#=GF ID   KSHV_K8
#=GF AC   PF07188.15
#=GF DE   Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_16868 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   42.10 38.60;
#=GF NC   24.30 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12604819
#=GF RT   Kaposi's sarcoma-associated herpesvirus K8 protein interacts
#=GF RT   with hSNF5. 
#=GF RA   Hwang S, Lee D, Gwack Y, Min H, Choe J; 
#=GF RL   J Gen Virol 2003;84:665-676.
#=GF DR   INTERPRO; IPR010805;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of Kaposi's sarcoma-associated herpesvirus
#=GF CC   (KSHV) K8 proteins. KSHV is a human Gammaherpesvirus related to
#=GF CC   Epstein-Barr virus (EBV) and herpesvirus saimiri. KSHV open
#=GF CC   reading frame K8 encodes a basic region-leucine zipper protein
#=GF CC   of 237 aa that homodimerises. K8 interacts and co-localises with
#=GF CC   human Pfam:PF04855, a cellular chromatin-remodelling factor,
#=GF CC   both in vivo and in vitro. K8 is thought to function as a
#=GF CC   transcriptional activator under specific conditions and its
#=GF CC   transactivation activity requires its interaction with the
#=GF CC   cellular chromatin remodelling factor hSNF5 [1]. 
#=GF SQ   3
#=GS KBZIP_HHV8P/1-238   AC Q2HR82.1
#=GS D0UZR3_HHV8/1-238   AC D0UZR3.1
#=GS U5NM23_9GAMA/1-156  AC U5NM23.1
KBZIP_HHV8P/1-238              MPRMKDIPTKSSPGTDNSEKDEAVIEEDLSLNGQPFFTDNTDGGENEVSWTSSLLSTYVGCQPPAIPVCETVIDLTAPSQSGAPGDEHLPCSLNAETKFHIPDPSWTLSHTPPRGPHISQQLPTRRSKRRLHRKFEEERLCTKAKQGAGRPVPASVVKVGNITPHYGEELTRGDAVPAAPITPPYPRVQRPAQPTHVLFSPVFVSLKAEVCDQSHSPTRKQGRYGRVSSKAYTRQLQQ..........................................................................
D0UZR3_HHV8/1-238              MPRMKDIPTKSSPGTDNSEKDEAVIEEDLSLNGQPFFTDNTDGGENEVSWTSSLLSTYVGCQPPAIPVCETVIDLTAPSQSGAPGDEHLPCSLNAETKFHIPDPSWTLSHTPPRGPHISQQLPTRRSKRRLHRKFEEERLCTKAKQSAGRPVPASVVKVGNITPHYGEELTRGDAVPAAPITPPSPRVQRPAQPTHVLFSPVFVSLKAEVCDQSHSPTRKQGRYGRVSSKAYTRQLQQ..........................................................................
U5NM23_9GAMA/1-156             ---MEDNDKRGSPQGAAHDGGMASADSEFSQNAQSFFSDGADSQEVSTQWRTLALAPYAELETPAVPVCDAVLDLTRPTGRGDAS---------------------------------------------------------------------------------------------------------------------------------------------------------snlsshrasgsnpdggvagyqrvtdrsagsqgahgpsrrsrrrplpredddyfyetvvgskrtgaptpkvetrn
#=GC seq_cons                  MPRMKDIPTKSSPGTDNSEKDEAVIEEDLSLNGQPFFTDNTDGGENEVSWTSSLLSTYVGCQPPAIPVCETVIDLTAPSQSGAPGDEHLPCSLNAETKFHIPDPSWTLSHTPPRGPHISQQLPTRRSKRRLHRKFEEERLCTKAKQuAGRPVPASVVKVGNITPHYGEELTRGDAVPAAPITPP.PRVQRPAQPTHVLFSPVFVSLKAEVCDQSHSPTRKQGRYGRVSSKAYTRQLQQ..........................................................................
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