#=GF ID   Imm19
#=GF AC   PF15563.10
#=GF DE   Immunity protein 19
#=GF PI   Imm11; Imm11_;
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   de Souza RF;0000-0002-5284-4630
#=GF AU   Anantharaman V;0000-0001-8395-0009
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   [1]
#=GF GA   25.30 25.30;
#=GF TC   25.50 25.30;
#=GF NC   24.70 24.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22731697
#=GF RT   Polymorphic toxin systems: comprehensive characterization of
#=GF RT   trafficking modes, processing, mechanisms of action, immunity
#=GF RT   and ecology using comparative genomics.
#=GF RA   Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL   Biol Direct. 2012;7:18.
#=GF DR   INTERPRO; IPR029086;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A predicted immunity protein with an alpha+beta fold and a
#=GF CC   conserved HxxRN motif. Proteins containing this domain are
#=GF CC   present in heterogeneous poly-immunity loci in polymorphic toxin
#=GF CC   systems [1].
#=GF SQ   22
#=GS A0A3R6IM49_9BACT/2-228   AC A0A3R6IM49.1
#=GS A0A194AG65_9DELT/23-173  AC A0A194AG65.1
#=GS A0A1M7J689_9BACT/71-245  AC A0A1M7J689.1
#=GS H7ELW7_9SPIR/11-180      AC H7ELW7.1
#=GS A0A3A8YSW7_9BACT/24-183  AC A0A3A8YSW7.1
#=GS R9M850_9FIRM/1-177       AC R9M850.1
#=GS A0A3A9BAC7_9BACT/1-176   AC A0A3A9BAC7.1
#=GS A0A327QY41_9BACT/26-214  AC A0A327QY41.1
#=GS Q5LEK7_BACFN/2-228       AC Q5LEK7.1
#=GS A0A519KTL2_9FLAO/3-166   AC A0A519KTL2.1
#=GS A0A1Y4I1D2_9BACT/2-228   AC A0A1Y4I1D2.1
#=GS A0A1D7QLK5_9SPHI/18-225  AC A0A1D7QLK5.1
#=GS D7VSD0_SPHSI/37-252      AC D7VSD0.1
#=GS R9JS66_9FIRM/1-177       AC R9JS66.1
#=GS A0A1M6J9E6_9CLOT/14-184  AC A0A1M6J9E6.1
#=GS A0A285ZPN9_9SPHI/7-211   AC A0A285ZPN9.1
#=GS A0A444HEI1_9FLAO/4-212   AC A0A444HEI1.1
#=GS A0A1M6XCN8_9FIRM/2-72    AC A0A1M6XCN8.1
#=GS A0A4Q3LV15_9FLAO/1-54    AC A0A4Q3LV15.1
#=GS A0A1H4GPZ4_9BACT/36-203  AC A0A1H4GPZ4.1
#=GS A0A2P8D316_9BACT/30-222  AC A0A2P8D316.1
#=GS A0A1T4TUT8_9BACT/45-213  AC A0A1T4TUT8.1
A0A3R6IM49_9BACT/2-228              .............................................................NVISEKEYSFSNALFWN.VMLH.HHIQAFDEERDVNFDEVWDEELAPALLDEKRYKEYWGWLSQI....ELETSENQGEIE..NP...RTLTLPIGSDVTLTMEFHPCSTYYFLNDFVIGEVSGNFHLKYLTYPELMRI.A.E..L..KYGD..V..LF..HLLLPLCAIREQEKEDTLNEIVQRLQQ...IP..L..F..R.EHSEY.IGKCILYGLSIPD..S..D..I...L.D.I.PE.IGIICLSNHSYRNALRYEDDKEDIKELNTLL..............
A0A194AG65_9DELT/23-173             ...............................................arnrydyfasqakk-----------------.----.---------------------------------EGYVQISQI....FAETALQEKEH-..AK...RLFKFMEGGDVEIQAA-YPCGVIGTTEENLVAAASGEHHEHESMYPEFADI.A.Q..E..EGFP..V..IA..AA-MRSIAVAEKQHEKRFLDLVENIRQ...GR..V..F..K.REEKV.VWRCINCGFIIEA..-..-..-...-.-.-.--.-------------------------------teppak........
