#=GF ID   Imm9
#=GF AC   PF15587.10
#=GF DE   Immunity protein 9
#=GF PI   Imm48; Imm48_;
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   de Souza RF;0000-0002-5284-4630
#=GF AU   Anantharaman V;0000-0001-8395-0009
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   [1]
#=GF GA   25.00 25.00;
#=GF TC   25.10 39.20;
#=GF NC   24.80 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22731697
#=GF RT   Polymorphic toxin systems: comprehensive characterization of
#=GF RT   trafficking modes, processing, mechanisms of action, immunity
#=GF RT   and ecology using comparative genomics.
#=GF RA   Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL   Biol Direct. 2012;7:18.
#=GF DR   INTERPRO; IPR028963;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A predicted immunity protein with an alpha+beta fold and a
#=GF CC   conserved lysine residue. Proteins containing this domain are
#=GF CC   present in bacterial polymorphic toxin systems as an immediate
#=GF CC   gene neighbour of the toxin gene, usually containing a domain of
#=GF CC   the Tox-URI2 family [1]. The protein is also found in
#=GF CC   heterogeneous poly-immunity loci.
#=GF SQ   34
#=GS A0A139SMM5_9GAMM/9-63     AC A0A139SMM5.1
#=GS A0A139SXY8_9GAMM/6-157    AC A0A139SXY8.1
#=GS A0A139SWB3_9GAMM/1-115    AC A0A139SWB3.1
#=GS A0A3R6LN15_9BACT/5-153    AC A0A3R6LN15.1
#=GS A0A212UHA1_9BACT/27-181   AC A0A212UHA1.1
#=GS A0A139SNH8_9BACT/6-157    AC A0A139SNH8.1
#=GS A0A0F5IPK8_9BACT/5-153    AC A0A0F5IPK8.1
#=GS A0A139SWD2_9GAMM/9-161    AC A0A139SWD2.1
#=GS A0A139SYC8_9GAMM/185-336  AC A0A139SYC8.1
#=GS A0A139SPX1_9BACT/1-148    AC A0A139SPX1.1
#=GS A0A139SYK3_9GAMM/107-197  AC A0A139SYK3.1
#=GS D7JC39_9BACT/5-153        AC D7JC39.1
#=GS A0A139SWS6_9GAMM/9-160    AC A0A139SWS6.1
#=GS A0A139SY13_9GAMM/8-158    AC A0A139SY13.1
#=GS A0A139SPX1_9BACT/171-322  AC A0A139SPX1.1
#=GS A0A3N2N1E8_9BACT/21-170   AC A0A3N2N1E8.1
#=GS R6DDV4_9BACE/2-51         AC R6DDV4.1
#=GS A0A139SW91_9GAMM/5-157    AC A0A139SW91.1
#=GS A0A139SYC8_9GAMM/358-510  AC A0A139SYC8.1
#=GS A0A139SWA2_9GAMM/36-121   AC A0A139SWA2.1
#=GS A0A139SYK3_9GAMM/395-546  AC A0A139SYK3.1
#=GS R6EAA0_9BACE/1-150        AC R6EAA0.1
#=GS A0A139SMR1_9GAMM/1-77     AC A0A139SMR1.1
#=GS A0A0D3LAQ5_9BACT/7-156    AC A0A0D3LAQ5.1
#=GS A0A139SPT5_9BACT/9-161    AC A0A139SPT5.1
#=GS E5CE83_9BACE/17-167       AC E5CE83.1
#=GS A0A327NN16_9BACT/7-156    AC A0A327NN16.1
#=GS A0A139SXY6_9GAMM/6-176    AC A0A139SXY6.1
#=GS A0A0P0CAH4_9BACT/5-154    AC A0A0P0CAH4.1
#=GS A0A5C0ZJ37_9SPHI/3-156    AC A0A5C0ZJ37.1
#=GS A0A369HZN5_9BACT/4-156    AC A0A369HZN5.1
#=GS A0A139SYK3_9GAMM/220-370  AC A0A139SYK3.1
#=GS F0IIB0_9FLAO/5-154        AC F0IIB0.1
#=GS A0A139SYC8_9GAMM/14-162   AC A0A139SYC8.1
A0A139SMM5_9GAMM/9-63                ..............vkvyrw------MGVPNLLEFADVYSVEKKVATYIESILPRINMED....ISGWELTLSI...NY---...-.------.-.-------.......---...------------------...---.--.-..............------.--.......--------------------------------------------fvs.....
