GenomeNet

Database: Pfam
Entry: MAML2_TAD
LinkDB: MAML2_TAD
Original site: MAML2_TAD 
#=GF ID   MAML2_TAD
#=GF AC   PF20804.1
#=GF DE   Mastermind-like protein 2, transcriptional activation domain
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Manual
#=GF GA   19.00 19.00;
#=GF TC   19.00 19.00;
#=GF NC   18.90 18.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12370315
#=GF RT   Identification of a family of mastermind-like transcriptional
#=GF RT   coactivators for mammalian notch receptors.
#=GF RA   Wu L, Sun T, Kobayashi K, Gao P, Griffin JD;
#=GF RL   Mol Cell Biol. 2002;22:7688-7700.
#=GF RN   [2]
#=GF RM   18758483
#=GF RT   Mastermind-like transcriptional co-activators: emerging roles in
#=GF RT   regulating cross talk among multiple signaling pathways.
#=GF RA   McElhinny AS, Li JL, Wu L;
#=GF RL   Oncogene. 2008;27:5138-5147.
#=GF RN   [3]
#=GF RM   33425921
#=GF RT   A Dynamic Role of Mastermind-Like 1: A Journey Through the Main
#=GF RT   (Path)ways Between Development and Cancer.
#=GF RA   Zema S, Pelullo M, Nardozza F, Felli MP, Screpanti I, Bellavia
#=GF RA   D;
#=GF RL   Front Cell Dev Biol. 2020;8:613557.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Mastermind-like proteins (MAML1-3) were first described as
#=GF CC   transcriptional co-activators for Notch signalling but more
#=GF CC   recently they have been also implicated as transcriptional
#=GF CC   co-activators in other signal transduction pathways including
#=GF CC   muscle differentiation and myopathies, tumour suppressor pathway
#=GF CC   (p53) and colon carcinoma survival (beta-catenin) [2,3]. The
#=GF CC   N-terminal basic domain (Pfam:PF09596) of MAML1-3 is the most
#=GF CC   conserved region of this proteins, outside this region their
#=GF CC   sequences are quite divergent. However, they all have
#=GF CC   transactivation domains (TADs) at the C-terminal end [1],
#=GF CC   suggesting different functions among them as they cooperate
#=GF CC   differentially with various Notch receptors in the activation of
#=GF CC   target genes. Recently, MAML1 and MAML2 have been identified as
#=GF CC   transcriptional coactivators of the Hippo pathway [3]. A
#=GF CC   structural feature of the MAML family is the presence of
#=GF CC   polyglutamine (polyQ) tracts, which, in some polyQ proteins,
#=GF CC   expansion of this tracts cause protein inestability and the
#=GF CC   formation of nuclear inclusions in neurons, leading to
#=GF CC   neurotoxicity [1]. This entry represents the TAD domain from
#=GF CC   MAML2.
#=GF SQ   60
#=GS A0A7J7VIS3_MYOMY/562-639  AC A0A7J7VIS3.1
#=GS F1M3B2_RAT/602-670        AC F1M3B2.4
#=GS A0A6P3R1V6_PTEVA/563-652  AC A0A6P3R1V6.1
#=GS A0A8B7SL55_HIPAR/576-648  AC A0A8B7SL55.1
#=GS A0A6P6BLT1_PTEVA/563-652  AC A0A6P6BLT1.1
#=GS A0A2K6GY24_PROCO/603-678  AC A0A2K6GY24.1
