#=GF ID LRS4
#=GF AC PF10422.13
#=GF DE Monopolin complex subunit LRS4
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Wood V;0000-0001-6330-7526
#=GF SE Pfam-B_63451 (release 22.0)
#=GF GA 24.20 24.20;
#=GF TC 24.40 24.30;
#=GF NC 24.00 23.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11163190
#=GF RT Functional genomics identifies monopolin: a kinetochore protein
#=GF RT required for segregation of homologs during meiosis i.
#=GF RA Toth A, Rabitsch KP, Galova M, Schleiffer A, Buonomo SB, Nasmyth
#=GF RA K;
#=GF RL Cell. 2000;103:1155-1168.
#=GF RN [2]
#=GF RM 17627824
#=GF RT The kinetochore proteins Pcs1 and Mde4 and heterochromatin are
#=GF RT required to prevent merotelic orientation.
#=GF RA Gregan J, Riedel CG, Pidoux AL, Katou Y, Rumpf C, Schleiffer A,
#=GF RA Kearsey SE, Shirahige K, Allshire RC, Nasmyth K;
#=GF RL Curr Biol. 2007;17:1190-1200.
#=GF RN [3]
#=GF RM 12689592
#=GF RT Kinetochore recruitment of two nucleolar proteins is required
#=GF RT for homolog segregation in meiosis I.
#=GF RA Rabitsch KP, Petronczki M, Javerzat JP, Genier S, Chwalla B,
#=GF RA Schleiffer A, Tanaka TU, Nasmyth K;
#=GF RL Dev Cell. 2003;4:535-548.
#=GF DR INTERPRO; IPR018479;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Monopolin is a protein complex, originally identified in
#=GF CC Saccharomyces cerevisiae, that is required for the segregation
#=GF CC of homologous centromeres to opposite poles of a dividing cell
#=GF CC during meiosis I [1][3]. The orthologous complex in
#=GF CC Schizosaccharomyces pombe is not required for meiosis I
#=GF CC chromosome segregation, but is proposed to play a similar
#=GF CC physiological role in clamping microtubule binding sites [2].
#=GF CC In S .cerevisiae this subunit is called LRS4, and in S. pombe it
#=GF CC is known as Mde4.
#=GF SQ 36
#=GS G8ZMA4_TORDC/5-217 AC G8ZMA4.1
#=GS G0VGI4_NAUCC/5-210 AC G0VGI4.1
#=GS A0A0C7NEW9_9SACH/5-195 AC A0A0C7NEW9.1
#=GS H2AZR8_KAZAF/5-197 AC H2AZR8.1
#=GS Q6CWV4_KLULA/5-168 AC Q6CWV4.1
#=GS A0A1X7R5U1_9SACH/5-279 AC A0A1X7R5U1.1
#=GS A0A1G4MG68_LACFM/5-201 AC A0A1G4MG68.1
#=GS A0A2P5D1A6_TREOI/674-844 AC A0A2P5D1A6.1
#=GS A0A078BE47_STYLE/18-243 AC A0A078BE47.1
#=GS J8Q3I6_SACAR/5-230 AC J8Q3I6.1
#=GS J5RU06_SACK1/5-232 AC J5RU06.1
#=GS J7S4Q8_KAZNA/5-118 AC J7S4Q8.1
#=GS A0A1S7HHK6_9SACH/5-237 AC A0A1S7HHK6.1
#=GS G8JT14_ERECY/5-262 AC G8JT14.1
#=GS A0A7H9B2G9_ZYGMR/5-200 AC A0A7H9B2G9.1
#=GS A0A4U0VYQ2_9PEZI/112-357 AC A0A4U0VYQ2.1
#=GS Q6FNM3_CANGA/3-218 AC Q6FNM3.1
#=GS A0A1E5R1Z9_9ASCO/27-261 AC A0A1E5R1Z9.1
#=GS A0A1E3P1L0_WICAA/92-348 AC A0A1E3P1L0.1
#=GS Q756D8_ASHGO/5-193 AC Q756D8.2
#=GS A7TJ97_VANPO/5-217 AC A7TJ97.1
#=GS A0A8C2TK13_COTJA/326-544 AC A0A8C2TK13.1
#=GS A0A8C8EW41_ONCTS/170-347 AC A0A8C8EW41.1
#=GS A0A8C2TKW9_COTJA/326-522 AC A0A8C2TKW9.1
#=GS A0A0H5C0N2_CYBJN/29-310 AC A0A0H5C0N2.1
#=GS A0A4C2E1C2_9SACH/5-204 AC A0A4C2E1C2.1
#=GS MDE4_SCHPO/1-408 AC O43068.1
#=GS C5DLX8_LACTC/5-186 AC C5DLX8.1
#=GS A0A1G4KAX5_9SACH/5-205 AC A0A1G4KAX5.1
#=GS A0A7H9HLW1_9SACH/5-203 AC A0A7H9HLW1.1
