#=GF ID   ISG65-75
#=GF AC   PF11727.12
#=GF DE   Invariant surface glycoprotein
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Pfam-B_785 (release 23.0)
#=GF GA   25.10 25.10;
#=GF TC   25.10 25.50;
#=GF NC   24.70 25.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   1587856
#=GF RT   Molecular characterization of two invariant surface
#=GF RT   glycoproteins specific for the bloodstream stage of Trypanosoma
#=GF RT   brucei. 
#=GF RA   Ziegelbauer K, Multhaup G, Overath P; 
#=GF RL   J Biol Chem. 1992;267:10797-10803.
#=GF RN   [2]
#=GF RM   18538880
#=GF RT   Heterologous expression, purification and characterisation of
#=GF RT   the extracellular domain of trypanosome invariant surface
#=GF RT   glycoprotein ISG75. 
#=GF RA   Tran T, Buscher P, Vandenbussche G, Wyns L, Messens J, De Greve
#=GF RA   H; 
#=GF RL   J Biotechnol. 2008;135:247-254.
#=GF DR   INTERPRO; IPR021057;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family is found in Trypanosome species, and appears to be
#=GF CC   one of two invariant surface glycoproteins, ISG65 and ISG75.
#=GF CC   that are found in the mammalian stage of the parasitic
#=GF CC   protozoan. the sequence suggests the two families are
#=GF CC   polypeptides with N-terminal signal sequences, hydrophilic
#=GF CC   extracellular domains, single trans-membrane alpha-helices and
#=GF CC   short cytoplasmic domains. they are both expressed in the
#=GF CC   bloodstream form but not in the midgut stage. Both polypeptides
#=GF CC   are distributed over the entire surface of the parasite [1,2].
#=GF SQ   83
#=GS F9W537_TRYCI/14-278     AC F9W537.1
#=GS Q57VX1_TRYB2/6-285      AC Q57VX1.1
#=GS F9W692_TRYCI/233-382    AC F9W692.1
#=GS F9W8D8_TRYCI/82-330     AC F9W8D8.1
#=GS F9WDT7_TRYCI/32-201     AC F9WDT7.1
#=GS F9WBE0_TRYCI/9-285      AC F9WBE0.1
#=GS F9W9G0_TRYCI/5-215      AC F9W9G0.1
#=GS F9W9G1_TRYCI/94-272     AC F9W9G1.1
#=GS F9WH30_TRYCI/89-272     AC F9WH30.1
#=GS F9WR99_TRYVY/36-272     AC F9WR99.1
#=GS A0A167S823_CORFA/3-136  AC A0A167S823.1
#=GS F9W9N2_TRYCI/2-147      AC F9W9N2.1
#=GS Q38A30_TRYB2/73-236     AC Q38A30.1
#=GS F9WEB0_TRYCI/5-251      AC F9WEB0.1
#=GS F9WPA5_TRYVY/26-284     AC F9WPA5.1
#=GS Q587F3_TRYB2/4-282      AC Q587F3.1
#=GS Q57VX4_TRYB2/110-276    AC Q57VX4.1
#=GS Q57VC0_TRYB2/19-257     AC Q57VC0.1
#=GS Q57VF0_TRYB2/9-290      AC Q57VF0.1
#=GS F9WFB9_TRYCI/2-217      AC F9WFB9.1
#=GS Q587F0_TRYB2/6-284      AC Q587F0.1
#=GS Q587F2_TRYB2/4-282      AC Q587F2.1
#=GS F9WM60_TRYVY/12-286     AC F9WM60.1
#=GS Q57XH5_TRYB2/9-266      AC Q57XH5.1
#=GS Q57VX0_TRYB2/6-287      AC Q57VX0.1
#=GS F9W6S5_TRYCI/9-182      AC F9W6S5.1
#=GS Q387A5_TRYB2/10-285     AC Q387A5.1
#=GS F9WIA9_TRYCI/2-158      AC F9WIA9.1
#=GS F9W8D9_TRYCI/5-275      AC F9W8D9.1
#=GS F9WB34_TRYCI/66-318     AC F9WB34.1
#=GS F9WL89_TRYVY/26-282     AC F9WL89.1
#=GS F9WJ81_TRYCI/5-276      AC F9WJ81.1
#=GS F9WRS9_TRYVY/26-284     AC F9WRS9.1
#=GS F9WV18_TRYVY/1-252      AC F9WV18.1
#=GS F9W4F8_TRYCI/5-253      AC F9W4F8.1
#=GS F9W681_TRYCI/23-290     AC F9W681.1
#=GS F9W4B5_TRYCI/10-272     AC F9W4B5.1
#=GS F9WKI8_TRYVY/26-273     AC F9WKI8.1
#=GS Q57VX3_TRYB2/74-280     AC Q57VX3.1
#=GS F9WIG2_TRYCI/13-282     AC F9WIG2.1
#=GS F9WI71_TRYCI/14-278     AC F9WI71.1
#=GS F9WI69_TRYCI/1-59       AC F9WI69.1
#=GS K0RBK1_THAOC/155-359    AC K0RBK1.1
#=GS F9WJ79_TRYCI/43-304     AC F9WJ79.1
#=GS Q57VX8_TRYB2/80-279     AC Q57VX8.1
#=GS F9W3Q3_TRYCI/2-217      AC F9W3Q3.1
#=GS F9WH52_TRYCI/7-175      AC F9WH52.1
#=GS F9WCN5_TRYCI/6-287      AC F9WCN5.1
#=GS Q587F4_TRYB2/4-282      AC Q587F4.1
#=GS F9WG73_TRYCI/3-275      AC F9WG73.1
#=GS F9W783_TRYCI/50-291     AC F9W783.1
#=GS F9W8E1_TRYCI/5-276      AC F9W8E1.1
#=GS F9W689_TRYCI/93-269     AC F9W689.1
#=GS F9WR01_TRYVY/29-284     AC F9WR01.1
#=GS Q57VX5_TRYB2/69-274     AC Q57VX5.1
#=GS F9WH53_TRYCI/37-199     AC F9WH53.1
#=GS Q57VF1_TRYB2/10-276     AC Q57VF1.1
#=GS F9WM06_TRYVY/36-275     AC F9WM06.1
#=GS F9WH73_TRYCI/1-217      AC F9WH73.1
#=GS F9WE82_TRYCI/1-116      AC F9WE82.1
#=GS Q57VX6_TRYB2/103-276    AC Q57VX6.1
#=GS F9W3Q7_TRYCI/221-385    AC F9W3Q7.1
#=GS Q57VC2_TRYB2/19-258     AC Q57VC2.1
#=GS F9WFT4_TRYCI/10-172     AC F9WFT4.1
#=GS F9W8E0_TRYCI/5-249      AC F9W8E0.1
#=GS F9W651_TRYCI/10-272     AC F9W651.1
#=GS F9WLX4_TRYVY/31-284     AC F9WLX4.1
#=GS F9W4F9_TRYCI/5-254      AC F9W4F9.1
#=GS F9WHN7_TRYCI/8-279      AC F9WHN7.1
#=GS F9WHA3_TRYCI/11-283     AC F9WHA3.1
#=GS F9WEZ5_TRYCI/6-276      AC F9WEZ5.1
#=GS F9WDT6_TRYCI/7-172      AC F9WDT6.1
#=GS Q57VX2_TRYB2/11-281     AC Q57VX2.1
#=GS F9WMH4_TRYVY/78-234     AC F9WMH4.1
#=GS F9WCS1_TRYCI/67-318     AC F9WCS1.1
#=GS F9WVN7_TRYVY/35-285     AC F9WVN7.1
#=GS Q587F5_TRYB2/5-282      AC Q587F5.1
#=GS Q57VX7_TRYB2/121-276    AC Q57VX7.1
#=GS Q587F1_TRYB2/4-282      AC Q587F1.1
#=GS F9WK68_TRYCI/8-290      AC F9WK68.1
#=GS Q57VC4_TRYB2/2-257      AC Q57VC4.1
#=GS Q585R8_TRYB2/78-250     AC Q585R8.1
#=GS Q57VE9_TRYB2/10-286     AC Q57VE9.1
F9W537_TRYCI/14-278                .......................thliiatfvalnlgaandndc---------------.------------GLQHKAVEVLCNLAASVRRT-EEIFEKLQ.NE.DEKKlLGE.LMIYKEQLK...DKVWEVNEMLRS-RG.....LYHINEEERERL..EKICNEAEE..RGEEQYKLAKRVTTLFSNISKEIRGA...ALEAL.GE...KFHIIt.cVNAKG.LLSILDCAVNGn...kPR.PG.G..T.SN.L....ENIC....K...N.HK...I....LSM.....L...T....S...E.......ATARRDLCQQ....VG...NQNI.CLPDTA..EEIKSALMDWEKMKEDG-...........------.--.----....-.....----.--------.---------------------------vyikrgvacvlneswrpileavvtkinnlkdmrnvlmnat..
