#=GF ID   M157
#=GF AC   PF11624.12
#=GF DE   MHC class I-like protein M157
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_2nyk
#=GF GA   25.70 25.70;
#=GF TC   26.00 26.40;
#=GF NC   24.40 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0343
#=GF RN   [1]
#=GF RM   17537914
#=GF RT   Structural elucidation of the m157 mouse cytomegalovirus ligand
#=GF RT   for Ly49 natural killer cell receptors. 
#=GF RA   Adams EJ, Juo ZS, Venook RT, Boulanger MJ, Arase H, Lanier LL,
#=GF RA   Garcia KC; 
#=GF RL   Proc Natl Acad Sci U S A. 2007;104:10128-10133.
#=GF DR   INTERPRO; IPR021073;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins represents M157,a divergent form of MHC
#=GF CC   class I-like proteins which is the protein product of the mouse
#=GF CC   cytomegalovirus. This protein is unique in its ability to engage
#=GF CC   both activating (Ly49H) and inhibitory (Ly49I) natural killer
#=GF CC   cell receptors. M157 is involved in intra- and intermolecular
#=GF CC   interacts within and between its domains to form a compact
#=GF CC   MHC-like molecule [1].
#=GF SQ   18
#=GS Q9DW45_RCMVM/86-291  AC Q9DW45.1
#=GS H2A248_MUHV1/86-329  AC H2A248.1
#=GS H2A2H8_MUHV1/78-291  AC H2A2H8.1
#=GS H2A2H6_MUHV1/32-291  AC H2A2H6.1
#=GS H2A2I4_MUHV1/42-268  AC H2A2I4.1
#=GS K7YA85_RCMVE/48-297  AC K7YA85.1
#=GS Q9DWD1_RCMVM/73-276  AC Q9DWD1.1
#=GS Q9DW34_RCMVM/28-282  AC Q9DW34.1
#=GS K7YNS9_RCMVE/75-315  AC K7YNS9.1
#=GS Q6XK74_MUHV1/51-299  AC Q6XK74.1
#=GS K7XY52_RCMVE/43-287  AC K7XY52.1
#=GS H2A2I2_MUHV1/44-309  AC H2A2I2.1
#=GS K7XR66_RCMVE/24-281  AC K7XR66.1
#=GS H2A2H1_MUHV1/91-306  AC H2A2H1.1
#=GS Q9DWC9_RCMVM/49-279  AC Q9DWC9.1
#=GS Q9DW35_RCMVM/47-275  AC Q9DW35.1
#=GS K7YNT0_RCMVE/30-288  AC K7YNT0.1
#=GS H2A2H7_MUHV1/30-286  AC H2A2H7.1
Q9DW45_RCMVM/86-291             ...................................tkwi-----------.------------.------.-------N.LTKE...DPEINFLLDQDQHINL..-M.QAY.FG.HVPdlV.G.........LRYECPLT...KDNF.......TCIIKF.MLNSDIV....ELS...........ESTPAPSE..S...--.MEL..........IEG....V....SKW.....L....N...INILK.NNSDILLDRWGLVCTGI......ANISDPNHM.SIMT--QVG..NGWTTCTGTTPSPTRFWL.....SVN..E.S..N.SvveiNSTYTR.......sNETGWATLN.V......ST...NPG.D..S--..P.SCSAKSILG.WTVVAN--------...-------------.---------qtqlegvyelpk..........
H2A248_MUHV1/86-329             .........................vlpngtinndvrwv-----------.------------.------.-------N.ITER...DGEYKFLMSQTEHVKK..FH.EVW.KQ.AGN..V.TrpqdfthigVRYNCRVS...HVTV.......RCRVKH.ERNFLQL....VQY...........NRNYRNHT..Yp.vGDvGKL..........FES....V....ARG.....V....G...VQHLD.HDNSHIYQRWKEVCVRV......-AHASMRR-.YANFSYERS..NGTVRCRIESPSPARFMA.....GM-..-.N..T.P....YGMYTR.......yNYTTGVSST.V......NV...EET.N..ETN..S.TCDFQTLFGrWSYELP--TPGHVRgceFKHVEIDIRR---.---------ffdtksktkpc...........