#=GS A0A2A4G4D1_9FLAO/15-157 AC A0A2A4G4D1.1
#=GS A0A1S7HUR7_9SACH/5-237 AC A0A1S7HUR7.1
#=GS A0A1G4JU86_9SACH/5-246 AC A0A1G4JU86.1
#=GS G0WET9_NAUDC/5-255 AC G0WET9.1
#=GS LRS4_YEAST/5-232 AC Q04087.1
#=GS G8BSR8_TETPH/5-277 AC G8BSR8.1
G8ZMA4_TORDC/5-217 ........................................LQLLANYYKNVIESQRI...........YHEN..........VQIYAS.PLEES-GSTG.SGS..........................SSRVAEEMFLLQRQ.......................VSHLTAEIQSLS.REND......................KLRGLQATHKAL....................................................................MESKLNNSK.KIIDKLK......REQRDYR..AAPDRESDS..T.PP....PPELSKK---..-GQAP.........FHLLSPln....vrkIDGAKHD.........................................................HITAASSKP......................................TGLRQVLT.....GGHQTL..FD.....GDQT.IENL-.......................................................---SADRTDD..VLFI---------.---------nsikhkdklgsvvlptealseded........................................
G0VGI4_NAUCC/5-210 ........................................LQLLSTYYKSVIESERI...........YNEY..........QLSANV.QHIPNNKNGS.S-Ssts....................istDSRIVDETLLLQKQ.......................LTQLTSQLQKLT.QENE......................TLKEVQKSNKAL....................................................................AETKIQNYK.KRIN---......--ILVQR..ENGKNTEK-..-.-D....ED--------..QKKPV.........LHLFSP.........LRKRGLD.........................................................ETKGRIKNKn....................................gSGLRDVIS.....TGKHTL..FD.....DDED.EDEND.......................................................DDTSPNRSED..VLFLQS-------.---------lnpsskgknnkrrklklsrk............................................
A0A0C7NEW9_9SACH/5-195 ........................................LQLLANYYEAVLESERI...........YNEH..........--SHDD.HPLTKRSVDP.ENR..........................DSMLVKETISLQRQ.......................VAQSIHECNVLK.QENE......................RQRQIHKTQIAL....................................................................LESKLDNAR.KNSA---......-----KS..KEGALAET-..-.--....---VNGG---..--SDK.........VHLLSP.........LGKDKQQaknpp..............................................eprnigK-------Alaravk.........................napadlnGGLRQAIS.....KNRGTL..FD.....----.---ED.......................................................TNEMAENSQE..TSFLTS-------.---------vkdkfkla........................................................
H2AZR8_KAZAF/5-197 .......................................v-QLISNYYKSVEKAEKI...........YNHY..........------.-IAREPNLST.TSS..........................APKIVNETLLLQKQ.......................LSDLTSQVQNLK.REND......................NLKESIKLYKAL....................................................................NESKISNYK.KIIDNLQ......NDNTVKD..N------K-..-.--....----DF----..----S.........FHLLSP.........VIDRKRS.........................................................VLGSHTIFD......................................KRVRSDSD.....EVEDVLvkFDtpslkDFSN.DDDDD.......................................................DDDDDEEEDA..FST-ASNTSKKRK.L--------tkrkinnirdddn...................................................
