#=GF ID Imm45
#=GF AC PF15572.10
#=GF DE Immunity protein 45
#=GF PI Imm26; Imm26_;
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 25.00 25.00;
#=GF TC 25.90 28.60;
#=GF NC 23.40 18.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR029077;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted immunity protein with an alpha+beta fold and a
#=GF CC conserved C-terminal tryptophan residue. Proteins containing
#=GF CC this domain are present in bacterial polymorphic toxin systems
#=GF CC as an immediate gene neighbour of the toxin gene, usually
#=GF CC containing a domain of the Tox-ColE3 family [1].
#=GF SQ 47
#=GS A0A1N7G0X3_9GAMM/4-96 AC A0A1N7G0X3.1
#=GS A0A4Y6ULY1_9PROT/20-110 AC A0A4Y6ULY1.1
#=GS E9SB61_RUMAL/4-101 AC E9SB61.1
#=GS A0A4Q7ZNN5_9ACTN/27-121 AC A0A4Q7ZNN5.1
#=GS A0A5C6HQQ6_9BACT/7-99 AC A0A5C6HQQ6.1
#=GS A0A0N0I9I3_9GAMM/3-93 AC A0A0N0I9I3.1
#=GS A0A1H8ZR95_9HYPH/6-95 AC A0A1H8ZR95.1
#=GS A0A1Q4Z3F5_9ACTN/6-100 AC A0A1Q4Z3F5.1
#=GS A0A3N1XIS9_9BURK/6-99 AC A0A3N1XIS9.1
#=GS A1WM29_VEREI/16-119 AC A1WM29.1
#=GS A0A2U3N2Y7_9GAMM/6-97 AC A0A2U3N2Y7.1
#=GS A0A085JJ16_9GAMM/1-41 AC A0A085JJ16.1
#=GS A0A7W3W9J6_9HYPH/14-101 AC A0A7W3W9J6.1
#=GS A0A2H1ECW4_9FLAO/3-98 AC A0A2H1ECW4.1
#=GS A0A3A8YLL1_9BACT/3-95 AC A0A3A8YLL1.1
#=GS A1WM29_VEREI/154-262 AC A1WM29.1
#=GS A0A363RRF1_9BURK/18-112 AC A0A363RRF1.1
#=GS A0A2L0WN73_9HYPH/8-100 AC A0A2L0WN73.1
#=GS X6CVH6_9HYPH/9-98 AC X6CVH6.1
#=GS Q6D5C1_PECAS/7-100 AC Q6D5C1.1
#=GS A0A8J7K7Y1_9NEIS/6-98 AC A0A8J7K7Y1.1
#=GS A0A2U3MYM3_9GAMM/6-96 AC A0A2U3MYM3.1
#=GS A0A418WPM7_9SPHN/3-94 AC A0A418WPM7.1
#=GS A0A1I0NRT8_9FIRM/4-100 AC A0A1I0NRT8.1
#=GS F9RG81_VIBSN/6-100 AC F9RG81.1
#=GS A0A1K2HYW5_9HYPH/356-442 AC A0A1K2HYW5.1
#=GS A0A5S9Q9D6_9GAMM/7-98 AC A0A5S9Q9D6.1
#=GS A0A2T5J2X5_9GAMM/7-100 AC A0A2T5J2X5.1
#=GS A1WM28_VEREI/14-119 AC A1WM28.1
#=GS A0A447IBR4_9HYPH/6-95 AC A0A447IBR4.1
#=GS A0A2S8WTH2_9MICC/6-99 AC A0A2S8WTH2.1
#=GS A0A1H2ZNR5_9PSED/7-99 AC A0A1H2ZNR5.1
#=GS A0A1V9FFM5_9BACT/6-97 AC A0A1V9FFM5.1
#=GS A1WM28_VEREI/154-263 AC A1WM28.1
#=GS A0A380QRV2_YERRU/3-93 AC A0A380QRV2.1
#=GS B2VDT2_ERWT9/6-96 AC B2VDT2.1
#=GS A0A2U2DW00_9HYPH/4-100 AC A0A2U2DW00.1
#=GS A0A081MZY1_9GAMM/3-99 AC A0A081MZY1.1
