#=GF ID   ImmE5
#=GF AC   PF11480.12
#=GF DE   Colicin-E5 Imm protein
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_2dfx
#=GF GA   25.00 25.00;
#=GF TC   28.20 28.30;
#=GF NC   24.40 20.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17099236
#=GF RT   Structural basis for sequence-dependent recognition of colicin
#=GF RT   E5 tRNase by mimicking the mRNA-tRNA interaction. 
#=GF RA   Yajima S, Inoue S, Ogawa T, Nonaka T, Ohsawa K, Masaki H; 
#=GF RL   Nucleic Acids Res. 2006;34:6074-6082.
#=GF DR   INTERPRO; IPR020127;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Imms bind specifically to cognate colicins in order to protect
#=GF CC   their host cells [1]. Imm-E5 is a specific inhibitor protein of
#=GF CC   colicin E5. It binds to E5 C-terminal ribonuclease domain (CRD)
#=GF CC   to prevent cell death. The binding mode of E5-CRD and Imm-E5
#=GF CC   mimics that of mRNA and tRNA suggesting an evolutionary pathway
#=GF CC   from the RNA-RNA interaction through the RNA-protein interaction
#=GF CC   of tRNA/E5-CRD [1].
#=GF SQ   19
#=GS A0A211ZG07_9PROT/24-106  AC A0A211ZG07.1
#=GS A0A1G7AZF0_9PROT/24-104  AC A0A1G7AZF0.1
#=GS F0IEM3_9FLAO/26-108      AC F0IEM3.1
#=GS A0A4V1EGS0_9BURK/24-103  AC A0A4V1EGS0.1
#=GS A0A494XQ71_9BURK/24-104  AC A0A494XQ71.1
#=GS A0A494WXK1_9BURK/18-98   AC A0A494WXK1.1
#=GS A0A0H3KJF4_BURM1/24-103  AC A0A0H3KJF4.1
#=GS B4F069_PROMH/28-109      AC B4F069.1
#=GS A0A1H9Y6M6_THASX/23-101  AC A0A1H9Y6M6.1
#=GS Q6D5P4_PECAS/1-82        AC Q6D5P4.1
#=GS D8MV97_ERWBE/27-108      AC D8MV97.1
#=GS A0A5D8YLS9_9GAMM/23-103  AC A0A5D8YLS9.1
#=GS G8Q464_PSEO1/24-103      AC G8Q464.1
#=GS A0A2D2DJT6_9BURK/24-103  AC A0A2D2DJT6.1
#=GS A0A6J5DD18_9BURK/1-81    AC A0A6J5DD18.1
#=GS A0A0L7T0T2_9GAMM/1-82    AC A0A0L7T0T2.1
#=GS A0A857J630_9BURK/24-102  AC A0A857J630.1
#=GS A0A085G0G7_9GAMM/27-108  AC A0A085G0G7.1
#=GS A0A085G0G6_9GAMM/27-108  AC A0A085G0G6.1
A0A211ZG07_9PROT/24-106             MTLTPQAALDVC.QSLIEKNLVALMIEGGIWRNPGLEPRLDCIWNA.RP.KNLSTSEgINITNKQAYKFIKEEHRLGHDVFILTV-e.
A0A1G7AZF0_9PROT/24-104             MFLSSEAAIEVClQCASKGQVVLG-IEGGNWKAQRFQIALDCIFDG.VE.PPVTANA.AH-ENNVRISEVIKKESKKRDVFIVT--sm
F0IEM3_9FLAO/26-108                 MKLSSLAAIDVC.KECTRREMYVWRIEGGIWHSPGFEARIDCIWDScFDpKSNSNSS.IKDNNRLAEEFVKEE-MNSCDVFIATI-y.
A0A4V1EGS0_9BURK/24-103             MKVSADPAIAIC.VAAAEHGLVVARIEGGIWHNSGFEARLDCIWDG.VD.PPVDRRT.TEQNNCAAADFVRS-ERKLHDAFVIT--a.