Q6CWV4_KLULA/5-168 ........................................LQLVAEYYQSVIKCEKI...........----..........------.----FRTNAK.QNDl........................sGLMLTRENISLRNQ.......................VQQLTLDLQLKK.EELD......................NAKKLHKTQKAL....................................................................LESKLENAK.AAVK---......KQTTQSS..ESG------..-.-S....EEIERVK---..-----.........FHLLSP.........IQNERSK.........................................................----SFEKQ.....................................pSRLRQVID.....RNQATL..FD.....----.---DE.......................................................TDDTANRTDD..VLFLN--------.---------slkpnndaryk.....................................................
A0A1X7R5U1_9SACH/5-279 ........................................LQLLLDYYRSVLESDRI...........YHEGilk....yqqQ-----.SNGDNVTGAL.NGEevdkdd.............asksvsvAPKIANETLLLQRQ.......................LTDLTSQLQDLK.RKNE......................ALQEQQKSYRAL....................................................................NESKIAKFK.RTIDSLK......RKNERHS..SEIDDHDD-..-.--....-QINED---D..SKKFD.........YHLLSP.........VAKRGLKrglkisng.........................................kgkgrkgtI--------......................................------FD.....SKKETF..TD.....DESS.ENSIDsptvkrltkqprmeheesflksfepqpsnnsnkkknkqldgfdipslndfsrdedEDEDQDESHG..NNEDLTTKNYHHKkQKPLKKR--kl..............................................................
A0A1G4MG68_LACFM/5-201 .......................................a-QLLSIYYESVIECERL...........YYRH..........------.-LEAQKGHANnDSS..........................ESLLAKETINLQRQ.......................VAQLTADLNIQK.RETE......................RIKELHKTQRAL....................................................................FESKLENAK.KTISKLK......RSGA---..---EIEDDK..D.AC....AENQQAK---..-----.........FHLLSP.........INRQTSFgngn.................................................davaGTPSG-KQH......................................RGLRHAIT.....NGNPTL..FD.....EDTT.DLADK.......................................................TEEAA-----..-------------.---------fieslksrdklaeivlptsrlsssgd......................................
A0A2P5D1A6_TREOI/674-844 ........................atspisekssppwssk-----------------...........----..........------.------ETDA.RHT..........................NEILSQEIIMLRAQ.......................VEDLTCKSQNLE.VELE......................KTTKQLKEVTAI....................................................................AVDEAEKCK.SAKEVIK......SLTAQLK..EVAERLPEG..H.TV....SFSTDSNAGH..ANKVS.........SHLLSEt.......tMTNMTTPerdsn..............................................gicmngN--------......................................--------.....------..--.....----.-----.......................................................----------..-------------.---------spneskaqtgkaewvvqdepgvyitlssl...................................
A0A078BE47_STYLE/18-243 ..............citlkyknmfqldlkwysnilnkais-----------------...........----..........------.ILGMMKLQTE.KCLqycs.................llmttSKKYSKERIFQYRQ.......................IFSLPSQLINIQ.QNNE......................HKKNIPLDDIAIykhsplvlvfasnelpkevkngtskviafninrtgyskiaslvempqesdipqysktrpenpldvttnPQSKVGNNE.STMK--K......KKKSNKV..EQEMITPSP..G.QA....EQKHKSK--H..QEQSS.........------.........-------.........................................................---------......................................--------.....------..--.....----.-----.......................................................----------..-------------.---------vlrqitmnevmqnntkerawsv..........................................