A0A139SXY8_9GAMM/6-157               .................vsa---LMSINVPGLDDFVVMDSIGKEINAYIESILPEIDIED....LSGWRLTFDI...NSFCT...D.LIAIYK.K.FWWYPSD.......REY...VISIAIPIPDNTQARYGM...LSG.TN.Gr...........vgCFRPVD.SN.......HFYALDPEYDKYFSLEQYILASAIKAIDYGLAKGFTCGAKKVKF........
A0A139SWB3_9GAMM/1-115               ....................-------------------------------------MED....LSGWKLSFSI...AYRCT...D.FIAIYK.K.FLRYPSD.......REY...VISFSIPIPDNTQAPYGM...PPA.VD.Gr...........igYFHPGR.SN.......SSHLLNPEYDQYDNLDQYILAAVIKAIDLGFTKGFTCYGKKIKF........
A0A3R6LN15_9BACT/5-153               ...................y-AVLISSEIPELGELDLLRSIYRELNGYMEDYNNQINLDD....LGDWKLLIQI...NLRNT...NgGIGIFK.R.AKRFPSN.......KEF...EISISIPVPNLEEARYGI...SDM.TG.-..............IYIPLN.IK.......NFYILSPCFSKYDNLYHYILESAKQAIDAAFTYGFTCNGKRIK-k.......
A0A212UHA1_9BACT/27-181              mqfsikghtslvlglfdlie-----------------TEGIDASLASLLQRATHATLHSK....LDEWEVVFKL...IFNGG..iS.DIRVYH.R.YSSDPRR.......REK...WVMVHVPIPTTVQVKWGA...PPQ.AViT..............LQAEVGdEK.......WFRTVPGDLSIASTLQEHCCIAARVGILLALTTGLTVGGQRVQ-v.......
A0A139SNH8_9BACT/6-157               ..................is--ALMSIKVPGLGNSADMDSIEKKINTYIESISPGISIED....LSGWRVTFDI...NSFCT...D.LIAIYK.K.FWGYPSD.......REY...VISIAIPLPDNTQAPYGM...PPG.EN.Gr...........sgSFPPVE.SD.......HFYPLAPEYDKYASLEQYIIVSAIKAIDFGLTKGFTCDGKEIKF........
A0A0F5IPK8_9BACT/5-153               ...................y-AVLISSEIPELGELDLLRSIYRELNGYMEDYNNQINLDD....LGDWKLLIQI...NLRNT...NgGIGIFK.R.AKRFPSN.......KEF...EISISIPVPNLEEARYGI...SDM.TG.-..............IYIPLN.IK.......NFYILSPCFSKYDNLYHYILESAKQTIDAAFTYGFTCNGKRIK-k.......
A0A139SWD2_9GAMM/9-161               ...................v-SIGLGIEVIGLRKFANVFSIDKKIATYVKSILPRINMED....LSGWRLQLHI...SYLPT...D.FISVYK.K.FLRYPSD.......REY...VISIGIPIPDNTQAPYGM...PTG.ED.Gki..........slFCRSAS.GK.......HSHLLYPEYDQYDNLNQYILASAIKAIDLGFTKGFTCYGKKIKF........