Q57VX1_TRYB2/6-285                 ...........................................r-HSYILASVITAVAF.AAAEKGQRPALKRFNKEGARALCIMYGLAGSM-QSVADGIL.NT.TAQK.IKF.IQNTSSALN...RTRQKVGKLVDSIKA.....KNATVGDAI---..KRHLDAVLN..ASAKADEEVKKQHEIITNASSKAVEH...AKKAV.GD...-----...SESKG.MNKVLTIYCNTtitgaKE.GK.K..S.HN.V....NNNC...dD...G.I-...-....--A.....A...A....A...G.......AGAFKIDCKS....IGg.sDNVT.AANVTY..EAMSNAINAWDGAKPGLAa........vkHTSKQW.NA.SCIS....H.....GYAS.EGPCTVPEeEWTGDYNSSLHELKKLEEATKSVHNAA..........................................
F9W692_TRYCI/233-382               ................................dtlkalstslel---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..--------------------------...-----.--...-----...-----.LRKILRWYCVGs..kkQQ.GG.K..G.VV.P....NANC...eK...SaYK...RdyyhRRH.....K...H....-...D.......PLEFSILCNY....--...KKIP.HSDVEAtpEAMEAALKRWNESKPQSI...........---EKK.TD.ICRM....GpsgvvGSSG.GKTCVVSE.DWLPGYEKTMETIKKLEDLHEKVVTA-t.........................................
F9W8D8_TRYCI/82-330                ....................................ttcflfal--------VAAAPIT.ASGGAGRNGDACKLQHEGINALCHLAYLASRS-YEVSEKLL.EQ.TGDA.VSSdINLYEEQIQ...HRLSGVRASLEAPNE.....KHTLTGDDVRKI..KNMCGDLEA..NNKKQHDRLWEALKTYHETARQASLQ...SDFLL.GK...QVENKq.cDQTDE.LLVVIN--CGKn..gkGT.GT.G..R.LD.V....VSLC....A...G.SA...V....PEG.....V...K....E...V.......AHRDTRNCPM....VG...RYRH.CHGSMG..AEIEGAMTKWKSIKSSAC...........QHSDKW.EA.R---....-.....----.--------.---------------------------aenltsim..................................
F9WDT7_TRYCI/32-201                .......................ayvgmvslmalipgsmsradv---------------.---------SASKLSEEATVFLCGIKNLLEDVRDGSSKHFA.ER.TEKA.YGD.VTTYREQVD...KEVYALKRLLEEAEA.....KKKFKEEDVRTL..KNAAEEIKR..SNDREYERATKLMHNFREQREKAMEA...TRRAL.EK...LQEKAm.gKSSQG.ASVTLVDVCNG.....--.--.-..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..------------------...........------.--.----....-.....----.--------.---------------------------rkhpiat...................................
F9WBE0_TRYCI/9-285                 ............................................CVALLIDFATSSTTG.QGNEVVQHEAEKMLDRFGASALCTMKVYCDRIVSDTAEYLV.EE.IGYQ.LYL.IKSDIHSIN...HYTGEINRYFGD---.....---LPQDQQEKV..MKACEVALN..ITKARREIAEAAKKKAEDLVLNATLA...ANLTL.GEigeDEDGNatvDNTTG.LARVINWHCGY....sKV.EN.E..T.EP.P....STSC....H...V.VG...K....RKR.....F...S....G...-.......GFRNTISCQR....LE...KSVS.YKNATA..ENMRRALMEWNVVKPMPK...........----EN.GK.ICQD....T.....DDHT.NHSCTVWE.GWVADYKKTTDLMKKLGGAERRARRA-r.........................................
F9W9G0_TRYCI/5-215                 ................................leaagrradllk---------------.-----------------------------------------.--.----.---.---------...---------------.....--KLVGSYHKKL..NNSIKKAPKkkPALKNSETVQEAHRRMHNLSKESRDA...WKRAR.HR...---ES...SAMKK.ITEVIQQHCVGtgsggSG.KS.E..G.QV.E....SKNC...dS...S.V-...L....SVTt..tgS...E....K...A.......GHNYAIQCGN....MS...ISDV.EKSVSH..QSMDDALKRWNKSKPKPD..........tKNLTQC.SS.EHHD....G.....KEPLvEGPCTVLE.SWLWDYEETKNAVKRLHRAFRVA----aavy......................................
F9W9G1_TRYCI/94-272                .........mqealgkdrmnqtqqyskmvnhierrmksecaisr---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..--------------------------...-----.--...-SHAT...NASKT.LSGVLENHCRA.....DG.GH.H.fR.WE.S....SANC...dR...A.AGdieP...lSNR.....H...H....A...N.......GSGFSISCPPk.avAG...YDTE.P---SF..SAMETALRRWNHSKPTPN..........lTNVLEC.ND.RGVS....G.....SSRH.TEPCTVLE.AWLRDYEKTRYSIKRLYDITRT-----amgmr.....................................
F9WH30_TRYCI/89-272                ..................................sdvlrdalge---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..------EKLRKHGGVVKLMNMSQVNA...ANAAE.ES...KLVAS...NASKL.LSDVLQWHCVGr...gN-.-K.H..N.SS.SgyvlNGNCd..pD...A.Y-...R....REF.....Y...YngdvN...D.......LEKHSIPCNY....KA...ISSE.ETEPTY..ERMERALNFWDVTKPKPD...........PDFTPCtDE.HFSD....T.....KQRE.QVSCTVLE.NWLQGYNDAKKKVKKLEN---------lvlmgvkm..................................
F9WR99_TRYVY/36-272                ......................................ntgken---------------.------------GLGVAGAAALCRLHALSEGV-PNVVDRLT.DE.NEKW.LGV.SERLWGSAM...SEVAQLELLRLKTHG.....LSNLTD-VISRT..TAAVTLAVN..LANQSRRSMLERYDAVKNATVTAEEM...SEEAIlGG...----E...SPYGG.LRNILLRYCGR.....--.--.-..-.PG.Q....SYEC...eA...E.L-...-....REE.....L...V....-...-.......--NGAIVCEK....LN...VSSS.A-NTTV..SAMVEALAEFNEHKTAIY...........PYNSQL.NE.KCEP....-.....--SP.EVICSVAE.DWVGPFYLAAQALGEVESA--------flwns.....................................
A0A167S823_CORFA/3-136             kssrsstrkennrrlaatvfgpaetaraerlsakllelakqpkp---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..-----------------ETSDANMEE...AADVV.ED...EAADA...GDATG.MVPVIQAHCTK.....-S.SK.Q..A.SQ.L....TDSCl..aM...D.VD...T....KRT.....A...S....K...R.......VGRKRIDKRK....TK...----.------..------------------...........------.--.----....-.....----.--------.---------------------------kasivfpkysdrika...........................
F9W9N2_TRYCI/2-147                 .......................................dahnk---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..------------------TLEAAKSS...TSKAL.GE...THVEGn.cLNTVS.ILGILQCYVKG.....EQ.RK.A..D.VN.I....ESIC....N...E.KD...Y....EKH.....L...P....D...H.......YGKTIANCNR....IG...KGKT.YCNGTG..AALKAAMEKWNTTDRKTS...........--D---.--.----....-.....--AN.GGTCDVKR.EWETY----------------------vlnasnhmsllddhvqtihdan....................
Q38A30_TRYB2/73-236                ................................rqvlrnvqdkit---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..--------------------------...-----.--...-----...EGVKG.INELFGRHCRRvslgiEG.GG.S..D.ML.S....NPNC...eD...S.DK...K....EGT.....G...E....A...TdqgsgtlSEEGIIQCEH....-GnflRDFL.I-RGAL..EAYRSQMEQWEKKKPTEGnktst.evkgdESSKKH.ED.QCQQ....M.....GYSV.HGACTVSEqKWRQHLEEAVKLMEG------------iivvkk....................................
F9WEB0_TRYCI/5-251                 ......................icvcwlmvlfpgvasggdvgac---------------.------------ELSDETARVLCTLADLLRAS-KHTADNYVqRH.LEEP.FEE.VKLHKIIID...QNSELLEELLAKAVN.....EGKYTEKDADEL..ESNAEGVQQ..VNDWDYERAKRAVETGREYQDWAVQA...ANEAL.GE...EDSSEd.cSLIAS.LVQLIRCHVSG.....--.GK.A..G.HT.T....TVFVkevgQ...G.AN...Y....TQR.....L...D....N...R.......TGEVLAHCNE....TG...GDKE.YCSGVG..TALKAALDRWRELKEDEE...........EEDR--.-G.GCP-....-.....----.--------.---------------------------dhtvweshahe...............................