J8Q3I6_SACAR/5-230 ........................................LQLLSNYYKAKIDSERI...........YNEY..........VQSQYE.FASLGKMNSN.KDDl........................lSKKVVDEALFLQRQ.......................IAQLNKQLQLSF.QENE......................KLFNVQKNQKAL....................................................................YQSKLTNKD.ALINDLKlk.lkvEQISINK..NDSENTPT-..A.FN....NQLHGVKAAH..ISKPT.........IHLLSP.........IVNRDEIknqsk..............................................drnnepDSPISKRKS......................................KGLRSLLS.....SGKNTI..FD.....SISK.NLDDE.......................................................IIENGPIRCD..NTSSKTADNSTSV.-SP------lprkp...........................................................
J5RU06_SACK1/5-232 ........................................LQLLSNYYKAKLDSERI...........YNEY..........IQSQYE.FASLEKLNNN.KSP..........................SKKVVDETLFLQRQ.......................IAQLNKQLQISF.QENE......................KQQNIQKNQRAL....................................................................YQSKLSSKD.AFIDDLKlk.lkvGQISIDK..ADMETAPST..A.SN....EQLNGVKEAH..ISRPT.........IHLLSP.........IVNRDTSknqtkd.............................................rngnepDSPITKRKS......................................KGLRSLLS.....SGKNTI..FD.....SISK.NLDDE.......................................................INENASMRHD..TASSKIADKSTSV.SPLLR----kppe............................................................
J7S4Q8_KAZNA/5-118 .......................................l-QLLWNYHRAVVHNERL...........----..........----A-.-AGTAPGGAG.A--..........................GEDPGGRALQMQRQ.......................VNTLTGQLQDMS.HEND......................VLRETAKSVRAF....................................................................SESKIAALK.RQLEALK......AEGGAG-..---------..-.--....----------..-----.........------.........-------.........................................................---------......................................--------.....------..--.....----.-----.......................................................----------..-------------.---------rrtkgvgghahtvathpmshgk..........................................
A0A1S7HHK6_9SACH/5-237 ........................................LQLLANYYNSVLESERI...........YHEN..........V----A.CSSSVPCPSL.QRE.........................pSPKVEQEMLLLQRQ.......................VHQLTSEVQVLH.REND......................TLKELQKTQRAL....................................................................MESKVNNSK.KTIEKLR......KQLNEPD..RKE---SN-..N.AT....PPPTQLK---..--KRE.........LHLLSP.........LTGRKLE.........................................................GVGVSQISKns.................................ngsMGLRRALS.....SGQHTL..FD.....----.-DHDI.......................................................GNQTLDHIAD..INFIDSIKNR---.---------ekllqielptnalsdneeaqrkpstkigkkrrlarkpiqklnndsd..................
G8JT14_ERECY/5-262 ........................................LQTLANYYESVIQCERI...........YSDY..........IIAQQS.IDPKT----K.QQH..........................ESILTKETISLKKQ.......................VEQLITESVSQR.QEID......................RLRNLNKTQRSL....................................................................LESKLEAAK.KRLARSKeg.vvnQDEQVLQ..KQEDLNGRG..G.NE....ATGGGSGSGS..DGSASnn....gagFHLLSP.........LRSPGGKv......................................................kaR-------Klngia............................vhnrvARLRQVIN.....EGRKTM..FD.....----.---ED.......................................................TDDSANLTDE..VMFMETFKRTD--.---------aagnssagdgqgntagnevhpededddenmegegssqlkkrklsrkriqtten...........
A0A7H9B2G9_ZYGMR/5-200 .......................................v-QLLANYYKSVVESERI...........YYEN..........-VIRKS.VTSDTSDKEL.REP..........................SPRMLQEMLLLQRQ.......................IGQLTVEIQVLR.KEND......................TLKELQKTQRAL....................................................................MESKLNNCK.KTIEKLK......KNGKDEL..SEQ-RNSN-..-.-L....QERDRAN---..-----.........FHLLSP.........LNVRTLDgvs...................................................tqnHYANSNGRP......................................TSLRHVIT.....NKQQTL..FD.....----.-GDDS......................................................rENLSADRLED..VAFVNSL------.---------knrgelakivl.....................................................
