#=GF ID Luciferase_N
#=GF AC PF05295.15
#=GF DE Luciferase/LBP N-terminal domain
#=GF PI Luciferase;
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_7906 (release 7.7)
#=GF GA 25.00 25.00;
#=GF TC 25.10 25.10;
#=GF NC 24.80 24.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK Luciferase
#=GF RN [1]
#=GF RM 11747464
#=GF RT Members of a dinoflagellate luciferase gene family differ in
#=GF RT synonymous substitution rates.
#=GF RA Okamoto OK, Liu L, Robertson DL, Hastings JW;
#=GF RL Biochemistry 2001;40:15862-15868.
#=GF RN [2]
#=GF RM 9256416
#=GF RT Three functional luciferase domains in a single polypeptide
#=GF RT chain.
#=GF RA Li L, Hong R, Hastings JW;
#=GF RL Proc Natl Acad Sci U S A. 1997;94:8954-8958.
#=GF DR INTERPRO; IPR007959;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family consists of a presumed N-terminal domain that is
#=GF CC conserved between dinoflagellate luciferase and luciferin
#=GF CC binding proteins. Luciferase is involved in catalysing the light
#=GF CC emitting reaction in bioluminescence and luciferin binding
#=GF CC protein (LBP) is known to bind to luciferin (the substrate for
#=GF CC luciferase) to stop it reacting with the enzyme and therefore
#=GF CC switching off the bioluminescence function. The expression of
#=GF CC these two proteins is controlled by a circadian clock at the
#=GF CC translational level, with synthesis and degradation occurring on
#=GF CC a daily basis [1]. However This domain is not the catalytic part
#=GF CC of the protein. It has been suggested that this region may
#=GF CC mediate an interaction between LBP and Luciferase or their
#=GF CC association with the vacuolar membrane [2].
#=GF SQ 26
#=GS A0A813FEU5_POLGL/1113-1188 AC A0A813FEU5.1
#=GS A0A813CF38_9DINO/6-81 AC A0A813CF38.1
#=GS A0A812IQJ3_9DINO/608-682 AC A0A812IQJ3.1
#=GS A0A812K2S3_9DINO/18-96 AC A0A812K2S3.1
#=GS A0A812FUQ6_9DINO/4-80 AC A0A812FUQ6.1
#=GS A0A813ALJ9_9DINO/122-201 AC A0A813ALJ9.1
#=GS A0A1Q9CAN7_SYMMI/1-78 AC A0A1Q9CAN7.1
#=GS A0A813D3Y2_9DINO/407-482 AC A0A813D3Y2.1
#=GS A0A812J3W3_9DINO/6-81 AC A0A812J3W3.1
#=GS A0A813DFX5_POLGL/9-83 AC A0A813DFX5.1
#=GS A0A812SCN3_SYMPI/1-80 AC A0A812SCN3.1
#=GS A0A812V319_9DINO/1362-1442 AC A0A812V319.1
#=GS A0A812N7Q9_SYMPI/19-94 AC A0A812N7Q9.1
#=GS A0A812PQZ1_9DINO/6-81 AC A0A812PQZ1.1
#=GS A0A1Q9BU22_SYMMI/3-80 AC A0A1Q9BU22.1
#=GS A0A812MUM2_9DINO/17-94 AC A0A812MUM2.1
#=GS A0A813DJZ3_POLGL/12-86 AC A0A813DJZ3.1
#=GS A0A813HCS1_POLGL/203-278 AC A0A813HCS1.1
#=GS A0A1Q9EBQ8_SYMMI/4-80 AC A0A1Q9EBQ8.1
#=GS A0A813FIJ5_POLGL/1735-1810 AC A0A813FIJ5.1
#=GS A0A812W0F7_9DINO/1-78 AC A0A812W0F7.1
#=GS A0A1Q9DDE3_SYMMI/409-484 AC A0A1Q9DDE3.1
#=GS A0A1Q9E6I6_SYMMI/1-81 AC A0A1Q9E6I6.1
#=GS A0A812NCC1_9DINO/619-698 AC A0A812NCC1.1
#=GS A0A812R196_9DINO/1-67 AC A0A812R196.1
#=GS A0A813FRJ5_POLGL/9-83 AC A0A813FRJ5.1
A0A813FEU5_POLGL/1113-1188 ........kqd---ELRQAL-KEAAVEDEICAYMSDVLKMTSIEDFVRFVSEAAYETELLTHILG.KVASFKS--...---DLLQLSRLRTAWRTEQ........
A0A813CF38_9DINO/6-81 ..........k-AAELKQYL-RNANLPEEFARHCLRTLQMGSLEDFVSYVSSSNYEAELKTRVVD.TCAATK---...--GKPLILARVRSAWRSA-r.......
A0A812IQJ3_9DINO/608-682 ....mdalrgv--------L-QSAKTSEHVNRYLTDTLKVASIEDLVFLVSAAAYETELKSLVTD.QVDAVR---...--DVPIELARLRAAWRRA-k.......
A0A812K2S3_9DINO/18-96 ......ltscf------------ARVKPELVTYMKDVLKMESLQDFFFYVAKDAWEAELDVKVVKpAVDASGSASvitEAMKPIQLARVRMAWQSA-a.......
A0A812FUQ6_9DINO/4-80 ....mkadalr------RCL-VDAKLPDAFVEHCLGTLKMESLDDFVNIVTIKDYETEIKAVLID.QCPETK---...--DNPLYLARARAAWRAA-r.......