#=GS A0A0U3L2W9_9BURK/6-111 AC A0A0U3L2W9.1
#=GS A0A4S5JHF8_9HYPH/4-97 AC A0A4S5JHF8.1
#=GS A0A6B2FLA2_9ENTR/3-93 AC A0A6B2FLA2.1
#=GS A0A7W6NI55_9HYPH/4-100 AC A0A7W6NI55.1
#=GS A0A1A9HRF9_9BURK/3-104 AC A0A1A9HRF9.1
#=GS A0A4P7J296_9ENTR/3-93 AC A0A4P7J296.1
#=GS A0A4Y6ULY1_9PROT/142-236 AC A0A4Y6ULY1.1
#=GS A0A380QRG1_YERRU/3-93 AC A0A380QRG1.1
#=GS A0A1X7PNL4_9HYPH/4-100 AC A0A1X7PNL4.1
A0A1N7G0X3_9GAMM/4-96 ..................ildfn-----QPIIHRGSILK.FINQHN---.........-LGDD--LCLMLCEV.VG-....KSEF..QLIVVNNYKAGC.IYWHLPKEANS.EN...DL.G..LSVKWLIEHKSKWE.TDYLTINNL--yi........
A0A4Y6ULY1_9PROT/20-110 ....fkqpyfsrggvfqinrket----------------.---------.........--QEEPVEFMILFNG.TGD....PTYM..GLLIRTGPEAGR.ILVNLPNECLD.EG...TR.M..INKQWLLKNWEKYV.C-DCDVKDVL-y.........
E9SB61_RUMAL/4-101 ................ltdhsgg-------YLCAGAKLR.FVGEYP---.........-FDAE-PVDFMICDY.PAAg.agRCNF..ALYCVSGYHAGS.LEYVFPQEAQA.EE...AR.A..ISTKWLAENWQKKV.YNGCSAENVTV..........
A0A4Q7ZNN5_9ACTN/27-121 .......................LTGYRAEYLSRGTVLR.CPADYP---.........--YES-VVDFLLIED.LES....PSGF..SLLVATGYKAGI.TLVRLPAEALLlRD..gIR.A..VDRAWLVANWNAWI.YERG-------pegvlv....
A0A5C6HQQ6_9BACT/7-99 ...................lldy----KQD-ISRGCVFR.CKAKYP---.........--YEE-VVDFMVAESfDNG....ELRY..VLYVISGYKAGS.LLVRLPKDALS.-T...NF.G..LNWKWVVENWNDWI.YLDCGVEDVWV..........
A0A0N0I9I3_9GAMM/3-93 .......................LIDYKSKSIKRGSIFR.LPAVWP---.........--YES-WVDFMVIDL.FD-....--AH..GLLVTSGHKAGL.ILISLPTESTS.TE...GR.A..LSTRWIIEHWSEWI.YPECDVENVHI..........
A0A1H8ZR95_9HYPH/6-95 ..............daigdrplp----------PGTVLR.FPAAWP---.........--YED-VVDLIVVAF.P--....-DGC..GLVVATGYKAGL.IVVILPGDAVP.EG...QI.A..LSAAWLAQNWTRWV.WPAGDAAEVRV..........
A0A1Q4Z3F5_9ACTN/6-100 .................lgghpe-------EIARGAVFQ.LPARWP---.........--YEE-TVEFMLAEL.PPG...aDDRM..GLIVTSGYKAGL.WVVSLPDEAYP.AG..rPW.A..LSASWLRGNRTAKV.YAETDVGKILV..........
A0A3N1XIS9_9BURK/6-99 ......................l-IDFERRSLRRGSLIK.FHAGYP---.........--FEDEVV-MMVCSS.PEG....SLNP..ALITITGHKAGInCYVAFPSEAQC.EG...VF.-..LDVKWLIDNWAKWV.WPEGSAEDVW-a.........
A1WM29_VEREI/16-119 ....................cgd----EADIIRRGCVLR.VPSVSPPDP.........TWYPDPVMGFIVVEA.MPFgaepYGVS..GLLVASGHKAGL.MHVIFPKESLP.KG..yVY.G..LSTAWLIANWKKWV.YPRGNAESVLI..........