A0A4U0VYQ2_9PEZI/112-357 ............................aakarreeerrl-----------------...........----..........------.----------.---..........................--------------.......................----------AR.LEAK......................KIEALEKNQAAI....................................................................LLSRMRAAEkAEQDRMR......KERAQDR..ERMRLAKRA..A.EA....QASAQLKWKT..TQRVG........eKTLWEG.........IVGRTWRnsrtldlggsvagdaeadadsdasadsdgeiserahrdhcgllggfslmqgyvctygNTASASAKK......................................GKVRTTPV.....VSAATL..AD.....PRSE.LAEDE.......................................................VN--------..-------------.---------ailrerglpakkaeemhpqaiarlwaadqdlsttelhdrlrryfikikgtrqeklqam......
Q6FNM3_CANGA/3-218 ........................................LQVVADYYRCVLENERI...........YYEYqlnrretvknSRSEDE.FSGSERTNAL.K--..........................----TDEQLQLQRQ.......................VNKLTVDLQSMA.HENE......................RLREFQKTQKQI....................................................................LESKIQQLK.KTVDSFK......NERNSSS..SSHVRTPP-..-.--....-RQTRSGAYT..QGKDTdls..rrggFHLLSP.........IVGNVNP.........................................................----GKEKA......................................GGLKETLK.....VGRNTI..FD.....KNSS.LLDDD.......................................................DDDDDDEING..TSVKERSRVTGRK.LR---SS--sslkdskn........................................................
A0A1E5R1Z9_9ASCO/27-261 ......................................ah--LVAEYYSLVIESERI...........YHRH..........---LRN.VITRKKDKET.KSK..........................TAKLMEE-VKCEKQ.......................VDGLFTQIMDLQ.KKNE......................HLQQSNKSDREK....................................................................YESKFDRQN.KKIQELY......KLVAEKS..SQPXQVVP-..-.-Q....DKQSSE----..---KA.........IHLLTPrkpmgfwssY---DKRxnqrs..............................................xnenigT-------Tavsies..........................evisdkRKFREVLS.....--QNTI..FD.....K---.S----.......................................................----------..-------------.---------ledivifngkrkptvqlnngnpsqnidkidevskenisnasekstfsnetfkklrql.......
A0A1E3P1L0_WICAA/92-348 .......................................k-----------------...........----..........------.-----KKSAN.Q--..........................-TSLQKETLSLKNQ.......................ITKLNSQLNESR.NEIG......................KVKQQFVTQKAV....................................................................LESKLENAK.KNIKNLK......DKNTLSP..SKALQPPSS..I.LS....PVKSQSK-TL..NNHQK.........LGLKRP.........LVSNFSTspfln..............................................knlhkaTSPSKDGKQqnnfqspvplnsqnllatstpgapnavsplkdlksrkpSGLKNLISpakppSNGATK..PN.....SKKKpSLFDD.......................................................DDDDDEDIFGnsIRKLDATKNTPRQ.---------eppseeskqdneeqdtkkkqpakrrrkiggkai...............................
Q756D8_ASHGO/5-193 ........................................LQLLADYYESVIRCEEI...........YIEF..........----IS.GLGPNKTKSG.QQS..........................GSVATEETISLKKQ.......................IEQLVSDSVKQR.QEIE......................KLRELNKTQRAV....................................................................LESKLETAK.KQVA---......RATGSAN..AGGARADDG..G.AA....QEEGGAG---..-----.........FHLLSP.........LRRGGRR.........................................................ASGGGAGAR......................................AGLRLALD.....AGNETI..F-.....----.---DG.......................................................ADEDTEAVLG..VEAVAGAGVRAREvGRALRCTGE................................................................
