#=GF ID LPD23
#=GF AC PF18838.5
#=GF DE Large polyvalent protein associated domain 23
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF SE Iyer LM
#=GF GA 27.00 27.00;
#=GF TC 28.20 27.50;
#=GF NC 26.60 24.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 28559295
#=GF RT Polyvalent Proteins, a Pervasive Theme in the Intergenomic
#=GF RT Biological Conflicts of Bacteriophages and Conjugative Elements.
#=GF RA Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;
#=GF RL J Bacteriol. 2017; [Epub ahead of print]
#=GF DR INTERPRO; IPR040696;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is an alpha-helical domain that is usually N-terminal to a
#=GF CC metallopeptidase domain [1]. The domain is found in both in
#=GF CC polyvalent proteins of conjugative elements and phages/prophages
#=GF CC [1].
#=GF SQ 39
#=GS A6L6L1_PHOV8/474-530 AC A6L6L1.1
#=GS A0A1G7CT62_9FLAO/7-66 AC A0A1G7CT62.1
#=GS A0A323URW8_9RHOO/738-795 AC A0A323URW8.1
#=GS A0A2K8I347_9CAUD/2217-2274 AC A0A2K8I347.1
#=GS N2IZY8_9PSED/1080-1137 AC N2IZY8.1
#=GS F4KJT5_PORAD/5-59 AC F4KJT5.1
#=GS R5KUU8_9FIRM/163-220 AC R5KUU8.1
#=GS A0A1I2TL80_9HYPH/120-177 AC A0A1I2TL80.1
#=GS A0A347VT82_9HELI/803-865 AC A0A347VT82.1
#=GS N2IZY8_9PSED/1940-1997 AC N2IZY8.1
#=GS A0A2D3WMN3_9PROT/1313-1370 AC A0A2D3WMN3.1
#=GS A0A1N6XKH7_9GAMM/296-353 AC A0A1N6XKH7.1
#=GS A0A0U1KXI5_9FIRM/567-627 AC A0A0U1KXI5.1
#=GS L7TID4_9CAUD/2153-2210 AC L7TID4.1
#=GS A0A6M3I6G7_9CAUD/3698-3755 AC A0A6M3I6G7.1
#=GS R6UCK3_9FIRM/85-142 AC R6UCK3.1
#=GS A1TPS0_ACIAC/1527-1584 AC A1TPS0.1
#=GS A0A7D5TPR2_9CAUD/3290-3347 AC A0A7D5TPR2.1
#=GS N2IZY8_9PSED/751-808 AC N2IZY8.1
#=GS A6KYZ4_PHOV8/547-603 AC A6KYZ4.1
#=GS A0A1I3LHZ4_9RHOB/131-188 AC A0A1I3LHZ4.1
#=GS A0A0D8IUC9_9FIRM/1228-1286 AC A0A0D8IUC9.1
#=GS J6UE11_9RHOB/115-173 AC J6UE11.1
#=GS A0A1I5PC38_9RHOB/125-182 AC A0A1I5PC38.1
#=GS A0A368UA59_9GAMM/1150-1206 AC A0A368UA59.1
#=GS A0A5D6WDM4_9FIRM/1253-1310 AC A0A5D6WDM4.1
#=GS N2IZY8_9PSED/1519-1576 AC N2IZY8.1
#=GS A0A5C1E782_9RHOO/657-714 AC A0A5C1E782.1
#=GS A0A5Q0ELI1_9GAMM/630-687 AC A0A5Q0ELI1.1
#=GS A0A2M8RXZ8_9PAST/1160-1217 AC A0A2M8RXZ8.1
#=GS A0A368UA59_9GAMM/2094-2151 AC A0A368UA59.1
#=GS Q5QF61_9CAUD/39-96 AC Q5QF61.1
#=GS R5YQ00_9PROT/609-666 AC R5YQ00.1
#=GS A0A166HBT0_9GAMM/2784-2841 AC A0A166HBT0.1
#=GS A0A3D8HXR9_9HELI/204-266 AC A0A3D8HXR9.1
#=GS A0A5Q0EGR4_9GAMM/1056-1113 AC A0A5Q0EGR4.1
#=GS K4NZ44_9CAUD/668-725 AC K4NZ44.1
#=GS A0A6G9LJE2_9CAUD/2165-2222 AC A0A6G9LJE2.1
#=GS A0A327JR81_9HYPH/139-197 AC A0A327JR81.1
A6L6L1_PHOV8/474-530 ...asrldrse-------G..A.....SLRLENLAVAREMEKSGKD...AGTIKAATGWERGA.DSK.WRYETAD------feyh..
