#=GF ID LcrV
#=GF AC PF04792.16
#=GF DE V antigen (LcrV) protein
#=GF AU Waterfield DI;0000-0003-2885-5126
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE Pfam-B_6155 (release 7.5)
#=GF GA 25.00 25.00;
#=GF TC 28.00 43.30;
#=GF NC 24.10 21.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF WK LcrV
#=GF RN [1]
#=GF RM 9642196
#=GF RT The V antigen of Yersinia pestis regulates Yop vectorial
#=GF RT targeting as well as Yop secretion through effects on YopB and
#=GF RT LcrG.
#=GF RA Nilles ML, Fields KA, Straley SC;
#=GF RL J Bacteriol 1998;180:3410-3420.
#=GF RN [2]
#=GF RM 7730287
#=GF RT Differential effects of deletions in lcrV on secretion of V
#=GF RT antigen, regulation of the low-Ca2+ response, and virulence of
#=GF RT Yersinia pestis.
#=GF RA Skrzypek E, Straley SC;
#=GF RL J Bacteriol 1995;177:2530-2542.
#=GF DR INTERPRO; IPR005413;
#=GF DR SCOP; 1r6f; fa;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Yersinia pestis, the aetiologic agent of plague, secretes a set
#=GF CC of environmentally regulated, plasmid pCD1-encoded virulence
#=GF CC proteins termed Yops and V antigen (LcrV) by a type III
#=GF CC secretion mechanism. LcrV is a multifunctional protein that has
#=GF CC been shown to act at the level of secretion control by binding
#=GF CC the Ysc inner-gate protein LcrG and to modulate the host immune
#=GF CC response by altering cytokine production. LcrV is also
#=GF CC necessary for full induction of low-calcium response (LCR)
#=GF CC stimulon virulence gene transcription. Family members are not
#=GF CC confined to Yersinia pestis [1,2].
#=GF SQ 12
#=GS U3CHY8_9VIBR/323-609 AC U3CHY8.1
#=GS LCRV_YERPE/1-323 AC P0C7U7.1
#=GS A0A6G0XZV1_APHCR/50-193 AC A0A6G0XZV1.1
#=GS A0A105T2T5_9PSED/2-313 AC A0A105T2T5.1
#=GS A7MZ25_VIBC1/407-605 AC A7MZ25.1
#=GS Q7N0X1_PHOLL/2-304 AC Q7N0X1.1
#=GS D2TXP6_9GAMM/24-319 AC D2TXP6.1
#=GS E3BLV6_9VIBR/671-753 AC E3BLV6.1
#=GS D0Z4V9_PHODD/396-608 AC D0Z4V9.1
#=GS A0A2A2KJC5_9BILA/113-316 AC A0A2A2KJC5.1
#=GS G3XD49_PSEAE/72-294 AC G3XD49.1
#=GS Q87P59_VIBPA/388-607 AC Q87P59.1
U3CHY8_9VIBR/323-609 atvnaeidqllvdlkdvkqqlelpqniktikqvvgqdisvlfekmaqgqsvetdfitrhkkllanlaqfse--------------------------------------------------------------------------------------------HLKNNIQS--....-QTDS..TqDNNEYVLKglDLFALID-ASTGDRLDDKILNALDEMRQGQFNKRDEIKNELEELTIILNLYNLIQAAIHNAQSG..EGKYNI...NQE---.-FKPEDFGYS.TQEEFENSPEFAFLNSQN-------...---PPITSHKGFLEQQGLDIDTS..QNSGIYEDTEDDGNKLSNLSTAISDKSKIVNTDVQLKTEEFSKMNSDYNATIQAMNQIVQKFISVLTDILR--sf....
