#=GF ID   L-fibroin
#=GF AC   PF05849.15
#=GF DE   Fibroin light chain (L-fibroin)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_9321 (release 8.0)
#=GF GA   25.00 25.00;
#=GF TC   26.20 119.50;
#=GF NC   20.60 18.90;
#=GF BM   hmmbuild  --aminoHMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Fibroin
#=GF RN   [1]
#=GF RM   10366732
#=GF RT   Determination of the site of disulfide linkage between heavy and
#=GF RT   light chains of silk fibroin produced by Bombyx mori. 
#=GF RA   Tanaka K, Kajiyama N, Ishikura K, Waga S, Kikuchi A, Ohtomo K,
#=GF RA   Takagi T, Mizuno S; 
#=GF RL   Biochim Biophys Acta 1999;1432:92-103.
#=GF DR   INTERPRO; IPR008660;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several moth fibroin light chain
#=GF CC   (L-fibroin) proteins. Fibroin of the silkworm, Bombyx mori, is
#=GF CC   secreted into the lumen of posterior silk gland (PSG) from the
#=GF CC   surrounding PSG cells as a molecular complex consisting of a
#=GF CC   heavy (H)-chain of approximately 350 kDa, a light (L)-chain of
#=GF CC   25 kDa and a P25 of about 27 kDa. The H- and L-chains are
#=GF CC   disulfide-linked but P25 is associated with the H-L complex by
#=GF CC   non-covalent force [1].
#=GF SQ   16
#=GS A0A6J2JLC8_BOMMA/18-256   AC A0A6J2JLC8.1
#=GS A0A6J1WD63_GALME/18-261   AC A0A6J1WD63.1
#=GS A0A6J1NAW1_BICAN/18-251   AC A0A6J1NAW1.1
#=GS A0A3S2NFE9_CHISP/19-262   AC A0A3S2NFE9.1
#=GS A0A2A4JXS4_HELVI/18-261   AC A0A2A4JXS4.1
#=GS A0A8R1XET8_BOMMO/18-256   AC A0A8R1XET8.1
#=GS A0A8J2W593_9NEOP/18-261   AC A0A8J2W593.1
#=GS A0A212EQ24_DANPL/18-262   AC A0A212EQ24.1
#=GS FIBL_BOMMO/18-256         AC P21828.1
#=GS A0A4C1Y9Z8_EUMVA/360-576  AC A0A4C1Y9Z8.1
#=GS A0A5E4PVG7_9NEOP/18-251   AC A0A5E4PVG7.1
#=GS A0A835GRS5_SPOEX/18-259   AC A0A835GRS5.1
#=GS A0A8B8HT70_VANTA/18-264   AC A0A8B8HT70.1
#=GS FIBL_GALME/18-261         AC Q26427.1
#=GS A0A7E5W904_TRINI/19-245   AC A0A7E5W904.1
#=GS A0A821XWV1_9NEOP/18-262   AC A0A821XWV1.1
A0A6J2JLC8_BOMMA/18-256              ..........PSVTINQYSD.NEIPRDIDDGK..A..SS..V..IS.R.AWDYVDDTDKSIAILNVQEILKDMASQGDYASQASAVAQTAGIIAHLSAGIPGDACAAANVINSYTDGVRSGNFAGFRQSLGPFFGHVGQNLNLINQLVTNPGQLRYSVGPALGCAGGGRIYDFEAAWDAILAS...S...D...S...G...FLNEEYCIVKRLYNSRNSQSNNIAAYITAHLLPPVAQVFHQSAGSIT..DLLRGVGNGNDATGLVANAQRYIAQA................
A0A6J1WD63_GALME/18-261              ..........PSVVISQDNI.NNIAPAVGNGRpiS..SA..L..ID.R.AFEIVDGGDTNIYILTIQQILNDLADQPDGLSQSLAVTQAVAALGELATGVPGNSCEAAAVIDAYANSVRTGDNSALSIAVANYINRLSSNIGLISQLASNPDSLRYSSGPVGNCAGGGRSYQFEAAWDAVLDN...A...NpyqV...G...LINEEYCAARRLYNAFNSRSNNVGAAITAGAVVAQTQAAQIILPSLV..NVLSAVAAGGNVAGAAAQAGQALAN-a...............
