#=GF ID   MC5
#=GF AC   PF20291.2
#=GF DE   ABC-three component (ABC-3C) system Middle Component 5
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Aravind L
#=GF GA   25.00 25.00;
#=GF TC   71.40 71.30;
#=GF NC   24.40 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   32894288
#=GF RT   Comprehensive classification of ABC ATPases and their functional
#=GF RT   radiation in nucleoprotein dynamics and biological conflict
#=GF RT   systems.
#=GF RA   Krishnan A, Burroughs AM, Iyer LM, Aravind L;
#=GF RL   Nucleic Acids Res. 2020;48:10045-10075.
#=GF DR   INTERPRO; IPR046901;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Middle Components (MCs) of the ABC-3C biological conflict
#=GF CC   systems occupy the central position between the catalytic
#=GF CC   effector and ABC ATPases of the systems. MCs are defined by
#=GF CC   distinctive patterns of conserved charged residues. As some MCs
#=GF CC   are HTH domains, they are predicted to function akin to kleisins
#=GF CC   as DNA-binding partners for the ABC ATPases, assisting in
#=GF CC   recognition and responding to invasive elements such as DNA
#=GF CC   viruses [1].
#=GF SQ   80
#=GS A0A0F7PTF0_9HYPH/4-173    AC A0A0F7PTF0.1
#=GS A0A7G9NYK4_9BACT/1-127    AC A0A7G9NYK4.1
#=GS Q63XH2_BURPS/1-151        AC Q63XH2.1
#=GS A0A374BVR2_9BACT/1-170    AC A0A374BVR2.1
#=GS A0A1K1XYU6_9GAMM/2-165    AC A0A1K1XYU6.1
#=GS A0A1N7SE45_9BURK/2-164    AC A0A1N7SE45.1
#=GS A0A4Q9RE46_9GAMM/2-167    AC A0A4Q9RE46.1
#=GS A2U2Q4_9FLAO/2-165        AC A2U2Q4.2
#=GS A0A0X3T956_9GAMM/4-167    AC A0A0X3T956.1
#=GS A0A5E7Y541_9SPHN/5-166    AC A0A5E7Y541.1
#=GS A0A1A9I4Q2_9BACT/2-166    AC A0A1A9I4Q2.1
#=GS A0A2P7QM45_9SPHN/4-167    AC A0A2P7QM45.1
#=GS A0A3G2TBX7_9FLAO/2-165    AC A0A3G2TBX7.1
#=GS A0A5S3NZ02_9SPHN/4-165    AC A0A5S3NZ02.1
#=GS A0A1H4HI61_9SPHI/2-171    AC A0A1H4HI61.1
#=GS A0A0Q5VU85_9HYPH/1-135    AC A0A0Q5VU85.1
#=GS A0A2S7T196_9BACT/2-166    AC A0A2S7T196.1
#=GS A0A2G8RE33_9RHOB/4-167    AC A0A2G8RE33.1
#=GS A0A255Z7M4_9SPHN/1-112    AC A0A255Z7M4.1
#=GS R8ANA3_PLESH/2-164        AC R8ANA3.1
#=GS A0A494XD98_9BURK/1-151    AC A0A494XD98.1
#=GS A0A7Y7DM25_9ALTE/4-172    AC A0A7Y7DM25.1
#=GS A0A519KZ20_9FLAO/2-170    AC A0A519KZ20.1
#=GS A0A515KSM3_9BRAD/1-119    AC A0A515KSM3.1
#=GS J2VL44_9HYPH/4-171        AC J2VL44.1
#=GS A0A1H0KAT8_9BACT/2-172    AC A0A1H0KAT8.1
#=GS A0A085GAR2_9GAMM/2-163    AC A0A085GAR2.1
#=GS A4EGM7_9RHOB/4-166        AC A4EGM7.1
#=GS K2JKI1_9GAMM/2-167        AC K2JKI1.1
#=GS A0A4V5NS28_9DELT/2-165    AC A0A4V5NS28.1