H2A2H8_MUHV1/78-291             ..................................hfpwm-----------.------------.------.-------N.VSEL...TQESAFFVEQERFVYE.yIM.NVF.KA.GRP..V.V.........FEYRCKFV...PFE-.......-CTVLQ.MMDGNTL....TRY...........TVDKGVET..L...GS.PPY..........SPDvsedDiaryGRG.....S....G...ISILR.DNAALLQKRWTSFCRKI......VAMDNPRHN.EYSLYSNRG..NGYVSCTMHTQVPLAYNV.....SLA..N.G..V.D....IYKYMR........MYSGGRLKVeA......WLdlrDLN.G..STD..F.AFVISSPTG.WYATVK--------...-------------.---------yseyprqs..............
H2A2H6_MUHV1/32-291             ....................................sif---SDTFVVGT.ISLNDSFPLVRI.DGGGQ-.-IRERDPS.VSDLtvnDPEVYFIREQRFHLTA..FR.RLL.GQ.SAA..VhN.........VTYECNFA...PRLV.......ECLVVY.TADGVSVrsstVTA...........WEKKKVVIadH...PS.DN-..........LTK....F....TTD.....L....D...LSLLR.NNDISIHGRWSSTRLKI......MRLAAPEHL.EFSFHVSVG.rHGFFCCSVWSPAPLPFDV.....TVR..G.G..G.L....RSVSLN........ASRRFFSDT.VallndfTT...SSF.E..PSD..L.VCVVRSSVG.WTVTLT--TPSHDE...AKIL---------.---------rtatmterep............
H2A2I4_MUHV1/42-268             ..........................vqfaaslsingsy-----------.-------RLLEW.QRGDLV.PLTWVVPNdTDEL...STEILFFETEGLYLAN..LR.DLE.RG.DQV..I.D.........VSYTCTF-...GDDV.......RCDVSR.TGDDRPL....L--...........-SP--LLA..D...AS.DPD..........IRL....D....HKK.....P....G...YDVLL.QNSERIKRVWSPVLDKL......IQFGKPPHT.EVEFCNVT-..-GGFRCTAISRSFLRLTV.....ILY..V.D..R.T....NF-LVD........TIPVLHYAK.A......SV...TAA.GnfSAT..P.VCKIYSATG.WLASVK--------...-------------.---------yegdlqhgcirr..........
K7YA85_RCMVE/48-297             ....................................cvf---DEKYIKHT.VSVNNSFPLLTM.FNGHRK.NIYTW-VD.ISEM...RTELEFLTLQESHIMD..LH.GKL.SQpTAP..L.V.........FIYICTFF...--PL.......SCT--F.SAILGGI....TII...........SNNGSYKY..YddwLG.SVN..........LSP....Y....YNG.....F....G...LDIIR.SRQNDVQNRWLRLCNIL......VERDVIKNH.KFSFTYNSD..KSLVRCRMHTAVPLTYSIvldgpNLI..R.K..T.G....VSVMTA........TSLSFFVSI.N......VP...SSY.N..VSL..C.VCRISSPTG.WTKILTK-------...-------------.---------pkrtdtivrkvntimpsti...
Q9DWD1_RCMVM/73-276             ...................................yewi-----------.------------.------.-------N.VSAM...EPERRLAAFQRTVLAD..LI.SRF.PG.NET..I.S.........VEFRI--A...DTAG.......LITVRV.DSSYAML....YMD...........SSPGTVAS..G...IE.EGV..........VRP....Y....AGN.....E....S...VVEFK.KAQSAVLERWRQACRDA......ARMDTGESM.NVTFLYRAN..VSTFECSVTTEAPMEHAI.....SLR..C.V..GrD....GSAITDv.....gpSGGSYEQTA.V......WV...DPEcG..IAD..A.KCIVDSQDG.WRVEVE--------...-------------.---------veivgdv...............
Q9DW34_RCMVM/28-282             .......................................SEWVREYSPRH.QLMVNGSHPVLM.LTGLKN.RTCHRCPN.LQHL...DIEYNFFMTQERYLLT..LG.DKW.EF.VAR..A.S.........IVHTCFLL...KSDF.......VCDTEV.VTNRGHL....TIH...........RSNNTVFG..H...GN.FMH..........LLD....S....MNV.....P....G...LQYLI.ENREAIRIRWREQLYVM......KKYAQPSHV.WVTLIRDSL..RNFVGCSAYCSSPFPIAV.....SLA..S.K..T.G....QTVYGK........EYWSFISVN.A......SV...QSN.D..LNL..K.YCRIESIVG.WSVAVTHIPEGYWT...MRLLEHDRRQELN.-SWMDETLI......................