A0A139SYC8_9GAMM/185-336             ..................ar--VRMAIEVPRLGNFVDINSINEKINTYLDSVPERINTED....LWGWGLIFRI...NAFCI...D.SIAVYK.K.MWTNAHG.......KEY...IIPIAIPLPDNTQAAYGM...PPG.EN.Gr...........sgCFLPVE.SD.......HFYALDPEYDQYVNLEQYIIESAIKAIDFGLNKGFPRDGKEIKF........
A0A139SPX1_9BACT/1-148               ...................m-----AIKVPKLGKFANINSISRKLNTYLESIPPRINIED....LSGGRLIFRI...NSFCT...D.RIAIYK.N.LDYDFAH.......REF...VISIAIPLPDNTQVPYGM...PPG.EN.Gk...........tgSFPPVE.SE.......HFYPLDPEYDNYDNLEQYILEAAIKAIEYGLTKGFTDGGIELKF........
A0A139SYK3_9GAMM/107-197             ............steterlf----------------------------------------....----------...-----...-.------.-.------S.......KKY...EASIIIPIPDNTQAPYGM...WPY.ES.Wk...........igDFSPAS.GT.......DCHLLDPEYDQYSGLEQYILVSAIKAIDFGFSKGFTCAGKEI--if......
D7JC39_9BACT/5-153                   ....................IKVFLQIEIPRLNEDVDIASIRQRLNDHVKSLIPMINIQD....LMDWSLLICV...TFRST...N.GIGVFK.R.ARRYSSD.......KEF...EFSISVTIPNDNQALYGL...SKV.KE.A..............FYTPLN.DK.......NFYILKFNFENYNNLHEYILESSKLAIDLAFTKGITCNGKKIKF........
A0A139SWS6_9GAMM/9-160               ..................vg--VSMGLEVLGLNDFVDTSSIRKKIKTYIESILPRINMED....LSGWRLTFFI...NYRHT...D.LIGVFK.K.FFRYPSD.......REY...EISIAMPIPDNTQAPYGM...PSA.KD.Grv..........gdF-LPIR.SD.......RFHPLDPEYHKYDNLDQYIIASAIKAIDLGFTKGFTCYGKKIKF........
A0A139SY13_9GAMM/8-158               ...............fhtrt------HEITGLYPYADMYSIEKEINTYFESIFPRINTED....LSGWSLAFFI...YYRCT...D.FIAIDK.Q.FTRCSLD.......KEC...EISMYIPIPDNRQAPYGI...PPI.DD.Gs...........igSFHPAI.EK.......IWHLAEPEYDQYVSLDQYVLAATIKAIDLGFSQGFTFYRKKIKF........
A0A139SPX1_9BACT/171-322             ...................v-TVVMGNNVPRLDDFADMSSIYKKIDTYIKSILPRINIKD....LSEWKLTVGI...DHVCA...E.CISILK.K.LGPYPSH.......KEY...VTLLAIPIPDDRQAPYGM...PRS.ED.E..............PIEPLE.LKr....ksDFHLLDPEYDKYADLNQYILASTIKAIELGFTKGFAREGKALR-f.......
A0A3N2N1E8_9BACT/21-170              ....................MNFDYSSGYPEMSCFD-----YNVIETYFQDLTGQIKVDD...sITNWTLSIEI...SLGGAigeK.EICIGK.R.GVTYLKD.......KEK...IIAIKISLPIKEEISWGI...DKK.HR.-..............FNEYAK.RKs....nkGVTIIPVDYAQFNDMTDYVESSIKLSLKQVFTDGITLKGHTIKL........
R6DDV4_9BACE/2-51                    ...............hiycl----------------------------------------....----------...-----...-.------.-.-------.......---...------------------...---.--.-..............------.-K.......NVRLIPVDFTKYDDMGSYIEDTIKIALQSLFEVGFTLKGCKVR-k.......
