#=GF ID   MC4
#=GF AC   PF20290.2
#=GF DE   ABC-three component (ABC-3C) system Middle Component 4
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Aravind L
#=GF GA   28.10 28.10;
#=GF TC   28.70 30.80;
#=GF NC   27.20 26.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   32894288
#=GF RT   Comprehensive classification of ABC ATPases and their functional
#=GF RT   radiation in nucleoprotein dynamics and biological conflict
#=GF RT   systems.
#=GF RA   Krishnan A, Burroughs AM, Iyer LM, Aravind L;
#=GF RL   Nucleic Acids Res. 2020;48:10045-10075.
#=GF DR   INTERPRO; IPR046902;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Middle Components (MCs) of the ABC-3C biological conflict
#=GF CC   systems occupy the central position between the catalytic
#=GF CC   effector and ABC ATPases of the systems. MCs are defined by
#=GF CC   distinctive patterns of conserved charged residues. As some MCs
#=GF CC   are HTH domains, they are predicted to function akin to kleisins
#=GF CC   as DNA-binding partners for the ABC ATPases, assisting in
#=GF CC   recognition and responding to invasive elements such as DNA
#=GF CC   viruses [1].
#=GF SQ   11
#=GS D5V5X8_ARCNC/27-159      AC D5V5X8.1
#=GS A0A345IZQ9_9PROT/28-159  AC A0A345IZQ9.1
#=GS A0A3M8CVV1_9BACL/58-195  AC A0A3M8CVV1.1
#=GS A0A2C6M8Q7_9FIRM/31-160  AC A0A2C6M8Q7.1
#=GS M7PJB6_9GAMM/27-159      AC M7PJB6.1
#=GS I3YEE7_THIV6/32-151      AC I3YEE7.1
#=GS A0A4Y9RM76_9BURK/28-160  AC A0A4Y9RM76.1
#=GS A0A0Q5PVK2_9BURK/2-134   AC A0A0Q5PVK2.1
#=GS A0A7R7AHJ4_9GAMM/28-160  AC A0A7R7AHJ4.1
#=GS A0A4Y9SSW6_9BURK/28-160  AC A0A4Y9SSW6.1
#=GS A0A1S2QUW4_9BACI/28-159  AC A0A1S2QUW4.1
D5V5X8_ARCNC/27-159                 ..........LSVTSKGNLVLDGERIMMYFYLVKNPHILNKLLILLSK..K..NI..QLKSYELASFKAENTDIDTLYD..NKSIKKYLQILISKELIAIKYSK.....KIGFIYTSAENTRKTIQK...IDTIYLKRVLVFINKLEQTISIPISKIT-t..................
A0A345IZQ9_9PROT/28-159             ..........LNSTARGLNILDIERLSIYVYLLKNPHILHRVLIKLGK..K..RF..TLKSYETSSYKSERNDTETFYD..NKIVRYYTQLLASNNLISITYNE.....KIGFVFTPNKDTEKYINA...-DSEYFKRNITLIEKIKQISSTSVSKINT...................
A0A3M8CVV1_9BACL/58-195             svsttpllyg------------RSKFAFYDFLIRYPFYLEKVINNSKK..K..KLsdKLNLNDYEKVDAFSPMINYLRGpwDPRYDSIFNYMVSKNLIQIKYTKitpsgDKQFCIILTDLGMEISNEvheIEGKWVHRME-------------------iineifpkkstnar.....
A0A2C6M8Q7_9FIRM/31-160             .ennegaieg------------ITKLAKLDFLLRYPTMLKHALEVKGAstR..DL..SIEDHELYSVESEMVRYRFGPW..DHRYRFYLNLLVGEGLIKVISEG.....RK-VIIALTDKGFAFANK...LSANSLMQI--------------------ytkragilkrhfdmtstnl
M7PJB6_9GAMM/27-159                 ..........LAQTSRNKKVLTIDKIQSFYFLVTKPAFLNKVLMLANK..R..QI..AIDDVDYYTVETLSVNVDELFD..RDRLLTMIKILSSKKYLSSEYSN.....SEGFLFDLTDAGRSIASK...LESGYFRKVKLFIEQLSSLQSQSPSKLN-g..................
I3YEE7_THIV6/32-151                 .gqrdtvegl-------------TKLAKLDFLLRYPVMLERALAAKGR..StrDV..QLADHERLSVESQMVRYRFGPW..DHRYREFLNILIGKGLVTVSVEG.....RK-VVIALTERGRTLASE...LSA--------------------------tpdfqdyakrsallkr...
A0A4Y9RM76_9BURK/28-160             ..........LSSTKKGKLLINNERLALMIFLLKNPLVAAKLLTNLGH..S..TL..QLSASESYSVRSLAPNLDELLD..QRLLKAILIFLAQRKMLAVSFRK.....LEGAMYTLTETGYQAAEA...LVGPFFSTVLVRLERLADLNSVPTKVLYQ...................
A0A0Q5PVK2_9BURK/2-134              ..........LGKSQQGKALLNNERLLIFMYLIKNPIILGQLLTRLGS..T..QI..DLTTEDVLSVTSLSVNVDSLFD..HHWMKGLLRHLASLNLIAASYRK.....ADGFVYSLTEKGEQASNA...LVGNHFDKVRRFLRALEPAKTQSTSSLNN...................
A0A7R7AHJ4_9GAMM/28-160             .....lalni-----RKNYKLDFNKIQFFMYLIRNPSKINKVLEEAGK..Q..QV..LLNEKQTYTIESLSVNVDILHD..RSKVKFLLKKLASIGLLDVVNDN.....KNGISYFLTNEGEKLASE...LCIGYFETIIQNLDNIKSLQSMSSTQL--fs.................
A0A4Y9SSW6_9BURK/28-160             ..........LSSTKKGKLLINNERLALMIFLLKNPLVAAKLLTNLGH..S..TL..QLSASESYSVRSLAPNLDELLD..QRLLKAILIFLAQRKMLAVSFRK.....LEGAMYTLTETGYQAAEA...LVGPFFSTVLVRLERLADLNSVPTKVLYQ...................
A0A1S2QUW4_9BACI/28-159             ..........LAYTQRGKLVINIDKLIIFDFLVKNPFLLRKVLEVKHR..I..KL..KLLNEEYGSVTTLFPSKMSLVD..IQSAKELIKLMISYNMLKVVEDK.....EE-LFYTLSDNGKSIFNE...LDTDYIIRIKELCKTMLVLRSLGTNELKK...................
#=GC seq_cons                       ..........Ls.ot+sphllsh-+LthahFLl+NPhhLpKlLpthG+..p..pl..pLsspEhhSVcShsssl-pLhD..p+ph+thLphLsScsLlslsacc.....ccGhhasLT-pGcphusc...Lsusahpplh.hlcplt.hpS.ssp.l.....................
//