A7TJ97_VANPO/5-217 ........................................LQLLANYYKSVIEGERI...........YYEN..........----VI.GKEERQQSSN.DGSt........................lTKSSGSDTLMLQRQ.......................ITQLNTDLQVLR.HENE......................QLKEMQKTHRAL....................................................................MESKLKSSK.KIIENLKndlrnnNNTDDQN..NGEQNTIDI..N.KE....ELQHSSRI--..----Stmvs.kkigFQLLSP.........MNERLLR.........................................................--GTGRNTDkn..................................qlSGLRYVIS.....TGKHTI..FD.....--ES.YQDDT.......................................................DNSKDDGVDG..VLLANPV------.---------knveklanlvl.....................................................
A0A8C2TK13_COTJA/326-544 ....................................vrdk--TMADLHSARLENEKL...........---K..........KQLADA.LAELKKITAL.KNE..........................QETVNTTEQELRRE.......................VEDLKLRLQMAAdHYKE......................KFKECQKLQKQVnkfteqagekmkcsvyadelakl.....................elkwkeqvkinegiklqlaamedqYKVQLAEKE.RRIKELA......SQLELFT..AEKELGKA-..-.AG....NQAGRMMEGQ..ISQPT.........LHFRNP.........YSEENG-.........................................................---------......................................--------.....------..--.....----.-----.......................................................----------..-------------.---------pvpavpsrlpvlqygnpyaiqerrdgadga..................................
A0A8C8EW41_ONCTS/170-347 ....................sqnqlpfshssssinkhwea-----------------...........----..........------.-----ELAAL.KGN..........................NAKLTAALLESTAN.......................VKQWKQQLAAYQ.EEAErlhtrvte......lecvsgqmT----------Viksqkte......................................................lnqtieeLESALKSKE.EELERLK......EEVESAN..EFQTQKESL..T.QK....LQARRMN--T..PHWAF.........THLFSF.........RDGGEEPd......................................................vgSSAGGVRAA......................................SG------.....------..--.....----.-----.......................................................----------..-------------.---------gqsagerglqees...................................................
A0A8C2TKW9_COTJA/326-522 ....................................vrdk--TMADLHSARLENEKL...........---K..........KQLADA.LAELKKITAL.KNE..........................QETVNTTEQELRRE.......................VEDLKLRLQMAAdHYKE......................KFKECQKLQKQVnkfteqagekmkcsvyadelakl.....................elkwkeqvkinegiklqlaamedqYKVQLAEKE.RRIKELA......SQLELFT..AEKELGKA-..-.AG....NQAGRMMEGQ..ISQPT.........LHFRNP.........YSEE---.........................................................---------......................................--------.....------..--.....----.-----.......................................................----------..-------------.---------ngpvpavpsr......................................................
A0A0H5C0N2_CYBJN/29-310 sliheatllktileqqmyvemnnskdshvqsslkqdlskv-----------------...........----..........------.----------.--QgekrsldrkisllqteiqnlkeralsNAQLQRENISLKNQ.......................VKKLTSQLDESK.SEIG......................KASKQFATQRAV....................................................................LESKLDNAK.KNIKTLK......DRTSPVKplTGSILSPQK..T.SS....NERINVLKKP..HLNSN.........FS-VSP.........FLRNRQSkqdlgsstpvqdnrnn.........................iktkifaqstpngnvfASPLKDAKPrrssg............................lknlvRPTNSLKA.....ALDNPD..KK.....NKPS.LFDDD.......................................................DEDDDGDIFG..NSVLKKAEKK---.---------dhdddttekktqp...................................................
A0A4C2E1C2_9SACH/5-204 ........................................LQLLANYYQSVVISELL...........YYQHi.......nrGNLNNPtSNGSDKKGG-.INS..........................SNGSEREMLLLQRQ.......................VHQLTSELQRQS.HEND......................TLKELQKAQRAL....................................................................MESKLNNCK.KTIGRLR......KQHYEKS..LNGDAIEEV..G.GG....QLKKREQ---..-----.........-HLLSP.........LVGRKLE.........................................................----GVGKT......................................KGLRRALT.....SGQQTL..FD.....--DG.NDDDD.......................................................RDGTVDRIND..VNFVGSIKRAGG-.---------knnrlaqavit.....................................................
