#=GF ID LepB_GAP_N
#=GF AC PF18172.5
#=GF DE LepB GAP domain N-terminal subdomain
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF04281
#=GF GA 27.00 27.00;
#=GF TC 63.60 37.50;
#=GF NC 21.80 24.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 23588383
#=GF RT Structural analyses of Legionella LepB reveal a new GAP fold
#=GF RT that catalytically mimics eukaryotic RasGAP.
#=GF RA Yu Q, Hu L, Yao Q, Zhu Y, Dong N, Wang DC, Shao F;
#=GF RL Cell Res. 2013;23:775-787.
#=GF DR INTERPRO; IPR041585;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is a subdomain of a Rab GTPase-activating protein (GAP)
#=GF CC effector from Legionella pneumophilia. This GAP modulates Rab
#=GF CC enzymes that act as molecular switches in regulating vesicular
#=GF CC transport in eukaryotic cells. This N-terminal subdomain belongs
#=GF CC to the the GAP domain of the protein. The catalytic arginine
#=GF CC finger (Arg444) is located within this sub-domain and it is the
#=GF CC only arginine residue required for GAP activity [1].
#=GF SQ 23
#=GS A0A0W0ZTU2_9GAMM/526-714 AC A0A0W0ZTU2.1
#=GS A0A222P4Y6_9GAMM/327-498 AC A0A222P4Y6.1
#=GS A0A0W0VUK7_9GAMM/330-494 AC A0A0W0VUK7.1
#=GS A0A0W0Y5W6_9GAMM/374-561 AC A0A0W0Y5W6.1
#=GS A0A0W0YHL1_9GAMM/327-511 AC A0A0W0YHL1.1
#=GS Q5ZSM7_LEGPH/331-522 AC Q5ZSM7.1
#=GS A0A078KT24_9GAMM/345-535 AC A0A078KT24.1
#=GS A0A0W0Z8U0_LEGSP/339-397 AC A0A0W0Z8U0.1
#=GS A0A078KX16_9GAMM/332-490 AC A0A078KX16.1
#=GS A0A0W0VLG2_9GAMM/366-561 AC A0A0W0VLG2.1
#=GS A0A378LPB4_9GAMM/527-717 AC A0A378LPB4.1
#=GS A0A0W0V9J5_9GAMM/333-496 AC A0A0W0V9J5.1
#=GS A0A0W0U1D9_9GAMM/337-501 AC A0A0W0U1D9.1
#=GS A0A0W0VDP4_9GAMM/368-567 AC A0A0W0VDP4.1
#=GS G9EPL4_9GAMM/336-524 AC G9EPL4.1
#=GS A0A0W1ABS5_9GAMM/335-523 AC A0A0W1ABS5.1
#=GS A0A098GBU1_TATMI/367-570 AC A0A098GBU1.1
#=GS A0A098G267_9GAMM/336-499 AC A0A098G267.1
#=GS A0A098GFD6_TATMI/331-505 AC A0A098GFD6.1
#=GS A0A222P6B9_9GAMM/408-613 AC A0A222P6B9.1
#=GS A0A6F8T7K4_9GAMM/330-479 AC A0A6F8T7K4.1
#=GS A0A0W0V4N6_9GAMM/346-526 AC A0A0W0V4N6.1
#=GS A0A378LVJ2_9GAMM/333-499 AC A0A378LVJ2.1
A0A0W0ZTU2_9GAMM/526-714 ..............ltgre-----GVSFPQVLSGWQEI.LVPLsQIN..LIDYTELNLNDLAKQFNEYVDFLAQQAEILNLWEREPSQ......TKNLLVKYSDENP..ELAH.GHAFIAQYRESTILRRL..FAL....DTSD.....LCTHRFRPYEGPNTQCREQLP..........ESYWGKVSTLLTAGSDVIAMLRTLKNLQTLKVSWe......dMS..R.TATLLKEAV....ERFEKAREAVAK---h............
