#=GF ID   MACPF_D2
#=GF AC   PF20779.1
#=GF DE   MACPF protein, D2 domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   ECOD:3182.1.1
#=GF GA   24.20 24.20;
#=GF TC   24.20 29.80;
#=GF NC   23.30 22.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RC   Paper describing PDB structure 3kk7
#=GF RN   [1]
#=GF RM   20944225
#=GF RT   Structure of a membrane-attack complex/perforin (MACPF) family
#=GF RT   protein from the human gut symbiont Bacteroides
#=GF RT   thetaiotaomicron.
#=GF RA   Xu Q, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X,
#=GF RA   Carlton D, Chen C, Chiu HJ, Clayton T, Das D, Deller MC, Duan L,
#=GF RA   Ellrott K, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Han GW,
#=GF RA   Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Krishna
#=GF RA   SS, Kumar A, Lam WW, Marciano D, Miller MD, Morse AT,
#=GF RA   Nigoghossian E, Nopakun A, Okach L, Puckett C, Reyes R, Tien HJ,
#=GF RA   Trame CB, van den Bedem H, Weekes D, Wooten T, Yeh A, Zhou J,
#=GF RA   Hodgson KO, Wooley J, Elsliger MA, Deacon AM, Godzik A, Lesley
#=GF RA   SA, Wilson IA;
#=GF RL   Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:1297-1305.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in proteins of the membrane-attack complex/
#=GF CC   perforin (MACPF) family from Bacteroidetes. These transmembrane
#=GF CC   pore- forming proteins are organized into three structured
#=GF CC   domains:  an MACPF domain (Pfam:PF01823) and two C-terminal
#=GF CC   domains, D2 and D3. This entry represents the D2 domain, which
#=GF CC   adopts an alpha/beta fold [1].
#=GF SQ   8
#=GS Q8A267_BACTN/391-493      AC Q8A267.1
#=GS A0A0A2EKI1_PORCN/371-469  AC A0A0A2EKI1.1
#=GS A0A239RKU4_9BACT/393-496  AC A0A239RKU4.1
#=GS A0A255T275_9BACT/398-501  AC A0A255T275.1
#=GS A0A1M5AC47_9BACE/82-185   AC A0A1M5AC47.1
#=GS A0A133Z6Q3_9BACT/1-91     AC A0A133Z6Q3.1
#=GS Q8A269_BACTN/381-485      AC Q8A269.1
#=GS F8N821_9BACT/396-500      AC F8N821.1
Q8A267_BACTN/391-493                 .EPYIEIIKMYIRKSNSGEK.LYDIVPVLNTRQGDKLIFSNPDAASQ.SDEELKANS.IPATFLTKSNAIKDEKSKYYQ..LKIKADPNKTINPIIQTTLSFQIN.NVDE...........
A0A0A2EKI1_PORCN/371-469             k-PFIEIMRI---KPDKNLN.LYDVGACLYTRNGDRVLLTKYLNPNYfEDKQMMEGYkSKEGFDKAAKALKEALAKIFT..LEIKVNSAARFNNH----------.----eeekffytfci
A0A239RKU4_9BACT/393-496             .DPKIEIVKVLAKTTSTGEK.LYEIAAILNTRQGDKIILSDGTYLNA.SDSELRTNN.DNQTMMGKVQKIFTKKKTIFQ.gLTFSTNYNTTYNPNVRKPLCIRMD.GFDE...........
A0A255T275_9BACT/398-501             .DPKFEIVKVLARTTSSGEK.LYEVAAVMTTRQGDKIVLSDGAYNSS.TDNELRANN.NNQTMMNKVQEIYAKKKTIFQ.gLQFSTNYNTTYNPNVRKPLCVRMN.GFNE...........
A0A1M5AC47_9BACE/82-185              .EPFIEIVKVFVRNDYRGDK.LYEVAAVLNTRQGDQIILSDGKAMSA.SDDELRANSiDGNVFKAKSLTIADEKRKYYQ..CEIRSNPKKTLNPIIRIPFNMSLP.GFDE...........
A0A133Z6Q3_9BACT/1-91                m----------VRSNSAYEA.LYDVVPVLITRQGDRIIFMNN-NNSK.SNEELARNE.DNVYFLQKVKFLSANRTNMFSdkIELDYNNNSSLKF-----------.----eiiatqlssas
Q8A269_BACTN/381-485                 p-PRIEIVRVLARTTPSNEA.LYDVAAVLVTRQTDRIILSDAMASSA.TDEELRKNE.NNEVFMQKVEKIATEKSKFFSsdIEISYNKETKLNPTLKSPLCIELT.GFNE...........
F8N821_9BACT/396-500                 s-TFIEISRYYVRYSSKYNKaLYGIAAILNTRQGDKIILIEPNDKNL.TDEELLKNN.DNDVFFAKASKIAEEMKKVFD..IEIKSNVYGRYNPQILDPLCETITvDFNN...........
#=GC seq_cons                        ..PhIEIl+lhsRsosssEK.LY-VAAVLsTRQGD+IILS-stssSt.oD-EL+pNs.sNpsFhsKsppItscKpKhFp..lEIcsNsssohNPplppPLshphs.sFsE...........
//