#=GF ID Imm40
#=GF AC PF15569.10
#=GF DE Immunity protein 40
#=GF PI Imm21; Imm21_;
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 25.00 25.00;
#=GF TC 25.10 26.40;
#=GF NC 24.40 24.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR029080;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted immunity protein with an alpha+beta fold and
#=GF CC conserved phenylalanine and tryptophan residues and a GGD motif.
#=GF CC Proteins containing this domain are present in bacterial
#=GF CC polymorphic toxin systems as an immediate gene neighbour of the
#=GF CC toxin gene, usually containing a domain of the Ntox19 family
#=GF CC [1].
#=GF SQ 43
#=GS A0A6L6Q664_9BURK/34-125 AC A0A6L6Q664.1
#=GS R6T252_9CLOT/14-103 AC R6T252.1
#=GS A9B0V1_HERA2/18-110 AC A9B0V1.1
#=GS A0A401ZWC5_9CHLR/143-231 AC A0A401ZWC5.1
#=GS A0A4Y9J4B1_9LACT/16-111 AC A0A4Y9J4B1.1
#=GS A0A5C4XGJ8_9HYPH/33-119 AC A0A5C4XGJ8.1
#=GS Q7DD41_NEIMB/15-96 AC Q7DD41.1
#=GS A0A1I5J541_9BACT/16-114 AC A0A1I5J541.1
#=GS A0A3P1V5K3_9STRE/14-103 AC A0A3P1V5K3.1
#=GS A0A1G9PMK2_9FIRM/20-109 AC A0A1G9PMK2.1
#=GS A0A3N2NBP2_9BACT/158-247 AC A0A3N2NBP2.1
#=GS A0A1E8GK42_9LACT/21-108 AC A0A1E8GK42.1
#=GS A0A4Y9J057_9BACT/158-247 AC A0A4Y9J057.1
#=GS A0A841J447_9SPHN/21-110 AC A0A841J447.1
#=GS K1LNZ4_9FLAO/20-122 AC K1LNZ4.1
#=GS A0A3E1NJ82_9BACT/2-75 AC A0A3E1NJ82.1
#=GS A0A3N2N5K0_9BACT/26-117 AC A0A3N2N5K0.1
#=GS R5P663_9FIRM/20-109 AC R5P663.1
#=GS A0A180FVG9_9BACT/18-124 AC A0A180FVG9.1
#=GS A0A1H7KGX4_9FIRM/16-103 AC A0A1H7KGX4.1
#=GS A0A1Z5HEK2_9GAMM/19-108 AC A0A1Z5HEK2.1
#=GS C8PKE0_9PROT/30-114 AC C8PKE0.1
#=GS C8PE91_9PROT/23-107 AC C8PE91.1
#=GS A0A3N2NFI2_9BACT/158-247 AC A0A3N2NFI2.1
#=GS K1M8H3_9FLAO/14-104 AC K1M8H3.1
#=GS A0A133Y7Z8_9BACT/20-112 AC A0A133Y7Z8.1
#=GS Q5F7U8_NEIG1/15-97 AC Q5F7U8.1
#=GS A7I3F8_CAMHC/12-101 AC A7I3F8.1
#=GS A0A1G7UA32_9BACT/138-225 AC A0A1G7UA32.1
#=GS A0A2K9EFQ1_9FIRM/17-106 AC A0A2K9EFQ1.1
#=GS R5NLP0_9FIRM/18-107 AC R5NLP0.1
#=GS A0A4Z0V4J8_9BACT/195-286 AC A0A4Z0V4J8.1
#=GS A0A0M2VD29_9GAMM/1-82 AC A0A0M2VD29.1
#=GS A0A1M5YXE3_9DELT/16-108 AC A0A1M5YXE3.1
#=GS A0A180FVE0_9BACT/25-119 AC A0A180FVE0.1
#=GS A0A0F2JHJ1_9FIRM/1-55 AC A0A0F2JHJ1.1
#=GS A0A1X9NDF0_9GAMM/16-108 AC A0A1X9NDF0.1
#=GS A0A6B3UP30_9CAUL/18-106 AC A0A6B3UP30.1
#=GS A0A562L6K1_9FLAO/16-110 AC A0A562L6K1.1
#=GS A0A4V1AL48_9FLAO/13-102 AC A0A4V1AL48.1
#=GS A0A1N6LH85_9BURK/18-97 AC A0A1N6LH85.1
#=GS R6TXD3_9FIRM/14-102 AC R6TXD3.1
#=GS A0A0H5DSF0_9BACT/16-108 AC A0A0H5DSF0.1
A0A6L6Q664_9BURK/34-125 ..........SLERIGVR.NWALEREAALKALQQLSAIG.VAILGGD..........VYVVQ.G.EN..IEPN..YD.........NWYCNRE.AEENEA..DFVARSVAKAQRYIVNYL...T....SAN-NVLFAIV-p...........................