A0A222P4Y6_9GAMM/327-498 ...................LRINDDFSFTEQMEVWLEA.LTKS.EAT..ILAADTIDLAKISLKFNDFLAKLLQQVELTY--TKNPKK......--KLPYQIYPLR-..----.----LPRCPEAIYLHHL..FML....NTNG.....T-----PVFNEKELEKLNLPL..........DSLWQEVKNVLTSCFHVVITIRIAQEINFSDNGEt......iNN..Y.ALSNLFFNL....KEHLTLFVTIHHSF-m............
A0A0W0VUK7_9GAMM/330-494 ...................LSVHTDLPFPDQLDIWLQG.LGHC.QGD..F--FDKINLAELIKQFHFFKDVLIKQAELLD---HQT--......--SLLNKENNHAE..----.------AINESELLHQL..FTL....NTDG.....-----TPAFNGPLSRSMQKPI..........ATHWNDVEKVLAVSFNVIVTIRVAQETEDTSIEH........AK..EyAFKTLLSAL....KEHLTTFHEVYKSLM.............
A0A0W0Y5W6_9GAMM/374-561 .eepfpilvkefikwtckd-------------------.----.---..--EFGQINISAIVHQLNNYIDFWAQQGELFNLWGNKG-Q......NQNIFTPFAPEIK..TEALrGHAFLPQYREATLLRRMaySYL...hVDEAhplgvFITHRIALYEGAIEGYVKTHQ..........NSYWVLCQNAITEAQSIVNALQVLQKLQSSPDAPs......lNE..E.HLKEFKEAV....SKFLYHNKKLEESF-q............
A0A0W0YHL1_9GAMM/327-511 ..............vtekg------ESFPEIIKQWHHI.LPVD.N--..-IDNSLVDLSILAHHFNDYVELLANQCDATNLWQHDSAH......SENLFTPYYQEKG..EAKY.GHAFVSQYKESTVLRRL..FTL....IPDT.....LNSVRFDAFESPCQEYAKAHE..........DAPWVKIQKLLTLGQGIINTLAVIKRAQEFGLDE.......vVG..E.YRGKLKLVL....AEFVQTEQEIPSVL-n............
Q5ZSM7_LEGPH/331-522 ...................LLMTSSTSFSETINQWADI.LKTT.DMEkfSFDSNPINLLELVKQFNLYVDELAITCEANNVWAKERID......STPNLFALYDNSG..GEAIhGHAFVPYYKESIVLRRL..FTV....DPNT.....FNLSRFAAFEGPCQLYCKEHK..........DSAWVKIQTLLTLGNGIINTLKIIKQAQAFGIDE.......aVT..E.NLKALKEQF....IAFQLAEADIKESLK.............
A0A078KT24_9GAMM/345-535 ...................ITIDPEGALPEQFELLHQI.IQKT.K--..ALDFRQIDFTRLAQQFNHHLDLLAHQTEVLNLWQHKPNS......NVNMFAPYSSGST..KAIL.GSAYVAQYRESTILKRL..YTM...sEDGS.....LISLRFGAYEDAVRNYARDPVk........vESLWLKIEALLTNSYAVINELHLLQNAQLSSDRD........VNnlE.NIGHHVQNL....NTYLGAFAESKRLL-d............
A0A0W0Z8U0_LEGSP/339-397 ..................i-EINDELTFPQQIVHWRNH.IAEVdELA..LFDFNTVLLPSLVAQFNRYLDNLLFQG------------......-------------..----.-----------------..---....----.....---------------------..........----------------------------------........--..-.---------....---------------gesvg........
A0A078KX16_9GAMM/332-490 ...................LKANPKLSFTEQLQHWQDL.LKLSdEID..GFDFNTIELAILTKQFNYFIESLLVKLEQLS---DKPE-......-------------..----.--------LENNILRKI..FAV....KADA.....------SPCYTPSKGEGKA-L..........SSDAKNISAVLTAGFGVLVTLRVIQDTQNGDPSTv......dKE..S.AIHFLFKALmecvDTFHSAYEDVLRQI-e............
