#=GF ID LPD22
#=GF AC PF18834.5
#=GF DE Large polyvalent protein associated domain 22
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF SE Iyer LM
#=GF GA 28.60 28.60;
#=GF TC 29.60 28.90;
#=GF NC 28.30 27.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 28559295
#=GF RT Polyvalent Proteins, a Pervasive Theme in the Intergenomic
#=GF RT Biological Conflicts of Bacteriophages and Conjugative Elements.
#=GF RA Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;
#=GF RL J Bacteriol. 2017; [Epub ahead of print]
#=GF DR INTERPRO; IPR040738;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is a predicted enzymatic alpha-helical domain with highly
#=GF CC conserved aspartate residues [1]. The domain is found in
#=GF CC polyvalent proteins of phage and prophage genes and is often the
#=GF CC immediate neighbour of a lysozyme gene [1].
#=GF SQ 49
#=GS A0A0Q4JIQ9_9SPHN/25-122 AC A0A0Q4JIQ9.1
#=GS A0A0A0EVV4_9GAMM/21-116 AC A0A0A0EVV4.1
#=GS A0A679KKF6_9CAUD/19-115 AC A0A679KKF6.1
#=GS A0A7L5YHF9_9PROT/41-137 AC A0A7L5YHF9.1
#=GS A0A1C9VHP3_9BURK/35-132 AC A0A1C9VHP3.1
#=GS A0A381E9H3_9GAMM/11-106 AC A0A381E9H3.1
#=GS A0A812NKJ1_9DINO/8392-8489 AC A0A812NKJ1.1
#=GS A0A4P2VSA8_9CAUD/39-133 AC A0A4P2VSA8.1
#=GS B6WT73_9DELT/17-111 AC B6WT73.1
#=GS A0A7Y7TP66_9DELT/1-69 AC A0A7Y7TP66.1
#=GS Q775D4_BPBPP/40-139 AC Q775D4.1
#=GS A0A5C5UCP2_9GAMM/19-112 AC A0A5C5UCP2.1
#=GS A0A7W6G728_9SPHN/34-131 AC A0A7W6G728.1
#=GS T0H2D0_9SPHN/34-130 AC T0H2D0.1
#=GS A0A2T1ARK8_9BURK/50-148 AC A0A2T1ARK8.1
#=GS A0A0R3Q2Z1_9BILA/1-93 AC A0A0R3Q2Z1.1
#=GS K4NZ44_9CAUD/42-139 AC K4NZ44.1
#=GS V7FHU5_9HYPH/19-123 AC V7FHU5.1
#=GS A0A8H7PDE3_9FUNG/1051-1150 AC A0A8H7PDE3.1
#=GS A0A2S8BAM0_9SPHN/31-127 AC A0A2S8BAM0.1
#=GS A0A1L3ZVI6_9SPHN/18-117 AC A0A1L3ZVI6.1
#=GS A0A196MP94_9SPHN/33-129 AC A0A196MP94.1
#=GS A0A6I5YUW6_9SPHN/27-122 AC A0A6I5YUW6.1
#=GS A0A0M4CXX7_SPHS1/38-136 AC A0A0M4CXX7.1
#=GS A0A377R1N8_9NEIS/18-114 AC A0A377R1N8.1
#=GS A0A1B7XA28_9DELT/57-156 AC A0A1B7XA28.1
#=GS A0A1B7X8P5_9DELT/31-130 AC A0A1B7X8P5.1
#=GS C1D7V1_LARHH/17-116 AC C1D7V1.1
#=GS A0A1B7XAY0_9DELT/33-132 AC A0A1B7XAY0.1
#=GS A0A1Y4GNW3_9BACT/40-145 AC A0A1Y4GNW3.1
#=GS A0A243PEU0_9SPHN/28-125 AC A0A243PEU0.1
#=GS Q6LJT0_PHOPR/42-141 AC Q6LJT0.1
#=GS N6X718_9GAMM/42-139 AC N6X718.1
#=GS A0A6F8VEA8_9PROT/19-118 AC A0A6F8VEA8.1
#=GS A0A1H4HT81_9BURK/50-149 AC A0A1H4HT81.1
