#=GF ID IrmA
#=GF AC PF18673.5
#=GF DE interleukin receptor mimic protein A
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF07735
#=GF GA 25.00 25.00;
#=GF TC 26.70 27.70;
#=GF NC 23.50 19.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0159
#=GF RN [1]
#=GF RM 26980835
#=GF RT Molecular and Structural Characterization of a Novel Escherichia
#=GF RT coli Interleukin Receptor Mimic Protein.
#=GF RA Moriel DG, Heras B, Paxman JJ, Lo AW, Tan L, Sullivan MJ, Dando
#=GF RA SJ, Beatson SA, Ulett GC, Schembri MA;
#=GF RL MBio. 2016;7:e02046.
#=GF DR INTERPRO; IPR040755;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The E. coli interleukin [IL] receptor mimic protein A (IrmA), is
#=GF CC a small (13 kDa) Uropathogenic E. coli (UPEC) protein that was
#=GF CC originally identified in a large reverse genetic screen as a
#=GF CC broadly protective vaccine antigen. It has a fibronectin III
#=GF CC (FNIII)-like fold that forms a domain-swapped dimer with
#=GF CC structural mimicry to the binding domain of the IL-2 receptor
#=GF CC (IL-2R), the IL-4 receptor (IL-4R) and, to a lesser extent, the
#=GF CC IL-10 receptor (IL-10R). IrmA binds to all three cytokines, with
#=GF CC the greatest affinity observed for IL-4. It is suggested that
#=GF CC IrmA may contribute to manipulation of the innate immune
#=GF CC response during UPEC infection [1].
#=GF SQ 23
#=GS A0A809S436_9PROT/33-139 AC A0A809S436.1
#=GS A0A2I8Q5A5_9ENTR/30-136 AC A0A2I8Q5A5.1
#=GS A0A2U2ACF7_9GAMM/15-117 AC A0A2U2ACF7.1
#=GS A0A0F7HGN1_SERFO/30-135 AC A0A0F7HGN1.1
#=GS A0A0H2V3L7_SHIFL/31-136 AC A0A0H2V3L7.1
#=GS U1ZR47_9BURK/27-132 AC U1ZR47.1
#=GS A0A1B7JVN6_9GAMM/27-136 AC A0A1B7JVN6.1
#=GS A0A2U2DSH8_9HYPH/8-115 AC A0A2U2DSH8.1
#=GS B4F2Q6_PROMH/2-82 AC B4F2Q6.1
#=GS A0A4S1EB01_9BURK/27-132 AC A0A4S1EB01.1
#=GS A0A485CWZ4_KLUCR/31-137 AC A0A485CWZ4.1
#=GS A0A5J5FTA5_9GAMM/25-132 AC A0A5J5FTA5.1
#=GS A0A059KP03_9BURK/15-117 AC A0A059KP03.1
#=GS A0A2A7URH9_COMTR/29-133 AC A0A2A7URH9.1
#=GS K8WHY4_9GAMM/28-137 AC K8WHY4.1
#=GS D3RWG4_ALLVD/71-175 AC D3RWG4.1
#=GS A0A0B3BT09_9PSED/23-126 AC A0A0B3BT09.1
#=GS A0A2I0FTQ2_9GAMM/30-135 AC A0A2I0FTQ2.1
#=GS A0A421DL88_9GAMM/29-134 AC A0A421DL88.1
#=GS A0A221KFT9_VITFI/22-126 AC A0A221KFT9.1
#=GS A0A1M7TPF9_9DELT/22-130 AC A0A1M7TPF9.1
#=GS S3NMQ5_9GAMM/27-135 AC S3NMQ5.1
#=GS A0A0L7TG90_9GAMM/30-135 AC A0A0L7TG90.1
A0A809S436_9PROT/33-139 ......VSIRHISTAYANQGICSLRFGLGTAM.....G.D.....GD.....AGEVSLKLKFI.....DTNGHE-LYQGEIR-TSLDDSEAGRYQEVFLEDSNVCFDQPTRIQVTRATATI.G.KKRYNLL-------rlrklvv...