A0A813ALJ9_9DINO/122-201 .makaqqdalr------RCL-QDARLPDSFIQYCVGDLKMASLEDFVNIVTIKDYEQELKTVLTD.NCAD-----...TKDQPLQLSRARAAWRAV-r.......
A0A1Q9CAN7_SYMMI/1-78 .....mavgve---QLETLLVSVHKVDLEIFKLL-RSDGVESVADFVGLFTEKEYDEGLKD-YTE.RSQNFK---...--GSKIQLSRLRVAWSVA-r.......
A0A813D3Y2_9DINO/407-482 ...kadalrrc--------L-VDAKLPDAFVEHCLGTLKMESLDDFVNIVTIKDYETEIKAVLID.QCPETK---...--DNPLYLARARAAWRAA-r.......
A0A812J3W3_9DINO/6-81 ..........k-AAELKQYL-RNANLPEEFARHCLRTLQMGSLEDFVSYVSSSNYEAELKTRVVD.TCAATK---...--GKPLILARVRSAWRSA-r.......
A0A813DFX5_POLGL/9-83 .........md---ELQQVL-KEAAVEEEICAYMIDVLRMTSVEDFVRFVSEAAYETELLSHILI.KVASFK--S...D---PLQLSRLRTAWRVA-r.......
A0A812SCN3_SYMPI/1-80 ...makakvea----LRRML-QEARLPEEFANHCITTLKMESIEDYVNIVTVKDYETELKVVLTD.QCAA-----...TKDSALMLARARSAWRA--gr......
A0A812V319_9DINO/1362-1442 ......maksn---EFRRCL-EDQKLPEPLIAWCESTLGIETLSDFCNIVTVNGYESELDVVILS.ACEDTK--A...APNKALLLARLRAAWRAA-r.......
A0A812N7Q9_SYMPI/19-94 ....ssclsis-------------RVKTELITYMKDKLSMESLQDFFLYVAKDAWESELEKKVID.PAVTATVIT...EAMKPSQLARVRLAWQSA-r.......
A0A812PQZ1_9DINO/6-81 ..........k-AAELKQYL-RNANLPEEFARHCLRTLQMGSLEDFVSYVSSSNYEAELKTRVVD.TCAATK---...--GKPLILARVRSAWRSA-r.......
A0A1Q9BU22_SYMMI/3-80 tpsldalracf----------QDARVPDELAEYAITVVGLQSVDDFVNLVTVAGYESELKEVLVE.PCAATK---...--GNVIALSRIRAAWRA--gr......
A0A812MUM2_9DINO/17-94 ...glmsclai------------ARVKPELVTHMKDVLKMESLQDFFFYVSKEAWEAELDSKVVK.LAVEASIIT...EGMKPIQLARVRMAWQSA-a.......
A0A813DJZ3_POLGL/12-86 .........md---EMRQVL-REAAVEDEICTCMADVLKMTSVEDLVRFVSEAAYETELLTHILG.KVASFKS--...---DLLQLSRLRTAWRVA-r.......
A0A813HCS1_POLGL/203-278 .......eaed---KFKNFL-KEAMLEPEIITYMINDAGMKAIADFAGYFGVDDHEAGVKADILQ.KT------S...FADNRIQLSRLRVACLNA-r.......
A0A1Q9EBQ8_SYMMI/4-80 ....mkadalr------RCL-VDAKLPDAFVEHCLGTLKMESLDDFVNIVTIKDYETEIKAVLID.QCPETK---...--DNPLYLARARAAWRAA-r.......
A0A813FIJ5_POLGL/1735-1810 ........kqd---ELRQVL-KEAAVEDEICTYMADVLKMTSIEDFVRFVSEAAYETELLTHILG.KVASFKS--...---DLLQLSRLRTAWRVA-r.......
A0A812W0F7_9DINO/1-78 .....mavgve---QLETLLVSVHKVDVEIFKLL-RSDGLESVADFVGLFTEKDYEEGLKD-YTE.RSQNFK---...--GNKIQLSRLRVAWSVA-r.......
A0A1Q9DDE3_SYMMI/409-484 ...kadalrrc--------L-VDAKLPDAFVEHCLGTLKMESLDDFVNIVTIKDYETEIKAVLID.QCPETK---...--DNPLYLARARAAWRAA-r.......
A0A1Q9E6I6_SYMMI/1-81 ......maksn---EFRRCL-EEQKLPEPLIAWCESTLGIETLSDFCNIVTVNGYESELDVVILS.ACEDTK--A...APNKALLLARLRAAWRAA-r.......
A0A812NCC1_9DINO/619-698 .aksnefrrcp----------EDQKLPEPLIAWCESTLGIETLSDFCNIVTVNGYESELDVVILS.ACEDTK--A...APNKALLLARLRAAWRAA-r.......
A0A812R196_9DINO/1-67 .....magsid---RLEAFMVSEHKLDPSVFQKV-KDLGAQSVSDFFGLYTECDYEEGVKELLLA.ALA------...-------------------esssvvcd
A0A813FRJ5_POLGL/9-83 .........md---ELRQVL-KEAAVEEEICTYMIDVLRMTFIEDFVRFVSEAAYETELLSHILI.KVASFK--S...D---PLQLSRLRTAWRVA-r.......
#=GC seq_cons ........thp......phL.p-A+ls-ElspahhssLpMpSl-DFVshVo.ssYEoELcshllc.pssshK........spsL.LuRlRsAWRuA.R.......
//