LCRV_YERPE/1-323 .......................................................................MIRAYEQNPQHFIEDLEKVRVEQLTGHGSSVLEELVQLVKDKNIDISIKYDPRKDSEVFANRVITDDIELLKKILAYFLPEDAILKGGHYDNQLQNGIKRVK....EFLES..S.PNTQWELR..AFMAVMHFSLTADRIDDDILKVIVDSMNHHGDARSKLREELAELTAELKIYSVIQAEINKHLSS..SGTINI...HDKSIN.LMDKNLYGYT.DEEIFKASAEYKILEKMPQTTIQVD...GSEKKIVSIKDFLGSENKRTGAL..GNLKNSYSYNKDNNELSHFATTCSDKSRPLNDLVSQKTTQLSDITSRFNSAIEALNRFIQKYDSVMQRLLDDT......
A0A6G0XZV1_APHCR/50-193 ................................................................ffnenta------------------------------------------------------------------------------------------------------....-----..-.--------..------------------------------------------------------------GAAS..SQNIYT...DYRGIN.LMNYQLYGYS.SQAEFKTKAEYQLLQKIV------S...FST--TVTIRQFLLSADKNSGAM..SRVEDSYKYDKDNNRLANFSTMVSDRSRPLSDSISEKTTRLNDISGRYNAAIEALNRFIQKYDSQ--------cytlay
A0A105T2T5_9PSED/2-313 ................................................................sishyth--------TTQFLSDVTSTALDQLRGHDAAALTELQSLLATLKIRVS-----HEGTE------LTS--AQMNKVLAFLLPPDAKLANGGYASQLQNGLNGVKktltEYANA..H.PHTAWPLS..DFLALNHFGLTADRLDDDVIDVYVGVLEKQDAKRLKLRDELKELTGELSIYSVVQAQINAKLSS..KSDIDIsktDAGGLN.LLDKALYGYS.EEQPWLKSAEYALLTRLD------T...AKNKTQISIKDFLSGVPKESGAIkaADLKNSYAFEKDNNPVANLATTVGDRSRSLNDKVSEKTTLLNDVSSRYNAAIEALNRFVQKHDSLLRDILNAI......
A7MZ25_VIBC1/407-605 ..............................................................isskevnae------------------------------------------------------------------------------------------------------....-----..-.--HALTAR..DLLSVIESSI-GDRFDERVLFALNERRVDRLEKRNEQKEQLEDLTIQLKVFSVVQSKIHSTQSV..DGTYKP...GDAANN.-FKASDFGYD.NDAAFKASPEYKYLKDNN-------...-----ITNHKDFLVKQGMEVG--..---SDSFKGD----KLSNFSSSVTAESKVLNDEVQIKTTELNDTSSQYNATVEAMNKFVQKYHSILQEILRA-l.....
Q7N0X1_PHOLL/2-304 .......................................................................EIRPYQNDPQLFLADLEKVSLAQLQGSGSSELDRLVNLIFDKGIKIT------SDSS-----VVTENKELLKKLIAYFLPADAVVEGGHLDSQIKNGINNLE....SFLNS..S.TLKTWTLK..DFLAAVHFNLTPDRLDDDVIDIFVSVMSGHDKKRLELRDELATLTAELKIYSVIQSEINAKLAA..NGELKI...DDNSFN.LLDHKKYGFS.DQPTFEKSAEYKLLRKIS------S...GSE---ISIKTFLESSNKQSGAM..AGLENSYEYDKENNRLANFSTSVNDRVSPLNNTVQEKTTRLNEASSRYNAAIEALNRFIQKYDSIIRNILGAI......
D2TXP6_9GAMM/24-319 .....ttatpdinkitnaiinklaqsgvkveldqsvaggkqtldaniaadrdklkqlfsqifqlalprnik-------------------------------------------------------------------------------------NLTDAENDIQDFMAKLD....NQRQG..A.SLVSA--N..MLLTVIESYFSYANLDEDIIAVFAKNMVYHDDKRKELKIELEEISAEMKIYSVIQSEINSALSAasSQTINT...DQNGIN.LMNYQLYGYS.SMAEFKTKAEYQLLQKIA------P...SS--TTVTIKQFLLSADKKSGAM..GRVENSYKYDKDNNRLANFSTMVSDRSRPLSDSINEKTTRLSDISGRYNAAIEALNRFIQKYDSVIQDILRAI......