K7YNS9_RCMVE/75-315             ......................plirkdddadpitapgi-----------.------------.------.-------N.ITEY...GPELQFLMLQDSVLEH..YY.RNIsNK.TGV..I.M.........IQYDCTFP...QFN-.......-CTITH.LASEERF....VTY...........KNGTLHDL..E...GN.WTK..........HT-....N....MNEseaaaFalgnG...TDILR.NKSEEIKARWEKLCNRIlseddpKKNAYVFRVlETSGKSNVQ..NETVECRMESDLPLNYNI.....SVY..N.K..S.D....NLKMTFladgfygnAKLMYYYFE.A......NV...KS-.-..LSD..M.VCEIRSPTG.WVVNMT--FFGQY-...-------------.---------spqlhlvst.............
Q6XK74_MUHV1/51-299             ......................................i-VTTSGFHKRT.ISVDNGRPVVVW.DVGDKDpKICKICPS.VGSI...NTEYLFLDIQKMRLSN.lLA.QSL.WG.TQR..I.C.........VRYACLFS...RFNV.......LCDVYH.TTDTVRV....TYT...........YQTGKINI..Q...GS.GTF..........TTS....D....AKG.....I....G...TYMLR.NRVQEIKNTWRPTVQQL......KQLGYMNAT.EVEFWYNT-..TGLTTCVVTSRSNVPFTV.....ELS..L.N..T.N....SSAIVT........DESTVDYQT.V......TL...KVS.D..SYP..Q.RCYVTSSLG.WKGVVT--PPSQYR...TK------RTPVN.ISSSKRTGI......................
K7XY52_RCMVE/43-287             .......ydfytlsldksfplvevtatnksdhiyswipf-----------.------------.------.--------.-EEM...TLELSFTLGQEEHVKE..LR.KSLgYE.NDQ..L.V.........FKYLCGFL...H-EF.......SCMFQIgLGDEIIL....TNN...........KSKITYAD..W...VN.KTM..........LSK....Y....SQG.....F....G...VNSLY.VHRVNLKTRWFGICKTL......ASMDKPLTF.AYTYTYHPS..QRTVRCTMKTVVPLIYEI.....SIK..G.TglT.T....KYGIYTl.....fnDEFIFSVST.T......LT...KGY.D..TSL..V.RCEIKSPNG.WLVILTQPN-----...-------------.---------dpyvaltkgyhttpkm......
H2A2I2_MUHV1/44-309             .......................................SENSTDYVARI.RSIMTFD-LMTI.QDGQIT.MSCNGCPN.ATDL...GSELALIANQSTYLQT..-V.REL.VG.DGP..L.E.........LEYTFRLRpnnMSDYyiglwsdTCRLYY.NSIKNRT....ITY...........GEPKPNNC..S...LN.DT-..........LWD....A....DNA.....R....R...LREFL.EHADGVRERWNATCLWN......VRSAKFSRL.EIDFWYEVEdgRNLTKCGVKSEGRRRMHV.....AIT..D.E..C.G....NIGYAGgr...lnyTGGGFYLEA.V......TE...SAP.G..L--..-.VCTVRTT--.WLGSVRNATSGRVR...RKSVQGYPRCPLNrRVRSEPSSV......................
K7XR66_RCMVE/24-281             ....................tawrreaynrsyyeiylns-----------.-----TTRLVSMrANGTVF.YSCPWCPS.PKNM...TSEINFLMKQVSYVDNltLSsNAT.VT.KDD..V.G.........VLYTFFFL...GTKI.......TYHVEH.IIGPCYT....TFI...........KSTNSSTS..E...NC.SS-..........LEF....D....VRG.....I....G...MEGLL.KDIINVRKRWTHVMETI......VYYQRIENV.NASFYINN-..-GLTYCLFSSKVPVHTSV.....KLY.gP.N..L.R....PVTIGT........MGNSDEGMF.I......TV...YNA.S..YPN..V.ACEIKSPTG.WTGIIR-FPIDS--...-------------.---------eenrviepvihkrkrlelqqcc
H2A2H1_MUHV1/91-306             .............................titegygwan-----------.------------.------.--------.DTDI...PIEHEFFKKQREYLKT..IR.ALLmEL.SSR..C.G.........VRYECTFN..aTFWY.......GCAVTI.VLNET--....-VI...........LKYNPAFV..N...GS.EHVliynetaaekLKA....N....NKG.....R....D...TDLLK.NKVTTLYPRWLKVYKAA......AKLGGPDSL.KTRFRTSN-..-NRTICEVWTYAPLYFSI.....EIE..V.AglL.P....VKGEVS........KSWFTIYMR.V......QN...QTS.D..SDLpnT.ICKIRSSV-.--------------...-------------.---------rgackdvrhpryv.........