MDE4_SCHPO/1-408 ........................................MSTISTSTDSKLDNLGLsvtsrrnqilfYLSKalnlahllrsDSLQKS.FLDALKQSAT.DSEllhknl.............deikflqNEKLNNEKLLEQEQneandyrlkverlehkisdyvqeINSLNSQLQIQK.SNPEkhedavsqnrlrgsldtvsspsKTHKANKDEKATrlhliianlkk..............................................alkekdaevlnLQSHVSSKE.SELDRFKik.letEESNWKV..RLQVLESKL..A.TQ....DRKLRMQKKS..TERKSllvsprvssPKLFSPsk.....qaIMGTRQPnatsgsplsvtpfl............................qktstsiglsssppqSSPSAQSSQpfsrdky.......................phsmtvspSNARYLKK.....HLDDTI..PS.....NVSD.INHNDhlkipqspsslspski......................pirkkrklkdtvsncefTEEDSESSFL..LETIQPTKSTLRRsISPLKKRND................................................................
C5DLX8_LACTC/5-186 ........................................IQLLANYYESVIECERI...........YYEH..........VNC---.--SKVQQEPM.Q-R..........................DSLLVKETISLQRQ.......................IAQLTADCNQQK.RENE......................RLKQVHKTQLAL....................................................................LESKLENAR.K------......-------..HSRPKTPD-..G.AT....RRDKDSK---..----S.........VHLLSP.........ISKKKPK.........................................................ANGSSNGIAgahgt...........................psagqsNGLRHAIY.....KNKPTL..FD.....----.---ED.......................................................ASEVAENSNE..ISF----------.---------ltsikgkdkladi...................................................
A0A1G4KAX5_9SACH/5-205 ........................................LQLLAKYYDSVIKSEQI...........YSDY..........IRTTES.GSSV------.KDA..........................DSMFIKETISLKHQ.......................LAQLITDLNQEK.RENE......................RLRELHKTQIAF....................................................................LESKLDSAK.RNISKLKd...qnP---DT-..NGDDNNDKNskA.LK....RTSGKSNETS..ALANK.........FHLLSP.........INRGSTRsea...................................................mdeT-------Dplp...............................kkapSGLRQAIY.....NRHQTL..FD.....----.---DD.......................................................TNDGADKTDE..FSFMNSIKHRG--.---------klaelqi.........................................................
A0A7H9HLW1_9SACH/5-203 .......................................v-QLLATYYKAVIESERI...........YYEN..........VNMYAS.PST--GTNSS.GSD.........................sSSRVVEEMFLLQRQ.......................VSQLTAEIQSLR.REND......................NLKSLQATHKAL....................................................................MESKLNNSK.KIIEKLK......REQRNDQ..GVA--SGE-..-.--....SASTPPPAKL..TKRQA........pFHLLSP.........MNSRKLE.........................................................DGRSKNHHQ.....................................pNRLRYVLK.....GGHQTL..FD.....G-DQ.TLENL.......................................................SADRSEEA--..-------------.---------ifvnslkhkdelanmvlp..............................................
A0A2A4G4D1_9FLAO/15-157 ...............................vaatsavqa-----------------...........----..........------.----------.---..........................-------------Qskv................ahinVQELLSQMPKMK.NAME......................ELKKLEATHRAT....................................................................LEASMTELK.NKYTQYEn....eAASKSDE..ENQKRAQEL..Q.GYqkgiQEAEQAAAQD..INKKR.........GDLLGP.........ITEEAKA.........................................................----A----......................................--------.....------..--.....----.-----.......................................................----------..-------------.---------iekvaaakgvdyvidasqggglivakgt....................................
