSSNEVLMVQSIFNTRSVCAPQGKWP.DSNT.YWLLFER........PYFIGSYVMLSPND..CVRNLQ-SSLSTVGSVLKCT-s....................
A0A183KX25_9TREM/2-41 ..........fnvr-------------------------------------------.----.------Q........VLFRGRYLLVQPDT..CVTVIRRSGLRSVGSIMKCL-t....................
A0A183N0L0_9TREM/19-63 .......strqqgv-------------------------------------------.----.----LGQ........PYYSGSYILLKPGQ..CVKNVRAYGLLSIGSILQCAQ.....................
A0A183N9E4_9TREM/1-39 ...........mpr-------------------------------------------.----.------Q........EMFRGRYILVQPDT..CISVIRRGGLRSVGSIMKCL-t....................
A0A5K4F0S5_SCHMA/26-113 ..............CLQLYDKTYEMGSYIEVYKSLGSLSPP--WTPGSVCVPFVNDT.KRDRpYWYLFEK........VNYKGRITGLGHGT..CIDDFTKSGFKGISSIQKCIQ.....................
#=GC seq_cons ..............CLRLYsph.tpG.W.DhCcSNphLSs..hapotSlCsPtsp...tppp.YWlla-p........s.FpGpYlhLs.sp..Clpslp+.GLpsluSIhpCh......................
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