#=GS A0A0Q4PSF8_9HYPH/4-172    AC A0A0Q4PSF8.1
#=GS A0A249SU41_9BACT/2-171    AC A0A249SU41.1
#=GS A0A1G7E041_9PROT/4-166    AC A0A1G7E041.1
#=GS A0A554VB14_9FLAO/2-154    AC A0A554VB14.1
#=GS A0A3R8U3P6_9PSED/2-167    AC A0A3R8U3P6.1
#=GS A0A6P1M4K2_9BACT/1-149    AC A0A6P1M4K2.1
#=GS A0A0D7F2R1_RHOPL/4-171    AC A0A0D7F2R1.1
#=GS A0A0A2M909_9FLAO/5-174    AC A0A0A2M909.1
#=GS U3AQB1_9VIBR/2-165        AC U3AQB1.1
#=GS A0A0A2EVW9_9PORP/2-158    AC A0A0A2EVW9.1
#=GS E4RSU3_LEAB4/2-166        AC E4RSU3.1
#=GS A0A365U1C5_9RHOB/4-167    AC A0A365U1C5.1
#=GS A0A1H7B687_9BACT/2-166    AC A0A1H7B687.1
#=GS A0A0Q0VFT8_9SPHI/2-171    AC A0A0Q0VFT8.1
#=GS A0A2N1CVJ9_9ALTE/2-166    AC A0A2N1CVJ9.1
#=GS B8GP93_THISH/4-167        AC B8GP93.1
#=GS A0A5J6QD51_9PSED/2-167    AC A0A5J6QD51.1
#=GS A0A180F353_9BACT/2-171    AC A0A180F353.1
#=GS A0A0Q4GKY5_9SPHN/8-168    AC A0A0Q4GKY5.1
#=GS A0A4R6YQ28_9GAMM/36-195   AC A0A4R6YQ28.1
#=GS A0A1V3RQ68_9BURK/2-164    AC A0A1V3RQ68.1
#=GS A0A7G6Y205_9SPHN/4-167    AC A0A7G6Y205.1
#=GS A7HUS9_PARL1/12-175       AC A7HUS9.1
#=GS A0A2S0NCN3_9HYPH/2-165    AC A0A2S0NCN3.1
#=GS A0A345Q930_9RHOB/4-173    AC A0A345Q930.1
#=GS A0A6L7G600_9RHOB/4-171    AC A0A6L7G600.1
#=GS A0A1E7R958_9GAMM/2-164    AC A0A1E7R958.1
#=GS A0A4Q5S2G9_9SPHN/4-163    AC A0A4Q5S2G9.1
#=GS A0A1H7XRN3_9BURK/2-164    AC A0A1H7XRN3.1
#=GS A0A2A3CGE9_9HYPH/4-171    AC A0A2A3CGE9.1
#=GS A0A6N6MAW1_9FLAO/1-138    AC A0A6N6MAW1.1
#=GS A0A8H3J951_9LECA/208-365  AC A0A8H3J951.1
#=GS A0A0B6S255_BURPL/2-168    AC A0A0B6S255.1
#=GS A0A654DYF4_9BACT/2-171    AC A0A654DYF4.1
#=GS A0A327LN72_9RHOB/1-120    AC A0A327LN72.1
#=GS A0A427U106_9VIBR/2-143    AC A0A427U106.1
#=GS A0A7Y3RYG6_9SPHI/1-143    AC A0A7Y3RYG6.1
#=GS A0A1M4N0E5_9RHOB/4-171    AC A0A1M4N0E5.1
#=GS A0A4U1BKH8_9GAMM/2-164    AC A0A4U1BKH8.1
#=GS A0A180FGA9_9BACT/2-166    AC A0A180FGA9.1
#=GS A0A4V3YX18_9BURK/2-167    AC A0A4V3YX18.1
#=GS A0A021XEQ0_9HYPH/4-161    AC A0A021XEQ0.1
#=GS A0A7D5IT81_9PSED/2-164    AC A0A7D5IT81.1
#=GS A0A246JSA2_9SPHN/4-171    AC A0A246JSA2.1
#=GS Q6AKU1_DESPS/2-166        AC Q6AKU1.1
#=GS A0A244CUL6_PSEDV/2-165    AC A0A244CUL6.1
#=GS C6BWE7_MARSD/2-166        AC C6BWE7.1
#=GS I4YS85_9HYPH/4-173        AC I4YS85.1
#=GS A0A2U2DKA8_9HYPH/4-171    AC A0A2U2DKA8.1
#=GS A0A6J5DRC9_9BURK/2-164    AC A0A6J5DRC9.1
A0A0F7PTF0_9HYPH/4-173               ........l-SYTPAYDPYHTVFRYLVLLTSAE..DLSL.S.YKAARSADFFLCFPWALKDV...R.APQ..N..VP..G....F...A...KsrnSL.V....KK...YPQS...DYDRFPSSRIVFERMELIQATAVSALAGADMIDPIALQTEKVSLIV.DSLSTD...LQS.K.VES.FRASKPDLVQFLASIFPKIGDLGKDGIYARSGLGEFSYD.....
