#=GF ID MACPF_D3
#=GF AC PF20785.1
#=GF DE MACPF protein, D3 domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE ECOD:3182.1.1
#=GF GA 25.00 25.00;
#=GF TC 25.30 29.00;
#=GF NC 24.90 24.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RC Paper describing PDB structure 3kk7
#=GF RN [1]
#=GF RM 20944225
#=GF RT Structure of a membrane-attack complex/perforin (MACPF) family
#=GF RT protein from the human gut symbiont Bacteroides
#=GF RT thetaiotaomicron.
#=GF RA Xu Q, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X,
#=GF RA Carlton D, Chen C, Chiu HJ, Clayton T, Das D, Deller MC, Duan L,
#=GF RA Ellrott K, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Han GW,
#=GF RA Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Krishna
#=GF RA SS, Kumar A, Lam WW, Marciano D, Miller MD, Morse AT,
#=GF RA Nigoghossian E, Nopakun A, Okach L, Puckett C, Reyes R, Tien HJ,
#=GF RA Trame CB, van den Bedem H, Weekes D, Wooten T, Yeh A, Zhou J,
#=GF RA Hodgson KO, Wooley J, Elsliger MA, Deacon AM, Godzik A, Lesley
#=GF RA SA, Wilson IA;
#=GF RL Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:1297-1305.
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This domain is found in proteins of the membrane-attack complex/
#=GF CC perforin (MACPF) family from Bacteroidetes. These transmembrane
#=GF CC pore- forming proteins are organized into three structured
#=GF CC domains: an MACPF domain (Pfam:PF01823) and two C-terminal
#=GF CC domains, D2 and D3. This entry represents the D3 domain, which
#=GF CC adopts an alpha/beta fold and functions as a wedge between D2
#=GF CC and MACPF [1].
#=GF SQ 9
#=GS C3J7W9_POREA/522-585 AC C3J7W9.1
#=GS Q8A269_BACTN/488-553 AC Q8A269.1
#=GS A0A239RKU4_9BACT/499-564 AC A0A239RKU4.1
#=GS A0A1N6SY99_9SPHI/488-550 AC A0A1N6SY99.1
#=GS F8N821_9BACT/501-568 AC F8N821.1
#=GS A0A1M5AC47_9BACE/188-251 AC A0A1M5AC47.1
#=GS A0A255T275_9BACT/504-569 AC A0A255T275.1
#=GS A0A1I2CCI4_9BACT/480-540 AC A0A1I2CCI4.1
#=GS Q8A267_BACTN/496-558 AC Q8A267.1
C3J7W9_POREA/522-585 ...pyy---YNEAKgQFMQYLYfvEGGKRYAFAI.YD----PYILDTYGIRALFNS.AKEEPLSIYDL-KNFRIIGL
Q8A269_BACTN/488-553 ......FYRFYYEK.TNIEYIY..DPATHLCLSY.YINKGDDRILDIYGIRNWIES.LPEKKISITTLANSYKIIGL
A0A239RKU4_9BACT/499-564 ......MTLFEDPN.SNMRYIY..DSSKKIAFSYlYDPEYGDGVLDYYGIRDWVES.LPKRKISLMIL-QNYTIIGL
A0A1N6SY99_9SPHI/488-550 ......MKKFYDAK.NNMTYLL..SQAQGVKFAY.AI--RFDYLLDTYGIRDWVNA.MATTTVTADDL-DTYTIVAL
F8N821_9BACT/501-568 ......MHWFGNSN.LNLKFIY..NKESKIAFTVyEDDLEGDYVLDEYGLRDWFDAnCTYKNISLGTVTRTFKIIGL
A0A1M5AC47_9BACE/188-251 ......MYKFKNDE.TNMWYIY..DSVKRYAFAY.YD--LDGMIPDIYGISNWIET.IPEKKLSMTVLSQFYKVIGL
A0A255T275_9BACT/504-569 ......MYLYEDTN.SNMRYIY..DPTNKIALSYlYDEDYEDYVLDYYGIREWVES.LPKRKISMMIL-QNYTIIGL
A0A1I2CCI4_9BACT/480-540 mkkfir--------.NNVTYLI..SQNSAVKFAF.SI--HDDYILDTYAIRGWINN.MPTTQLTDREL-DKYTIVAL
Q8A267_BACTN/496-558 ......MYKFKNAN.TNIWYIY..NPTSMYCFAY.YD---DDYIPDAYGILDWVNG.IPIKAVTMTTLYQRYKIYGL
#=GC seq_cons ......MhhFtssp.sNhpYIY..sssp+lsFuY.YD..hsDYlLDhYGIRsWlpu.hPp+plShtsL.psYpIIGL
//