#=GS F7C7G7_CALJA/578-654      AC F7C7G7.3
#=GS A0A2K5M890_CERAT/602-676  AC A0A2K5M890.1
#=GS A0A2K5CJI1_AOTNA/480-559  AC A0A2K5CJI1.1
#=GS A0A8C4M0D5_EQUAS/420-510  AC A0A8C4M0D5.1
#=GS A0A397Y613_BRACM/153-215  AC A0A397Y613.1
#=GS A0A7J8H3G0_ROUAE/416-490  AC A0A7J8H3G0.1
#=GS A0A1A6HDT0_NEOLE/416-498  AC A0A1A6HDT0.1
#=GS A0A7J7X105_PIPKU/571-654  AC A0A7J7X105.1
#=GS A0A8D2K048_THEGE/602-677  AC A0A8D2K048.1
#=GS A0A2K5M856_CERAT/431-506  AC A0A2K5M856.1
#=GS MAML2_HUMAN/609-681       AC Q8IZL2.2
#=GS A0A087X0G5_HUMAN/439-511  AC A0A087X0G5.1
#=GS A0A7J8H2H6_ROUAE/416-490  AC A0A7J8H2H6.1
#=GS A0A2K6RIZ9_RHIRO/604-676  AC A0A2K6RIZ9.1
#=GS A0A2R9AVW7_PANPA/600-678  AC A0A2R9AVW7.1
#=GS A0A7J8H1U4_ROUAE/576-650  AC A0A7J8H1U4.1
#=GS A0A671G1M9_RHIFE/564-653  AC A0A671G1M9.1
#=GS A0A8C9IMI8_9PRIM/601-672  AC A0A8C9IMI8.1
#=GS A0A5E4B3L0_MARMO/323-381  AC A0A5E4B3L0.1
#=GS A0A2K6DTY8_MACNE/604-677  AC A0A2K6DTY8.1
#=GS A0A2K5UXJ0_MACFA/602-677  AC A0A2K5UXJ0.2
#=GS A0A162TG62_MUCCL/125-172  AC A0A162TG62.1
#=GS F7C2A0_HORSE/559-649      AC F7C2A0.3
#=GS H2Q4L2_PANTR/595-675      AC H2Q4L2.1
#=GS A0A2K5I007_COLAP/609-681  AC A0A2K5I007.1
#=GS H2NF11_PONAB/600-680      AC H2NF11.2
#=GS A0A8D2F2X8_THEGE/432-507  AC A0A8D2F2X8.1
#=GS A0A7E6E099_9CHIR/559-646  AC A0A7E6E099.1
#=GS A0A2K6UEN0_SAIBB/573-664  AC A0A2K6UEN0.1
#=GS A0A2K6JMN7_RHIBE/598-672  AC A0A2K6JMN7.1
#=GS A0A2K5QV42_CEBIM/412-495  AC A0A2K5QV42.1
#=GS A0A0D9S1N0_CHLSB/371-448  AC A0A0D9S1N0.1
#=GS A0A1I7VET9_LOALO/74-135   AC A0A1I7VET9.1
#=GS A0A2I3G3H9_NOMLE/430-509  AC A0A2I3G3H9.1
#=GS A0A7J7FDI7_DICBM/560-641  AC A0A7J7FDI7.1
#=GS A0A2K6DTY6_MACNE/442-516  AC A0A2K6DTY6.1
#=GS A0A1A6GI72_NEOLE/437-519  AC A0A1A6GI72.1
#=GS F6W556_MACMU/601-676      AC F6W556.3
#=GS A0A2K5QV80_CEBIM/458-541  AC A0A2K5QV80.1
#=GS A0A8B7SJB0_HIPAR/576-648  AC A0A8B7SJB0.1
#=GS A0A8C6E2T5_MOSMO/439-513  AC A0A8C6E2T5.1
#=GS A0A096MQX1_PAPAN/609-683  AC A0A096MQX1.3
#=GS A0A2K6GY69_PROCO/432-508  AC A0A2K6GY69.1
#=GS A0A7J8ET21_MOLMO/559-636  AC A0A7J8ET21.1
#=GS A0A5E4B3B2_MARMO/396-454  AC A0A5E4B3B2.1
#=GS A0A8K0N5A1_COCNU/65-121   AC A0A8K0N5A1.1
#=GS A0A2K5M845_CERAT/431-506  AC A0A2K5M845.1
#=GS G3SBJ0_GORGO/602-680      AC G3SBJ0.2
#=GS A0A8B7C4K0_PHODC/26-84    AC A0A8B7C4K0.1
#=GS A0A6J2LWY8_9CHIR/559-646  AC A0A6J2LWY8.1
#=GS X6PB55_RETFI/231-283      AC X6PB55.1
#=GS A0A6J3JA61_SAPAP/581-656  AC A0A6J3JA61.1
#=GS A0A2K5ZAV0_MANLE/602-676  AC A0A2K5ZAV0.1
#=GS A0A6I9J2R7_CHRAS/575-642  AC A0A6I9J2R7.1
A0A7J7VIS3_MYOMY/562-639             ......nsdqanqqmpsvlps--------------.-QNKPTLLHYTQQQ..QQQ.......QSSMSAQQQQQQQQQ--QQRQQQQ.....QQQQQQA...QQPPSQP.T.QPLSNQPLLR.........................
F1M3B2_RAT/602-670                   .....................-----QQQQQQQQQ.QQQQGSLAAQQQQ-..-QA.......QSSLAAQQQQQQQQQ---QQQQQQ.....QQQQQQQ...QQP-SQP.T.QALSSQPLLR.........................
