#=GF ID Imm15
#=GF AC PF15561.10
#=GF DE Immunity protein 15
#=GF PI Imm9;
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 22.90 22.50;
#=GF TC 23.00 22.80;
#=GF NC 19.80 20.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028264;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted immunity protein with an alpha+beta fold and several
#=GF CC conserved polar and hydrophobic residues. Proteins containing
#=GF CC this domain are present in heterogeneous poly-immunity loci in
#=GF CC polymorphic toxin systems [1].
#=GF SQ 18
#=GS A0A8J3X0U0_9ACTN/26-172 AC A0A8J3X0U0.1
#=GS A0A5J5G4X2_9GAMM/11-159 AC A0A5J5G4X2.1
#=GS A0A344L162_9PSEU/16-130 AC A0A344L162.1
#=GS A0A1G7U1V1_9BACT/5-159 AC A0A1G7U1V1.1
#=GS A0A1I4Z4T2_9ACTN/19-115 AC A0A1I4Z4T2.1
#=GS A0A7W8ZBX8_9ACTN/16-165 AC A0A7W8ZBX8.1
#=GS A0A6G9YR35_9NOCA/154-241 AC A0A6G9YR35.1
#=GS D4MAC7_9BACT/20-177 AC D4MAC7.1
#=GS A0A1E3G6A0_9GAMM/13-149 AC A0A1E3G6A0.1
#=GS U7UXK2_9FUSO/89-219 AC U7UXK2.1
#=GS A0A4V2EMR0_9PSEU/16-104 AC A0A4V2EMR0.1
#=GS A0A090V285_PSEVU/11-160 AC A0A090V285.1
#=GS A0A1G7K2T2_9BACT/5-159 AC A0A1G7K2T2.1
#=GS A0A2S6IBV6_9ACTN/16-81 AC A0A2S6IBV6.1
#=GS A0A7W8VFL6_9ACTN/19-119 AC A0A7W8VFL6.1
#=GS A0A3R8UWQ9_9PSED/12-120 AC A0A3R8UWQ9.1
#=GS A0A2C6DMR7_9GAMM/11-160 AC A0A2C6DMR7.1
#=GS A0A1K1NBN3_9BACT/5-167 AC A0A1K1NBN3.1
A0A8J3X0U0_9ACTN/26-172 ...................l-IRD.EGLDQFGE-LMEAD.P.FEEVPLYSRYAQLEFLDT.LCVSEKNRVLIRAA.VA.HMVKVVEYSRDYYED-RSCDYLCMVSVV..G.WEDsDGRS....ELLIPNLWIGNMRDDRLRSMRLHPA-....----.--------------------.......------------qsrrsefvadaldgdagltlseglshflgesyvd.....
A0A5J5G4X2_9GAMM/11-159 ....................LLHK.EGLDKVDVYYADYD.T.FEEVPLFSRWNHISFLSS.LSFDEKNKLFIKKG.TE.LVSYSYEKSKEYLDKDEQKDYFICMSLT..G.WND.C-EI....NCLTPNIVLSRRKGWLLTHLKLKKTG....SDEE.RLVKQYLSSLALTDFDVFAS.......-EGGKANKRVYV.......................................
A0A344L162_9PSEU/16-130 ...............lladg----.-DLLDFDGLM-SYD.GyFDELPLYATYRQISFLDE.LPPLERNQVLVRAA.AA.HLGRVLAHAEEFYAGRE-FDFFCAVTVT..G.WDH.LPEG....DPLTPHFWLANP--------------....----.--------------------.......------------srgvfehlrlrppgs........................
A0A1G7U1V1_9BACT/5-159 ....................IIKEiKDFIDEHNILRDYE.T.FEQMQMFYRIKDLDCLSTsIAKEHYTPFFADMA.IM.FVNMGLLYAKSQLSEEEQKDYLIYWGIE..Y.IEEnIVED....GFLHVDVCYTRKGKEHLS--YLNEVV....DYKN.TKIYKYVKDVIGMSEFTCYYt....ksEEDECESVEYYC.......................................
A0A1I4Z4T2_9ACTN/19-115 ....................LIHH.QLLDDFDSFLKRVD.D.FDEPPLYTQYAQLAFLGG.LTTEQKNRLLIRAT.VA.HLPR-------IVEHGHGHDFYCMVSIL..G.WDE.FENG....GLIRPAFWYTN---------------....----.--------------------.......------------pstr...................................
A0A7W8ZBX8_9ACTN/16-165 ......lihdegldrfgelm----.-----------EAT.L.FEELPLYSRYSQLQFLDP.LSMSEKNRVLIRAA.VA.HMVKVVEYSHNYYAD-RTYDYVCMVSVT..G.WGDsDGRS....EWLTPNLWIGNPRNDKLRSMRLY---....----.--------------------.......------------paqgrqsefvadaldgdaglilneglshflgephvdrvy
A0A6G9YR35_9NOCA/154-241 ........egwhdlspimhv----.-------------K.T.FDELPMYSRLDQLGFLEG.LSIEDQNRLMIEAAtIR.LSEIREIE---CRRQAERDGYLHMVSVT..G.WWD.----....--------------------------....----.--------------------.......------------rsvggleind.............................