A0A2U3N2Y7_9GAMM/6-97 .................kefned--------LERGLILR.CKGQQP---.........--YEE-YVDFMIVEQ.QEE....QRKY..GLMVISGYKAGL.MYVSFPKEAIS.LK...GF.D..LSYEWVKLNWSNWG.YVDCALDDVYI..........
A0A085JJ16_9GAMM/1-41 .......................----------------.---------.........---------------.---....----..------------.MLVELPPESAS.SE...GH.A..LSTEWVINNWTKWI.YPECAVEDVYI..........
A0A7W3W9J6_9HYPH/14-101 ...........tfyhgerllfpg----------------.-------DG.........IIHED-WLEVMLCKF.SEY....GGGY..GFVILSGRKAGR.ILTTLPKEAET.PR...HE.A..VSSAWLIENFNEWV.YEDTDIQDVYV..........
A0A2H1ECW4_9FLAO/3-98 ......................l-LEYKEETINRGYILR.CKGVHP---.........--YEE-IVDFLICES.TNI....DIES.yMLIVSSGYKAGL.KYSQLPKESIP.NG...VRmG..LSTNWLIENWSKWG.YFDCKIEDVY-l.........
A0A3A8YLL1_9BACT/3-95 .......................LTEYRKSDLWHGTVFR.FPAAYP---.........---FEPSVDLMLMDY.PSE....SGF-..ALYCISGYHAGS.LELVLPKEAAS.PA...KC.S..ISAQWMADNWSSWV.YAGCTAADVEI..........
A1WM29_VEREI/154-262 .......................LTTYGSDVIRRGCILR.VPSVPPPEQewddavgclTWYPDPVVDFIVVDA.ESF....EGRS..GLLVASGHKSGL.VPVVFPKESVL.QS...AG.G..LSTAWLIANWQKWV.YPWGSAESVLV..........
A0A363RRF1_9BURK/18-112 ......................l-SSWPSTLIYRGTVFRcLKAVWP---.........--YEN-VVDFMVVVD.HES....PCGF..AFIVTTGYKAGH.ILVKLPVDARA.PN...AQ.A..LSTDWIIANWAYWI.YPECPVECVRV..........
A0A2L0WN73_9HYPH/8-100 ................isecpdc-------LFYKGTVFR.FPAAYP---.........--YEK-IVEFMLVLS.DSQ....DGLK..-VVVRSGYKAGH.IVANLPSNAMA.PN...KI.A..LYGSWIVENWQTWF.YPEGDPA----vvla......
X6CVH6_9HYPH/9-98 ddfliigdiiqlsdnydvgpgsg----------------.---------.........------TVDLMVFDP.QED....EAGL..GLMVTSGYKAGL.VFAVLPEESRF.EK...KP.G..LSKAWLIENWDKWF.-----------vftyqggpv.
Q6D5C1_PECAS/7-100 .......................LVNYPSKALVHGTVLR.LPGQWP---.........--YEE-LVDFMVFDM.PGG....DRSN..GLMVSSGHKAGL.ILVLLPQDSEL.KE...VR.G..LSTQWVIDNWEKWI.YPECNINDVHV..........
A0A8J7K7Y1_9NEIS/6-98 ....................lan---CKKKSFGRGVVFR.FPAKAP---.........--FEK-IVDFMIIEE.HDS....PTFY..KLICSSGHHAGQ.TELVFPAEAK-.HE...TG.A..VSVAWLKKNWQTWI.YPECEVEAV--sy........
A0A2U3MYM3_9GAMM/6-96 ......................l-IDFNEQYLQRGYLLK.FKAHYP---.........--FEEE---VIMMVC.EGG....CSQK..GLITISGYKAGInMYVLFPEEANP.D-...-G.G..ISTKWLITNWTKWV.WPESDVNSVLV..........
A0A418WPM7_9SPHN/3-94 .......................LIKFESDVIVRGSVIR.FPAKWP---.........--YED-IVDFMVFDP.LEC....DTGM..GLIVSSGYKGGL.ISVILPKESEI.R-...-R.S..ISAKWLKENWKKWV.YPECSVDDVYV..........