#=GS A0A4Y5NY71_9CAUD/23-121 AC A0A4Y5NY71.1
#=GS A0A106BIY4_THIDE/34-130 AC A0A106BIY4.1
#=GS A0A502C2R0_9SPHN/21-115 AC A0A502C2R0.1
#=GS A0A6F9WZE4_9DELT/23-117 AC A0A6F9WZE4.1
#=GS A0A0U1KXI5_9FIRM/21-119 AC A0A0U1KXI5.1
#=GS A0A850H902_9SPHN/38-133 AC A0A850H902.1
#=GS H8FP78_MAGML/35-133 AC H8FP78.1
#=GS A0A650ETA3_9CAUD/24-124 AC A0A650ETA3.1
#=GS K7ZRM7_9CAUD/19-115 AC K7ZRM7.1
#=GS A0A073ITB4_9BACT/38-142 AC A0A073ITB4.1
#=GS A0A4S4AWA1_9RHOO/40-137 AC A0A4S4AWA1.1
#=GS A0A679KGH5_9CAUD/19-115 AC A0A679KGH5.1
#=GS A0A1N6KP96_9BURK/42-140 AC A0A1N6KP96.1
#=GS A0A1G8AP24_9RHOO/26-123 AC A0A1G8AP24.1
A0A0Q4JIQ9_9SPHN/25-122 ......rrdaai-----SRRI-QDANAEQAARVSQLARELD.......YPETLVSAD.L...PAFEARA........KSYRAQ..G.VI..AQYP..AIGA..WS.AKGSNADIAAD..DY..DKLGLFGKAFYGLKNVG---gtl......
A0A0A0EVV4_9GAMM/21-116 ............RAREAAITS-PAIAPDDMAKAQRLGAAHG.......IGPQAVADD.L...KHYDELD........QVDRME..R.FA..TSTP..GASR..WL.-TPERAALVRD..DV..DTLERLGRALPSKGATMRA-t........
A0A679KKF6_9CAUD/19-115 ............RARAAGVTA-PQVDPDAMGRAMRLADQRG.......LPPGVVADN.L...PEYDQQQ........QQDALG..D.AA..SASP..VLAR..WL.GDPNHSALSKD..DT..GVLAGLGRQFNSGLLSA---ket......
A0A7L5YHF9_9PROT/41-137 .........arl---RTSLYGAVKQNPDEVARATQLARQTG.......LPTPIVQRN.L...QTVQQRA........TLDRAE..Q.MR..IDTP..ALAR..QM.ENPDFAAIAHD..D-..GTLSRIETVLKNSGRA----lasg.....
A0A1C9VHP3_9BURK/35-132 ...........r-AVRGSLTATAQTTPERAAQLNYLAQVSG.......MPRAVVETD.E...GSAKAVA........QLREIW..D.AS..ADSP..VLRA..KL.ANPQFTELAKD..DV..GVLSQIERGVQATTRYIM--ga.......
A0A381E9H3_9GAMM/11-106 ..........aa--RRLRLLDALHLNPDKRAEDRTIGMATG.......TPIGLVDDN.T...RRQYRVN........QLDAQM..Q.GL..AVLP..AAVR..KS.--ETFATLAQD..DL..ETLASLEKVTKARQRRAN--ai.......
A0A812NKJ1_9DINO/8392-8489 ........lesy-------RQSLASDPTYAANIQRLARRRG.......LPTDALSDLkP...NQVRELIa......mEQLELR..D.LA..THSP..ILAE..QL.KDRSFAQIAHD..DL..DNLQGIEGWFEEMRRNYR--ag.......
A0A4P2VSA8_9CAUD/39-133 .......dfmst------LEVVGEVNPDQFAKATAVSKYSG.......IPAEVLHKQ.Q...DQMEKLL........KNNRYA..A.VF..DSFP..KTAA..AL.SNGQTAALAQD..DI..DNLTRIEYA-----------kqitkfenq
B6WT73_9DELT/17-111 ..........ir--AALEVADADGVTAQRVASARATALQLG.......LPDSVVEAD.L...QYAQREA........QARRIE..-.--..QNSP..FALW..AA.RSKERAALARD..DT..DGLAGVFSTAKAFGEIRQY-e........
A0A7Y7TP66_9DELT/1-69 ...........m----------------------------G.......IPASILPKN.P...VELRRLE........YPNTLD..G.L-..DPSS..ATAS..FL.SEPGNMAVGHD..DI..ENLSAIEKTFDVLK------rsggs....