A0A7G9NYK4_9BACT/1-127               ........m------------------------..----.-.-------------PTFIDQI...R.-FP..R..TL..M....S...W...R...KK.V....IR...-PAN...KYISTGHPLLIFEQMRPVHDAAARLMASKAIIAPDKFVNGQIEPDL.QQIPNSlrdIAE.R.LNT.QTDNEIALIEFLAIGLGSVALAGPDGLKNRSGLLESRYD.....
Q63XH2_BURPS/1-151                   .........------------MFRMLLIAE--R..VSGI.E.VEKARILDFYLVFPGMVKKI...R.-LP..D..TL..K....V...L...R...AH.A....KG...-AGN...VYRDPVSSTSTFMEMRHIQEAALKSIAASGLIDLERFSAGYVVRSQ.APVPPS...LAA.K.LDE.FVAANSPMAESILNGLSQIPLLGSNGLKHRSELMEYRYD.....
A0A374BVR2_9BACT/1-170               ........m-MYNPAFDPFNGIYRMLNILRHFG.vGEII.E.VDRLRIYDFYLLFPYKTYKI...R.FKR..T..EE..N....F...R...K...RL.T....QYv.eKKEN...PYNTSSNDRRLFERLRPYQMIALSHLASYGLISPSQLLEYRVKIID.YGKMQQ...VLS.Q.LEM.MPAAESNIISWLCYCFRTTPLNGNYGLKYRTKLLESKYD.....
A0A1K1XYU6_9GAMM/2-165               .........LLYNKALDANHTLLRMTALLISWK..EKSL.D.GDALRLFDFLIANPAHIQKL...S.-VP..R..DE..L....T...D...K...NE.F....KN...-YKN...RYQNF-DPKSLFNAMKEIHCLAIERFVDLGVLQIDKNSSEYNVFIE.NIPEGL...KSL.A.ESK.ENSISSQTIDFIVDNLASISVTGSNGLKKITSLMDYKHD.....
A0A1N7SE45_9BURK/2-164               .........LIYHPAYDAYHCVFRMLLIAE--R..VSGI.E.VEKARILDFYLVFPGTVKKI...R.-LP..D..ML..R....E...L...R...TR.A....KG...-AGN...VYRDPVSSTSTFMEMRHIQEAALKSIAASGLIDLERFSAGYVARSQ.APIPPS...LAA.K.LHE.FLVANSPMAEGILEGLSQIPLLGNNGLKHRSELMEYRYD.....
A0A4Q9RE46_9GAMM/2-167               .........LMYHPAFDANHCLYRIVSILHATT..GTQI.N.WQLLRMLDFYYLFPSQLKNI...K.PWP..R..EI..G....K...L...K...IQ.V....MK...-IPD...QFEDLSNPARTFFELETFQKTAVLELIAKGVLSKSSFDKGIMALEP.DTLPTA...YKA.L.LDG.DDFLKSDAFEVITKALPSTKFNGSNGLKFRSGLMEYIYD.....
A2U2Q4_9FLAO/2-165                   .........LIYNQAYDLYHTMFRVLQIME-KT..EDVI.E.IDKLRILDFYLAFPSELMEI...R.-SF..R..GF..K....K...Y...K...KY.I....KA...-EKN...KYERVIDRKRLFFKMEHIQLSAIKALISYGIFDAEEFKKGNIKKTY.EKLSDD...LLS.R.IQS.ANEENPNLITLITGPLASMNLFGHLGLKERTNLIEFKYD.....
A0A0X3T956_9GAMM/4-167               .........RIWYPQLDIYHAIRRIAALLYFWE..KKTA.P.LERLYIFDFYFANPPLLHNV...H.MPA..D..VR..E....T...F...K...EL.V....IQ...KPEK...TFLTYPTPSILFHKMESIQKKAVQAMVAKNLLSSEALHKGKASLSS.LGEEFV...ESR.V.VGR.LSEKDAKLIEFLARSFSQVAEGDSVDLRKRTGL---RR-m....
A0A5E7Y541_9SPHN/5-166               .........RVWFASRDPYHCVFRMVRLLC-AK..GEAM.P.VEQLRVLDMFLMFPVMLERL...S.LPS..E..IK..A....R...F...R...EL.R....SD...TEKS...TFARLPGTASVWQDLQIYQATALKQLTGLGLLKRDALRDRYASLEF.KQVPAE...ILA.K.ATE.RNTDDAALMRFLVVDLASLPMTGKNNLFKRAGL------pa...