A0A494XQ71_9BURK/24-104             MRMTTQAAIAVC.SEAAERGLVVARIEGGIWHNPGFEARIDCIWDS.AE.Y-PPKVD.AINTNNLAAANFIHAQERDYDVFIVTT-i.
A0A494WXK1_9BURK/18-98              MKLTTEAAIGVC.EQAAQRGLLVSRIEGGIWHNPGFEARIDCIWDG.GD.PPLDVQA.AHENNLAAIEFIRSELP-EHDAFIIT--sl
A0A0H3KJF4_BURM1/24-103             MKLSAGAAIEIC.ERAAEQGLVVSRVEGGIWHFPGFEARLDCIWDG.AD.PPVDSTA.ANQNNLAAADFIRAES-NVHDVFVVT--a.
B4F069_PROMH/28-109                 MYLSPKAAIEVC.QEATKRNLWISGIDGGHWLNPGFRPDGSASWSG.KT.KLFNENK.ISENNQLAIENIQEDAAAGYTAFIVTL-r.
A0A1H9Y6M6_THASX/23-101             MKLTPAAAIEVC.RRSTDLNYIVSRVEGGIWHNPGFEMRLDCIWDR.GI.VC--NGK.QLSACEEAIRFIENES-EEHSAFIIS--lq
Q6D5P4_PECAS/1-82                   MKLSPKAAIEVC.QEATKRNLPIGMIEGGHWLNPGFQPDGNTRWDG.FD.KLTDKSE.IKKSNDNAIENINDDSSKGYNAFIITIV..
D8MV97_ERWBE/27-108                 MKFTPKGAKELC.EEATKRNIFIGRIECGNWSVSGFCPDGNMTWDS.KS.DLVAAGK.IKENNDLAIENINEDASEGYNAFLFTL-p.
A0A5D8YLS9_9GAMM/23-103             MRLSPAAAASAC.EQAASRGIVVARVEGGIWSAPNFEARGDCIWDG.LD.QPVSQPQ.AAANNLAAAQFIHA-HANSHSAFILT--ty
G8Q464_PSEO1/24-103                 MRLSPTAAVEVC.MTAAAHGRVVARIEGGIWHSPGFEARLDCIWDG.AD.LPISESN.AHLNNLVAGDFIREEM-DCHTAFILT--a.
A0A2D2DJT6_9BURK/24-103             MRLSPDAALLVC.AQAARQGLVIARVEGGIWHAPGFESRLDCIWDG.QD.PPLDEDQ.ASRNNKDAARFIASQAS-AHSAFILT--a.
A0A6J5DD18_9BURK/1-81               MKLTPEAAIEVC.ERAAKRGLLVSRIEGGIWRNPGFEARIDCIWDG.AE.PPLDAKA.AHENNLIAIEFIRSEFP-EHDTFIITM-l.
A0A0L7T0T2_9GAMM/1-82               MKLTAKAAKEVC.AEATTRNVFIGRIEAGHWLNSGFRPDGNATWDA.KS.ELESAGR.FQQNNQLAIKNIADDKREGYNTFIITTV..
A0A857J630_9BURK/24-102             MKLSPEAALSVC.KIATFRRVSIGRIEGGIFNASGFEARGDCVWDS.KV.AVIFDSP.-GENNELAAKFILEEK-FVHNAFILT--v.
A0A085G0G7_9GAMM/27-108             MKLSPKAATEVC.EEATRRGIFIGAIEGGHWLNPGFKPDMNTNWDS.LK.YYQADAD.LKTNNDRAIENINDDAKEGYTAFIITLI..
A0A085G0G6_9GAMM/27-108             MALSPHAAREVC.EEATLKGFFVGTVEGGHWHNPGFQPDSNTRWDS.LR.YYQADAD.LKTNNDRAIENINDDVSEGYTAFVITLI..
#=GC seq_cons                       M+LSPcAAl-VC.ppAsc+slhluRIEGGIW+sPGFEsRhDCIWDu.tc..shsssp.hppNNphAhc.Ipc-ttpsasAFIlT....
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