Q775D4_BPBPP/40-139 ............QAARAGFVLASDTDPDAYAEAQRVARRAN.......LPIETVLNQ.P...KEAKRQDt......iGAIDFD..T.LG..KTSP..ATAA..LL.ADVEKAKIAHD..NV..DNMTGIESVLSSLGTAVKY-l........
A0A5C5UCP2_9GAMM/19-112 ...........q-QTATVIAATEGQTSQATAEVIDLSQRTG.......APVGAVRAD.P...EGARQHV........ERQQLD..T.LA..AASP..TVSA..WVtGDPDRYALARD..DV..PLLGRF--------------aaplpdwrq
A0A7W6G728_9SPHN/34-131 ...rderirsnl---------MMAQNPEQVAQASALARQMG.......VSPAEIDGL.L...PEAAQAQ........KAKALV..Q.VA..QDHP..DIGA..HLaNNPRTAAVAQG..DH..ASLGILGEAWRVLKDT----ynp......
T0H2D0_9SPHN/34-130 ...........r-DDELAYRI-KVARPDEEARARALAEPRG.......LAPSAVASN.L...PAFEAEA........RAAKAK..N.VM..SQYP..AIGR..WS.AKPGNAAIAAD..DY..DNLSLFGKAFYGLKNFGKT-l........
A0A2T1ARK8_9BURK/50-148 ..........rt--ANDNLLAAQPSKPDVAARAMQLAPQVG.......VPAPAVEAD.L...PTYEQQL........QLQQNR..Q.TL..QGNP..VLAQ..WIaSNPPAARIAQD..DF..DNLDMVSKAMAALKS-----gvvsa....
A0A0R3Q2Z1_9BILA/1-93 ........msvg----------LGANPDMEAELRKVARRTG.......VPVDTARAY.P...EELKRQAa......mGQMDFD..S.LA..QQFP..RTAG..FL.SGTENAKVAHD..DV..ENMGLIETMINSFQR-----gipa.....
K4NZ44_9CAUD/42-139 ...........q-DFVHSMETVSNISPDAYAKATAVSRYSG.......VPAKVLHDN.A...DRMNQLL........RGNQYA..G.IY..TNYR..KTAN..AL.RDGNLAAVSQD..DL..DQLVRIEGAASDTRFNQQS-t........
V7FHU5_9HYPH/19-123 .........vga---AQVVLGSVNEKPDEIAGDLNLANEFGkatgnpvPPLPMVREY.R...NVFQQKI........EEQKNK..T.IL..SSKP..RLTE..WL.RSPDNAALARD..DL..QNLSWFEGFGRGVTNTLS--rs.......
A0A8H7PDE3_9FUNG/1051-1150 ...........q-TAQSNIALAIGANPDYEAEMQRLAQQTG.......TPVDSVKAF.P...DAVKQKAa......vASIDFQ..N.LA..KQFP..TTAA..FY.QSQNNAKIAHD..DV..LGMQAVEQATANLTPAGNT-v........
A0A2S8BAM0_9SPHN/31-127 .........ves----TAISLLNAPPPDTVADAARLAQRFG.......INAMQVAGN.L...EEFKRRQ........RIEDLT..S.TA..LSIS..GFGS..WA.QNPQNAAIAAD..DT..ENVGVLGSIWQGIKNVGS--sa.......
A0A1L3ZVI6_9SPHN/18-117 ..........qd-ARAASMAV-VGINPDSDADLQRKAQSLG.......IPIESARRD.P...QGFEQRVr......eTNTDWD..E.MA..RTRP..ITTR..LM.GSASKAAIAQD..DV..ANMAELERKFGSIRAQRQ--pe.......
A0A196MP94_9SPHN/33-129 ............RDEEMAFRI-KVAKPDEAARAGAIAKARG.......LPAAVVESN.L...PAFEMEA........RAARAK..A.AA..QDYP..AIGR..WS.AKGNNAAVAAD..DY..DNLSLLGKAFYGLKNVGKT-v........
A0A6I5YUW6_9SPHN/27-122 .......niqrt-------EMARLPDPDRAARTSAVARQYG.......VTPTQADAD.L...DDWEKRR........RIDGAL..A.TH..DAYP..AIGR..WA.GQGNNAAIAAD..DY..DNLGLFGKAFYTLKGV----gssl.....