A0A1I0NRT8_9FIRM/4-100 .................vdnesl-------ELYRGTVFR.IKGEYP---.........--FREEYVDFMLCDY.PNC...sENKSpfALYCISGYCAGE.LEYVFPLEAMS.ES...SR.S..IRREWILENWNKRI.FDKCDIDDVEI..........
F9RG81_VIBSN/6-100 .....................lv--ELEDENLWRGTVFR.FPATYP---.........---FEPVVDFMLFLD.SAS....ESGF..SLVCTTGYKSGH.HEGGLPLEARA.KG..kVQ.A..ISKTRLIENWTNWV.YPETSVTEVQV..........
A0A1K2HYW5_9HYPH/356-442 ..................dgplp----------AGTILR.FPGGHP---.........--Y-EPIVDFMVVEI.PGG....E--I..GLAVASGFHAGR.IPQILPAEASG.VG...GQ.A..PDAQWLAQNWQHWV.WPACAARDVEV..........
A0A5S9Q9D6_9GAMM/7-98 ..................pllad------KQIFRGAVFR.FSGKHP---.........--FED-VVDFMLIDE.GDS....DIGL..KLICSTGYHAGQ.TELILPKESGY.E-...NG.G..LSLDWLLANWEKWV.YPECSVNDVLV..........
A0A2T5J2X5_9GAMM/7-100 ......................l-NDYPQPVIAVGSVFR.LPAAYP---.........--YES-VVDFLVFNP.REA....DYGL..GLMVSSGYKAGL.TLVILPLASQG.TW...SQ.G..IDKAWLIANWSTWV.YPPCTVDKVW-l.........
A1WM28_VEREI/14-119 ..................aaygd----EADIIWRGCVLR.VPSVSPPDP.........TWYPDPVMGFIVVEA.MPFgaepHGVS..GLLVASGHKAGL.VHVIFPKESLP.KG..yVY.G..LSTAWLIANWKKWV.YPRGNAESVLI..........
A0A447IBR4_9HYPH/6-95 ......................l-ADWPDSMIYTGMRLR.FPAILP---.........--YED-WVEFMLVVI.P--....DQEN..ALLVATGYKAGR.IPQVLPPDAGP.TG...--.A..VSCKWLMENWTKWV.FPSTPPEQVWV..........
A0A2S8WTH2_9MICC/6-99 .....................ik--DYRRATLNAGTVFR.FPAQVP---.........--FES-IVDWMLMED.SIS....DSGF..SLFCVSGYHSGQ.VELRLPAEAKT.ET...NR.S..IMTRWVCENWQQWI.YTHAKVSDVWI..........
A0A1H2ZNR5_9PSED/7-99 .......................LTTCGKDSFGRGVVFR.FPAKQP---.........--FEK-VVDFMIIED.HDS....PAFY..KIICSSGYHAGQ.TELVFPAEAK-.HE...PS.G..ISVDWLKKNWSLWV.YPECELANV--ny........
A0A1V9FFM5_9BACT/6-97 .................lidske-------DLVRGSILR.CKGMYP---.........--YED-YVDFMVIEQ.QG-....--EY..ALLVISGYKAGL.TFVVLPQESVP.AN...NE.GyaINIEWLKSNWSKWG.YIDCPVTDVHI..........
A1WM28_VEREI/154-263 .......................LTTYGSDVVKRGCILR.VPSASPPEQewddsvdvfTWYPDPVIDFIVVDA.DSF....EGRS..GLLVASGHKAGV.VYVIFPKESIP.EG..dAR.G..LSTAWLIANWKKWV.YPWGSAESVLV..........
A0A380QRV2_YERRU/3-93 .......................LVDYKNKSIKRGSVFR.LPAVWP---.........--YEA-WVDFMVIDL.FD-....--AH..GLVVSSGHKAGL.ILISLPVESGS.TE...GR.A..LSPEWVINNWAEWI.YPECDVGDVHI..........