F9WPA5_TRYVY/26-284                ..............................tnlarqsypldrye---------------.----------QGGLDKEGAAAICRLHALSEGV-PSAADELV.RK.SERW.VGM.AERLWTSVG...VEWGRLQLVSMKVHG.....-LDSFTDAVARA..EVKMTEAVH..TANSTMEQVRRHNATVFEAVALAEEE...AISAIdGD...----G...SPFGG.LFNILERHCGN.....ER.CK.T.sK.QA.R....CQNC...aK...P.L-...-....---.....M...E....M...-.......FPTTGIKCGE....LG...VPVA.RTAASV..SAMTEALARWDKVRPKFA...........--EDYI.AL.HERG....C.....EPTT.EYSCTVLE.DWAVHFYTATKKLSEAEEALVG-----carav.....................................
Q587F3_TRYB2/4-282                 ............................yllvfaiiatripvll--------------A.TNGGDKHVKANKKLTKEGAAALCKMKHLADKVAEERSQELK.DR.TQNF.AGY.IEFELYRID...YWLEKLNGPKGRKDG.....YAKLSDSDIEKV..KEIFNKAKD..GIAKQLPEAKKAGEEAEKLHTEVKKA...AKNAR.GV...RLSEG...TNSSG.LYRILDWYCFK.....--.EG.E..N.AG.K....SDNC....D...G.VK...F....SVH.....Y...E....T...H.......RRRNVIDCSS....TG...YEEN.Y-DWSA..NALQVALNSWENVKPKKV...........-ESAGS.DM.NCNI....G.....QSSE.SHPCTMTE.EWQTPYKETVEKLRELEDAYQRGKKAH..........................................
Q57VX4_TRYB2/110-276               ..............................kslgnsiikymggt---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..--------------------------...-----.GE...RAKAAa.aNASAA.LDQVLTWHCVDrt.asHE.SS.Y..S.ST.P....NANCe..pN...A.YK...R....DYY.....Y...E....HsrlD.......PHKYSILCNY....KV...VSST.TTQTTF..SNMERALEIWNQVKPKPY...........---SAR.VM.ICGAgapaH.....QAAPaGRPCTVLE.NWVRDYRVTAHLIAKLEKD--------atlalrvm..................................
Q57VC0_TRYB2/19-257                .......................................vvans---------------.----------NAKLNRDGALALCKLTDLAKTVGDKKADKIG.RD.TEGF.AHG.LKLWLDSLD...SWLQTLQDPAHSNDG.....YSKLSDADTKKV..KDIYEKAKD..KLKEKLPEAKKWGDEAKKHCQAVTEA...AKRAR.GW...GLDDE..gQNSSG.LHLVLEWYCGK.....--.-R.G..E.NA.Q....STSC....E...G.IT...F....KTH.....Y...S....G...-.......TGRNTIDCEA....TG..yTALF.YLHVSA..GTMKQALEDWEKKKPKKI...........----SA.--.----....-.....----.-----DYE.KWKSDYDSAVKKMEELEESHEQGKKT-h.........................................
Q57VF0_TRYB2/9-290                 ............................................GHILLVFSAVASASE.ESYKIDRYKADRKLDKEGAIALCKLRDVLTNISEETTDYLV.EE.VQKM.GES.LKTDMDAIN...YYVKRVRSLKESGRE.....DAKINESDSNEI..DSLCKEAKA.hANKKSRDQVDQTVAKIRRVSGIVKDA...ATKTL.GD...ENELEd.hDNADG.IFKVFNWHCGG.....DR.IG.E..V.HA.G....SQSC....D...V.IG...F....RKN.....F...S....A...-.......GQRNVISCKKwkdeYG...ETIP.HENVTV..TQMESYLSRWFEARPKRV...........-----G.ED.ICKD....G.....EYHS.PHSCTVWE.GWVTGYEETMEKMEELRNNIKKLNRI-r.........................................
F9WFB9_TRYCI/2-217                 ........rallegvsarvdtfqditqkslaearerishvssnt---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..--HMQ---E..ALGKDRMNQTQQYSKMVNHIERRMKS...ECAIS.--...RSHAT...NASKT.LSNVLENHCRA.....DG.GH.H.fR.WE.S....SANC...eHaagD.IE...P...lSNR.....H...H....A...N.......GSGFSISCPPk.avAG...YDTE.A---SF..SAMETALRKWNHSKPVPN..........lTNVREC.ND.RGVS....G.....PKGH.TEPCTVLE.AWLRDYEKTRYSIKRLYDITRT-----amgmr.....................................
Q587F0_TRYB2/6-284                 ............................lvfaiittripvllvi---------------.-GSEDNRVPGDKKLTKEGAAALCKMKHLADKVAEKGAEDLK.KK.TQNF.AGF.IEFEQEKVD...NWLEKLRNRKQYSDG.....YAKLSDSDVEKV..KEIFDKAKD..GITKQLPEAEKEAREAERLYDEVKKA...AQDAR.GQ...DLDDD..tAKSTG.LYRVLNWYCIT.....--.KD.N..N.KD.I....THNC...dD...G.IK...F....RDH.....Y...L....S...-.......VNRSAIDCSS....TG...YKED.Y-DWSA..NALQSALNDWENVKPKEV...........KPESGG.ND.VCKK....D.....ESSE.SHPCTMTG.GWQTHYKDSILKLKELEDAHKRGKAAH..........................................
Q587F2_TRYB2/4-282                 ............................yllvfaiiatripvll--------------A.TNGGDKHVKANKKLTKEGAAALCKMKHLADKVAEERSQELK.DR.TQNF.AGY.IEFELYRID...YWLEKLNGPKGRKDG.....YAKLSDSDIEKV..KEIFNKAKD..GIAKQLPEAKKAGEEAEKLHTEVKKA...AKNAR.GV...RLSEG...TNSSG.LYRILDWYCFK.....--.EG.E..N.AG.K....SDNC....D...G.VK...F....SVH.....Y...E....T...H.......RRRNVIDCSS....TG...YEEN.Y-DWSA..NALQVALNSWENVKPKKV...........-ESAGS.DM.NCNI....G.....QSSE.SHPCTMTE.EWQTPYKETVEKLRELEDAYQRGKKAH..........................................
F9WM60_TRYVY/12-286                ...............lllvcppvevcalridmtrhsypldstld---------------.----------KGGLNVSGAAALCRLRALSENV-PNVAAELA.AK.SERW.VGV.AERLWASVS...AEWGRLQLLNVAAHG.....LSSADS-ATARA..HGRVLDAVK..VANRTMSLVRSRATTVIGASVAAEEA...AADAI.DG...---DG...SPFGG.LKNILERHCGS.....-K.RC.K..V.TS.N....RLRC....K...S.C-...-....MTT.....L...V....E...M.......FPTTDIRCDK....LS...APAV.RAAASI..GAMTEALARWDEIRPKFD..........pEYRMFD.VN.NC--....-.....EPTP.EYSCSVLE.DWSPHFFAAVRLLAEAQAALAECA---eav.......................................
Q57XH5_TRYB2/9-266                 ..............................avvliassasvfsh------------VGKaRASETQTNEADDKLSRAAADVLCAMTVLTKNIVNPLADRLV.EL.AAED.TAN.ITRDAELVD...AYVDDIDGMLGK---.....DSDDPDGTKKRI..KELCDGAKT..KIKDMPENATTREASIKEKAVKAKES...GKKTLeGT...EASEG..gNPVVG.LKEVMSSYCRG.....--.--.-..-.--.-....GRKC...eE...G.V-...-....-VS.....S...T....L...D.......PPEGEISCTN....VT...LDEK.E-KWIS..TLMVEAESNWTTSKPKKV...........------.-V.NCST....-.....--AG.EPPCTPLD.QWGTHYNDTKSHV--------------vgivgeldksy...............................
Q57VX0_TRYB2/6-287                 ...........................................r-HSYILASVITAVAF.AAAEKGQRPALKRFNKEGARALCIMYGLAGSM-QSVADGIL.KS.MHDK.IAY.IEEAFVLIK...ARHEEVVQMERE---.....EGETIEDAAKFSraKKELEDALE..VLDWGQRKLKEQHEIIAGASRKAVEH...AKKAV.GD...-----...SESKG.MNKVLTIYCNTtitgaKE.GK.K..S.HN.V....NNNC...dD...G.I-...-....--A.....A...A....A...G.......AGAFRIDCKS....IGg.sDNVT.AANVTY..EAMSNAINAWDGAKPGLAa........vkHTSKQW.NA.SCIS....H.....GYAS.EGPCTVPEeEWTGDYNSSLHELKKLEEATKSVHNAA..........................................