R6T252_9CLOT/14-103 ...kslfisq-------Y.ELAWKITDADDFIEDAILNQ.VIVLGGD..........ILD--.-.AN..LQYT..LD.........NWYYEPD.KSISRK..VNSLQSCNCMKKYIERYI...E....RNGSDFY-AII-ic..........................
A9B0V1_HERA2/18-110 ..........LLSELGTQ.EYALDQQDAMNAIVIIEDLA.IPILGGD..........VYLQS.L.EG..IEIS..YE.........NWSINRQ.PGESLD..NYVRRSCAYTRNYIARFP...V....QAEKLPLFVLVL............................
A0A401ZWC5_9CHLR/143-231 .........s-LNDRGFS.EVGWLYKDIFEVLSIYQQEK.YKVLGGD..........VYRYS.N.RD..IFHT..YD.........SWSTDSF.----KN..DLFEKGYSYTFSYIENYY...K....LHGDSYIYTLT-v...........................
A0A4Y9J4B1_9LACT/16-111 ..........SLASLGMDgEYAWLAEDIWEVCEYLERNN.RIILGGD..........VISYD.G.VN..LNST..YD.........SWHVSRE.ELNTLNilDYSKYSVNKAIDYITKYI...E....KNGLDYLYLLVI............................
A0A5C4XGJ8_9HYPH/33-119 .......ehr--------.NWALSRPEALSALAELRKRG.IGVLGGD..........LLVFQ.S.GR..FEHT..YD.........NWHCDPV.EHERND..VFVNRSINAAIGYVEAYP...E....G-ESPPFFVIV-p...........................
Q7DD41_NEIMB/15-96 ..........SLIGIGIR.EAALPVPIAIDILNLFINER.ILVLGGD..........IYIKK.D.NY..FYQT..YD.........NWYYEG-.------..------------------...-....------------snlfnsidkamhylsqiklenayvsfv.
A0A1I5J541_9BACT/16-114 .........p-LYPLGID.GYAYIKKDALLIIHFFRDNC.FPITGGN..........VYTIS.K.EK..ICYTegYN.........GWSCDRL.QNEPWN..DYVRRSYKIAYKYINSYS...RfpslFNRKEFLFSI--ny..........................
A0A3P1V5K3_9STRE/14-103 .........n-LSEIGIH.NYAYSWECIGEILDEIKSSK.LIILGGD..........VYISD.D.AE..LILT..LD.........NWYYNLK.--KSPL..DY-SQSLDRAREYIYNYI...E....QNDRDCYFSFVL............................
A0A1G9PMK2_9FIRM/20-109 .........n-LESIGIS.EIAWKSEDIIKVIDFLVDKK.YVILGGD..........VYSLN.G.NI..LEST..YD.........SWYIDGS.---VNQ..SLLEDSRKKACEYINKYV...K....NNGNYYIYSVV-c...........................
A0A3N2NBP2_9BACT/158-247 ..........SLESIGVD.GIAYTKSEALRIAEEYYNSN.IPILGGD..........VYFFN.N.GN..IKPT..YD.........NWYCNRN.KSETSY..EYVARSCQVTCDYIKKYP...D....NANI--------ffsiv.......................
A0A1E8GK42_9LACT/21-108 .........d-LEGLGIY.AYAWKFSDFKKIIAYIEKNKsCRILGGD..........VYTYE.K.DT..INLS..SN.........NWYISDD.--KAID..E----SYKITEDYIDKFY...K....INGNNYLYSVV-f...........................
A0A4Y9J057_9BACT/158-247 ..........SLESIGVD.GIAYTKSEALRIAKEYYNLN.IPILGGD..........VYFFN.N.GN..IKPT..YD.........NWYCNQN.NSETSY..EYVARSCQVTCDYIKKYP...D....NANI--------ffsiv.......................
A0A841J447_9SPHN/21-110 .......lge---SNGIK.NWALTRSQALNALSQLMATG.WPILGGD..........IIQHA.GgNS..FTYT..YE.........NWHCEMQ.HDEQSE..DFLARSIQVARSHILH--...-....------------lddvskfvvlv.................