A0A6P3R1V6_PTEVA/563-652             .......nsdqanqqmpsvlp-SQNKPSLLHYTQQ.QQQQSSISVQQQQQ..QQQ.......QQQ---QQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPPSQP.T.QPLTSQPLLR.........................
A0A8B7SL55_HIPAR/576-648             ....................p-SQSKPSLLHYTQQ.QQQQSSISAQQQQQ..QQQ.......QQ----QQQQQQQQ---QQQQQQQ.....QQQQQQQ...QQPPSQP.T.QPLSSQPLLR.........................
A0A6P6BLT1_PTEVA/563-652             .......nsdqanqqmpsvlp-SQNKPSLLHYTQQ.QQQQSSISVQQQQQ..QQQ.......QQQ---QQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPPSQP.T.QPLTSQPLLR.........................
A0A2K6GY24_PROCO/603-678             .....................---QQQQQQQQQQQ.QQQQSSISTQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ....qQQQQQQQ...QQPPSQP.T.QPLSSQSLLR.........................
F7C7G7_CALJA/578-654                 ....................s-LLHYTQQQQQQQQ.QQQQSSISAQQQQQ..QQQ.......QSSISAQQQQQQQQQ---QQQQQQ.....QQQQQQQ...QQPSSQP.T.QSLPSQPLLR.........................
A0A2K5M890_CERAT/602-676             .....................----QQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ....qQQQQQQQ...QQPSSQS.A.QSLPSQPLLR.........................
A0A2K5CJI1_AOTNA/480-559             ....................p-SQNKPSLLHYTQQ.QQQQSSISAQQQQ-..-QQ.......QSSISTQQQQQQQSSISAQQQQQQs...sISAQQQQ...PQPSSQP.T.QSLPSQPLLR.........................
A0A8C4M0D5_EQUAS/420-510             .......nsdqasqqmpsvlp-SQNKPSLLHYTQQqQQQQGSISAQQQQQ..QQQ.......QQQ---QQQQQQQQQQQQQQQQQQ.....QQQQQQP...QQPTSQP.T.QPLSSQPLLR.........................
A0A397Y613_BRACM/153-215             ...........gsggskkskk--------------.--------------..--V.......SSSIGTQQQQQQQQQIALLNHQQQ.....NQQ----...-------.-.----------rmlpfypnqgeikplvitalpgprp
A0A7J8H3G0_ROUAE/416-490             ....................p-SQNKPSLLHYTQQ.QQQQSSISVQQQQQ..QQQ.......Q-----QQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPPSQP.T.QPLASQPLLR.........................
A0A1A6HDT0_NEOLE/416-498             ...................si--LHYTQQQQQQQQ.QQQQGSLAAQQQQQ..QQQqqqqtqpQSSLVAQQQQQQQQH----QQQGS.....IAAQQQQ...QQPPSQP.T.QPLSSQPLLR.........................
A0A7J7X105_PIPKU/571-654             .......nsdqanqqmpsvlp-SQNKPSLLHYTQQ.QQQQ--------QQ..QQQ.......QSSMSAQQQQQQQRQ-QQQQQQQQ.....QQQQQQA...QQPPSQP.T.QPLSNQPLLR.........................
A0A8D2K048_THEGE/602-677             .....................--QQQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPSSQS.A.QSLPSQPLLR.........................
A0A2K5M856_CERAT/431-506             .....................---QQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ....qQQQQQQQ...QQPSSQS.A.QSLPSQPLLR.........................
MAML2_HUMAN/609-681                  .....................-----QQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A087X0G5_HUMAN/439-511             .....................-----QQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A7J8H2H6_ROUAE/416-490             ....................p-SQNKPSLLHYTQQ.QQQQSSISVQQQQQ..QQQ.......Q-----QQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPPSQP.T.QPLASQPLLR.........................
A0A2K6RIZ9_RHIRO/604-676             .....................----QQQQQQQQQQ.QQQQSSISAQQQQQ..QQQ.......QSSISAQQQQQQQQQ---QQQQQQ.....QQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A2R9AVW7_PANPA/600-678             .....................--QQQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQq..qqQQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A7J8H1U4_ROUAE/576-650             ....................p-SQNKPSLLHYTQQ.QQQQSSISVQQQQQ..QQQ.......Q-----QQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPPSQP.T.QPLASQPLLR.........................
A0A671G1M9_RHIFE/564-653             ........sdqanqqmpsvlp-SQNKPSLLHYTQQ.QQQQ-----QQQQQ..QQQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQqqpQQPPSQP.T.QPLSSQPLLR.........................