A0A139SW91_9GAMM/5-157               .................qvg--FSMGIAVPRLGNFADISSIKKEIATYVESILPKINIED....LSGWKLTFHT...TYACT...D.FIGVYK.K.FLRYPSD.......REY...VISIAIAIPDNTQAPYGI...PPR.RD.Gt...........igSFRPAR.SN.......RSHLLDPEYDKYDNLDQYILAAAIKAIDLGFTKGFTCYGKKIKF........
A0A139SYC8_9GAMM/358-510             ..............vrssmp------IAVQRLRHFADINSINKKINAYVESILPRINIED...lSAGWRLSLIT...DYLCT...D.FVGIDK.E.FKCYPSF.......KEY...GISIAIPIPDNTQAAYGM...PPG.ED.Gk...........igCFHPAS.SN.......CSHLLDPEYDQYDDLEQYIVASAIKAIDFGFKNGFDCDGKKIKF........
A0A139SWA2_9GAMM/36-121              ...............vraim-----PISVPGIWNFADMGPIERKVNTYIDSILPRINIED....ISGWRLLLHI...NSVCS...D.LISVYK.K.FLRYPSD.......REY...VIYLP-------------...---.--.-..............------.--.......--------------------------------------------slspiirk
A0A139SYK3_9GAMM/395-546             .................vra---RMSIEVQRLGHFADMESVGEKIDAYVESILPRINIED....LPGWRLFLLT...DYLCT...D.FIGIDE.K.FKWYPSV.......KEC...GISIVIPIPDNTQAPYGI...LPD.RD.Vk...........igCFRPAR.SN.......YSHVLDPEYEQYVSLEQYMVASVIKAIDFGFSKGFDCDGGKIKF........
R6EAA0_9BACE/1-150                   ....................MNFDYSSGYPEMSCFD-----YNAIETYFQDLTGQIKVDK...sITNWTLFIEI...SLGGAigkK.EICIGK.R.GITYLAD.......KEK...FISVNISLPIKEEISWGI...DKK.YR.-..............FNEYAK.RKs....dkGLTIIPVDYAQFKDMTDYVESSIKLSLKQVFTDGITLKGHTIKL........
A0A139SMR1_9GAMM/1-77                ...................m----------------------------------------....----------...-----...-.------.-.-------.......---...--MISPPIPDNRQAPYGI...PPL.GK.K..............IKAFRP.IKn.....vRFHALDPEFHKYDNLEQCILASAIKAIDFGFTKGFACYGKKIKF........
A0A0D3LAQ5_9BACT/7-156               .....htsyviefldvgfss------------------ENISQIIEYEVDNLLELHSYIN....RTDWELYFRA...TYTNA...R.QLLISK.N.--KFGAN.......RSVkvkEVTVPIPIPLLEESEWGV...TKE.QH.T..............FDKNHY.DKi....sqNFWSIDVEFKDFTDRTGYILDCMRKAVKLSLATGLTVDGVTVKI........
A0A139SPT5_9BACT/9-161               ....................LSIGLGIEVVGLTKFADVFSTDKKIATYVKSILPRINIED....LSGWRLQLHI...SYLPT...D.SISVYK.K.FLRYPSD.......REY...VILIGIPIPDNTQAPYGM...PTG.AN.Gki..........slFCRSAG.DK.......HNHLLDPEYDKYADLNQYILAAAIKAIDLGFTKGFTCYGKKIKF........
E5CE83_9BACE/17-167                  ...............hqlfe-----KCEWPELNCFD-----REMVEGYFSDLVNGIQTDE...aLDDWTLTVVLyigTYLGA...N.HISIWK.H.GITDTVT.......KEK...VLTIGIPLPCSKTIRWGV...KKK.GR.-..............FTGKIP.DEsf...rrNNRLLPVNFVKYDNMETYIEDNIRIALLNLFEVGFTLKGYKVK-k.......