F9W6S5_TRYCI/9-182                 ........................................vgsl----LVAVLLSGGAT.GNAGN--ANGVCRLNENAAGLLCTIAKLVEKAKNITENHDY.KD.IDET.WGY.VALHKDVVD...HRVKNLPDIIETAKA.....KGTLTDKDAEHL..TTLYLDAHN..KNTQQHNKSKTAMDAHNKTHEDAKNS...TALAL.GE...GYVTGn.cNMVSS.LLGILQCYVKG.....EQ.--.-..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..------------------...........------.--.----....-.....----.--------.---------------------------phsnlnve..................................
Q387A5_TRYB2/10-285                ............................................CRALLLTLASWAAAS.GDDDEPSTRLHKSLGSDALQVVCHIKRIADLARKDTPTYIL.NR.IRER.EAS.ALHAVGRVK...HYIDQVNAIIAMRKGt...pDGEKTEPLMTKI..YQLCGEAEA..AANSASSTVGKARAKAETAAGDVMKH...AAEVS.GS...PQDRT...TDGTG.LRQLLDWHCKG.....--.-N.V..R.IP.T....EFEC....V...S.YG...P....SSS.....S...S....D...G.......SSGSTVDCTQ....RR...PDVN.YKTLDS..AKMKAAMEKWVSVKPPAS..........eTVSTGC.RN.----....-.....-YNTnEYLCAELE.KWVPSYRRLTEGMLTLEQALREVSFV-a.........................................
F9WIA9_TRYCI/2-158                 .....................................hkiqfdr---------------.-----------------------------------------.--.----.---.---------...-HAKLMEKLSEETKQ.....KGILTAQEADRL..KSTADEAQK..KNDEVHGKAHEVMKNHTVHHERTKNA...TKKAL.GE...TLIEGn.cRTTAS.LLHVLQCHVKG.....EQ.WK.T..N.VN.I....ETAR....S...G.KN...Y....PKH.....L...K....G...H.......FGKNIDNCKG....IG...RK--.------..------------------...........------.--.----....-.....----.--------.---------------------------kilqwyrrsaqgsigkvdkn......................
F9W8D9_TRYCI/5-275                 ..........................................gl--VFVCLSWLALLSG.VASSSNDNNGVCKLGDEAAAVLCAIAHLVEKAKEVADSYDL.KD.IEET.WGN.VQLHKEVVD...HRVKNLPDIIERAKG.....NGVLTSQDAGKL..EEAYREAHK..KNTEQYEKAQEAKRIYNDAYKTAKDV...TSTAL.GD...GKTRQn.cKSTAS.LLDIIQCHVKG....eQS.QG.S..S.VS.V....SDVC....N...R.KD...Y....KQV.....S...S....V...D.......VASLLTNCEG....IG...KSKK.YCNGTG..AALKEALEKWESQGTN--...........------.-N.----....T.....DSRN.IGNCNVKN.DWEKHAQKAKDHMLTLDQQVQVIHDA-n.........................................
F9WB34_TRYCI/66-318                .................................gtdvsnssgvc---------------.------------KLNGEAASVLCAVAKLLEGAKNTVHKYKE.KY.ARDA.LND.VKWHKQRLD...REKELLDKLLEEAKT.....KQSITSEEVDKI..QSIAHEAET..KTTEESDRANKVMAVYKVHYDHAKKS...TKTAK.GE...ALTPGs.cQQTYS.LLDILQCHVVG....eEV.QG.K..N.IS.V....SEVC....E...E.EA...Y....HKH.....F...S....E...Q.......FWEQLAECNE....-V...KTRK.YCGGLG..DAIQTALEKWKIVSREG-...........------.--.----....-.....ADAG.SPICTVQN.EWESLVEAASDNMLQLD----------hvlgtiyhak................................
F9WL89_TRYVY/26-282                .....................................fharsds------------ADT.TAHQYRLYGADQRLDHDGAFALCLLRNQVWRL-IDQSKTLV.MQ.ARGH.FSA.SDHSFAVVR...DAAKRLRELHGLK-K.....LSRGQVETIEKV..QKRVDDLLR..SSESIFKHTKQEADAAVASGAEVQRL...ATVAL.GS...SGHTY...KESSG.IRRVLEWHCRG.....--.--.-..N.SG.P....SANC....K...P.S-...-....--A.....Y...-....-...R.......GSSFAIDCRN....--...--LP.ELPSNF..KIMQHVMALWEKVKRRPA...........-VQDGK.AP.MCAP....E.....GRSA.GETCTVLE.DWAVDYNSSMANLGKLEAAVETG----etn.......................................
F9WJ81_TRYCI/5-276                 .........................................glv---FVCLSWLALLSC.VASSSSDNNGVCMLQGDAAAVLCAIAHLVEKARSIAHNYDL.KG.AEDA.LDY.VKLHKDQLD...HRKTRLEELLEEAKT.....KGTLTPEQADKL..KGAAGEAQK..KNDEEHKRATEVMANYTAHHDKTKNV...TTTAR.GE...TLTRQv.cLSTAS.LIDILQCHVQG.....KI.PDrS..E.GN.I....ETIC....R...D.KG...Y....EKH.....I...S....E...P.......LKNNLESCKG....IG...GSKK.YCNGTG..AALKEALEKWGR------...........----QG.NN.--NG....G.....DSRN.IGNCKVKN.HWEKHAHEAKDHMLTLDHILETVHSA-k.........................................
F9WRS9_TRYVY/26-284                ..............................tnlarqsypldrye---------------.----------QGGLDKEGAAAICRLHALSEGV-PSAADELV.RK.SERW.VGM.AERLWTSVG...VEWGRLQLVSMKVHG.....-LDSFTDAVARA..EVKMTEAVH..TANSTMEQVRRHNATVFEAVALAEEE...AISAIdGD...----G...SPFGG.LFNILERHCGS.....ER.CK.T..SkQA.R....CQNC....V...K.P-...-....LME.....-...-....M...-.......FPTTGIKCEQ....LG...VPVA.RTAASV..SAMTEALARWDKVRPKFA...........--EDYI.AL.HERG....C.....EPTT.EYSCTVLE.DWAVHFYTATKKLSEAEEALVG-----carav.....................................
F9WV18_TRYVY/1-252                 ......................................dsadtt---------------.-AHQYRLYGADQRLDHDGAFALCLLRNQVWRL-IDQSKTLV.MQ.ARGH.FSA.SDHSFAVVR...DAAKRLRELHGLK-K.....LSRGQVETIEKV..QKRVDDLLR..SSESIFKHTKQEADAAVASGAEVQRL...ATVAL.GS...SGHTY...KESSG.IRRVLEWHCRG.....--.--.-..N.SG.P....SANC....K...P.S-...-....--A.....Y...-....-...R.......GSSFAIDCRN....--...--LP.ELPSNF..KIMQHVMALWEKVKRRPA...........-VQDGK.AP.MCAP....E.....GRSA.GETCTVLE.DWAVDYNSSMANLGKLEAAVETG----etn.......................................
F9W4F8_TRYCI/5-253                 ......................icvcwlmvlfpgvtsggdvgac---------------.------------ELSDEAARVLCTLADLLRASKHTAENYVQ.HY.LEEP.FEE.VKLHKIIID...QNSELLEELLAKAVN.....EGKYTEKDADEL..ESNAEGVQQ..VNDWGYWKAKEAVETGREYQDWAVKA...ANEAL.GE...EDSSEd.cSLIAS.LVQLIRCHVSG.....--.GK.A..G.HT.T....TVFV....K...E.VG...Q....GAN.....Y...TqrldN...R.......TREVLAHCNE....TG...GDKE.YCSGVG..TALKAALDRWRELKEDEE...........EEDR--.-G.GCPD....-.....----.--------.---------------------------htvweshahets..............................
F9W681_TRYCI/23-290                ..........................................gf--SCVVSLWVVVLVS.GRASGNNGDGVCKLNENAAGLLCAIAKLMEKAHQITETHDY.KD.IDGT.WGN.VELHKDQVE...ARTKTLQTEIEAAKH.....KGTLTDEDGKRL..TNVSLDAQD..KTLEEHKKAENAIKAHNGTHSDAKSS...TSKAL.GG...TRVEGn.cHSTAS.LLGIIQCYVKG.....ET.PQ.G..D.VK.I....ETLC....N...G.KD...Y....QRH.....L...S....E...H.......FGESIANCNG....IG...KRKT.YCNGTG..SALKAVLKRWNTTDKTKA...........------.--.----....-.....--DS.GGTCAVKG.DWEKHALNASDQMHQLDKNVQTIHEA-n.........................................