Q9DWC9_RCMVM/49-279             ............tvvfrtesttmlaslveqcvvspyswv-----------.------------.------.-------N.VSQC...EAERRLALSQVETLAR..MV.SAF.PR.NVS..F.M.........LWYTVSAW...ASAAi.....vAVDSTV.VTFDGNF....SSA...........MTNEDVQV..D...TE.Q-F..........KMY....A....GRE.....N....F...TEFLR.S-KDAVLKRWRENCQGT......VDRDKADSA.NVTFSYHSD..TKEFECSVDK--TVPVDY.....LLA..L.E..C.G....KTASNQrm...pkvTVGNVTRQT.M......SW...TDP.D..CDAsvA.KCVVQSGNG.WEKKVGA-------...-------------.---------ivissgss..............
Q9DW35_RCMVM/47-275             ...........................sfpstmelirig-----------.------------.ESGSIL.RLCSWCPQ.RDEL...RSEIDFIVAQEVHLRA..-F.QNG.AD.DRS..A.H.........STYEFILG...GDTC.......SYQVNH.TNDECET....IYR...........SSGERIDT..R...SQ.CNL..........TNE....Q....VRG.....V....R...VRDFL.EVCSVLSEKWIFVYRKL......VDAHRINKV.YALFWKEFGkdGNYTTCILRSSAPFINRI.....TMS..G.P..GlE....DVSGAT........DEGAND--T.V......TE...AYN.H..TYP..NmRCHIESPTG.WSAIIV--RPS---...-------------.---------nrkekisliq............
K7YNT0_RCMVE/30-288             ...............................tsvsstrv--------PRAiIRLNRSYPLFTI.YNGSID.KSCISCPS.YREI...QHELSFISSHVDYFAY..-L.HKI.YG.KNI..L.N.........LYYDFLLS...LDDP.......SYRIEL.YTSNCYL....SYS...........SYSNGSAI..S...RS.DNV..........ACV....S....ENL.....F....KasnLSILFmKSAWDRLHFWKNVDKTQ......RELNDVREV.VVSFWYTLKdgENVTTCSLTTRSRTRNNS.....VMI..V.T..G.D....MFVAGEv.....fdSHDEVTIEA.T......TS...TVP.N..V--..-.KCEVSAIGM.WYVVLQQPTSMKIS...RFL----------.---------vdytenvrvrethnhr......
H2A2H7_MUHV1/30-286             tasmtglhdtvtttvglkqtvplltvhnngtvcstgwvi-----------.------------.------.--------.LTKN...DPEFIFMQGQKQHLSQ..VR.ELL.SE.AYE..I.S.........VVYECHLS...-VNF.......YCSVIH.SLNATDV....LFYnvgrenqvvspFDNGDVDG.iS...GL.VDL..........VRA....L....ATG.....Y....G...VFDLT.THSGDLRSKWKSLCSII......MEKAAEERT.TFSFS--SM..SGGVVCEVAVSSPVKLWM.....TIAgsDvQ..L.N....ASSAFD........NTKNISWVR.A......FS...SAS.L..NNS..P.RCEIICSAG.WNVTIRRPNSSTVV...T------------.---------ervalsda..............
#=GC seq_cons                   ...................................h.hh.......................................s.lo-h...ssEhpFhhpQcpaLpp..hh.pth.ht.sss..l.s.........lpYpCths...tssh.......tCplph.ssspstl....shh...........psstssss..p...ss.ssh..........lps....s....sps.....h....u...lphLp.ppssslppRWpplsppl......hchspspch.psoFhhpst..pshspCshpopuPlthsl.....slt..s.s..s.s....ssshss........stsshthts.s......ss...sss.s..sss..s.tCclpSssG.Wpshlp...................................t.h.t................
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