A0A6J1NAW1_BICAN/18-251              .......pyt---NVNFYNI.ENAPSIPDNGQliN..SN..V..TT.G.ALEWIDGGDVPLYLQILMTSVNDIAA----VNQAAAAIQTIVILGETAPGIPGDACEAAALINA------SANNAGLRPSLVSFIQRIAGYIDTIVRLVNNPNSVRYSSGSRGNCLGGGRSCQFEAAWDRILRE...SspyD...F...G...LLNEEYCAAKRLSTAWNLRSNNVATAITAATIPEVREVVRLGLPEVG..EFLRVLSYGG----------------npgpagqaakaallqr
A0A3S2NFE9_CHISP/19-262              ........vp--VTLTQYSI.NEIPPLNENGR.fI..SS..A..LT.RnALDNVDGGDSNVYTLTLLEGVHDLANQQDRNSQSLAIAQTIAILGELATGVPGQSCEAAAVINAFAGSVRTGNKSGLRPAVMNYLARLANNIDLIVGLVNNPDSLRSAVGPRGNCAGGGRRYEFEAVWDAVLNS...A...NintV...G...LLNEQYCSSKRLYSAFNIRTNNVGAAATAAAVPQVTRAVGQALNAVV..PFLKVVANGGNPAGLAAGAKQA----llra............
A0A2A4JXS4_HELVI/18-261              ..pgvnlsir--------NV.NEVVPPRHNGR..A..VSafL..TN.Q.AFENIDGGDTVPYVLNFQQVVDDLANQGDKSSQALAAGQVIAILGSLSTGIPGDACAPANFIDSYVASLRNGNSV--APALGKFVGAIKQHIDQIVQYLNNPNQLKNAVGPRGNCNGGGRNYQFEAAWDAILSN...AsgaS...A...G...LVNEQYCAAKRLYSAFGLQSSSLGAYVTAVSLPPVNRVLQDALEPVA..KFVASLSSGNYAAA------------aagaknaldnalry..
A0A8R1XET8_BOMMO/18-256              ..........PSVTINQYSD.NEIPRDIDDGK..A..SS..V..IS.R.RWDYVDDTDKSIAILNVQEILKDMASQGDYASQASAVAQTAGIIAHLSAGIPGDACAAANVINSYTDGVRSGNFAGFRQSLGPFFGHVGQNLNLINQLVINPGQLRYSVGPALGCAGGGRIYDFEAAWDAILAS...S...D...S...S...FLNEEYCIVKRLYNSRNSQSNNIAAYITAHLLPPVAQVFHQSAGSIT..DLLRGVGNGNDATGLVANAQRYIAQA................
A0A8J2W593_9NEOP/18-261              .......pta---LVNFVDV.NEARPVIDNGQ..L..VSkaM..TD.K.AFELIDGADIPLYAQMVIQSVNDQANSGDAASQASAVVLAINAIAELASGIPGDACESAALVNAYAYAVSTGNNAGLRSALINYVQRINANIDTIVRLVNNPDSVRYSSGPRGNCIGGGRSYQFEEAWDDILNN...A...NpfqI...G...LLNEEYCAAKRMYTASSIRSNNLAATVTASLSRYVNQIGQNALGPLA..EFLRAAASGGNVNASAGNAKAA----lsra............
A0A212EQ24_DANPL/18-262              .......pta---LVNFVDV.NEARPVIDNGQ..L..VSraL..ID.K.VFELIDGADIPLYAQMMIQSVNDQANSGDAASQASAVVLAINAIAELANGIPGDACESAALVNAYAYAVSTGNSAGLRSALVKYVQRINANIDAIVRLVNSPDSVRYSSGPRGNCIGGGRSYQFEEAWDDILNN...A...NpfqI...G...LLNEEYCAAKRMYNAPSVRSNNLAATVTASLSRYVNQIGQNALGPLA..EFLRAAAIGGNLNVSAGNAK------aalsral.........
FIBL_BOMMO/18-256                    ..........PSVTINQYSD.NEIPRDIDDGK..A..SS..V..IS.R.AWDYVDDTDKSIAILNVQEILKDMASQGDYASQASAVAQTAGIIAHLSAGIPGDACAAANVINSYTDGVRSGNFAGFRQSLGPFFGHVGQNLNLINQLVINPGQLRYSVGPALGCAGGGRIYDFEAAWDAILAS...S...D...S...S...FLNEEYCIVKRLYNSRNSQSNNIAAYITAHLLPPVAQVFHQSAGSIT..DLLRGVGNGNDATGLVANAQRYIAQA................
A0A4C1Y9Z8_EUMVA/360-576             ...srprlpt----------.-----------..-..--..V..TA.G.AFELSDGGETNIYTLTIQEIINDLSKQPDAQSQAIAFGTTLAVLGELAAGSSGDACAYANAVDAYVGYLGSGNSAGLRGALGGVVGRLNGAIDSIAGLATNPGSLRYSRGASGGCAGGGRSYQFESAWESVLGS...AginN...A...G...LLNELYCASRRLYNAYNDRSNNVGAAASAAAIAPVAKVVGGAIGPIT..NLNDDV--------------------eiaahsamaglt....