F9W4B5_TRYCI/10-272                .........................................gsl----LVAVLLSGGAT.GNAGN--SNGVCRLNENAAGLLCTIAKLVEKAKNITENHDY.KD.IDET.WGY.VALHKEVVD...HRVKNLPDIIETAKA.....KGTLTVKDAEHL..TTLYLDAHN..KNTQQHNKSKAAMDAHNKTHEDAKNS...TALAL.GE...GYVTGn.cNMVSS.LLGILQCYVKG.....EQ.PH.S..N.LN.V....ETLC....K...E.K-...-....NYN.....L...D....E...S.......QHTLLTNCNK....IG...NRKT.YCNGTG..AALKVALDKWNGMDKKKA...........------.--.----....-.....--AD.NGNCEVKK.DWEERTKKAQEHMSRLDEHVQIIHDA-k.........................................
F9WKI8_TRYVY/26-273                ............................vsfrkdmlqvnrgeen---------------.------------GLGVAGAAALCRLHALSEGV-PNVVDRLT.DE.NEKW.LGV.SERLWGSAM...SEVAQLELLRLKTHG.....LSNLTD-VMSRT..TAAVTLAVN..LANQSRRSMLERYDAVKNATVTAEEM...SEEAIlGG...----E...SPYGG.LRNILLRYCGR.....--.--.-..-.PG.Q....SYEC...eA...E.L-...-....REE.....L...V....-...-.......--NGAIVCEK....LN...VSSS.A-NTTV..SAMVEALAEFNEHKTAIY...........PYDSQL.NE.KCEP....-.....--SP.EVICSVAE.DWVGPFYLAAQALGEVESA--------flwnsr....................................
Q57VX3_TRYB2/74-280                ....................................qswkylkt---------------.-----------------------------------------.--.----.---.---------...---------------.....-----------V..QEIFQKVSE..HDDMKAALGEKKLQEMHNVMAISATTgtyVGEAW.GK...AKRAA..aNSSKV.LKELLKWHCINk..eaIR.DS.F..D.HM.A....NANCd..pS...A.YK...H....DYH.....RnfgH....D...D.......ARAYVIYCEY....KS...IPAA.KTDVTF..SNMEGAVEAWNRAKPKAD..........aRDAVEC.SSgHSSR....S.....ASSS.DKPCTLLE.SWRWDYDLAAHCIEKLERYTRN-----alqtvhyaq.................................
F9WIG2_TRYCI/13-282                .........................wvmvmvvvaggtaggtgtg---------------.-------SNGECQLNENAAGLLCAIAKLVEKAKNITHNHDY.KN.VHGT.WDY.VALHKEQVD...YRVDKLPGLIEEAKA.....KKTLTAKEAEDL..TPLYLDAHN..KNTQQHNKSKAAIEAHNRTHAEAKNS...TAWAL.GE...GYVTGn.cNMVSS.LLGILQCYVKG.....SQ.PE.G..N.PN.V....ETLC....K...E.KS...Y....RLD.....E...S....H...-.......-NTLLTNCNK....IG...KGKT.YCNGTG..AALKAALDKWNGMDKRKK...........DT----.--.--SS....G.....SGSS.NENCEVKT.GWEERVRKAQEHMSLLDEHVQTIHDA-k.........................................
F9WI71_TRYCI/14-278                ..........................thliiatfvalnlgaand---------------.---------NDCSLQHKAVEVLCNLAASVRRT-EEIFEKLQ.NE.DEKKlLGE.LMIYKEQLK...DKVWEVNEMLRS-KG.....LYHINEEERKRL..EKICNEAEE..RGEEQYKLAKRVTTLFSNISKEIRGA...ALEAL.GE...KFHIIt.cVNAKG.LISILDCAVNGn...kPR.PG.G..T.SN.L....ENIC....K...N.HK...I....LSM.....L...T....S...E.......TTARRDLCQQ....IG...NQNF.CLPDTA..EEIKSALMDWDKMKEDGV...........------.--.----....-.....----.--------.---------------------------yikrgvacvlneswrpileavvtkinnlrdmrnvlmnat...
F9WI69_TRYCI/1-59                  ...........................................m---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..--------------------------...-----.--...-----...-----.-----------.....--.--.-..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..--------EWNVVKPMPK...........----EN.GK.ICQD....T.....DDHT.NHSCTVWE.GWVADYKKTTDLMKKLGGAERRARRA-r.........................................
K0RBK1_THAOC/155-359               ................................cvttiddcirdn---------------.-------SQQMKKISLEAAKLIAAMDDIRRET-ETQADSLQ.DN.LDQV.QSS.LEGKMSYAEcesKIKVHVRRLVDQIKGkspplYAEEDEADF---..-KNVANALH..AMFNSLKESKADKSEVAHLRSQVISS...QLNTE.GP...SRREG..sLDYKG.LRKVLGSYCRN.....DS.LD.S..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..------------------...........------.--.----....-.....----.--------.---------------------------rldtkapkdmtdkrlshaehmldkimqtvddiwsairtrpps
F9WJ79_TRYCI/43-304                ......................ttcflfalaaaapitasggagy---------------.-------NGDACKLQNEGINALCYLARLVSRS-YEVSEELL.KQ.TGDA.VRSdINLYGEQIQ...HRLSGVRASLEAPNE.....KHTLTDGDVRKI..KDMCEGLEA..NNKKQRDRLRGALETYHETARQAKRE...SDFLL.GK...QVENKq.cDQTDE.LLVVIN--CGKt..ggEA.GI.S..R.LS.L....ETLC...aD...S.AV...P....EGV.....K...E....V...-.......AHHDTRNCPM....VG...RYRH.CHGSMG..AEIEGAMTKWKSIKSSAC...........QHSDKW.EA.RA--....-.....----.--------.---------------------------knltsimkslddltntitna......................
Q57VX8_TRYB2/80-279                ......................kvareifqkvsehddmraalgq---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..KMLDQMRGVQRVANRTKRSVEEAWEK...AKRAA.AN...-----...-SSKV.LKELLKWHCINk..eaIR.DS.F..D.HM.A....NANCd..pS...A.YK...H....DYH.....RnfgH....D...D.......ARAYVIYCEY....KS...IPAA.KTDVTF..SNMEGAVEAWNRAKPKAD..........aRDAVEC.SSgHSSR....S.....ASSS.DKPCTLLE.SWRWDYDAARYAILKLETLVR------nslgvthya.................................
F9W3Q3_TRYCI/2-217                 ........rallegvsarvdtfqditqkslaearerishvssnt---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..--HMQ---E..ALGKDRMNQTQQYSKMVNHIERRMKS...ECAIS.--...RSHAT...NASKT.LSDVLENHCRA.....DG.GH.H.fR.WE.S....SANC...dR...A.AGdieP...lSNR.....H...H....A...N.......GSGFSISCPPk.avAG...YDTE.A---SF..SAMETALRRWNHSKPAPN..........lTNVREC.ND.RGVS....G.....PRRH.TEPCTVLE.AWLRDYEKTRYSIKRLYDITRT-----amgmr.....................................
F9WH52_TRYCI/7-175                 .........................vgmvslmalipgsmsradv---------------.---------SASKLSEEATVFLCGIKNLLEDVRDGSSKHFA.ER.TERA.YGD.VTTYREQVD...KEVYAIKRLLEEAEA.....KKKFKEEDVGTL..KNAAEEIKR..NNDREYERATKLMHNFREQREKAMEA...TRRAL.EK...LQEKAm.gKSSQG.ARLTLVDVCNG.....--.--.-..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..------------------...........------.--.----....-.....----.--------.---------------------------rkhpiatg..................................
F9WCN5_TRYCI/6-287                 ...................................vipmaplla----------ATVTF.VVAENDQEPADGKLNPDATKALCTLHALATSL-EAESDRLM.AN.MRDD.MRY.IENTFASAK...AKQEGFGDIVEKM--.....--QLDKTGEMAT..KGEFAETLA..AIAKARDLAKKQLSVAANVSRVAVRH...AKEAI.GK...-----...ANGTG.LNAVMLTYCNTtkpsgRS.SR.W..F.KV.T....NGTC...gG...G.L-...-....--V.....V...P....L...N.......GSIYRIDCAG....AAk.pDASA.VGSVTY..QTMMLALRAWEAHKPKPKsma....sdwkSTARRE.QK.GCSK....D.....GYSS.EVACTASEkGWVGHYNSSAKELRKLEGASHAMQAAA..........................................