A0A1A9I4Q2_9BACT/2-166               .........LVYHPAFDLYHCVFRILQILEHMK..RKDV.E.VDRLRIWDFYLTFPNEARKI...R.-FP..Q..DL..K....E...L...K...RV.F....KS...NAPN...PYEDLMDAKRILLRMRSYQEAALKCLASYKLIDTEELNRGIIRRTD.QTIPDE...IKE.K.LAQ.LNIEQQNVLKLV-EGFNELPLFGKSGLKERTGLIDFKYD.....
A0A2P7QM45_9SPHN/4-167               .........LVYHPAFDPYNALLRTCRLLDE-M..ADGI.D.VTALRVLDFLLLFPEHLAAV...R.LSP..A..LK..G....A...V...R...RL.K....AQ...-PRF...PYDRLPTPRALFRRMAAPYEAAVQTLVSRGLVDVDE-KTGVMRLNE.GVVPAS...LMS.L.TKL.RNEEEADLMSVLQQLGGEYSAYGPGGLKDRSHLDEFLYD.....
A0A3G2TBX7_9FLAO/2-165               .........LIYNPAYDIYHTMYRIILLSS-RI..AKTI.E.IDKLKILDFYYVYPTELLDI...K.-KP..V..GF..K....K...Y...E...KF.L....KR...-EKN...KYDRINNPKRIFYKMNSIQFQAMKILVAYGYLDSESFENGIVKVTE.KSFGEE...FQI.M.VEK.SVELNTNLITLLAGPIADIDLYGHLGLKERTGLIEFRYD.....
A0A5S3NZ02_9SPHN/4-165               .........RIWYPQLDAFDCIRRMVAILSFAD..DEGL.S.MERAQMADLFLSSPPLLHSV...T.MPM..Q..VR..S....N...F...R...EL.G....IA...RPEK...SFLSYPAAPLLFHKMEPVQRRAIRAMVGKNLIDLRLYEKRALSLTD.DAR--S...LLD.T.RLK.HSVAELKLAQFIVSDILAIGEDNIEELRKRTGL---R--rl...
A0A1H4HI61_9SPHI/2-171               ........i-VYNQAFDYYHAIYRMIRLLTHVK.kDNFV.E.LDRLRIRDFYLLFPEQIHTI...T.LKEgdK..DI..K....E...L...R...AR.F....VK...QRNN...PYNQVFDNKKVFEKLRPYQLTALQCLASYGIINKDLLKEGRVSIIS.QEVLKD...YEG.R.FED.LSFTEQNIITMMVYHFSSISMFGTDGLKSRTKLMVSKYD.....
A0A0Q5VU85_9HYPH/1-135               ........m------------------------..----.P.TDTLRIVDLYYVFPYLLADL...E.-FP..K..GA..G....V...K...G...RK.L....AG...-TAS...RFNTLPSPKTFLAQSKGLHKLIVAALAGRELISGDALKVGIVKRTE.NLVPDE...LLR.-.--H.ATPEDLDLAGYLGTKIATVPLLGKEGLKARSKLMEFRYD.....
A0A2S7T196_9BACT/2-166               .........LVYHPAFDIYNCVFRMLQLLTHMK..QSEV.E.LDRLRIWDFYSTFPNEARKI...S.-YP..N..SL..S....E...L...K...TI.F....KK...KPEN...PYEDLIDPKRIIERMKPYQMSALKCLISYGLIDSKLFGKNIIRRTQ.KEIPIE...LLD.R.FND.LTVEKENIIKLIVG-FNELPLYGKAGLKFRTGLIEYKYD.....
A0A2G8RE33_9RHOB/4-167               .........RLWYPQLDVASAARRFLRILDGWQ..GDAL.S.IERLFVLDYFVATPALIGDI...K.MTN..T..YR..N....R...Y...G...EL.G....LP...KKKD...EFVVFPPATLLFHSMTPIQKRALVSLVAKEILSKESYDVGAVALTN.IGRRTA...SDL.S.NVH.QGETETIALDFMVSLMATDEFASNSDLRSRTGL---RY-y....
A0A255Z7M4_9SPHN/1-112               ........m------------------------..----.-.--------------------...-.-PS..E..VR..K....L...F...M...EL.K....IC...RPEK...VFLSYPAAPLLFHKMEPVQRRALKAMAAKNLLDRGKFDQRQIDLTD.LGR--D...VLR.E.QFD.YTCAERELAQFIAIELIAIGEDSIEDLRKRTGL---R--rl...