A0A5E4PVG7_9NEOP/18-251              ..........PSASVSFYNA.NQIDSPVDNGN..LvnRY..V..IS.G.PFDYLDVSDIPLYSNMMLQILGDLSIVPDSVAQTSAVIQAIATLGELTNGIPGDSCEAAGLINAFAYASSSGNNAGLAQALANFVQRLSNNIDSITQLIVNPSSARYSAGPRGNCLGGGRTYQFEEAWDAILSN...S...S...P...-...------AASSRMYNAFNIRSNNVGAAVTATNIPQVVQVAQYAVQYLT..NFLRVVASGSNPSQAGAAAKSALAQ-g...............
A0A835GRS5_SPOEX/18-259              pgaylniisi---------D.EAIP-PKDSGR..A..VS..AfrID.Q.ATEIANQGEASAYLLTFEQIIKDLGNDSNKVSQALAAAQAIGYLGAVSSGVPGDSCAAADLINAVVAASRSGNNQAVRSATAKFVSYLSSLIDNIVELSVNSESMRFAVGPRGNCPAGGRNYQFEAAWDSILAS...A...P...A...SsvhLVNEQYCAAKRLYKGFSVVSNNAGAILTAVSLPSVNLAFQNVLPQAA..NFLAALPSGNAGSA------------asalkqalyn......
A0A8B8HT70_VANTA/18-264              ..........PSVVGVQFKNfNEVAPVSDNGK.lV..SS..Y..ITdG.SIAYIDGGDTPLYAQMIIQSINDMADTSDTDSWANAVIQTIATVGELANGVPGDACEAAALINAYAYSVSTGNSAGLRAALPNFVQRIAGYVDTIVQLVVNPNGVRYSSGPRGKCLGGGRSYQFEEAWDGILDK...A...N...AyqiG...LLNEEYCAAKRLYNAFNIRSNNVAAGVTAVTTRPVNQLVQLALPQLAqvSFLRVVANGGNPAQAGANAKNALL--qs..............
FIBL_GALME/18-261                    ..........PSVVISQDNI.NNIAPRVGNGRpiS..SA..L..ID.R.AFEIVDGGDTNIYILTIQQILNDLADQPDGLSQSLAVTQAVAALGELATGVPGNSCEAAAVIDAYANSVRTGDNSALSIAVANYINRLSSNIGLISQLASNPDSLRYSSGPAGNCAGGGRSYQFEAAWDAVLNN...A...NpyqI...G...LINEEYCAARRLYNAFNSRSNNVGAAITAGAVVAQTQAAQIILPSLV..NVLSAVAAGGNVAGAAAQAGQALAN-a...............
A0A7E5W904_TRINI/19-245              ...grvnqvs----------.------YDDVG..S..NS..V..IE.G.ILDSVDGGDLTFNILTFEAIIKDLVSLPDPRSQALGFGQAIALVGSLATGIPGDACAAAQFIDNYVNGVRDG------QSVFNFVNSLASQIDLVAQISSDSNALRFATGPRGNCNGGGRNYQFEAAWDLIFDSatpS...Q...F...N...YINEQYCTAKRLKSSVNVNSNNAAAVITAVSLPVVNNILLNSLNEIT..AFAGAVGQGNARAAAGAAKQ------allraa..........
A0A821XWV1_9NEOP/18-262              ......psna---AVTFYNT.NEVGSVPDNGGlvN..SY..I..VS.G.PVDYLDGGSIPLYAQMLLQILNDLANSPNPVSKATAVIQTIAALGELSHGTSGDSCEAAGLINAYAYSAKSGNKSGLRQAIANFVARLSNNIDTIAQLIVNPNAVRYSVGPRGSCIGGGRTYQFEESWDAILSS...AapaQ...S...A...LLNEEYCVARRLYNAFNIRSNNVAAGVSAAAIPQVIKVAQYALQPLA..QFLRAVASGENPLQPAAAAKAG----lnqa............
#=GC seq_cons                        .............sls.hss.NplssshDNGp..s..sS..l..Is.p.Aa-hlDGGDtslYhLsl.pIlsDlAspsDtsSQA.AVsQsIuhlGELusGlPGDACtAAslINAYssuV+oGNsuGLRtALusFlsRlusNIDhIsQLlsNPsulRYSsGPRGNCsGGGRsYQFEAAWDuILss...A...s...s...G...LLNEEYCAAKRLYNAaNlRSNNluAslTAsslPsVsplsptuLssls..sFL+uVusGssssu.sAsApth....t...............
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