Q587F4_TRYB2/4-282                 ...............................yllvfaiiatris-----------VLLA.TNGGDKHVKANKKLTKEGAAALCKMKHLADKVAEERSQELK.DR.TQNF.AGY.IEFELYRID...YWLEKLNGPKGRKDG.....YAKLSDSDIEKV..KEIFNKAKD..GITKQLPEAKKAGEEAEKLHTEVKKA...AKNAR.GV...RLSEG...TNSSG.LYRILDWYCFK.....--.EG.E..N.AG.K....SDNC....D...G.VK...F....SVH.....Y...E....T...H.......RRRNVIDCSS....TG...YEEN.Y-DWSA..NALQVALNSWENVKPKKL...........-ESAGS.DM.NCNI....G.....QSSE.SHPCTMTE.EWQTPYKETVEKLRELEDAYQRGKKAH..........................................
F9WG73_TRYCI/3-275                 ..........................................gl--ICVVPLWITLIVS.KEASGNNGDGVCKLNENAAGLLCAIAKLVEKARNITHNYDY.RD.IDGT.WGN.VELHKVQVD...YRVDKLPSITEEAIK.....KGTLTEKDSEEL..KKTYLDAHK..KNNEQHSKSKAAMDTHNKTHEAAKNS...TSKAL.GE...VHIQGn.cLSTVS.LLGILQCHVKG.....EQ.RQ.G..D.VN.I....ETLC....N...G.MN...Y....QKH.....L...T....E...H.......FGNNIADCNR....IG...KGKT.YCNGTG..AALRAALDKWNTTDRKKA...........-VTS--.--.----....-.....SGTT.SETCTVKS.DWEEHARNAKEHMLKLDEHVQTIHDA-n.........................................
F9W783_TRYCI/50-291                .................................hatnpptinst---------------.-------VAAGAQLNGPAAKALCTMKDLAEQVAHRGVAVFT.EE.AARD.KAV.AAKDAESVS...HYVENLRSLLQG--A.....PNSMDDFDRTAL..ETSIEEAAK..QTTDHLSNIDKQTEKVLVNVNKAEES...AAKAV.GS...AGNGT..aGSATG.IQKVLAEFCSD.....--.--.-..-.--.-....VNRC....R...G.V-...-....--K.....A...E....D...E.......GAGKAIVCEA....--...DSSE.DGKWIS..EQMQETLSAWRRVKPGPD...........------.DA.DCG-....-.....--AT.GGWCRDWA.KWQEDYIDTTEIMIDVV----------rsldnsyr..................................
F9W8E1_TRYCI/5-276                 ..........................................gl--VFVCLSWLALLSG.VASSNNDNNGVCKLGDEAAAVLCAIAHLVEKARGIAHNYDH.KG.AADA.LDY.VKLHKEQLD...YRKTRLEELLEEAKT.....KGTLTPEQADKL..KGAAGEAQK..KNDEEHKRATEVMANYTAHHNKTKNV...TITAR.GE...TLTRQv.cLHTAS.LIDILQCHVQG.....KI.PDrS..E.EK.I....ETIC....R...D.KG...Y....EKH.....I...S....E...P.......FKNNLESCKG....IG...GSKK.YCNGTG..AALKEVLEKWGGKG----...........------.NN.--NG....G.....DSRN.IGDCKVKK.DWEKHAHEAKDHMLTLDHILETVHSA-k.........................................
F9W689_TRYCI/93-269                .......gsitadqrevkikeltayvnyggrtameataasrrar---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..--------------------------...-----.--...-----...---RL.LVRVIKWHCVKm..drKE.NI.H..R.FI.G....NANCd..pD...V.YE...H....ENE.....H...HvdqdT...D.......MSNSFTICQK....DA...SPEG.SLKVSF..DTMTSALTHWNIVKPRPD..........mARIREC.KE.INKP....N.....TPIHdEMPCTVLE.NWLQAYNKSTHALKTLSD---------ladksasl..................................
F9WR01_TRYVY/29-284                ................................arqsypldsyeq---------------.-----------GGLDKEGAAAICRLHALSEGV-PSAADELV.RK.SERW.VGM.AERLWTSVG...VEWGRLQLVSMKVHG.....-LDSFTDAVARA..EVKMTEAVH..TANSTMEQVRRHNATVFEAVALAEEE...AISAIdGD...----G...SPFGG.LFNILERHCGS.....ER.CK.T..SkQA.R....CQNC....V...K.P-...-....LME.....-...-....M...-.......FPTTGIKCEQ....LG...VPVA.RTAASV..SAMTEALARWDKVRPKFA...........--EDYI.AL.HERG....C.....EPSP.EYSCTVLE.DWAVHFYTATKKLSEAEEALVG-----carav.....................................
Q57VX5_TRYB2/69-274                .................esealsqlskaktvlsnvtisdnirts---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..--LTKKKQE..EILMTRELVEAVRKHIEAAYKRTKEA...ALDAS.--...-----...---RL.LSDILKWHCIDv...eKM.RG.SpyN.YS.T....GANC....D...P.DA...F....SRErfhyyH...V....N...D.......RRNNSILCDY....KV...IRSG.DTVASF..ETMGRALDKWNFVKPKPNl.........tRLSECW.NG.QWRD....E.....ATET.LVPCMLRE.SWLEDYNASRYSMRRLYDLTHV-----avrir.....................................
F9WH53_TRYCI/37-199                .........................vslmalipgsmsradvsac---------------.------------ELSEEATVFLCGIKNLLEDVRDGSSKHFA.ER.TEKA.YGD.VTTYREQVD...KEVYALKRLLEEAEA.....KKKFKEEDVRTL..KNATEEIKR..NNDREYERATKLMHSFREQREKAMEA...TRRAL.EK...LQEKVm.gKSSQG.ASVTLVDVCKG.....--.--.-..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..------------------...........------.--.----....-.....----.--------.---------------------------rkhpi.....................................
Q57VF1_TRYB2/10-276                ............................................GFVLLVCYSGKLA--.ESSSDAQHVADGKLSRDGANALCALKETVQKIGTEGADNLV.KK.AEDN.VTH.LKDYRKRVG...YFGSQVISLSGR--G.....DPDSDDDAKKEL..KEFCEEAEN..ETRDDLRDAKELYTEIEKDAKKSKEA...AKATL.GE...EAKG-...TDSKG.LSGVLHRHCGE.....-S.QG.K..N.KA.P....SQHC...dT...D.V-...-....-YN.....N...E....S...D.......GGKYTISCGT....--...DNTH.HRGSPS..ARLHKAFDEWESKKPKKA...........----GG.NL.KCGA....A.....AENS.SSPCTVSE.GWKENYEELNVSLSTLEENGHHIENAT..........................................
F9WM06_TRYVY/36-275                .....................................ndgnygg---------------.-------------MGVAGAAALCRLHALSEGV-PNVVDRLT.DE.NEIW.LGV.SERLWGSAM...SEVAQLELLRLKTHG.....LSNLT-DVMSRT..TAAVTLAVN..LANQSRRSMLERYDAVRNATVTAEEM...SEEAIlGG...----E...SPYGG.LRNILLRYCGR.....--.--.-..-.PG.Q....SYEC...eA...E.L-...-....RKE.....L...V....-...-.......--NGAIVCEK....LN...VSSS.A-NTTV..SAMVEALAEFNEHKTAIY...........PDDSQL.NE.KCEP....-.....--SP.EVICSVAE.DWVGPFYLAAQALGEVESA--------flwnsrda..................................
F9WH73_TRYCI/1-217                 .......mrtllegvsarvdtfqditqkslaearerishvssnt---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..--HMQEALG.kDRMNQTQQYSKMVDHIERRM----KS...ECAI-.-S...RSHAT...NASKT.LSNVLENHCRA.....DG.GH.H.fR.WE.S....SANC...dR...A.AGdieP...lSNR.....H...H....A...N.......GSGFSISCPPk.avAG...YDTE.P---SF..SAMETALRRWNHSKPVPN..........lTNVLEC.ND.RGVS....G.....SSRH.TEPCTVLE.AWLRDYEKTRYSIKRLYDITRT-----amgmr.....................................
F9WE82_TRYCI/1-116                 ............................................---------------.------------------------MKYLLEKVEGSGVTEIW.NS.TKRR.YQE.VLMNKKHVD...RSVEEIRLLLEENKT.....NKRYERGKAENL..INTAIQAQQ..YNDREYEEANQTMSQLEDQQKTARMA...AKEAL.EK...-LYDS...EKSGG.LY---------.....--.--.-..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..------------------...........------.--.----....-.....----.--------.---------------------------w.........................................
Q57VX6_TRYB2/103-276               ........................qhqqmqymktrlddiaylmn---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..--------------------------...--ATE.GR...AKKAA..aNASAA.LDEVLKWHCVDrt.esRE.SS.Y..S.ST.P....NANCe..pN...A.YK...R....DYY.....Y...E....HsrlD.......PHKYSILCNY....KV...VSST.TTQTTF..SNMERALEIWNQVKPKPY..........hMRVMIC.GA.GAPV....H.....QAAPpGRPCTVLE.NWMRSYEVATHLIARLHR---------dldvalfv..................................