A0A0M4CXX7_SPHS1/38-136 ............RDRQTRLDLLLSASPDTVGRATTIAKEIG.......VPPMHVEDR.L...AEAEKGR........HVRRFM..S.VA..ERYP..AIGK..WAvTQPRGAAAASD..DW..DSLSLLGKTWRSTREVATG-i........
A0A377R1N8_9NEIS/18-114 .....rsliana-------EAGAGVSPDEAAKRRQTAQRLG.......VPVQAVNDA.P...VSAVLQE........QFDKVW..R.DT..QGLG..TLRG..KM.TQPDFYNLAKD..DT..PQLGTIGELANSAAR-----gffk.....
A0A1B7XA28_9DELT/57-156 ............RSAAPMLEYAVTRNPDTVADAQKIAKRTG.......MDADFVEQN.Y...DQLSAQD........RAERQQ..R.LM..ETMD..AGGTmyFM.RDPVNAGMAHD..DL..ENLIRIEQESNPFRALGKT-a........
A0A1B7X8P5_9DELT/31-130 ............RSAAPMLEYAVTRNPDTVADAQKIAKRTG.......MDADFVEQN.Y...DQLSAQD........RAERQQ..R.LM..ETMD..AGGTmyFM.RDPVNAGMAHD..DL..ENLIRIEQESNPFRALGKT-a........
C1D7V1_LARHH/17-116 ..........dq--LAGSLRDALQVNPDDYAKTVRLAKAAG.......VEVEAVPLY.A...DVAQEAQy......lEGIGFR..S.LW..KDSP..KTAE..FL.SDARNARLAHD..DV..ANLSVLEKLARSAGAGLTA-a........
A0A1B7XAY0_9DELT/33-132 ............RSAAPMLEYAVTRNPDTVADAQKIAKRTG.......MDADFVEQN.Y...DQLSAQD........RAERQQ..R.LM..ETMD..AGGTmyFM.RDPVNAGMAHD..DL..ENLIRIEQESNPFRALGKT-a........
A0A1Y4GNW3_9BACT/40-145 .........del---ERSYERYVTENPDEAAARAWNAERVG.......VPLWVQERS.D...KYANEAKkrlallekGTPDWK..K.LA..DASP..VTAS..FM.TGDGVMASAHD..DV..QGLADIEDVTHSLSYLR---lny......
A0A243PEU0_9SPHN/28-125 ...........a-AARRSIIMHNAASPDAAARANVLSRENG.......LPPTIVEQH.L...PAFEIAR........RSERAN..A.LM..AKHP..AIGR..WS.SDPRNIAAAAD..DY..DNLGKLGAAFASRIARDK--rd.......
Q6LJT0_PHOPR/42-141 ..........fq--LSTSMKYGREADPERAGRVFRQQLKTG.......LPSELIERN.L...DDIEKQS........AEKDFD..P.VAfrNKSP..LLSG..WL.QKPENAKVSHD..DL..ENLSTMEWLFRAPVEAYQD-g........
N6X718_9GAMM/42-139 ..........vl---ARSVNQAVTEQPDDLAYIRRLSEDTG.......LSPYIVREN.R...DDIERRV........KQREMG..AqIE..GFSQ..PGKE..WL.SRPDNLGVAQD..DL..PALRALDDAIANRD------wyaqds...
A0A6F8VEA8_9PROT/19-118 ............QAARVGFSAASDTNPDAFAEAQRVARRTG.......VPVDTVINM.P...KEMKRQDa......aGSIDFD..A.MA..KTSP..ATAS..LL.GDIEKAKIAHD..NV..DNLVRIEETLRPITRSAR--sa.......
A0A1H4HT81_9BURK/50-149 ...........q-TAQSNIALAVGANPDYEAEMQRLAQQTG.......TPVDSVKAF.P...DVVKQKAt......vNSIDFQ..N.LA..KQFP..TTAA..FY.QSQNNAKIAHD..DV..GGLQSVEQATTNLGPAS---nvv......
A0A4Y5NY71_9CAUD/23-121 ........klkd-----SLLYGVQQQPDMQARMRRYARDLN.......VPLPAALED.H...QYVGQVG........AVQDLDpnG.MV..LGSP..KTAT..WL.AEPDNAAVAHD..DV..PILQQVENGVRHLGQLGKA-s........