A0A1S7HUR7_9SACH/5-237 ........................................LRLLANYYNSVLESERI...........YHEN..........VTRSSS.TPSP----SL.QRE.........................pSPKVEQEMLLLQRQ.......................VHQLTSEVQVLH.REND......................TLKELQKTQRAL....................................................................MESKVNNSK.KTIEKLR......KQLNEPD..RKE---SSN..-.AT....PPPTQLK---..--KRE.........LHLLSP.........LTGRKLEgv....................................................gisQVPKNSGGS......................................MGLRRALS.....SGQHTL..FD.....----.-DHDI.......................................................ENQTLDHIAD..INFIDSIKNR---.---------ekllqiklpndtlsdneeaqrkpstkigkkrrlarkriqklnndsd..................
A0A1G4JU86_9SACH/5-246 ........................................LQLLAQYYEAVIESDRI...........YHEH..........ISSNLT.TGADVNDEAQ.--Q..........................DSILMKETISLQRQ.......................VTQLIAECNLLK.QENE......................KHKQLHKTQIAL....................................................................MESKLENAK.KRAT--K......PKSTSPK..DGPINTHK-..-.--....----------..-----.........VQLLSP.........ISKDKLQgkeivds..........................................qgvskiagALEMAAKQN......................................EGLRHAIN.....KNMPTL..FD.....----.---DD.......................................................TNDFAENSHE..HSNG---------.---------nsfshtvrekgklnkvvlprdnlphsssdteepkhshdrasineaegfpkakqkkrrlikkrvq
G0WET9_NAUDC/5-255 ........................................LQLMANYYKAVIANEKI...........YYDYliqe.hehdkNQSEQS.ISAPLSSSSF.--Appttgt..............ittastTPRMIDETLLLQKQ.......................LTTLTAQLQELT.KEND......................HLKELQKSTKSL....................................................................METKLNSYK.KRLS--K......TAFNNNN..NSSSSNNSN..N.SL....KLDTTSG--K..NDNDT........gFHLLSP.........INTNRNKsklpgkk...........................................sllhnnyNSTSIKGKAekdknegv......................fddepsnrTSLREVLS.....SGKHTL..FD.....----.--DDD.......................................................EEGEKDGSED..VNVDTS-E-----.---------kndrgkastadstsd.................................................
LRS4_YEAST/5-232 ........................................LQLLSNYYKAKLDSERI...........YNEY..........VQSQYE.FASLDKLNNN.KGD..........................PKKVVDETLFLQRQ.......................IAQLNKQLQLSF.QENE......................KLLSVQKNQKAL....................................................................YQSKLSSKD.AFIDDLKlk.lkvEQISVDK..HNKERTPST..G.RD....EQQRNSKAAH..TSKPT.........IHLLSP.........IVNRDKPnnqtnd.............................................rggndpDSPTSQRRS......................................RGLRSLLS.....SGKNTI..FD.....SISK.NLDDE.......................................................INENAHIRND..TTSSKIAGKSPSR.LSALQKSPE................................................................
G8BSR8_TETPH/5-277 ........................................LQLLYNYQMSVIESERF...........YYTH..........LLEEKE.LNTKNEALIK.NNDntavlvd............ditgkqqEHSLSKELISLQRQ.......................LTKVSIELQTMK.LSNE......................QLKEAQKVTKNT....................................................................MNQKLNNSL.KTIERLK......SELSVNN..SSHGDEDAS..SvTP....PKIFNTFKNNeiKQKNN.........IHLLSP.........VTRKESGh.......................................................lESNNKIEKL......................................SGIRNIVN.....SKKHTL..FD.....MDTE.SEADN.......................................................SLNSIENVLK..INT----------.---------lkrnevlanmvlpkdalpessdinssqnilsvdiplikgntveekqvknhhetkkrtltktr..
#=GC seq_cons .........................................QLlusYYpuVlcsE+I...........Y.c....................s..ptps..ptp..........................spplscEpl.LQ+Q.......................lspLssplQ.hc.pENE......................+L+clpKop+Al....................................................................hESKLsstK.+plcpLK......pphs.pp..ppt..sss......t....ppttpst.......p.s.........hHLLSP.........lsppptp.........................................................t...t.ttt......................................psLRphls.....psppTl..FD.............-p.......................................................tppsspt..t..h......................t..p.htt........................................................
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