#=GF ID IglC
#=GF AC PF11550.12
#=GF DE Intracellular growth locus C protein
#=GF AU Pollington J;0000-0002-8158-8998
#=GF SE pdb_2qwu
#=GF GA 25.00 25.00;
#=GF TC 26.30 113.60;
#=GF NC 23.10 18.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 18474647
#=GF RT MglA and Igl proteins contribute to the modulation of
#=GF RT Francisella tularensis live vaccine strain-containing phagosomes
#=GF RT in murine macrophages.
#=GF RA Bonquist L, Lindgren H, Golovliov I, Guina T, Sjostedt A;
#=GF RL Infect Immun. 2008;76:3502-3510.
#=GF RN [2]
#=GF RM 15519043
#=GF RT Expression of IglC is necessary for intracellular growth and
#=GF RT induction of apoptosis in murine macrophages by Francisella
#=GF RT tularensis.
#=GF RA Lai XH, Golovliov I, Sjostedt A;
#=GF RL Microb Pathog. 2004;37:225-230.
#=GF RN [3]
#=GF RM 17905833
#=GF RT New protein fold revealed by a 1.65 A resolution crystal
#=GF RT structure of Francisella tularensis pathogenicity island protein
#=GF RT IglC.
#=GF RA Sun P, Austin BP, Schubot FD, Waugh DS;
#=GF RL Protein Sci. 2007;16:2560-2563.
#=GF DR INTERPRO; IPR021048;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC IglC protein is involved in the escape of F.tularensis live
#=GF CC vaccine strain [1]. It has been shown that the expression of
#=GF CC IglC is essential for F.tularensis to induce macrophage
#=GF CC apoptosis [2]. IglC adopts a beta-sandwich conformation that has
#=GF CC no similarity to any known protein structure [3].
#=GF SQ 2
#=GS A0A8J2Z6U6_9GAMM/5-215 AC A0A8J2Z6U6.1
#=GS Q5NEC5_FRATT/1-211 AC Q5NEC5.1
A0A8J2Z6U6_9GAMM/5-215 epklarsvvldakplsfklge------------------------ADFAGSHSKARIWFDSLTILGQDMGKFLFAIDGGQNLNDVTSPTAACNLIEFHLSGPQMKASLEVTIGLPISPKMKTTLEGLISSVKKSEAKDTSIKFGKTNASQEYKNDEKWDVITDLSELVLVPVENSAFNIDFQQYGFLGGSTAAADYYILTISGVMVdkknfSKAALDVVHGESTEKG----------qygllsid
Q5NEC5_FRATT/1-211 .....................MIMSEMITRQQVTSGETIHVRTDPTACIGSHPNCRLFIDSLTIAGEKLDKNIVAIDGGEDVTKADSATAAASVIRLSITPGSINPTISITLGVLIKSNVRTKIEEKVSSILQASATDMKIKLGNSNKKQEYKTDEAWGIMIDLSNLELYPISAKAFSISIEPTELMGVSKDGMRYHIISIDGLTT.....SQGSLPVCCAASTDKGVAKIGYIAAA........
#=GC seq_cons .............................................sshhGSHspsRlahDSLTIhGpchsK.lhAIDGGpslscssSsTAAsslIchplossphpsolplTlGl.Ipsph+TplEthlSSlhpupApDhpIKhGpoNtpQEYKsDEtWslhhDLSpL.LhPlpspAFsIshp.hthhGsSpsuhcYaIloIsGlhs.....SpuuLsVsputST-KG..................
//