A0A1G7CT62_9FLAO/7-66 ..........g-EKGARNLpdA.....DKILRDKDEAEDMLRGGYD...PEIVRRQTGWYEGG.DGK.MRYELQDKNFHLN......
A0A323URW8_9RHOO/738-795 ...........FSFAGRDA..E.....TADLHGLGNAQRRIAAGEN...PEAVRQATGWHRGA.DGM.WRFEISDEQARL-a.....
A0A2K8I347_9CAUD/2217-2274 ...........YSFAGRNA..V.....GANLHALSTAQQRIAIGEN...AEAVRRDTGWHRSA.DGK.WRFEISDHQASI-a.....
N2IZY8_9PSED/1080-1137 ...........FAFAGEEA..V.....SAPLELLAQAKVMHSQAAD...SADIWATTGWSIGM.DGR.WRFEIDDSTATLH......
F4KJT5_PORAD/5-59 ekgiantenae--------..-.....-VLKAALHTAKQEMRMGTT...MSCIKMRTGWELGV.EGL.WKFEYPD------pf....
R5KUU8_9FIRM/163-220 ...........YSYGGRNS..N.....NVDLRELQRTNEMEKEGES...FEEIFKKTGWFRGI.DNI.WKYEIDDSKMTFN......
A0A1I2TL80_9HYPH/120-177 ..........r-MFGGWNA..E.....TADHAALSKAQNLKATGAD...RQAIWDQTGWFQAP.DNY.WRFEIPDDLATL-g.....
A0A347VT82_9HELI/803-865 ...........YIFAGEKA..LqqkgfNTQIKNLKTAKDLESKGES...AESIWQKTGWYKDK.DSK.WKFEIDSSKGKLK......
N2IZY8_9PSED/1940-1997 ...........YSFAGVNA..H.....TAPLLALADARLRLELGEK...AESVWQATGWLHGS.DGK.WRFEIDDSAASV-l.....
A0A2D3WMN3_9PROT/1313-1370 ..........l-TFAGEKA..I.....KADVAKLDDAMKLADSGAK...ESDIWRSTGWFKGD.DGK.WRFEVDDSGAKM-l.....
A0A1N6XKH7_9GAMM/296-353 ...........YQYGSTHA..E.....AANTEQLSIAKSLKQAGAD...PESIRQMTGWHQWI.DGR.WRFEIDDSRASLK......
A0A0U1KXI5_9FIRM/567-627 ...........HQYAGTQA..L.....TADRLNLQEAQKLEAAGEDvgaAGSIRQKTGWHKGQ.DNK.WRFEIDDSKAKM-v.....
L7TID4_9CAUD/2153-2210 ...........YSFAGRNA..V.....GANLHALSTAQQRIAIGEN...AEVVRRDTGWHRSA.DGK.WRFEISDHQASI-a.....
A0A6M3I6G7_9CAUD/3698-3755 ...........YSFAGRGA..Q.....GADLLSLRTAQRRIAVGEN...AETVRQETGWHRGA.DGK.WRFEISDDQAEI-a.....
R6UCK3_9FIRM/85-142 ..........h-SLAGQYS..Q.....TAKLNSLSGAVRMNENGTP...MDTIRARTGWWLGK.DGK.WRYEIDDSALSF-d.....
A1TPS0_ACIAC/1527-1584 ...........FSFAGRNA..R.....SADLGELERAEAMARSGMS...SAVIQQETGWHRGV.DGR.WRFEISDDTAEF-r.....
A0A7D5TPR2_9CAUD/3290-3347 ...........FSFAGRGA..L.....GADLLALSTAQRRIGAGED...AETVRQETGWHRGA.DGK.WRFEINDSQADI-a.....
N2IZY8_9PSED/751-808 ...........FAFGGELG..A.....DLNLESLDVAQIMLAQGDD...SETIRQATGWFTGI.DGK.WRFEIDDSQAEL-v.....
A6KYZ4_PHOV8/547-603 ...asrldrse-------G..A.....SLRLENLAVAREMEKSGKD...AGTIKAATGWERGA.DSK.WRYETAD------feyh..