R8ANA3_PLESH/2-164                   .........LIYHPAYDAYHCLFRMLAIIE--K..AGKV.E.VDKLKILDFYILFPSMISDI...R.-MP..R..QF..S....K...I...K...KV.A....GR...-FYN...EYHDPINPNVTFKEMRHIQDTAMKCMLATGYIQADEFDVGYVVRTE.KNLPEK...LTL.E.MKE.FLDEKEPVSGFITNHLSKFDLSGSDGLKSRTKLMEHRYD.....
A0A494XD98_9BURK/1-151               .........------------MFRMLLIAE--R..VSGI.E.VEKARILDFYLVFPGMVKKI...R.-LP..D..TL..K....V...L...R...AH.A....KG...-AGN...VYRDPVSSTSTFMEMRHIQEAALKSIAASGLIDLERFSAGYVVRSQ.APVPPS...LAA.K.LDE.FVAANSPMAESILDGLSQIPLLGNNGLKHRSELMEYRYD.....
A0A7Y7DM25_9ALTE/4-172               .........LTYSSAYDPYHAVFRLLTLTKTVP.lGTEH.D.FEALRIVDFYHCFPWLLADF...S.AFT..K..IA..Gf..qK...A...K...NSvV....RA...YPKS...RFDVLPDRHMVFQRMLPSQLAARAAMLETGSLEHLEEK---LRFKE.TTVESD...TLR.RaLDL.YFAENKELLSFLGKYLLHVPLYGSGGLKDRSGLGEFRYD.....
A0A519KZ20_9FLAO/2-170               ........i-TYNQAFDYYHAIYRMIRILTNYR.hTEFV.E.LDRIRIWDFYLLFPEQVHTI...T.-LK..Q..DE..K....E...IrqlR...KN.F....IR...-KDN...PYNKLIDSKKVFERLRPYQLTALHCLASYGIINKSLLAENRISIIS.KELLSE...YES.K.FEP.LTPTEQNVVTIMVNHFYKLSMFGPDGLKSRTKLMVSRYD.....
A0A515KSM3_9BRAD/1-119               ....mrlap------------------------..----.-.--------------------...-.---..S..HQ..H....Y...K...A...LA.E....KY...AHLA...PYGEQPDSQLLFERMKPMQIAALETLALRGYIDEGSFKAGIFKPTQ.NEIPIE...LAD.R.ISR.INYEQSDLVDFLRILATGYDVSGENGLKARSQLMDSRYD.....
J2VL44_9HYPH/4-171                   ........l-SYNEAFDPYHTVFRFLRLFFGCK.lERAV.P.YDKFRILDFYLLHPFRLQNL...Q.LFA..D..DT..R....W...R...A...VS.R....SY...ARLK...PYGELPDDNSLFERMAAFQKAAASSLARVGIISEDEWTRNRVLFVP.ARLGGE...VEK.R.CLE.LNDTMPDIIGILYEINERYALNGRDGLKARSGLLEYRYD.....
A0A1H0KAT8_9BACT/2-172               ........i-TYNPAFDLYHSIFRMAHIVNSLQ.eGECL.E.IDKIRIWDFYLLYPSKTYDI...D.IRP..R..KE..K....DiyaA...R...KQ.W....ID...RERN...PYEYKGDNRKLFEWIKPVQVSALSCLVSCGILKKEEYLNNKVCVSD.RQALDD...FVS.H.AGP.LTAGERNTLAFMSYFSRMMPLSGFNGLKARTQLLESMYD.....
A0A085GAR2_9GAMM/2-163               ........i-IYHPFRDANHCLYRIINLLY-KN..ESEV.N.EGNIGFMDFYYLFPSQLTCI...D.KWP..R..SN..S....K...L...A...KN.I....RE...-IQS...EYENIENPRRIFFELNIVRKNTLSHLLSKGVVSL---NEDVLCLHE.NKVPQN...LIT.T.LDN.DSFRDTVEYQIITKEIPKLPIKGSRGLKARTNLMEYRYD.....
A4EGM7_9RHOB/4-166                   .........RLWYSQFDVYDCVRRLGGLLLEWR..-QPV.H.LERLYILDFFFANAPLLHRV...T.MTA..G..VR..S....A...F...R...DL.A....IP...KPDK...VFLSYPASPLLFHQMESAQTSALRALAGKGLLNNESFASKSAELNT.LGSSLF...VDI.K.NRT.DSPQEIGLARFLVNQYSASHDNGMSTLRSSCGL---R--rs...
