#=GF ID   L_biotic_typeA
#=GF AC   PF04604.17
#=GF DE   Type-A lantibiotic
#=GF AU   Waterfield DI;0000-0003-2885-5126
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_4608 (release 7.5)
#=GF GA   21.70 21.70;
#=GF TC   21.70 21.90;
#=GF NC   21.60 21.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0400
#=GF RN   [1]
#=GF RM   7601145
#=GF RT   Biosynthesis and biological activities of lantibiotics with
#=GF RT   unique post-translational modifications. 
#=GF RA   Sahl HG, Jack RW, Bierbaum G; 
#=GF RL   Eur J Biochem 1995;230:827-853.
#=GF DR   INTERPRO; IPR007682;
#=GF DR   TC; 1.C.21;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Lantibiotics are antibiotic peptides distinguished by the
#=GF CC   presence of the rare thioether amino acids lanthionine and/or
#=GF CC   methyl-lanthionine. They are produced by Gram-positive bacteria
#=GF CC   as gene-encoded precursor peptides and undergo
#=GF CC   post-translational modification to generate the mature peptide.
#=GF CC   Based on their structural and functional features lantibiotics
#=GF CC   are currently divided into two major groups: the flexible
#=GF CC   amphiphilic type-A and the rather rigid and globular type-B.
#=GF CC   Type-A lantibiotics act primarily by pore formation in the
#=GF CC   bacterial membrane by a mechanism involving the interaction with
#=GF CC   specific docking molecules such as the membrane precursor lipid
#=GF CC   II [1].
#=GF SQ   24
#=GS A0A6I6RZM6_9ACTN/1-36   AC A0A6I6RZM6.1
#=GS A0A265QAL3_9FIRM/1-50   AC A0A265QAL3.1
#=GS A0A3S4Y533_9ACTN/1-51   AC A0A3S4Y533.1
#=GS Q99Y19_STRP1/4-51       AC Q99Y19.1
#=GS A0A059W2A7_STRA9/1-37   AC A0A059W2A7.1
#=GS A0A7D4BIL7_9BACL/23-67  AC A0A7D4BIL7.1
#=GS A0A7X6N1S4_9STRE/1-57   AC A0A7X6N1S4.1
#=GS A0A291KJB5_BROTH/1-45   AC A0A291KJB5.1
#=GS I6XQR7_ARAPF/1-51       AC I6XQR7.1
#=GS A0A0A8EVL8_9ACTN/9-48   AC A0A0A8EVL8.1
#=GS A0A4R1QWX5_9FIRM/1-47   AC A0A4R1QWX5.1
#=GS A0A1E3L342_9BACL/1-45   AC A0A1E3L342.1
#=GS A0A1G6ADN6_9STRE/1-51   AC A0A1G6ADN6.1
#=GS A0A4P6YU33_9LACO/1-52   AC A0A4P6YU33.1
#=GS B2JB92_NOSP7/7-57       AC B2JB92.1
#=GS A0A1R1SE91_9ACTN/1-30   AC A0A1R1SE91.1
#=GS A0A3E2N8H5_9CLOT/1-47   AC A0A3E2N8H5.1
#=GS A0A421BDH3_9LACT/1-56   AC A0A421BDH3.1
#=GS F9ECH4_9ACTO/2-44       AC F9ECH4.1
#=GS A0A3S8RWB3_9BACL/1-57   AC A0A3S8RWB3.1
#=GS A0A421BHK0_9LACT/1-54   AC A0A421BHK0.1
#=GS A0A1H3PL14_9PSEU/1-33   AC A0A1H3PL14.1
#=GS A0A0X3V1S6_9ACTN/1-36   AC A0A0X3V1S6.1
#=GS A0A1E5LFE1_9BACI/1-48   AC A0A1E5LFE1.1
A0A6I6RZM6_9ACTN/1-36              ......................mn------......NAQVQTQEISDADLDNVSGG....lVGGVLSTVTT----.---..-------ttd.
A0A265QAL3_9FIRM/1-50              ...................meder-----Ld...yfNMNEVIDEISNEELEMATGA....gEGEWYRTITKKCPS.---..-SLFTCC....