A0A1I3LHZ4_9RHOB/131-188 ..........g-IFAGVKA..A.....NAPTDMLRRAEEMTAAGAN...RDDVWRETGWFQGV.DGK.WRWEIEDSDAFL-e.....
A0A0D8IUC9_9FIRM/1228-1286 ...........YSFVGEKAnlN.....RTERAALETAKGMEQDGET...NEDIRRQTGWFRGA.DGK.WRMEVDDSDA---vy....
J6UE11_9RHOB/115-173 ..........g-VFGGPGA..K.....TADHAALAEAKRLAAGGAP...MPEVYKATGWYEDP.ATKaWRFFIPDDAMTV-t.....
A0A1I5PC38_9RHOB/125-182 ..........n-IFAGPGA..A.....NADRSALSRAEQMEQAGVD...RDHIWRSTGWGRGV.DDQ.WRFEIDDSAARV-g.....
A0A368UA59_9GAMM/1150-1206 ...........FSFAGVGA..Q.....TADIHQLDYAKKALKDGLS...AEQVRQQTGWFQGD.DKK.WRFEIDDSQAR--y.....
A0A5D6WDM4_9FIRM/1253-1310 ..........n-QMAGVNA..Y.....GAAKGSLLRAKSMDAKKQS...PDKIFDKTGWLKGA.DGK.WRFEIPDN-----ldnih.
N2IZY8_9PSED/1519-1576 ...........FSFAGPRA..L.....SAERSSLLKAKERHASGES...AQAIRQVTGWFLGA.DDK.WRFEIDDSKAN--ar....
A0A5C1E782_9RHOO/657-714 ...........FSFAGRKA..Q.....GADLHALNTAQQRLARGED...AEAVRQATGWHRGA.DGK.WRFEISDHQASI-a.....
A0A5Q0ELI1_9GAMM/630-687 ...........GSFAGRNA..R.....TANADRLARAEQMETDGAD...ARTIWRETGWYKDV.DGK.WRFWINDNAASI-k.....
A0A2M8RXZ8_9PAST/1160-1217 ...........YSFAGEKA..K.....TADHSLLEQAKADIAKGVN...PEIVRQETGWFRGV.DGK.WRFEISDNEVSFK......
A0A368UA59_9GAMM/2094-2151 ..........l-SFAGESA..R.....TADRLTLAYAQKALAAGMA...PNLVREQTGWHQGV.DGR.FRFEINDSKARL-l.....
Q5QF61_9CAUD/39-96 ...........YSFAGRNA..V.....GANLHALSTAQQRIAMGEN...AEAVRRDTGWHRGT.DGK.WRFEISDHQASI-a.....
R5YQ00_9PROT/609-666 ...........FQFGGVEA..K.....FADFKKLAEAYKLEQQDYS...PRLIWSRTGWYRGG.DGR.WRFEINDSGAKLK......
A0A166HBT0_9GAMM/2784-2841 ...........YSFGGELS..L.....NANMEQLNRAKEMHVDGES...RTAIWHETGWFKDV.DDH.WKYEIDDSGAGI-h.....
A0A3D8HXR9_9HELI/204-266 .........qi--LAGEKA..LlsqtyAPQKAKLEHAKALQIEGKS...AAEIWENTGWYQDI.DKN.WKFEINP------qggele
A0A5Q0EGR4_9GAMM/1056-1113 ...........GSFAGPNA..K.....TANAQTLDNAQQMLADGAD...GPTIWKATGWYQDE.DGM.WRSEIDDNAAVF-n.....
K4NZ44_9CAUD/668-725 ..........d-QFAGQTA..W.....SADMPSLADAEQRIADGDN...AEQVRRETGWSQGA.DGK.WRFEIDDSQAQF-a.....
A0A6G9LJE2_9CAUD/2165-2222 ...........YSFAGRNA..V.....GANLHALSTAQQRIAIGEN...AEAVRRDTGWHRSA.DGK.WRFEISDHQASI-a.....
A0A327JR81_9HYPH/139-197 ..........g-VFGGRLA..Q.....TADHAALARAEAMRAAGES...RKAIWRETGWFTDPaDGR.WKFYIPDEAMTV-t.....
#=GC seq_cons ...........hsFAGppA..t.....sAshpsLspApphhssGps...scslhppTGWacGs.DGK.WRFEIsDstAph.h.....
//