A0A8C9IMI8_9PRIM/601-672             .....................-----QQQQQQQQQ.QQQQSSISAQQQQQ..QQQ.......QSSISAQQQQQQQQQ---QQQQQQ.....QQQQQQQ...QQPSSQP.T.QSLPSQPLLR.........................
A0A5E4B3L0_MARMO/323-381             ....................q--------------.---------QQQQQ..QQQ.......QSSISAQQQQQQQQQQQQQQQQQQ....qQQQQQQQ...QQPPSQP.T.QPLSSQPLMR.........................
A0A2K6DTY8_MACNE/604-677             .....................----QQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPSSQS.T.QSLPSQPLLR.........................
A0A2K5UXJ0_MACFA/602-677             .....................--QQQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPSSQS.A.QSLPSQPLLR.........................
A0A162TG62_MUCCL/125-172             .....nmseiafnnnsnnnws--------------.--------------..---.......----------------RNSDQQQQ.....QQSQQQQ...QQPSYKP.S.NRIPSN----nvh......................
F7C2A0_HORSE/559-649                 .......nsdqasqqmpsvlp-SQNKPSLLHYTQQqQQQQGSISAQQQQ-..-QQ.......QAATQQQQQQQQQQQ-QQQQQQQQ.....QQQQQQP...QQPTSQP.T.QPLSSQPLLR.........................
H2Q4L2_PANTR/595-675                 ....................q-QQQQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQq..qqQQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A2K5I007_COLAP/609-681             .....................-----QQQQQQQQQ.QQQQSSISAQQQQQ..QQQ.......QSSISAQQQQQQQQQ--QQQQQQQ.....QQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
H2NF11_PONAB/600-680                 .....................----QQQQQQQQQQ.QQQQSSISAQQQQQ..QQQ.......QSSISAQQQQQQQQQQQQQQQQQQqqqqqQQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A8D2F2X8_THEGE/432-507             .....................--QQQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPSSQS.A.QSLPSQPLLR.........................
A0A7E6E099_9CHIR/559-646             .......nsdqanqqmpsvlp-SQNKPSLLHYTQQ.QQQQ-------QQQ..QQP.......QSSISAQQQQQQQQQQRQQQQQQQq...qQQQQQQQ...QQPPPPP.T.QPLSNQPLLR.........................
A0A2K6UEN0_SAIBB/573-664             ........psqnkpsllhytl-QQQQQQQQQQQQQ.QQQQSSISAQQQQQ..QQQ.......QSSISAQQQQQQQQQXXXXQQQQQ.....QQQQQQQ...QQPAPQP.T.QSLPSQPLLR.........................
A0A2K6JMN7_RHIBE/598-672             .....................--QQQQQQQQQQQQ.QQQQSSISAQQQQQ..QQQ.......QSSISAQQQQQQQQQ---QQQQQQ.....QQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A2K5QV42_CEBIM/412-495             ...................yt--LQQQQQQQQQQQ.QQQQSSISAQQQQQqqQQQ.......QSSISAQQQQQQQQQQQQQQQQQQq...qQQQQQQQ...QQPSSQP.T.QSLPSQALLR.........................
A0A0D9S1N0_CHLSB/371-448             .....................--QQQQQQQQQQQQ.QQQQSSISAQQQQQ..QQQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A1I7VET9_LOALO/74-135              ...............attttt------TTTTTTQQ.QQTTTTTTTQQQQQ..QQQ.......QTTTTTTQQQQQQQNNNNK-----.....-------...-------.-.----------ttnntttttttt.............
A0A2I3G3H9_NOMLE/430-509             .....................----QQQQQQQQQQ.QQQQSSISAQQQQQ..QQQ.......QSSISAQQQQQQQQQQQQQQQQQQqq.qqQQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A7J7FDI7_DICBM/560-641             ....................p-SQNKPSLLHYTQQ.QQQQSSISAQQQQQ..QQQ.......QQQQQQQQQQQQQQQQQQ-QQQQQ.....QQQQQQQpqpQQPPSQP.T.QPLSSQPLLR.........................
A0A2K6DTY6_MACNE/442-516             .....................---QQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPSSQS.T.QSLPSQPLLR.........................
A0A1A6GI72_NEOLE/437-519             ...................si--LHYTQQQQQQQQ.QQQQGSLAAQQQQQ..QQQqqqqtqpQSSLVAQQQQQQQQH----QQQGS.....IAAQQQQ...QQPPSQP.T.QPLSSQPLLR.........................