A0A3S4Y533_9ACTN/1-51              ........................MQNKYD.....dQTLDNLAELSDTEIEELLGA.....GWGSIFSFTHECNT.NTM..TQLFTCC....
Q99Y19_STRP1/4-51                  ........................MKNSKD......ILTNAIEEVSEKELMEVAGGk...kGSGWFATITDDCPN.---..-SVFVCC....
A0A059W2A7_STRA9/1-37              ......................mn------......NAQVQTQEISDADLDNVSGG....lVGGVVNTVTT----.---..-------tvgs
A0A7D4BIL7_9BACL/23-67             ................npagdvym------......-------ELEEAELDQVVGG....tEAQAFATIGAKCTV.ETC..SAVIWC-....
A0A7X6N1S4_9STRE/1-57              ........................MKNTNIi...diEATNALQELSFEELDTIIGAkk.kgNDGAIPTISHDCHM.NSW..QFIFTCC....
A0A291KJB5_BROTH/1-45              .......................m------......KNLNLLEEVTEEELDTILGA.....GNGAIRTISHECHM.NTW..QFLFTCC....
I6XQR7_ARAPF/1-51                  ......................mq--SNYD.....dQILDNLAELSDTEIEELLGA.....GWGSIFSFTHECNT.NTM..TQLFTCC....
A0A0A8EVL8_9ACTN/9-48              ....................kgni----MN......NAQVQTQEISDADLDNVSGG....lVGGVLSTVTT----.---..-------tvg.
A0A4R1QWX5_9FIRM/1-47              ........................MRN---......DILNLTNPMEEKELEQILGG.....GNGVIKTISHECAM.NTW..QFLFTCC....
A0A1E3L342_9BACL/1-45              .................mkelfvd------......--LSAVEDITEAELQAAVAP.....GDGWITTLTDDCPN.---..-SIIVCC....
A0A1G6ADN6_9STRE/1-51              ........................MMNAT-......ENQIFVETVSDQELEMLIGG....aDRGWIKTLTKDCPNvISS..ICAGTII....
A0A4P6YU33_9LACO/1-52              ........................MKMN-E......VALTALDEVSELELNDILGAk..gkGSGVIKTLTHECKM.NTY..QAILTCC....
B2JB92_NOSP7/7-57                  nqnpkqasdyieinedgelvvkdp------......KLAESLQELTPEELEQIAGG.....DNGN----------.---..-------cnc.
A0A1R1SE91_9ACTN/1-30              ...................mnnap------......--KVATQEISDAELDNVAGG.....VGHVV---------.---..-------gd..
A0A3E2N8H5_9CLOT/1-47              ........................MRN---......DILELTNPMEEKELEQILGG.....GDGVIKTISHECAM.NTW..QFIFTCC....
A0A421BDH3_9LACT/1-56              ........................MKQKNKqsdaeiKAVDALQEVSLEELDKIIGA.....GNGVVYTLTHECNL.ATW..TKKLKCC....
F9ECH4_9ACTO/2-44                  .....................tad------......----ILVEMTDAELDATLGA.....GNGVFHTISHECYY.NSW..AFIFTCC....
A0A3S8RWB3_9BACL/1-57              ........................MNNLNV......NAMAAIEDISDEELMVITGAaavaaSGGVICTISHECHY.NSVspAAWATCC....
A0A421BHK0_9LACT/1-54              ........................MKDTNIi...diEATNTLQELSLDELDTIIGA....gKEGVVPTISHDCHM.NSW..QFIFTCC....
A0A1H3PL14_9PSEU/1-33              ...................mseqe-----Ik....nEAAETPEEVTIEELDQLAGG.....GGE-----------.---..-------ti..
A0A0X3V1S6_9ACTN/1-36              ......................mn------......NAQVQTQEISDADLDNVSGG....lVGGVLNTVTT----.---..-------tad.
A0A1E5LFE1_9BACI/1-48              ........................MENL--......KFNAVIEDVTDQELDLATGAga.kpGDGWISTITDDCPN.---..-SIIVCC....
#=GC seq_cons                      ....................................phhstlpElS-pEL-plhGu.....ssGsltTloc-C..........hhsCC....
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