#=GF ID Latrotoxin_C
#=GF AC PF15658.10
#=GF DE Latrotoxin C-terminal domain
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 25.00 25.00;
#=GF TC 25.60 25.70;
#=GF NC 24.90 24.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028047;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A toxin domain present in arthropod alphaproteobacterial,
#=GF CC gammaproteobacterial endosymbionts and also at the C-termini of
#=GF CC the latrotoxins of the black widow spider. The domain is
#=GF CC characterised by a conserved, hydrophobic helix and is predicted
#=GF CC to associate with the cell membrane [1].
#=GF SQ 9
#=GS A0A8J3HVE1_9RICK/3389-3522 AC A0A8J3HVE1.1
#=GS A0A4Y2AFH8_ARAVE/14-154 AC A0A4Y2AFH8.1
#=GS A0A7J6YLU1_9COLE/4779-4911 AC A0A7J6YLU1.1
#=GS A0A4Y2W4S6_ARAVE/1012-1139 AC A0A4Y2W4S6.1
#=GS A0A8J5E371_9DIPT/4177-4311 AC A0A8J5E371.1
#=GS T1I1I0_RHOPR/123-259 AC T1I1I0.1
#=GS A0A5E4MFZ9_9HEMI/991-1115 AC A0A5E4MFZ9.1
#=GS A0A5E4MC34_9HEMI/1022-1146 AC A0A5E4MC34.1
#=GS A0A8W7INT1_AEDAE/3614-3744 AC A0A8W7INT1.1
A0A8J3HVE1_9RICK/3389-3522 ..............................qa--DVNGTVLLADVLLAKRGKRQIYASSMDQG.LSQSEILKYISSIQQEFEKAVKHAARESGILMHRL.NIDFIGVQKEIKEKMMSSKFDEILGVLSAHIEKACPSRQAgCPGRLS--..-----------------------pkkfdkfmailnneldvalnq...............
A0A4Y2AFH8_ARAVE/14-154 ...............................s-IDTNGTLLLLDVFIRKITGQKCASTADQPT.ISLPKAVFYASDIINGFERAVEQTASKSGMSMQRLvDIDSMEMREEITGKIMGGKFNEIPRVLISYAEKACPGKEAgCPGKLSPKkfDKFMTIFKHRINITLDESV----lqil................................
A0A7J6YLU1_9COLE/4779-4911 ...............................p-IDVNGTIMLLDVLIR-KVMGQKYISSADQP.TSLLEAQGYALNITKEFGKVVEQAARDSKISIHRL.DIDYMGMQKEITRKVMSGKFNEISGILKSYVEKACPGEEA.GKLSPKKF..EKFIAQFN---------------kgllnqsieqil........................
A0A4Y2W4S6_ARAVE/1012-1139 ................ldflirskgqkhistq----------------------------VKD.ISEQEARAYAFEITQEYKKIVEQAASKSGISMHRL.NINFMEIPKEITGKIMSNKFNEISGVLKSHVEKALPGRESgDPGRLSKKnfDKFMTTFNNRINITLDESI----lqil................................
A0A8J5E371_9DIPT/4177-4311 vdgnstmllldmlirkgtgqkhvytqqrnnsa-------------------------------.---LESVGYAIDITEKFEKIMKRAAAKSKLSFESL.EIDFPKLQGEITGKIVGCKIQEILDILKKCAKNSIKPEEW.SGTDATKM..RLFMEIVDNKIEKYFAKILSKM-t...................................
T1I1I0_RHOPR/123-259 ................................TFDVHGSLLLANVCIAKKFNCQLYNPGSSES.ITYDEALVNGINITEAFEVEITRTAKEYGLTGHSL.DIDFVEVQNAVIGLIMANKLKEIFELLIIKAEKAYPFNEL.VPSQIAHK..EKFIYRMVELINKFVSKSVEHML....................................
A0A5E4MFZ9_9HEMI/991-1115 ...............................p-IDVNGTIMLLDVLI-RKVTGQKYISSVDQA.ISLLEAQNYALNITNEFEKVVKQAASKSEISTHRL.NINFMKIHDEITEEIIGGKFNEISGILKSHIEKACPDREA.--------..-----------------------gypgklspkkfdkfkdelnk................
A0A5E4MC34_9HEMI/1022-1146 ...............................p-IDVNGTIMLLDVLI-RKVTGQKYISSVDQA.TSLLEAQNYALNITNEFEKVVKQAASKSEISIHRL.NINFMKIHDEITEEIIGGKFNEISGILKSHIEKACPDREA.--------..-----------------------gypgklspkkfdkfkdelnk................
A0A8W7INT1_AEDAE/3614-3744 ..............................pi--DEIGTLMLLDVMI-RKVSGQNYSPTIDGStMAPLEAQSYALNITEAFGKAVEQAALRSHLSIQHL.NIDYTEMQGKILTKVLSGKLDDILDILKS-----------.--------..-----------------------yvmnalysdgkerlneenqikfeqfigefntllnvt
#=GC seq_cons ...............................s..DspGTlhLhDVhI.++sttQhY.su.sps.hS..EA.sYAlsITpcFEKsVcQAAp+StlShHRL.sIDFhclpcEITtKIhuuKFsEI.slLKSahEKAhPscEu.s..p.t...........................h..h................................
//