F6W556_MACMU/601-676                 .....................--QQQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ.....QQQQQQQ...QQPSSQS.A.QSLPSQPLLR.........................
A0A2K5QV80_CEBIM/458-541             ...................yt--LQQQQQQQQQQQ.QQQQSSISAQQQQQqqQQQ.......QSSISAQQQQQQQQQQQQQQQQQQq...qQQQQQQQ...QQPSSQP.T.QSLPSQALLR.........................
A0A8B7SJB0_HIPAR/576-648             ....................p-SQSKPSLLHYTQQ.QQQQSSISAQQQQQ..QQQ.......QQ----QQQQQQQQ---QQQQQQQ.....QQQQQQQ...QQPPSQP.T.QPLSSQPLLR.........................
A0A8C6E2T5_MOSMO/439-513             ....................p-SQSKPSLLHYTQQ.QPQQSSITVQPQQQ..QQQ.......QP----QQQQQPQQQ-QPQQPQQQ.....QQQQPQA...QQPAAQP.T.QPLLNQPLLR.........................
A0A096MQX1_PAPAN/609-683             .....................----QQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ....qQQQQQQQ...QQPSSQS.A.QSLPSQPLLR.........................
A0A2K6GY69_PROCO/432-508             .....................--QQQQQQQQQQQQ.QQQQSSISTQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ....qQQQQQQQ...QQPPSQP.T.QPLSSQSLLR.........................
A0A7J8ET21_MOLMO/559-636             .......nsdqanqqmpsvlp-SQNKPSLLHYTQQ.QQQQ-----QQQQQ..QQQ.......QSSISAQQQQQQQQQ---------.....-QRQQQQ...QQPPAQP.T.QPLSNQPLLR.........................
A0A5E4B3B2_MARMO/396-454             ....................q--------------.---------QQQQQ..QQQ.......QSSISAQQQQQQQQQQQQQQQQQQ....qQQQQQQQ...QQPPSQP.T.QPLSSQPLMR.........................
A0A8K0N5A1_COCNU/65-121              ................kgrrp--------------.--------------..---.......-HSIMAQQQQEQLEQEQERQQENQa..tlPEQQRQQ...QQPKGQP.EmESLPRQPM--ak.......................
A0A2K5M845_CERAT/431-506             .....................---QQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ....qQQQQQQQ...QQPSSQS.A.QSLPSQPLLR.........................
G3SBJ0_GORGO/602-680                 .....................---QQQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQqq.qqQQQQQQQ...QQPSSQP.A.QSLPSQPLLR.........................
A0A8B7C4K0_PHODC/26-84               ................kgrrp--------------.--------------..---.......-HSIMAQQEQQQLEQEEEKQQQEQqgtlpEQQRQQQ...QQPKGQPqM.QSLPRQPM--ak.......................
A0A6J2LWY8_9CHIR/559-646             .......nsdqanqqmpsvlp-SQNKPSLLHYTQQ.QQQQ-------QQQ..QQP.......QSSISAQQQQQQQQQQRQQQQQQQq...qQQQQQQQ...QQPPPPP.T.QPLSNQPLLR.........................
X6PB55_RETFI/231-283                 meslhdetrisetnvqcilsa--------------.--------------..---.......-----------------IISQQQQ.....QQQQQQQ...QQPSNQR.T.RCYDSQRL--vl.......................
A0A6J3JA61_SAPAP/581-656             .................hytl----QQQQQQQQQQ.QQQQSSISAQQQQQqqQQQ.......QSSISAQQQQQQQQQ------QQQ.....QQQQQQQ...QQPSSQP.T.QSLPSQPLLR.........................
A0A2K5ZAV0_MANLE/602-676             .....................----QQQQQQQQQQ.QQQQSSISAQQQQ-..-QQ.......QSSISAQQQQQQQQQQQQQQQQQQ....qQQQQQQQ...QQPSSQS.A.QSLPSQPLLR.........................
A0A6I9J2R7_CHRAS/575-642             ...................pp--QNKPSLLHYTQQ.QQQQQQQ-QQQQQQ..QQQ.......QSSISAQQQQQQQQQ---------.....--QQQQQ...QPPPPQP.T.QPLSSQPLLR.........................
#=GC seq_cons                        ........................pp.p..p.pQQ.QQQQSSISAQQQQ....QQ.......QSSISAQQQQQQQQQpQQQQQQQQ.....QQQQQQQ...QQPsSQP.o.QsLsSQPLLR.........................
//
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