A0A2I8Q5A5_9ENTR/30-136 ......ISIRNTDSMWI-QGVCSLVFRLDNGG.....N.G.....E-.....FSNLSVTIQLN.....DKAGNP-LSEGTLDVPPFGDSDATRSIDVAKEFDCDKLEKASTITIVDASETRsN.HAVVKLPLSTFDP-q.........
A0A2U2ACF7_9GAMM/15-117 mpitsd---------YIGQGYCSYLFKVDNGG.....S.G.....SE.....FKNLKLSLNAK.....DMFGQI-IDQQKLEIEGFGDSNATSTTFGLLETECI--DALHEFEIVDAQERQpD.GRWLQLP-------lylfsv....
A0A0F7HGN1_SERFO/30-135 ......ISIRNTDTVWVPGNVCVYQFRLDNGG.....S.G.....EG.....FGPLILSLRLK.....DKSGNT-LAMGNMEVAAFGDSDAMRSQEASLENECV--ENVSSVEIMKATEEH.N.GYQIDLPLSIFDP-q.........
A0A0H2V3L7_SHIFL/31-136 ......ISIRNTDTIWLPGNICAYQFRLDNGG.....N.G.....EG.....FGPLTITLQLK.....DKYGQT-LVTRKMETEAFGDSNATRTTDAFLETECV--ENVATTEIIKATEES.N.GHRVSLPLSVFDP-q.........
U1ZR47_9BURK/27-132 ......VQMWHSDTVFANQGMCAANFTFDSQM.....-.-.....EP.....VQQLRVHIQVL.....SKKNNKLVAEDVIEVDDFGSSSADRYATGYWYNEIACDQNL-RVVVTGATAVM.N.GERVDLLAKDLLEV..........
A0A1B7JVN6_9GAMM/27-136 .....a-SITHTSSNFINQGYCGYSFTLDNGG.....S.H.....MGldhaeFGGLELTLRMK.....DGQGKV-LGDTILEVEPFGDSSATRA--TFTGLEIPCE-DIAEFEVVKAVEDQ.N.GHKVELPLSIFQ--an........
A0A2U2DSH8_9HYPH/8-115 ...lvl---VNTYSWFGGQGYCAYDFAVIEQA.....-.-.....NA.....YENVQITLRPQydpqnTASGNTELQDETITLESLGTSGMDSQQAVKIETDCN----VTGFAVVRATANA.D.GRQVDLLRE-----kavei.....
B4F2Q6_PROMH/2-82 .vldha--------------------------.....-.-.....-E.....FGALELTLRMK.....DGQGKV-LGDTVLEVEPFGDSSATRAM--FTGLEIPCE-DVAEFEVVKAVEDQ.N.GRKVELPLSIFE--an........
A0A4S1EB01_9BURK/27-132 .....l-DMWHSNTVWANQGMCAANFTFDSGM.....-.-.....EL.....VGNLKVSIVAV.....EKGTNKIKGQGVIELEDFGESSADRYAIGYWESELACDDNL-YLVVTEAKADI.D.GVREDLLEKGLL--ra........
A0A485CWZ4_KLUCR/31-137 ......ISIRNTDSAWI-QGVCSLVFRLDNGG.....D.G.....-E.....FKALAISLQLT.....DKSGKA-LETGSLDVEPFGDSDATRSIDAATEFSCDAVENTANIVITKVDEIYpD.GSVHALPTTVFD--pq........
A0A5J5FTA5_9GAMM/25-132 ......IEIWHTDTVWAGQGACSAQFTLDNGG.....AfG.....EP.....VGKLEISVDVL.....DKSGKV-LQKDTLNVEPFGDSNATRYQTALLEGENYCESDL-TINITQVIEIA.G.RAKKALPVNEF---sar.......