B2VDT2_ERWT9/6-96 .......................LLNYPEKSIRRGRVFR.LPAVWP---.........--YED-IVDFMVIDL.AH-....--TH..GLVVSSGFKAGS.MLVELPSESAS.SE...GH.A..LSTEWVINNWSKWI.YPECAVKDVYI..........
A0A2U2DW00_9HYPH/4-100 ......................l-TETAAEALWVGDILR.LPENYDLG-.........--PGSPPVDLIVYEP.NDA....ECGL..GLLVISGYKAGL.IYALLPLPSLL.KG...TR.A..LDLGWLKDNWDRWFcYE---------hgddmrvi..
A0A081MZY1_9GAMM/3-99 ....................lvd---CNMDWFPHGTVFR.LPGKYP---.........--YEN-LVDFMVYDP.AIT....DRGQ..GLMVSSGYKAGL.ILVLLPKESST.KGdlyRH.S..IEKNWLIKNWSQWV.YPECPVSEVYV..........
A0A0U3L2W9_9BURK/6-111 ......................l-LDYPFNEVYGGSIIR.VPTMKPYNG.........EWYIDPVVDFLVFEA.YSLm..pDAGL..GLMVISGPKAGK.VNVVFPNSSYT.PN...TR.G..LNKRWLIDNWKKFF.YRDGE------phqawivsag
A0A4S5JHF8_9HYPH/4-97 ................lldietp-------QIWRGAIFR.VRGSYP---.........--YEE-TVDFMVVET.TDE....TRPL..GVMAATGYSAGH.TFVHLPPEAIV.LG...TK.S..ISVAWLKANWAKWV.YPECPVEDVL-f.........
A0A6B2FLA2_9ENTR/3-93 .......................LLNYPEKSIRRGRVFR.LPAVWP---.........--YED-IVDFMVIDL.AH-....--TH..GLVVSSGFKAGS.ILIELPLESAS.SE...GH.A..LSTEWVIKNWSKWI.YPECAVEDVYI..........
A0A7W6NI55_9HYPH/4-100 ...................laet----GEEALFVGDIIR.LPDNYDLGP.........---DTGPVDLIVFEP.NDE....ECGL..GLLVISGYKSGL.IYALLPTESMK.GG...SR.A..ICIDWLRREWDRWFcYAHG-------dgmkvm....
A0A1A9HRF9_9BURK/3-104 ......................l-IDLPGNVVQIGSIMR.VPTVYTYRG.........DWYPEAIVDLLVFNA.QGFs..kESAT..GMIAITGYKAGL.INVIFPLASKP.AQ...QF.G..LSKQWLIDKWTEWV.YPAGNVQDVWI..........
A0A4P7J296_9ENTR/3-93 .......................LIDYKNKSIKRGTIFR.LPAVWP---.........--YEK-WVDFMVIDL.FE-....--TH..GLVVSSGHKAGL.ILISLPIESAS.IE...GR.A..LSTEWVITNWAKWI.YPECNVEDVYI..........
A0A4Y6ULY1_9PROT/142-236 ......................l-ADYEEDFLDFGGVFR.LDAEWP---.........--YEE-KVDFIISEI.PSSs..kDRKY..ALVVSSGVKSGH.ILVFLPNEC-L.DE...NE.K..LSKNWMLENWEKWV.YPEADIQNVY-y.........
A0A380QRG1_YERRU/3-93 .......................LVDYKNKSIKRGSVFR.LPAVWP---.........--YEA-WVDFMVIDL.FD-....--AH..GLVVSSGHKAGL.ILISLPVESGS.TE...GR.A..LSTEWVINNWAEWI.YPECDVGDVHI..........
A0A1X7PNL4_9HYPH/4-100 ...............lteledar--------LYAGDILR.LPHSYDLGP.........GS---GPVDLLVFDP.RDG....KAGL..GLITASGYKAGL.VFCVLPKDSTH.SG...GA.G..LSAKWLIRNWDRWI.T----------ytyhpetrip
#=GC seq_cons ............................tp.lh+GslhR.hPuhaP..............YE-.hVDFMlh-...s.....ptth..uLlVsSGaKAGh.lhlhLPtEuhs.pt...sp.u..lSspWLlpNWs+Wl.YPcsslpsVhl..........
//