K2JKI1_9GAMM/2-167                   .........LMYHPAFDANHCLYRVVSILRATS..DTKV.S.WQLLRMLDFYYLFPSQLKNI...K.PWP..R..DI..G....K...L...K...AL.V....MK...-IPD...QFEDLTNPARTFFELETFQKTATLELIAKGVLSKAAFDKGIMELEP.DSLPSA...YIA.L.LDT.DDFLKSDAFEVITKGLPSTKFSGSNGLKFRSGLMEYIYD.....
A0A4V5NS28_9DELT/2-165               .........LLYNKALDPNHALLRTSTILTALK..RDKI.E.EDRLRIFDFLLANPFHISTM...K.-LG..S..GL..M....K...Q...R...NE.F....KI...-YKN...RYNTY-DPFILFELMKPIQQAVFCSLVQMNCLIPLENTSHYKVNIN.KLPPEL...STI.I.SSE.TNSMPKDAISFIREHLTHFDLLGPSGLKFASTLMEYRYD.....
A0A0Q4PSF8_9HYPH/4-172               ........v-TYVAAYDPYHAVFRILVMLSLEQ..ETIL.D.IEAARIVDFYICYPWLVGNF...K.AAR..E..IS..G....Q...L...K...AA.N....AA...KRKNtpsAYQVAPEPSLIFRRMRPSQLAAMSSLASKGLVDRDRLALGALQRTQ.KRLPEK...LSA.A.VDR.ELADRPELYTFITS-ILKLPLKGIGGLKSRSGLEEFRYD.....
A0A249SU41_9BACT/2-171               ........i-IYHQAFDLYHSVYRMLQILTYYK.rKEYV.E.TDRLRIWDFYLLFPSEVHKI...K.IFR..EeeDL..K....K...L...I...RS.Y....IY...KQEN...PYEEILDGRKMFEKIKSYQLHAIKCLASYDIIDKDHLNENRVTIIS.KTLLEK...YSA.K.FEP.LSVSEINTIKLMTSEFAQISMYGPKGLKARTKLLESRYD.....
A0A1G7E041_9PROT/4-166               .........RLWHPFMDPYHCCFRLISSLSVIE..GQVM.P.MDRARFLDLFVLFPGLLYKL...S.LTH..E..QK..R....T...L...K...KI.G....VA...PAAT...YFATLPDIKILYRRLRSNQRPAISQMIATQVIDVNEFRDDKIKLNL.EKLPSE...ILE.R.AIA.RVARSPEVFEFLHSDLAVYEFNGPEGLLDRAGI------yg...
A0A554VB14_9FLAO/2-154               ........i-IYHPLTDVYHSINRGLILFN--H..FSKI.E.MDRYSIYDYFLLFPQDLRKT...S.-LP..N..GF..R....E...F...K...KI.K....FQ...---N...KYNLIKNRKNTFKRLKEIQNITINSLIMYGIVDANDFKDKGILTVK.NNS---...--N.F.NQS.SSETDEKVIELINKYFNNITLR---ELKERTKLTEYRY-e....
A0A3R8U3P6_9PSED/2-167               .........LMYHPAFDANHCLYRIVSILNATR..ETQI.S.WPLLRMLDFYYLFPGQLKCI...H.PWP..R..EI..S....K...M...K...AQ.V....SK...-IPE...QFEDLTNPARTFFELETFQKSATLELIAKGVISKSAFDKGIMELEP.ESLSSA...YID.L.LAT.DDFLTSDAFAVITKGLPSVQFDGSKGLKRRSGLMEYIYD.....
A0A6P1M4K2_9BACT/1-149               .........---------------MLQLLEEAP..ENSY.E.LDKMRILDFYMVFPSLINAM...K.-MP..Q..SA..R....K...Y...R...KH.F....KS...--VT...SYEDKGNPKSLFQRAEPYQMLAVKYLQALEVIDETQIQLGVICRTK.KELPKE...LRD.S.IST.RTQSMQDVVKFLVEELAGVQLSGDGGLKARTKLMEYQYD.....