E3BLV6_9VIBR/671-753 ........................................................vdfltnkinnfdtav------------------------------------------------------------------------------------------------------....-----..-.--------..----------------------------------------------------------------..------...------.----------.-------------------------...-----------------------..-----TYQDTKDSQKLSNLSNQLSETTKLVNTDVQLKTTDLNDTNSQYLNTIEAMNKFIQKYMNIIETILRAI......
D0Z4V9_PHODD/396-608 .....................................................rlskitkeekdnkavnae------------------------------------------------------------------------------------------------------....-----..-.--HALTAR..DLLSVIESSI-GDRFDERVLFALNERRVNRLEKRNEQKQVLEELTIRLKFFGVVQSRIHSFQSR..DASYD-...-PFGVEgRFKASDFNYS.NDNEFKASPEYKYLSKNK---IE--...-------KHGDFLR----KEGLT..VPYDVSYQDTKDNKKLSNFSSSVSDKSKLLNDEVQIKTTELNDTSSQYNSTVEAMNKFVQKYHSILQEILRAI......
A0A2A2KJC5_9BILA/113-316 .............................................................qlvnlgerls------------------------------------------------------------------------------------------------------....-----..-.--------..--------------MDELVMAAMGLRMRKQKTERTELSEQLKSLTAELKIFSVIQSKVNVVMAD..KGTFDL...QDPGFN.LFDPNLYDL-.DAAAWETSPEHRLLASYGTAAVTVQqflAAKPTGLSPDSSVHRRHRVSGPM..DDLKAEYTWHKDNNPLANFSQALSDRTRIVNDRVTEKTTLLNDAGSRYTTSTEVMMKFVETWFSMLSKIMQ--n.....
G3XD49_PSEAE/72-294 .....................................................................gq------------------------------------------------------------------------------------------------GLEVLR....EVLQArrQ.PGAQWDLR..EFLVSAYFSLH-GRLDEDVIGVYKDVLQTQDGKRKALLDELKALTAELKVYSVIQSQINAALSA..KQGIRI...DAGGID.LVDPTLYGYAvGDPRWKDSPEYALLSNLD----TFS...GK----LSIKDFLSGSPKQSGEL..KGLSDEYPFEKDNNPVGNFATTVSDRSRPLNDKVNEKTTLLNDTSSRYNSAVEALNRFIQKYDSVLRDILSAI......
Q87P59_VIBPA/388-607 ..................................................................rknlg----------------------------------------------------------------------------------------ALKDRLLNITEQEK....KDLEV..R.AEHSLTAR..DLLAVVESSI-GDRFDEQVLFALNERRVNRLEKRNEQKEALQDLTVQLKIFGVVQSKIHSTQSV..DGTYKP...DDNAFS.ASDFNYNSVT.D---FQNSPEYKYLTDNG-------...-----ITTHTDFL----KKQGVT..VADGASFKDEEKTKKLSNFSSSVSDKSKLLNDEVQIKTTELNDISSQYNSTVEAMNKFVQKYHSILQEILRAI......
#=GC seq_cons .....................................................................ht.....................................................................................................................tth.hp..thhshhc.sh..sRhD-cll.shsphh.tp.pKRpc.+ppLppLThpLKlauVlQupIpst.Ss..pushph...sstuhs.hhchphaGYo.spttFcsSsEYphLpc.s................hoh+sFL.tts+psGsh..sshpsSYph-KDNN+LuNFSosVSD+S+.LNDcVp.KTTcLNDhSScYNuslEAhN+FlQKYcSllpcILpAh......
//