A0A0W0VLG2_9GAMM/366-561 ...................LTVDSEIPFPALVNNWMTY.LSRA.KEG..KIDYQQLDIDKLAELFNHYIDVIAQQAEICNFWQHDPLT......SDNMLVKYYAGDN..ELDM.GHAFVPQYRESTILRYL..FMF....NPKT.....WSTNRLRAYEKAVAEYNHQNA..........DSFWKTMMQFSVQSVAVMQALKALKNQQAVQKKHpelsseeqMG..A.LLDGLEKGL....REFTQANEQLSKLLK.............
A0A378LPB4_9GAMM/527-717 ...................LTCSRDVSFSQVLKDLDHYfLPLS.QVN..LLDYKQINISDLAKQFNEYIASLAEQAETLNLWDHHPEQ......TANFFTAFSEKNK..EFDF.GYAFIEQYRESTILKRL..LSL....DPET.....TGTNRIKPYEVPAARYRHQYP..........ESYWNKVIMLLTAGSDVISLLRTLKQLQLADVPWe......gMS..E.TAISLKEAV....TRFKEAKESVENHI-e............
A0A0W0V9J5_9GAMM/333-496 ...................LKVQFDLSFPDQLEFWQEI.LTKQ.NAN..L--FREIEMEELVAQFHSFRDELISQAESIHS--LKP--......--------S----..----.GTSSIPASEEGKFLQQA..FNL....YPDG.....SP----VSQDSTLMTEHKKPH..........SLVWQEAEHTLSAAFNLLVIIRVSKETLAKQILEe......aQQ..E.AVNYLLKTV....IDQIIDFKECYQRL-l............
A0A0W0U1D9_9GAMM/337-501 ...................LPVNLVTPFAEQMKIWFSI.LSAS.DEK.sIFDFNTVELAKLVKQFNGFSNSLLRQAEILTG-------......---VLSTANREG-..----.---SIPSHRTGHFLRCL..FTM....EDDL.....TP--RFISYTEKRSPD----V..........QPYWQAIEMVLTYSFNVVVLIKVLQNTQNSAELG........KA..S.AIHFLFGAL....KDSLESFGIAYQGL-m............
A0A0W0VDP4_9GAMM/368-567 ...................LKLDGTLSLPAIAEAWTTD.LALA.KAA..EIDFSEIQLHALIERFNSYIEAIAAHAEASNFWQKNRSEddgipaNHNMLSPHHDGNN..GLQY.GHAFVPQYRESTILCRL..LTL....NPQN.....QGAIRIKPYEEPSRLFSSEHE..........ESVWNILQTISLAGLDIFTSVRAVKKLQEDNSSDlts..qenIA..I.SINNLKQAL....QTLKESHGKLLKLFE.............
G9EPL4_9GAMM/336-524 ...................LQMEQEQPFPELIRTWAGL.LGQI.GVE..SVRTEEVNFGQLAKCFNDYLNTVAEHCEQQNIWQHKREE......NHNFFTAFKPDAS..KAALhGHAYIAHYKESVILRHL..SIV....DPKT.....LGMLRFAPYEAPSTDYCRHFP..........DSPWAKMQRLATAGQNIILQLRLIQNGQMLEDDF........MK..E.KLPVLQKAL....DDFMQYKTEVDALL-a............
A0A0W1ABS5_9GAMM/335-523 ..................m-KINQGESFSQSVGNLHTL.LDVSgKTK..TVDCTNLDIIELTKQFNGYVSRLAQFSETQGFWSPDNSQ......VYNIFSPHYTKEG..QAEY.GFAFLPQYKEGTILEHL..FSI....DLKT.....LNIYRFAPFEGPILAYCKSHP..........NSKWVKLQSILSKGQDIINTLSVIKNAQQLGIDD.......aVT..E.QLPNLMTFL....KDFLEAEKTL-----dikf.........