A0A1M7J689_9BACT/71-245             ...........................................psgewlngltgteeeepw-----------------.----.------------------------------------------....------------..TG...YTFIHPLNEEVTLYAEFRPHETVYFFNDTYLGNTGGHFHLSLFSWEELKAI.T.A..KaaHNES..L..LF..LLLLPLTVGNVEEQAEIEAAIAQHLQN...TSleL..S..G.EQLEL.ITQFLTRHLIFED..HeqN..V...F.E.LlKN.VGPVINRKHSERSRQKEDED-----------ilpvneiik.....
H7ELW7_9SPIR/11-180                 ......................lsnknfipwflmnnfpeginkttdstlseliqenfdiet-----------------.----.------------------------------------SWVNQLtgyyDEVFEESDGYIE..NP...KSVELKLNEKQKFSVEFHPGDTLYYLDEIQIGSTGPSYTIRTIPFKIFLDC.T.N..N..ITLN..E..-K..LLLLPMIKIKQTEKNDFEILIKSLLLS...VS..F..Q..E.SLIDA.VIDCIL-------..-..-..-...-.-.-.--.-------------------------------encm..........
A0A3A8YSW7_9BACT/24-183             ...............................lalsdegedisvsermeelctqeicgwwkt-----------------.----.----------------------------------FTGW---Y....DGALDESDGYLD..DP...TFLEAPLAQGKTLKIEFHPGDTLYFVDGEEIGSTGPHWKLGTVPYKELEEL.L.P..L..EHGR..Q..LF..LLLLPLASLEREDASAAQWAI--KAQM...MH..Y..F..DaDLCED.VSRCLVSGLV---..-..-..-...-.-.-.--.-------------------------------gdrs..........
R9M850_9FIRM/1-177                  ............................................................m--ISLHEIDFSNRNFWV.GFIAtSFPTALEEETDMSLTELMIENGMCDTSWWDNFTKYYDG----....--VLEESDGYVD..EP...ETIICEFVPTQILKIEFHPGDTVYYINDKQIACTGGHYNIQVIPFKELLNS.I.K..D..R---..Q..IF..LLLLPLAVIDSPDKDEATQIISNVLQG...IF..D..K..R.LCGQY.-ANCIVNGLM---..-..-..-...-.-.-.--.-------------------------------se............
A0A3A9BAC7_9BACT/1-176              ............................................................m--ISLHEIGFSNRNFWVgYMAT.SFPTALEEETDMSLTELMVENGMCDTSWWDNFTKYYDG----....--VLEESDGYVD..EP...ETLICELAPTQTLKIEFHPGDTVYSINDKQIACTGGHYDIQVIPFKELLNT.I.K..D..R---..Q..IF..LLLLPLAVIDNQNKDEATQIISNVLQE...IF..D..K..H.LCSQY.AG-CIVTGLM---..-..-..-...-.-.-.--.-------------------------------s.............
A0A327QY41_9BACT/26-214             ......................................letmltdylvenfdfpthewieg-----------------.----.------------------------------------------....-LTGTEEETDNW..NG...YTFVHRINDEVTLFVEFHPQETIYFFNDTYLGNTGGNYRLSLLSWDELQAI.L.Q..H..QHND..Y..LLllLLLLPLTIGRSQERT-AIEANVRRLLKataLE..L..D..E.VNVEL.FTQFIVRHLIFEE..E..D..MntlQ.Y.Q.EN.IGFVTNRNHSERS------------------lsnnpveitavnkv
Q5LEK7_BACFN/2-228                  .............................................................NVISEKEYSFSNALFWN.VMLH.HHIRAFDEERDANFDEVWDEELVPTLLDEKKYKKYWCWLSQI....DLKTSENQGEIE..IP...RTLTLPIGSDIVLTIEFHPCCTYYFLNDTLIGEVSGNFHLKYLTYSELMRI.T.K..E..KYGD..V..LF..HLLLPLSAIKEKEKDTALFEIVQRLQQ...IP..L..F..K.EHSEY.IGKCILNGLLVSN..S..D..I...Q.E.N.SK.IGTICTSNHSYRNALIYDDEKQEIKELNILL..............