A0A327NN16_9BACT/7-156               .hsslvinfldvgfdsnqls--------------------------IRAKTIADQILLNNyfseKNDWLINFIA...SYNNG...R.QLLITR.NkIGTYSKD.......KIK...EITLAIPIPSIRTVTWGV...EDN.QY.I..............YGPDHY.DQi....lkNFWAEEVNFHQFSNRSDYVYSCLKKGIERAFFEGFTVGGIKV--vv......
A0A139SXY6_9GAMM/6-176               ...................i-KIHTRFDVTALCDFADMDFVDEKIKIHAKSILPRINIED....FAGWKLVFDI...DFRCA...N.FIGIDK.K.IRRLESGpydsfkyKEY...VILIAIPIPDNTQAPYGI...PPV.EN.GslrpyssgiprrkpV-----.-MevagkstRFRLLDPGYNQYVKLEQYALASAIKAIDLAFSKGFTLGGKKIKF........
A0A0P0CAH4_9BACT/5-154               .....ithssyvinfldvnf----------------DSKKLSKTLKLEADRILRQITFEN....LQDWEIEFRG...AYGKG...E.KIRVYK.K.TRSYTTD.......KIK...LIVIHIPIPINTIVPWGV...EES.QQ.V.............dLTIPKN.SE......rYFDVLPVDYNSFSNINDYLLDSFRRGIEHSFKDGFKVNGNLV--if......
A0A5C0ZJ37_9SPHI/3-156               ........mkvrhvsyvldf-----------MDKDFDTDSISDALTKEFSGVFESIKNSK....SQMWEIQFRA...TYTNG...K.MLLISK.NkFGNYTSD.......KIK...EITIPIPIPVDETVSWGV...KPQ.QH.T..............LKVDHY.DKl....lnNFWELDVDYTKFFNRTDYIMDCMRRAINLCFEKSYTVNGVKL--nk......
A0A369HZN5_9BACT/4-156               ...rivhssllsnflnvdfs-----------------TRQLSAQFKTLVDSILLKNGLST....KNDWLIVFRV...VYNNG...R.QLLISKnR.FGTFYSD.......RIK...EIQIVIPIPSIQGVPWGV...KDN.QY.I..............YGPDHY.QTl....lkNFWVEEVHVLQFNIRADYIYDCLRRAIERAFFEGFTVGGVKI--va......
A0A139SYK3_9GAMM/220-370             ..................ar--VRMEIELPGLDDVVDIDSINNKLNAYVESIAPSINIEC....LSGWMLVFHV...NHFCV...D.LIAVYK.K.LSRDSAE.......KEY...IIPIAIPLPDNTQAAYGMlpgEDG.KT.G..............SFRPVE.SN.......HFYPLDPEYDQYDNLEQYIIESVIKAIDFGLSKGFVI-GKEI--sf......
F0IIB0_9FLAO/5-154                   ...................v-KVCLQVEIPRLSEDVDIDSVRQGLNDYVKSIIWGINVAD....LEDWRLMIRV...TLRST...N.GIGVFK.G.AMRYPSD.......KEF...EFSISVAIPNEKEASYGV...SEKvEE.A..............FYVPLN.DK.......NFYVLETNFENYSNLYEYILESSKLAIHLAFTKGIRCNGKKI--if......
A0A139SYC8_9GAMM/14-162              ................ehhg--------VYGVRNFADLDSIGKKIENYVESILPRIDIEG...lAEGWKLDLFI...DCECT...D.RIAVYK.K.FYQKTED.......KIY...GISIDIPIPDETQAPYGM...PLD.ED.G..............KIGRFY.RKd....igLYHLLEPEYDQYVNLEQYILLSAIKAIDFVLSKGLYSDGKEIKF........
#=GC seq_cons                        ...................h.......tl.tltphsshtulpcplpsYhcolhspIsh-D....lssWcLhhpl...shhss...c.hIulhK.+.hhpasuc.......+Eh....IoIsIPIPssppAsYGh...sst.pp.s..............hhhsht.pc.......paalLcs-YcpYssLppYIlsosh+AI-huFocGFTstG++IK.........
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