A0A0D7F2R1_RHOPL/4-171               .........LTFEPALDPFHAIFRFLRLRDVFE.cIGPV.P.RDLARMLDFYLLFPFRIEGI...R.LKP..Q..DR..K....Y...K...S...LS.K....AY...AASK...PYGEQPEDRILFSRMEPMQIAALDTLADQNFIARERWSMGEVMTMV.KEPPLR...IAE.R.ISD.VNQADSNLINFLSVLGSTYTLLGKDGLKDRTGLLEYRYD.....
A0A0A2M909_9FLAO/5-174               ........i-LYHQAFDLYHSVYRLLQILTYFD.rNEYV.E.VERLRIWDFYLLFPNKMSNI...K.-LK..R..DE..K....D...V...RlmiKI.F....IL...KDSN...PYELLSDNRKMFEKIKPYQLGALKCLASYGIIDKDYLHSNRVTIVS.KKILST...YTS.K.FEP.LEPKEVNAIRLLTSHFYLMPLFGEFGLKARTQLLESKYD.....
U3AQB1_9VIBR/2-165                   .........LVYNKSIDVNHTVLRLSALSMELD..GKEV.E.KDRLRILDFILAHPVHISKM...K.-LG..R..DM..V....K...E...R...NV.F....KS...-FTN...NYQNY-SDNNLFEIMKPVQDMAICYLETLGVISFVKENNRLELNYD.RVSPEI...KSI.L.SEE.VNSISSQAVSFIKDYLIDMDLVGDNGLKSASNLMGCKYD.....
A0A0A2EVW9_9PORP/2-158               ........i-VYHPVYDIYHCLTRTLKILRCLG..NKSY.E.KDRIKIYDYYFLFPCETDNI...T.-LP..R..QF..S....A...Y...K...KI.C....RA...---N...RYNKVYDVRNTFSQLESVQETAYRALASFGFIENGLLFDDIVKLTN.NSIPEN...LLF.E.---.LTDAEATYMELVTAFFENIS---IVELKKRTKLMEYRY-e....
E4RSU3_LEAB4/2-166                   .........LVYHPAFDIYNGVFRMLQLLTLMK..QDEV.E.LDKLRIWDFYLTFPTEARNI...T.-FP..Q..SL..S....E...L...K...KI.F....KK...DKQN...PYEDLIDSKRIFERMQPFQMTALKSLASYGLIDNKQFSKGWVKRTE.KEIPQD...LLG.K.LNE.LTVEKSNILKLVLG-FNELPLYGKTGLKYRTGLLEFKYD.....
A0A365U1C5_9RHOB/4-167               .........RLWFPQLDVYDAVRRLGGLLGLWQ..SKTL.PsAERLFIMDFFLANAPLLHKT...H.MPQ..E..VR..K....A...F...G...AL.G....VP...RPEK...SFVSYPSPQILFQKMDEVQRQAFRTLSGKGLIALPQLESGNVAPSE.EGR-TV...FQE.E.FLPlFSDSERQIGAFLVG-RYAPENRPISEIRQSTGL------rrl..
A0A1H7B687_9BACT/2-166               .........LVYHPAFDIYNCAFRILQIMNLMK..QDEI.E.VDRLRIWDFYLTFPNEARKI...T.-FP..N..DL..A....E...L...K...KV.F....KS...KSEN...PYEDLMDPKRIIERMEPYQTSALRCLVSYGLIDGSSLSKSVVKRTE.KDIPAE...LAV.K.LSD.LSKEKLNIIKLILG-FRELPLYGKVGLKFRTGLIDFKYD.....
A0A0Q0VFT8_9SPHI/2-171               ........i-VYNQAFDYYHAIYRMIRLLTHVK.kDDFV.E.LDRLRIWDFYLLFPEQIHTI...T.LKDgdK..DI..K....E...L...R...AR.F....VK...QRNN...PYNQVFDNKKVFEKLRPYQLTALQCLASYGIINKDLLKENRVSIIS.REILKD...YEG.R.FEE.LSYTEQNIITMMVYHFSSISMFGTDGLKSRTKLMVSKYD.....
A0A2N1CVJ9_9ALTE/2-166               ........i-IYHPAKDPNHCIYRLISLLMNI-..EGGC.S.FEKIRVLDFYYSFPHLLKKI...S.PWP..N..DI..K....A...Y...K...KY.V....VN...-IPG...AYEKISNQRRLFFEMNEIHKEAVGILCAKGILNKELFENGTIALDK.DNLPVG...VAD.L.VIH.DTFVKSDVFKVITEGLLSSKWGGKSGLKEKTGLLEYKYD.....