F9W3Q7_TRYCI/221-385               .................veglikevgvdrkingtlkalstslel---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..--------------------------...-----.--...-----...-----.LRKILRWHCVGs..kkQQ.GG.K..G.VV.P....NANCe..kS...A.YK...R....DYR.....HrphK....H...D.......PLEFSILCNY....--...KKIP.HSDVEAtpEAMEAALKRWNESKPRSI...........---EKK.TD.ICQM....GpsgvvGSSG.GKTCAVSE.GWLPGYEKTMETIKKLEDLHEKVVTA-t.........................................
Q57VC2_TRYB2/19-258                .......................................vvans---------------.----------NAKLTKDGALALCKLTDVADLVATKKADKIR.KD.TEGF.ADE.LKLWLDRLE...HWLQTLETRAHSNNG.....YSKLSDADTKKV..KEIYEKAKG..KVSEQLPKAKEFGEEAGKRHQEVTEA...AKRAR.GW...GLDDE..gQNSSG.LHQLLEWYCGT.....--.-K.G..D.NA.N....NQKC....D...G.VK...V....KEH.....Y...L....G...-.......RERNPIDCKG....TG...STVPfYLDVTS..GTMKEALENWERKKPKSD...........-----G.EP.----....-.....----.-----VNN.NWKADYDSATNKLKELEESHEKGKK--tv........................................
F9WFT4_TRYCI/10-172                ..................mmvwvmvmvvvaegttggtgtgsngv---------------.-----------CQLNENAAGLLCAIAKLVEKAKNITERHEE.KD.VKDA.LGD.VALHKEQLG...RHKELLEENLEEARQ.....KGTLTAQQAQQL..SPTAAEAQN..KNKEVHDQAHEVMKNHTAHHDRTKNA...TKMAL.GE...TLIQA...-----.-----------.....--.--.-..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..------------------...........------.--.----....-.....----.--------.---------------------------ncgttasfmtvlkch...........................
F9W8E0_TRYCI/5-249                 ..........................................gl--VFVCLSWLALLSG.VASSSNDNNGVCKLGDEAAAVLCAIAHLVEKAKEVAHNYDH.KG.AEDA.LGY.VKLHKEQLD...HRKTRLEELLEEAKT.....KGTLTPEQADKL..KGAAGEAQK..KNDEEHKRATEVMANYTAHHDKTKNV...TITAR.GE...TLTRQs.cLSTAS.LIDVLQCHVQG.....KIpDG.N..K.EI.I....ETIC....R...G.KG...Y....EKH.....I...S....E...P.......LKNNLEGCKG....IG...GSKK.YCNGTG..AALKEVLEKWGKVE-KAA...........----GG.NQ.-CD-....-.....----.--------.---------------------------vkkdweky..................................
F9W651_TRYCI/10-272                .........................................gsl----LVAVLLSGGAT.GNAGN--SNGVCRLNENAAGLLCTIAKLVEKAKNITENHDY.KD.IDET.WGY.VALHKEVVD...HRVKNLPDIIETAKA.....KGTLTDKDAEHL..TTLYLDAHN..KNTQQHNKSKAAMDAHNKTHEDAKNS...TALAL.GE...GYVTGn.cNMVSS.LLGILQCYVKG.....EQ.PH.S..N.LN.V....ETIC....K...E.K-...-....NYN.....L...D....E...S.......QNTLLTNCNK....IG...NHKT.YCNGTG..AALKVALEKWNGMDKKKA...........------.--.----....-.....--AE.NGNCEVKK.DWEERTKKAQEHMSRLDEHVQIIHDA-k.........................................
F9WLX4_TRYVY/31-284                ...................................rsypldryh---------------.----------EGGLDKEGAAAICRLHALSEGV-PSAADELV.RR.SERW.VGI.AERLWTSIG...VEWGRLQLVSMKV-H.....GFDSFADAVARA..EAKLTEAVR..IANSTMEQVRRHNATVFEAIALAEEE...AIDAI.DG...---DG...SPFGG.LSNILERHCGN.....ER.CK.T..S.KKmR....CQNC....M...V.P-...L....VEM.....F...-....-...-.......-LTTGIKCKQ....LG...VPTV.RTAASV..SAMTEALARWDEVRPKFT...........---EGY.NN.LREH....N.....CEPTpEYSCSVLE.DWAVHFYVATKKFSEAEEALIDCAR--av........................................
F9W4F9_TRYCI/5-254                 ......................icvcwlmvlfpgvtsggdvgac---------------.------------ELSDETARVLCTLADLLRAS-KHTADNYV.QHyLEEP.FEE.VKLHKIIID...QNSELLEELLAKAVN.....EGKYTEKDADEL..ESNAEGVQQ..VNDWGYWKAKEAVETGREYQDWAVKA...ANEAL.GE...EDSSEd.cSLIAS.LVQLIRCHVSG.....--.GK.A..G.HT.T....TVFV....K...E.VG...Q....GAN.....Y...TqrldN...R.......TREVLAHCNE....TG...GDKE.YCSGVG..TALKAALDRWRELKEDEE...........EEDRG-.--.GCPD....-.....----.--------.---------------------------htvweshahetsl.............................
F9WHN7_TRYCI/8-279                 .......................................gllsi-----TVLISGSAST.TREDGNNGDSACKLNENATGLLCTIAKLVERARQFTANHEE.KE.GRDA.LAD.VEMYKEKLD...YHSKLLEGLLEEAKQ.....KGTLTEQDVNRL..KSTADEAKR..KNNDVHGKAHEVMKNYTHHHNRAKKS...TKNAK.GD...TLIKGn.cHSTAS.LLYVLQCHIEG.....KE.HD.H.nE.KN.I....DTIC....K...G.RD...Y....SEH.....L...T....E...H.......LGKLNDDCGG....-S...KGKR.YCSGTG..TALKEALEKWDGMGTNDT...........------.--.---T....T.....GKRK.AGNCTISS.AWEKHALNARDHILELDHILETVHNA-s.........................................
F9WHA3_TRYCI/11-283                .......................mvwvmvmvvvaggttggtgtg---------------.-------SNGECKLHDEAAGLLCAMAKLVEKAKNITHNHDY.KD.VKDA.WSN.IQYNKDVVD...HRVNHLPDIVEEAKN.....KGTLTEKDAEKL..KKAYTEVHE..KNKEQHDKAAKSNEAHNNTHRDAKSS...ISKAL.GD...TLARS..nCRSTGsLLDILQCHVKG....tES.QG.A..N.AS.L....SEIC....K...D.A-...-....KHN.....E...D....P...G.......VSQLLTTCLK....IS...KSKT.YCNGTG..AALKVTMEKWKTADKRKK...........DT----.--.--SS....G.....SGSS.RETCNVTD.EWEKYVLNASTHMSLLDEHVQTIHDA-n.........................................
F9WEZ5_TRYCI/6-276                 ......................lcallslllshpnevpavnans---------------.----------VKPLSDEALNVVCALKGYTDFVRGHTASHLL.ST.TKEH.EAS.AAHALAKVR...QYSSDINAMLTLRGTet.daSNSTERGKVAVA..LRICNEAER..LVSQENANAAQAREKAERAAKNAATS...ATKAA.GA...PNGG-...-GSTG.LQQLLDRQCGD.....--.--.-..E.FR.G....SKSC....E...C.VR...R....HDG.....G...S....L...P.......DGVGAVDCTH....DG...PKAA.YKRVTS..AKMAATMEKWESLKPSSA...........---ESK.RS.GCR-....G.....VDTT.KYLCAELE.GWVPSFRECLSQMTLLERALEEAEAA-k.........................................
F9WDT6_TRYCI/7-172                 .........................vgmvslmalipgsmsradv---------------.---------SASKLSEEATVFLCGIKNSLEDVRDGSSKHFA.ER.TEKA.YGD.VTTYREQVD...KEVYALKRLLEEAEA.....KKKFKEEDVRTL..KNAAEEIKR..SNDREYERATKLMHNFREQREKAMEA...TRRAL.EK...LQEKAm.gKSSQG.ASLTLVDVCKG.....--.--.-..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..------------------...........------.--.----....-.....----.--------.---------------------------rkhpi.....................................