A0A519KTL2_9FLAO/3-166              nqitqkdlenntffwyayicwfrgyddvneinidealevleidpkelaawendffprsety-----------------.----.------------------------------------------....-----------E..LT...KYIGRKLNEQISFFIEFQEFEIVFFLNDIYIGNLGGHFEAWFFTWAELLTF.Q.K..F..---E..H..LF..LLFLPLIGIEEHQIEEARIVIGNHLKT...IP..R..F..E.KNAEY.IANCI--------..-..-..-...-.-.-.--.-------------------------------..............
A0A1Y4I1D2_9BACT/2-228              .............................................................NVISEKEYSFSNDFFWN.VILH.HHINAFDKENDENFDWMWDEKYSPASLDKKRFTEYWSNLSQW....DLKTPENEGEIE..NP...KSLVLPIGSDIALTIEFHPCCTYYFLNDFMIGEVSGNFHLKYLTYPELLRM.A.K..L..KYGD..V..LF..HLLLPLSAIREQEKEEALNEIVRRLQQ...IP..L..F..R.EHSEY.IGKCILYGLLIPD..S..D..V...L.D.I.PE.IGTVCISNHSYRNALRYEDDKEDIKGLNVLL..............
A0A1D7QLK5_9SPHI/18-225             ...............................itqfpfavddekemmlsdymmenfnmpsee-----------------.----.-------------------------------------WCKEL....SGLTDENGLE-E..DPwygYTYVHEINDQVTLFAEFHAYNTVYFFNDIYLGNTGGHFHLSLFSWTELKEI.I.A..N..DKSE..LspLF..LLLLPLTIGNESEREEIESRILDCLKQ...TA..LelN..E.DQLDQ.MTRLMVRHLIFQD..R..EknI...LtH.Q.EH.LGLVTCRNHSERNLKQVDEDLIKINEI----isla..........
D7VSD0_SPHSI/37-252                 ....................ldlsnkdfclflmtefpfgsneeketmlsdyivenfqmpse-----------------.----.------------------------------------SWFEEL....AGKTDESGQEVQpwNG...YTWMYPINDNVTFYAEFHPNETIYFFNDTYLGNTGGHFHLSLLRWTELKSIiAkE..D..KDSS..L..LF..FMLLPLTMGDISEQQDIRSEIAVHLAK...TS..I..K..A.DDLIMhDITNFLTSHVVAD..Q..G..F...E.Y.R.KG.VGFVTQRNHSERNHMHSEEDLRTINEI----irla..........
R9JS66_9FIRM/1-177                  .........................................................mill-----QEIDFSNRDFWVgYMAT.SFPTAWEEETDMSLTELMIENGMCDTGWWDNFTKYYDG----....--VLEESDGYVD..EP...ETLICELAPAQTLKIEFHPGDTIYFINDKQIASMGGHYNIQVIPFKELLNA.I.K..D..RQ--..-..KF..LLLLPLAVIDYQDQDKAAQIISNALQE...IF..E..K..H.LCSRY.AG-CIVTGLL---..-..-..-...-.-.-.--.-------------------------------se............
A0A1M6J9E6_9CLOT/14-184             ..........cetfwpfffskcypngyfekedielaeyirgkyclpiewvddftkyyagvf-----------------.----.------------------------------------------....----DEEDGYVK..NP...RKVIVDFANNNLLEIEFHPGDTIFYLNKENIGCTGPHFELHKISWNELKKLlL.N..V..EYKE..F..KL..FMILPMVFIQDNEIDEVFKVITECLTK...LP..F..K..S.EDYTI.ISKCIVEN-----..-..-..-...-.-.-.--.-------------------------------iig...........