A0A106BIY4_THIDE/34-130 .........avr----AGATLALDSNPDEIARQKRIAQSLG.......VPLAAVEAD.P...EFATREQ........RVRSIE..Q.AT..ANSP..ALRQ..KF.SDADFAKLAAD..NV..DNLSGIEQLLRSAKRGFT--ag.......
A0A502C2R0_9SPHN/21-115 .........ptr----QSLVQTSHLNPDREVENRAIADQLG.......LPGQFIRDN.E...AEARRIK........AQRDAA..A.TA..ASIRgtKTAS..FL.ADTSKAAIAHD..DV..GVLAKIGHW-----------fgenwan..
A0A6F9WZE4_9DELT/23-117 ........qlkg-----SLYSSVDTNPDEEAGLHKLSQKVK.......IPVEALRAD.R..gAEARRLA........AVQGRD..-.--..-DLP..TAST.nFL.SSPDNAKLAHD..DV..DNLSLTERLLTSAGNFLR--nd.......
A0A0U1KXI5_9FIRM/21-119 .......lgqvm-------QVAKNLPQDQAAKILKYSLASG.......DAPILVANN.L...HAYETDI.......vDQIDWD..N.VL..QQSP..KTYE..FL.NNPLHMAAVRDqqNV..ATLSNLENSWL---------swhdlkegg
A0A850H902_9SPHN/38-133 dklredmqfspp--------------PDQIARQERVAREAG.......VEPYEVQNV.-...DDTERAL........QTRKFV..G.LT..EQFP..EVGR..WSaQNPRGAIMAQD..DA..ESLGTLGSIWDT--------ikklpata.
H8FP78_MAGML/35-133 .......arlgs-----NLIAAADTNPDAHAKAMEIGRQIG.......APADAIAAN.L...GEGERMA........KLQKMR..E.AL..GSAP..KLAE..FLtSDPDMAKLSSD..DF..SALTRLEGSMTAAASFGR--gv.......
A0A650ETA3_9CAUD/24-124 .........tql---KANVSEAVKIDPVQHSEITNLSKESG.......VPEFAVKSN.P...KKVKQQLd......lSKVDLD..G.MV..QRSP..NTSK..FLaADMNNAVIAQE..DVfgGLLEGIEETFRGLGR-----sig......
K7ZRM7_9CAUD/19-115 ............RARAAGITA-PQVEPDAMGRAMRLADQRG.......LPPGVVADN.L...PEYDQQQ........QLDALG..D.AA..SASP..ALAR..WL.GDPNHTALSKD..DT..GVLAGLGRQFNSGLLSA---ket......
A0A073ITB4_9BACT/38-142 .........kle---EVYTKY-AAEDPEAHARRVWTAEAVG.......VPQWIQERD.EmyaKEA---ErrlalltkGMPDWR..G.LS..EKYP..LTAR..FF.EDEDVMASAND..DV..EALAAKEGEARRAGAVAKA-l........
A0A4S4AWA1_9RHOO/40-137 ...........r-AVQSTLDRALKIAPQRAATVQQLAERTG.......LPADLVERN.F...EDIERRD........RVREVQ..R.LA..ASSP..ILAR..QL.FDPQFAALAHQ..DV..EQLGIAERIARQLA------ggalea...
A0A679KGH5_9CAUD/19-115 ............RARAAGVTA-PQVDPDAMGRAMRLADQRG.......LPPGVVADN.L...PEYDQQQ........QQDALG..D.AA..SASP..VLAR..WL.GDPNHSALSKD..DT..GVLAGLGRQFNSGLLSA---ket......
A0A1N6KP96_9BURK/42-140 .........qaa--QGVAVAN-SEQSADAAGRAAGIAKQIG.......APQAAVETD.L...PRYEAQA........KAQNNA..Q.IL..SQSP..RLAD..WVaNNPDSARVAQD..DF..DGMSQLEGLTSAQSAQAL--ta.......
A0A1G8AP24_9RHOO/26-123 .......kalre-----QYRA-TSITPDDAAKVIDISARTG.......IPKPVVVRN.Q...SEAAKLA........AEPDWD..G.LQ..VTAP..VTVR..ELaANTKLFDLAHD..DT..DNLSELERTMNRRSEGQ---igg......
#=GC seq_cons ...............t.shthssshsPDphAcspplAcptG.......lPsshVcss.h...sphcppt........ptpchp..s.hh..ps.P..shup..ah.sssspAslApD..Dl..ssLutlEpthpshtt.h...s........
//