Q57VX2_TRYB2/11-281                ...........................................s-LQLLVPFWFTLVSF.ASAEN-QQPADGHFDANSAKILCSLYTLANTV-GEGEKNIV.NH.TKHK.ITY.IDNATDLIK...KEREGLEKLSDG---.....KGSKDLAAVEKA..KKELDEALA..VVGSAKTEVEKQLGVIQSGISKVKEP...ARKAV.GE...-----...SEDTG.IRKVLRSYCQTis.kkPS.NA.H..S.DN.E....NNNC....R...G.V-...-....-ST.....K...S....V...G.......EGIYEIECRG....--...---Q.PKGLDH..LGMGAAMEKWNDVKPKPSs........ptHRNEYA.ET.ACRM....D.....GYFT.STACTVDEsGWIEHYKKAIDAMKPVVDACQAVQNAV..........................................
F9WMH4_TRYVY/78-234                ...............lfshalceaadekvdlklrryvisnvsae---------------.------------GLTEKGAATLCRLHALTTNV-PSATKRLL.EE.TAYW.LET.AKNLQHNLT...LEERRLKSARNR---.....AGELPTEELKHA..ESKLENAKK..LASAAVTLIREKESTVREAAEIAVAN...ASSAR.GE...--NTT...VRSAG.LHGALATH---.....--.--.-..-.--.-....----....-...-.--...-....---.....-...-....-...-.......----------....--...----.------..------------------...........------.--.----....-.....----.--------.---------------------------..........................................
F9WCS1_TRYCI/67-318                ..................................tdvsnssgvc---------------.------------KLNGEAAAVLCAVAKLVEGAKNTVHKYKE.KY.ARDA.LND.VKWHKQQLD...REKELLDKLLEEAKT.....KQSITSEEVDKI..QSIAHEAET..KTTEESDRANKVMTVYKVHYDHAKKS...TKTAK.GE...ALTTGs.cQQPYS.LLDILQCHVVG....eEV.QG.K..N.IS.V....SEVC....E...E.EA...Y....HKH.....F...S....E...Q.......FWEQLAECNE....-V...KTRK.YCGGLG..DAIQTALEKWKIVSREGA...........------.--.----....-.....-DSG.SPICTVQN.EWESLVEAASDNMLQLD----------hvlgtiyhak................................
F9WVN7_TRYVY/35-285                .....................................sgsqtyg---------------.-------------LNFSGAAALCQLYGLSREI-PDVLSELA.EK.SDRW.VTV.AERLWTRAV...VEWGRLQVLSVKVHG.....AGSLAGAAG-RA..ESQVLEAVR..VANSTLELARRSNAVISDAVAAAEDA...ARNAIeGD...----G...SPYGG.LQNILERHCGN.....ER.CK.T..N.SV.V....GARC...rN...C.V-...-....-EG.....L...R....D...M.......FKHSGILCGE....LV...PRAV.PHDASV..SGMVEALARWDAVGPQFD..........eDCRYLS.DD.RCEP....T.....A---.EFSCSVLE.DWSPHFFSATRKAAEAAEAL-------agcasav...................................
Q587F5_TRYB2/5-282                 ...........................llvfaiiatripallvi---------------.-GSEDNRVPGDKKLTKEGAAALCKMKHLADKVAEERSQELK.DR.TQNF.AGY.IEFELYRID...YWLEKLNGPKGRKDG.....YAKLSDSDIEKV..KEIFNKAKD..GIAKQLPEAKKAGEEAEKLHTEVKKA...AANAR.GQ...DLDEY..rQKSTG.LYRVLNWYCIT.....--.KE.E..R.HN.A....TPNC....D...G.IQ...F....RKH.....Y...L....S...-.......VNRSAIDCSS....TG...YEEN.Y-DWSA..NALQVALNSWENVKPKKL...........-ESAGS.DM.NCNI....G.....QSSE.SHPCTMTE.EWQTPYKETVEKLRELEDAYQRGKKAH..........................................
Q57VX7_TRYB2/121-276               ........................................mggt---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..--------------------------...-----.GE...RAKAAa.aNASAA.LDQVLTWHCVDrt.asHD.VL.P..G.YG.R....NENCl..pN...A.YK...R....DYY.....Y...E....HsrlD.......PHKYSILCNY....KV...VDSV.ITQTTF..SNMERALEIWNQVKPKPY...........---SAR.VM.ICGAgapaH.....QAAPaGRPCTVLE.NWLWNYRVTAHLISKVEKD--------atlalrv...................................
Q587F1_TRYB2/4-282                 ............................yllvfaiiatripvll--------------A.TNGGDKHVKANKKLTKEGAAALCKMKHLADKVAEERSQELK.DR.TQIF.AGY.IEFELYRID...YWLEKLNGPKGRKDG.....YAKLSDSDIEKV..KEIFNKAKD..GIAKQLPEAKKAGEEAEKLHTEVKKA...AANAR.GV...RLSEG...TNSSG.LYRILDWYCFK.....--.EG.E..N.AG.K....SDNC....D...G.VK...F....SVH.....Y...E....T...H.......RRRNVIDCSS....TG...YEEN.Y-DWSA..NALQVALNSWENVKPKKL...........-ESAGS.DM.NCNI....G.....QSSE.SHPCTMTE.EWQTPYKETVEKLRELEDAYQRGKKAH..........................................
F9WK68_TRYCI/8-290                 ......................................tiltar-------LVVSIVLF.VVAERDQEPANGRLHLDGARALCAMYDLVDSV-GKVTHKVM.EG.MEKN.DKF.IRNVSSVME...AKREEFQELLRKV--.....-HLNNETEENET..TKEFAEALA..AIAKARDLAKKQLSVATNVSRVAVRH...AKEAI.GK...-----...ANGTG.LNAVMLTYCNTtkpsgRS.SR.W..F.KV.T....NGNC....D...G.G-...-....-LV.....V...P....L...N.......GSIYRIDCAG....AAk.pDASA.VGSVTY..QTMMLALRAWDAHKPKPKsma....sdwkSTARRE.QK.GCSK....D.....GYSS.EVACTASEkGWVGHYNSSAKELRKLEGASHAMQAAA..........................................
Q57VC4_TRYB2/2-257                 ........................ircslvavtfaglllravea---------------.--------NGETKLNKEGALALCKLTDLAKTIEKRRADKIR.EK.TQGF.ADD.IQLWLDRLE...HWLQTLENRAHSNDG.....YSKLSDADTKKV..KDIYEKAKD..KLKNKLPTAKMYGEEAKKRCQAATEA...AKKAR.GW...ELDYD..gQNSSG.LHQLLEWYCGK.....--.-K.G..D.NA.Q....TTSC....E...G.IT...F....KTH.....Y...S....G...-.......TGRNTIDCEA....TG..hKTTL.YDDISS..GTMKQALEEWENKKPKGQ...........------.QP.----....-.....----.-----VTN.NWKADYDSATNKLKELEESHEQGKK--th........................................
Q585R8_TRYB2/78-250                ......................................qlskmv---------------.-----------------------------------------.--.----.---.---------...---------------.....------------..---------..-------------EGNKSLGRRAMEL...AEEVK.SE...---AA...KSARG.LSTVLSTHCRN.....PD.EN.H..H.LP.F....SQNC...dR...S.V-...S....PIE.....P...P....D...H.......KLKEEITCDA....TVe.sGANS.TRGPSS..RDMNNLVRMWDEVKPTASkgadgnsyrskQSYEAA.AS.KCKI....D.....GYST.-MPCTVSEkHWRSSFVAATLKLRELEV---------vveeatgq..................................
Q57VE9_TRYB2/10-286                ............................................GFVLLVCCSGGFADE.ESYGKSHYKAERKLDVAAGRALCAMTDYSTKVSGESADYFV.EE.SDRL.AAL.LADDKKRVS...YYLEYIGPRLDE---.....KSNSYATVAAKL..REQCEAAQK..DIDQGEATAQEVAEKIKGSIDGAKGA...AAQAL.GE...DEIED..hNKATG.LLKVLNWHCGGd...iKR.GL.K..L.SP.Y....SHNC....Y...V.IG...R....RRD.....Y...S....D...-.......GARNVIHCDG....LR...KSTP.YQNVTG..TKMKLALDKWDKHKPKAK...........----SG.KP.PCED....K.....SKYSgPDICTAWE.GWLGDYKRAMTKTHAIVTELRKAQRAV..........................................
#=GC seq_cons                      .........................................hst............................tLstpusthLCthttlscts...htp..h.cp.hpph.hs..hph.ht.lp.....httlpthhtp..t......tphsttthpch..pphhpcA.p..tsspphppspchhpthppttppspps...sppAh.Gp...t..tt...ssssu.LhplLppaCts.........t.t..p..s......sspC....p...s.h.........p.p.....h...p....t...........htp.hlpCpt....hu...hspt.hhssoh..sshptALpcWpphKsp....................t...t..............tt.t.sCslhc.tW..ta.tshpthtplpp.........t.........................................
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