K1LNZ4_9FLAO/20-122 .....vnpds-------D.EVALTVSDALVAVNLLEKEK.MPILGAD..........VLLEY.E.EG..LKYL..YQilgdeyiylNWYCDEL.DNENEE..EYIQRSHNIAKEYINSIA...K....IEKEYNI-----qcyvvlvl....................
A0A3E1NJ82_9BACT/2-75 ...qlmnfya--------.------------------AR.IPILGGD..........IYECT.N.NV..MSSN..YD.........NWYCDKL.PGEATD..EFLNRSIMKSKNYIEAYQ...N....KDPDKIFFVLV-p...........................
A0A3N2N5K0_9BACT/26-117 .........s-LELLGVN.GFAYPRKEALKIANGYFNSN.KPILGGD..........VYKLV.N.GR..IEST..SD.........SWYCDKK.ESESSY..DYVVRSYHIACDYIRDYP...G....KANTFFSI----vie.........................
R5P663_9FIRM/20-109 ..........SLLSLGIN.EYAWDKDNIKDIFEELSKRK.IGILGGD..........VYKIE.N.ET..IKMT..FD.........SWYMNKD.---SSE..EFYQKSKLRALSYIEDYE...K....NNCGEFIYTIVI............................
A0A180FVG9_9BACT/18-124 ....lseinp-----GSD.ETALSVSDALLALNILKDNQ.LIILGGDilsedeqgklVYVIH.Y.WG..YEYC..YL.........DWYCNRI.NNESEN..EYKKRSYDIAKRSIAIAD...T....IA----------kklnkkclisfvi...............
A0A1H7KGX4_9FIRM/16-103 .........r-LKVIGFN.EYAFSYEQIKKIIELLRIKK.LSILGGD..........VYMKK.G.EK..IIIT..PD.........SWYINKD.---KIN..D-YEYSYKKTINYIEIFE...S....KE-EDYIYSIVI............................
A0A1Z5HEK2_9GAMM/19-108 .....daeng--------.EVALKKSDAIKSLILLSDTD.IGVLGGD..........VYELE.S.DG.yFRPT..YN.........NWYCDKN.-TDRKV..TFSEESRKVAYEYLSNYR...E....KIDSITMYVLVI............................
C8PKE0_9PROT/30-114 .......lre---EYGIY.DIAWKFDDVMEVLKITRGKG.MIILGGD..........VYRLN.G.NE..PIIT..YD.........NWYTEEE.DDNAF-..-------ELAIEYITKYR...A....RNGDDF------aycpti......................
C8PE91_9PROT/23-107 .......lre---ELGFY.EIAWKFDDVMEVLKITKSKD.MVILGGD..........VYRLS.G.NK..PIIT..GD.........GWYTNKG.DDDA--..-F-----EVAIEYITKYR...A....RNGDDFAYC---pvi.........................
A0A3N2NFI2_9BACT/158-247 ..........SLESIGVD.GIAYTKSEALRIAEEYYNSN.IPILGGD..........VYLFN.N.GN..IKPT..YD.........NWYCNRN.NSETSY..EYVARSYQVACDYIKKYP...D....NANI--------ffsiv.......................
K1M8H3_9FLAO/14-104 ..........SLVNYGVN.NIAFNIQDIKKVLNILKRLN.IAVKGGD..........IWIMR.N.GE..LHLT..YD.........NWFCDQL.ENEMYL..MYVERSIEKTQTYIDNYP...L....DDH---------ayveivi.....................
A0A133Y7Z8_9BACT/20-112 ..........SLKNLGIE.GYAFPYQEALKIVQICKLLA.IPILGGD..........VYSMN.S.ST..IENS..DD.........NWYYDRT.PNESYY..DYVQNSCNKAESYISTFK...N....HFCDRPLFSFVI............................
Q5F7U8_NEIG1/15-97 ..........SLIGIGIR.EAALPVPTAIDILNLFINER.ILVLGGD..........IYIKK.D.NY..FYQT..YD.........NWYYEG-.------..------------------...-....------------snlfnsinkamhylsqiklenayvsfvl
A7I3F8_CAMHC/12-101 ....elffkn------LN.EIAYNYENVIKKIKVLELKG.FVILGGD..........VIKYD.G.DT..VKYT..YD.........NWYFNPD.--EYSY..DILKYSAQKAIDYIEKYN...E....IDK---------dcfyslcv....................
A0A1G7UA32_9BACT/138-225 ....gdriai--------.----SLNDSLYMIEILRQRL.FPILGGN..........ILKYE.S.NQ..FSHT..HI.........NWSCDVI.--EPYS..DFVKRSCDIARREIEEVIstyS....TNEKDGLYV---ymt.........................