D4MAC7_9BACT/20-177 ....................IIRE.TGLYNLDYFIEEHEgG.YEEMPILDYFPQAKFLKRvIKKEEISALLLDIA.LF.FVNVILLYAYNKLTEKQFANFFIAIFVV..D.FDH.LEEDygdyGHFNPRILVSREADKYTF---VSQEMl..fDYKRcEKFYKHVSKVAGLGDFMFYR......hYDDKNDLDTIY-m......................................
A0A1E3G6A0_9GAMM/13-149 likieelepkkffglymktd----.--------------.-.VEEVSLYSRYHRADFLRQ.IPEDEANKLILEFS.LQ.HLKRLMTYANEHFSLEQKSKLLLCLSFP..Y.D-D.IVEE....PLLIPNFSIS----------------....----.--------------------.......------------pncyhvfryanyymegrneldklkriaktletypdlsi.
U7UXK2_9FUSO/89-219 ....kikeavafgaidflik----.--------------.-.------------------.----PYNQARLDTA.IGkFLKKNELLIKTTMDQEECDEYFSFDSTQteF.PKG.INEK....TLEKIELFLSENRKKWWNANKLSEEL....NIST.VTLNKYLKYLVSINKLTVNT.......------------sygevgrpenfyky.........................
A0A4V2EMR0_9PSEU/16-104 ................llad----.GDLLDLDPLLSYDG.Y.FDELPLFATYAQIAFLDG.LPPAERDRVLVRAA.VA.HLERILAHAA------GHPDFFCAVTVT..G.WDE.----....--------------------------....----.--------------------.......------------pllvprfwra.............................
A0A090V285_PSEVU/11-160 ....................LIKK.GGLDNPRVYFAEYD.T.FEEIPLFSRWNDISFLSQ.LSFDERNKVLLKAA.ID.LLKKNLKPAKSIAKDVELADFFSCVTIT..G.WDD.AIEM....GSLRPNILLTQRKKWLLSNLNLKQSD....VPEA.NLIKDYLSSISALNYSAFIS.......-NGFEKNKRVYI.......................................
A0A1G7K2T2_9BACT/5-159 ..................if--KQiIKYIDEHDILYDYE.S.CEAMSVFCL-PDLNSLSGfVNKEDYIPFCINMA.IM.YVNQGLLHAKSKLSKKDYDNYILYFNVD..LnIDNeSDYG....DYITVDVCFSRKAKEHLN--YFNEQI....DYKD.TEICKYVEDVIGISEFTCYYte...ffKDDE-DDDELY-f......................................
A0A2S6IBV6_9ACTN/16-81 ...................l-LQV.EGLDDLDRLTGSVN.T.FDEPPLSSRCDHIAFLKH.LPVTEANTQLIRAA.VE.HLDR------------------------..-.---.----....--------------------------....----.--------------------.......------------inahleaep..............................
A0A7W8VFL6_9ACTN/19-119 ...........daglcdfda----.---------LMEYD.GyFDELPLFATFSAVAFLDG.LEPRERDRVLVRAA.VA.HLGRILGHAERHYAD-REPDFFCAVTVT..G.WDL.LAEG....--------------------------....----.--------------------.......------------dplvprfwranpsrgv.......................
A0A3R8UWQ9_9PSED/12-120 ............iqkknfke----.-PYNNTDIFVTDYE.S.FEEIPIVSRYSRLKYFKReLGLKGVRDLLISLS.IF.VLKTSLLVSGRKKST---RDTFFCDHLH..K.HRSlQRRQ....IYNTQNIYISRRARTRLS--------....----.--------------------.......------------.......................................
A0A2C6DMR7_9GAMM/11-160 ....................LLKK.EGLLQKDLYFADYE.T.FEEVPLFSLWHHIDFLKD.FTFDEKNTILINQA.IG.LADNAHKNSVDSLAQ-DADEYFICVSVT..G.WDE.AEEI....NCITPNLFISRRKTWLLSCLALEQHH....TPQE.VLINRYLAASGLEGYQAYSS.......KSAKDDEVRIYI.......................................
A0A1K1NBN3_9BACT/5-167 ....................VIERiKKFIDEHEVLRDYE.T.YEQMPTFYRYKELDCLKSsIKEEYYIPFLINLA.IM.YVNQGLLLAKSQLTEEELKNYLIYFGIW..W.DEEeVEEM....GFSCIDVYFTRKAKEHIK--LFNTDYcrpiDCKD.TKIYKYVKDIIGISEFTCYHskwtdkyEDGSEEVSEFYF.......................................
#=GC seq_cons ..........................th.p.c.hhh-h-.s.FEElPLaupasplsFLcs.LshcEtNplLlctA.lt.alspslhhupphhsp.ctp-ahhhlols..s.a--.h.ct....shhpsslhhop.tt.hh................................................................................................
//