A0A285ZPN9_9SPHI/7-211              .......................................................feeikg-----------NPYFWY.MYI-.KWFRGFDDKNELNLDEA----MEAIDIDQNQVQ---QWEEDF....FAEIS-----DE..NV...KLIAGKLNDEMSFRIEFQEYEIVFFLNETYIGNLGGHFEAWFLTWQELLAF.E.K..H..---P..L..LF..MLLLPMTGIEQHQIEDAKALIAKHLKI...IP..K..F..E.KEAAY.ITYCILNGLIMDD..-..G..F...L.N.H.NE.IGTINIQNHSARNVEKYPRYSDDVKKLNIE-l.............
A0A444HEI1_9FLAO/4-212              ......................................................qitkedl---------EDNPLFWY.VYIS.-CFRAYDDKNEINIG----EALKTLNIDEVELHK---W--EK....EFF-TENASE-E..DI...RFIGGKLNEDIFFHIEFQECETVFYINDIYIGNLGGHFEAWFFTWEELLAF.Q.-..-..KY-D..F..LF..LLLLPMAGIERHQISEAQKYVTDQLKT...IP..K..F..E.DNAEY.ISYCIINGIII-N..G..H..F...F.N.Q.ND.VGIVNNQNHSIRNIEKYPRYADDVTKLNY--al............
A0A1M6XCN8_9FIRM/2-72               ...............................................ihnisweqlkqftl-----------------.----.------------------------------------------....------------..--...---------------------------------------------------.-.N..F..KYVD..I..IM..FLILPMVYISKSETDEFIKFIEEKMPL...LP..F..D..R.EDSSL.ISNCVLENLI---..-..-..-...-.-.-.--.-------------------------------l.............
A0A4Q3LV15_9FLAO/1-54               .............................................................-----------------.----.------------------------------------------....------------..--...---------------------------------------------------.-.-..-..----..-..--..---------------------------...--..-..-..-.--AEY.IANCILNGLKIE-..G..Q..F...F.E.Q.DE.VGIVNNQNHSVRNIEKYPRYREDVIKLNGI-l.............
A0A1H4GPZ4_9BACT/36-203             ..............................................eeltgatedpwngyt-----------------.----.------------------------------------------....------------..--...--YVHRLNETVTFFAEFHIYQTVYFFNDTYLGNTGGNFHLSLLTWKELQMI.I.D..K..DQTDpsL..LF..FLLLPLAVGSQSERPEIEAAIAMRLHE...MA..LelS..T.DQLTA.ITRFLCSHLIFDE..E..EknI...FeH.I.PD.VGLAINRNHSERNRQNREED-----------ligvnqvin.....
A0A2P8D316_9BACT/30-222             ............................lvdyvienfdmpagawlteltgatddagneasp-----------------.----.------------------------------------------....-----------W..LG...YTFAHPVNEAVTFYAEFHPYETVYFFNDVYLGNSGGHFHLSLLSWREFKTI.V.A..NepAVPA..L..LF..LLLLPLVIGNETEQEEIGAEIKKYLRQ...TA..L..QprE.EQLQT.LTHMLCRHLIFRDrvS..N..V...L.R.Y.QEhTGWVTSRNHSERNESIADDDLRKINEV----ikma..........
A0A1T4TUT8_9BACT/45-213             ..........................................wweeltgktaepwqgytyv-----------------.----.------------------------------------------....------------..--...----HRLNETVTFFAEFHPCETIYFFNDTYLGNTGGNFHLSLLRWTELQTL.V.SkdE..TAPS..L..LF..FLLLPLVAGNQSERAEIEVAITNRLKE...MA..LdlP..A.DQIKV.LTRFLSSHLIFEEeeG..N..I...F.EhT.PD.IGWVINRNHSERNRQNRGED-----------llainqli......
#=GC seq_cons                       ............................................................h.........................................................................t.pt...p..ps...hhhhh.lspshshhhEFHPt-TlYFhNDhhlGssGGpaclphlsapELhph.h.p..p..c..s..h..LF..hLLLPLsslppp-pp-htthIsppLpp...hs..h.....c.cphch.lspCIlpsLlh......................................................h.............
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