A0A098GBU1_TATMI/367-570 ...................LRMEEPIAFPARLEAWLKH.FADP.R-T..PIDFSQIDYDLLIKDYNHYVAVLGRQGDLYNIWHHDFQS......SSGNLLALSSKASfdSTVQtGYAYVPQYREGALLRHL..YAF...aAPGR.....HASERFSHYDKLDADYCREENeyctthkeaqPSAWLKVVTALQRAHGIMTLIKELQRTKGKE-KE........FA..E.YIPIWKEDLlsqlHEFKKASDIITDLFE.............
A0A098G267_9GAMM/336-499 ...................LPVNMVTPFAEQMNIWLNI.LSSS.DEK.sIFDFNRLERDKLAKQFNCFMENILRQAERLNQYASEM--......-----PPVSPDNA..----.--------SESHVLREL..FIL....NAD-.....-----LTPHYSSNFEIKHSYR..........QLYWQVVHTVLTTSFHAVVTIRVLQNTQNATEFE........KA..S.AIHFLFDTL....KEHLQTLNKAYQVF-i............
A0A098GFD6_TATMI/331-505 ...................LQANGALNFPGQLKIWRDT.LASSdQKT..CFDFNSIDLPILTRQFNGLIDYLLEQFEEINPSIEGDNQ......TGHGIQELSSEQE..----.--------KPSSILRHL..FTL....KPDA.....TP---FYSCQNSDKDFNES-S..........KVHLKHLASVLTLGFDIVVTVRVIRETQNLKGHD........MTkaS.AVRFLFNAL....QNYIDAFQESFSTF-s............
A0A222P6B9_9GAMM/408-613 kvnnetvfsdfvedltnfv--------------NYKDE.LNLA.QAI..WIDFSRINLQQLAKQYNHYIDLLTQQAEIFNLWQHHPSR......NLNALVPYNAKRT..DELQaGHAFVPYYRESTILRRL..STI....EPQS.....LGLYRFQPYEEPARQYSQE--..........NPTWKKLQDITSAGNQIIGFLKAAQGQYNFITEE........IQ.sS.KIKLNPQEI...kIKYEKGMQDVLKHL-sdaiiafnerret
A0A6F8T7K4_9GAMM/330-479 ...................LSFNEKEAFPAIMDNWEKK.LTKTnDGR..TLDISNLDLSTLAEHYNCYLNEIAEQCEQSNIWDHTD-D......SANMFQPFDFSNG..ALIH.GHAFISSYKESTVLRRL..FSI....NPSN.....LNLSRFAAFEDPSNDYSKKYP..........ESVWHKLELLLVTGQGVSISI-------------........--..-.---------....---------------qf...........
A0A0W0V4N6_9GAMM/346-526 ...ltlqnmgadllgsmhd-------------------.----.---..QIGLNEVN--VFVRKFNDFVDSIARHAEEVNFWQHQK--......TQNILAPFFTGQK..DTFYhGDAFVPHYREATIIRRL..YSMlpfgKEKL.....EGASRFQPYDE---NHLQEID..........DENWKKIQALLSKGVLIITMMKKIKDFKEFAKST........EE.lE.QITIFTDQIirdvKEFMGCYLEIE----nrll.........
A0A378LVJ2_9GAMM/333-499 ..................l-FVNHIIPFQQQMSIWLNT.LSLS.DER.sIFDFNCINRTLLAQKYNPFIECLARQVALIEQFSKDQ--......-----NNVYVHDE..----.----IKSRAITKTLMNL..FSL....DMD-.....-----LKPGE-SDMEQRIPFK..........QPCWRLVEALLSTSFNIVITIRVMQSTQSTSMLT........SA..S.AIHFLFDAL....KKYLHDFNTFYETL-i............
#=GC seq_cons ...................Lphs.thsFsp.hphWtph.Lshs.php..hhDasplslspLs+QFNpal-tLupQuEhhNhWp+cs.p......s.shhsshtsppt..t....G.AalspY+EoslLR+L..Fsl....sscs.....hs..Rhtsa-ssstpapcp............pohWpclpslLotu.sllstl+llpptQths.pp........hs..p.tlphLhpsL....pcahpshpplhp.h..............
//
