#=GF ID   LcrG
#=GF AC   PF07216.16
#=GF DE   LcrG protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_16974 (release 10.0)
#=GF GA   24.10 24.10;
#=GF TC   24.20 25.40;
#=GF NC   23.20 23.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9484897
#=GF RT   Heparin interferes with translocation of Yop proteins into HeLa
#=GF RT   cells and binds to LcrG, a regulatory component of the Yersinia
#=GF RT   Yop apparatus. 
#=GF RA   Boyd AP, Sory MP, Iriarte M, Cornelis GR; 
#=GF RL   Mol Microbiol 1998;27:425-436.
#=GF DR   INTERPRO; IPR009863;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several bacterial LcrG proteins.
#=GF CC   Yersiniae are equipped with the Yop virulon, an apparatus that
#=GF CC   allows extracellular bacteria to deliver toxic Yop proteins
#=GF CC   inside the host cell cytosol in order to sabotage the
#=GF CC   communication networks of the host cell or even to cause cell
#=GF CC   death. LcrG is a component of the Yop virulon involved in the
#=GF CC   regulation of secretion of the Yops [1].  
#=GF SQ   10
#=GS Q87P58_VIBPA/1-94      AC Q87P58.1
#=GS A0A1X7AQR5_9GAMM/4-96  AC A0A1X7AQR5.1
#=GS Q7N0X0_PHOLL/2-92      AC Q7N0X0.1
#=GS E3BLV5_9VIBR/1-96      AC E3BLV5.1
#=GS T0P9I1_PHOTE/2-92      AC T0P9I1.1
#=GS Q9I326_PSEAE/8-98      AC Q9I326.1
#=GS LCRG_YERPE/5-95        AC P69957.1
#=GS A0A105T3G0_9PSED/3-94  AC A0A105T3G0.1
#=GS A7MZ32_VIBC1/10-105    AC A7MZ32.1
#=GS U3C923_9VIBR/1-96      AC U3C923.1
Q87P58_VIBPA/1-94                 .....MKQPFTQAIENAELAIRNADERNDIFSELLEGLGVGPVAGEVLLGGLNASpkLMQHAEQELIEEVQRRRQQQHQ..lQGVQGKRRKRPTMMRGMVI....
A0A1X7AQR5_9GAMM/4-96             ...es--DDLRAFLADSDKLIKASEKSLKSMEAMRKDIGLQAGASKELLEQVPESqdAYRAAQKELNQFLRDNQSESAE..aDTKDKKRKKKRSKM-----artv
Q7N0X0_PHOLL/2-92                 ...qe--EPNAKVLQAAEAAIKDSDHRLQLLQEMWQSLGINPNVGTELFGHTDVT..LVQNAEQELLTEVNRLRSNQPP...SLEEGKRLRRPPRMRGIIV....
E3BLV5_9VIBR/1-96                 .....MKSPFSETIEKAELAIRSAEDRGDIFNELLEGLGVGPVAGELLLSGLNTSpkVMKLAEQELVEEVQRRRQQQPQlqtTNTQGTRRKRPTMMRGMVI....
T0P9I1_PHOTE/2-92                 ...qe--EPNAKVLQAAEEAIKDSDHRLQLLQEMWQSLGINPNVGTALFGHADTS..LVQDAEQELLTEVNRLRSNHPH...SLEEGKRLRRPPRMRGIIV....
Q9I326_PSEAE/8-98                 ....t-EDTLRATVQAAELAIRDSEERGRLLAEMWQGLGLAADAGELLFQAPERE..LARAAEEELLAELRRMRSSQPT...QGEQGTRPRRPTPMRGLLI....
LCRG_YERPE/5-95                   .....HFDEYDKTLKQAELAIADSDHRAKLLQEMCADIGLTPEAVMKIFAGRSAE..EIKPAERELLDEIKRQRERQPQ...HPYDGKRPRKPTMMRGQII....
A0A105T3G0_9PSED/3-94             kdpct----HANTVQAAKLAIENNAQRSRLLSEMWEGLGLSPEVRDRVFRPGPSR..LIEAAEQELLKEVERMRAAQRP...AAEEGSRMRRPARMRGLMV....
A7MZ32_VIBC1/10-105               .....MKQPFTETIENSELAIRNAEDRTDVFNELLEGLGVGPVAGNILLDGLNASpqLMKQAEHELLEEVQRRRQQQHQpqaASTKGTRRKRPTMMRGMVI....
U3C923_9VIBR/1-96                 ....m-QKPFSETIEQAKLAIKSAEERTDVFNQLLDGLGVDPIVGEILLSDIKTTpeMMKKAEQELMDEVQRRRAQQPLlqvSTSSGTRRRRPTMMRGLII....
#=GC seq_cons                     .......cPascTlpsAELAI+su-cRsclhsEMhcGLGlsPsAGchLhushsso..Lh+sAEQELLcEVpRpRupQPp...sspcGpRhRRPThMRGhlI....
//