A0A2K9EFQ1_9FIRM/17-106 .........s-LEPIGIF.EMAWKSQDALKVIDFLTSKG.YAILGGD..........VYKQD.E.NG..IEST..YD.........SWYINKT.---VSK..SFIEESRIKSHEYIKEYS...K....NNGDCYLYSII-f...........................
R5NLP0_9FIRM/18-107 ..........SLLSLGIN.EYAWDKDNIKEIFEELSKRK.IGILGGD..........VYKIE.N.EN..IKMT..FD.........SWYMNKD.---SSE..EFYQKSKLRALRYIEDYE...K....NNCGEFIYTIVI............................
A0A4Z0V4J8_9BACT/195-286 ..........SLESIGID.GFAYSKNEALRIVEEYYHSN.EAILGGD..........VYKVK.N.GK..IKLT..YD.........SWYCERN.SAETIS..EYVNRSYKIARDYISRYH...S....TTNILFGFVI--e...........................
A0A0M2VD29_9GAMM/1-82 .........m--------.----SKDQVLAVFDKFVDQR.ISVLGGD..........VYELV.D.GA..PESN..YD.........NWYCERE.GGEPLD..VFALRSISQARDYVNNYN...N....PRGKETFYILV-a...........................
A0A1M5YXE3_9DELT/16-108 ..........SLENIGVN.NWALDNKQALEVLDEFERQG.IAVLGGD..........VYEIV.D.GI..PESN..YD.........NWYCEQY.DDEPFL..DFSKRSIAKAREYINNYK...Q....SSSKSVMYTIV-a...........................
A0A180FVE0_9BACT/25-119 dlsdpsvvkr--------.--GLTKQEAIDVLKYSEQIE.VAILGGD..........VYFLDhN.GN..IDMT..HD.........NWYSDKR.DDETTE..EYIRRSINESKKYIGKYK...N....NSYKDFII----lfefv.......................
A0A0F2JHJ1_9FIRM/1-55 ......mtny--------.--------------------.-------..........-----.-.-E..LNST..YD.........SWYINKD.ETKTWS..EYVAESKDKAVSYLNQYH...D....RNGDEFYYSVV-f...........................
A0A1X9NDF0_9GAMM/16-108 .........p-LNRLGEK.SWALSKYQALKALHQLKLEG.AVIIGGD..........MYQLS.D.GE..LQPN..GD.........SWYFERF.CGESDE..EFSQRTVDCTFNYLVEYE...H....PNKLETYFAF--if..........................
A0A6B3UP30_9CAUL/18-106 .........s-LEPFGVQ.GWALPQVDALAAIERLRGLG.VPVVGGD..........AFERK.S.GE..LVLA..YA.........NWCCELF.PGEEIA..SYVDRSALVARRFVSEYR...G....------------rdpyfaiv....................
A0A562L6K1_9FLAO/16-110 ........pi--HEAGIN.SWAFLKKEALEILNRLEELN.VFILGGD..........VYVLS.Y.DF..FKPN..YD.........NWYCNRF.SNETDI..EFTKRSVKTAKDFIMNYN...I...vDTEASQIF----fafvl.......................
A0A4V1AL48_9FLAO/13-102 .........f-LKSFGVN.NWAFTKDEALNVLKELEDVT.TPILGGD..........VWILQ.N.EQ..MNHN..YD.........NWYCERL.PNEPYS..DYVHRSICKANNYINNYP...Q....NG----------niyfell.....................
A0A1N6LH85_9BURK/18-97 ..........SLEDMGLK.EAALDLSEAGQALDLFAGQK.WLLLGGD..........VYRAT.S.DGrsLEPT..YD.........NWFYEG-.------..------------------...-....------------nnvdegisaardflhslrdrslf.....
R6TXD3_9FIRM/14-102 .........d-LTSDGIN.NYAFDLPSAMAFICEAVSHG.FLILGGD..........IIIRE.G.KH..YIES..CD.........NWYCNENnPMETA-..---QKAM----EY-----...-....------------lsayylrncdsdkkwwvsvlt.......
A0A0H5DSF0_9BACT/16-108 ..........SLEKFGMN.DLAWEKDAAVTLINSLMNDD.IGILGGS..........VYKID.S.NN..FMPM..YD.........NWSCNPD.SKEVSK..DFNFRSKTRALEYINKYP...I....YLDERILFSLV-f...........................
#=GC seq_cons ...........L.thGlp.phAhshp-Alcllp.hpppp.hsILGGD..........VYhhp.s.sp..lp.T..YD.........NWYsscp..tEs.t..-ahp+ShphAhcYIppY....p....pstt..hh................................
//