A0A059KP03_9BURK/15-117 ......IEVWHSNTVFGGQGQCVATLTLDSGL.....-.-.....DE.....FRQVRLQATVL.....DKAGRRLMA-QTLDLPSIGSSSAERFAEVMIDGEALCDEQL-QLQITSATAVA.N.GKRIDLLR------tgql......
A0A2A7URH9_COMTR/29-133 .....l-ELWHYGTLRLSPQRCEATFMFDAGR.....-.-.....AT.....YREVRVQAIAK.....DRQGQH-LARFALAPDDMGVDGRNRFASATWISPHACNPEV-VVLFKTATAQV.D.GMATDLLATQ----qlrl......
K8WHY4_9GAMM/28-137 .....a-SITHTSSNFINQGYCGYSFTLDNGG.....N.HmvldhAE.....FGALELTLRMK.....DGKGKV-LGDTVLEVEPFGDSSATRAT--FAGLEIPCE-DVAEFEVVKAVEDQ.N.GHKVELPLSIFE--an........
D3RWG4_ALLVD/71-175 ......IRFWNTNKLFANQGQCSAVFFFDSGL.....-.-.....QS.....IENLQVSFSAL.....NASGES-IATGTLEIATFGNGSADRYADAFAESEHFCDDDL-TIVVDQATAII.E.GKQVDLLAQKV---lvp.......
A0A0B3BT09_9PSED/23-126 ......VEFWHSSTIWAGQGQCSAVFSFDSGL.....-.-.....HE.....ITDLRVAVKAL.....SPEGET-VLEGELAIDQFGQSSAERYADAFLEGEAVCAENL-TIQIEEATARL.D.GRMIDLLAT-----hslt......
A0A2I0FTQ2_9GAMM/30-135 ......ISIRNTDTVWTPGNICVYQFRLDNGG.....S.G.....TG.....FGQLNVSLRLK.....DKADKT-LAQGVMEVASFGESDATRSQDAFLEHECV--EGVSAVEIVKVTELS.G.GHHTDLPLSIFDP-q.........
A0A421DL88_9GAMM/29-134 ......ISIRNTDMVWVPGNVCVWQFRLDNGG.....S.G.....EG.....FGPLTLSLRLK.....DKGGNT-LAMGNMTVAAFGDSDATRSQEASLENECV--ENVSSVEIMKATEER.N.GYQIDLPLSVFDP-q.........
A0A221KFT9_VITFI/22-126 ......IEFWHSNTVWAGQGQCSAVFTFDSGT.....-.-.....ED.....TKNLQVAVNLL.....DKAGKK-LASGTLEVQQFGQFSANRYADAFLESEETCADDL-IITVAKATAII.N.GKRVDLLKT-----ktltt.....
A0A1M7TPF9_9DELT/22-130 ......IDIWHSDNGYH-QGYNIYTLTLDAQDvlfepSiE.....GG.....IEKIELFVDAY.....DVKD-QLIYSGILNVRPFADCQATRTTIIYLETEE----EVQKMLIRKASAII.N.DKRVDLLKT-----svgls.....
S3NMQ5_9GAMM/27-135 .....v-YVRNTHASYVNGGMCSLAFDVTAND.....S.I.....EN.....LENIEFTVTMQ.....DKAGKI-IARDVVTADEFNFVGGKSYGGFFIEGEEACNAFGETLLISKAIVNY.NdGRKS----------edivkskklk
A0A0L7TG90_9GAMM/30-135 ......ISIRNTDTVWTPGNICAYQFRLDNGG.....S.G.....VG.....FGPLAVSLRLK.....DKAGNT-LATGTMDVAPFGNSDATRTQEAFLEHECV--ESVSAVEIIKATEER.N.GYQSDLPLSVFDSQ..........
#=GC seq_cons ......lplhpososassQGhCuhsFplDsGs.....s.......ps.....atsLplolphp.....D+sGps.Lupssl-lcsFG-SsAsRhtpualEsEpss.-sltplpls+Aotph.s.G+pl-L.ho.h...p.........
//