B8GP93_THISH/4-167                   .........RVWYPQLDIYHAIRRVAALLYFWE..KSTA.P.LERLYISDFYFANPPLLHSV...H.MPA..D..VR..A....T...F...K...DL.E....IQ...KPEK...SFLTYPTPSILFHKMESIQKKAVQAMAARNLLSSDALHEGNASLSC.SGEEFA...ESR.V.VGG.LSERDIKVIEFLARSFSQISEGDSVDLRKRTGL---RR-m....
A0A5J6QD51_9PSED/2-167               .........LIYHPAQDINHCVYRLLLILEFSE..HEKL.S.IDVYRMIDFYTLFPSLLKLI...T.PLP..Q..SL..S....T...L...R...KE.F....SN...-IPE...PFESLRNIKRILYELESFQSTAIQNLIAKELLSKEDFESGFLKRTE.KGLLTS...FME.Q.ALS.GRLVSERWFQILINEFPKVKFAGRDGLKSRTGLMEYRYD.....
A0A180F353_9BACT/2-171               ........i-VYNHALDMYHTIFRFLQFLNRFD.vETQI.E.VDRLRIWDFYLLFPNEIHTI...R.L-K..K..DE..S....D...I...RqllKQ.F....VK...EDEN...PYEIIAEERKIFEKIKPYQLAALNCIASYGIIDKSVLNRQRILITN.KDLLNE...FVN.N.FGE.LPAKERNIISLMTSHFYQMSMFGKDGLKQKTNLMESKYD.....
A0A0Q4GKY5_9SPHN/8-168               .......rq--WYAHLDSYDTIRRIMALLSRWS..RPAP.T.LERLFICDFFLASPALLHET...H.MPG..P..IR..E....A...F...R...SF.Q....IA...RPAA...EFLSYPAAPVLFAKMEGVQRDALQTLLGKGLLDFELFRQGRVALQQ.SYNEES...VL-.-.-PH.LTDRESLAADFIAAYFATIGENEPGALRNSTGL---R--ra...
A0A4R6YQ28_9GAMM/36-195              .........LIYHPAQDAYHCVFRMTAIVE--R..IALL.E.FDKARLIDFYLVFPASLQSI...R.-FT..R..GL..S....K...F...R...RY.A....KD...-RSN...IYRDPSNPLEAFRALRPMQEAAVRCLASAGIIDSALLGKGLISRRAaTSVWPK...LAA.S.IAA.FTEDLGPLSEAIIG----LGELQLAELKERSGLMEHRY-g....
A0A1V3RQ68_9BURK/2-164               .........LIYHPAFDAYHCVFRMLAITS--E..KRIL.E.FAKLRILDFFLCFPAEVAVV...Q.-LP..Q..EH..S....E...I...R...RL.A....RV...-ARN...PYRGPINSARTFRELEPIQSAAARLLGLTGVFSIADLENGRVIRTG.QEIPED...LKR.L.SDA.ASAFSSPLDRYVVSTMSEIPLAGFGGLKQRTGLMEYRYD.....
A0A7G6Y205_9SPHN/4-167               .........LVYHPAFDPYNALLRTCRLLDEM-..AGGI.D.VTALRVLDFLLLFPEHLASV...R.LSP..A..LK..G....A...V...R...RL.K....AQ...-PRF...PYDRLPTPRALFRRMAAPYEAAVQTLVSRGLVDVDD-KTGIMRLNE.GVVPPL...LMS.L.AKL.RNKEEADLMSVLQQLGSQYSAYGPDGLKDRSHLDEFLYD.....
A7HUS9_PARL1/12-175                  .........RLWYPQLDVYDAIRRIGGLLSFWS..TDAApS.PERLFIADFYLANPPLLHKT...H.MTR..E..VR..K....E...F...T...GL.G....IP...RPEK...AFISYPSPPILFQKMDEVQRQAFRTLTGKGLIDLPKLEKGAVAASA.AGFELF...EDR.F.VPL.FGDAESQVAKFIARSFA-LADTDIGALRRSTGL------rrv..
A0A2S0NCN3_9HYPH/2-165               .........LVYHPAFDLSHGMFRMLRLIEANP..ERQM.K.WDTFRILDLYYLFPHLLETA...R.-LP..R..SM..T....K...R...K...RD.F....GR...-LGS...KYTRVPTPRMFIQQLRGIHESTARSLAAKGFLVPAEFDEGVLVRTG.REIPPE...LLR.M.FA-.DAVEDAPLVQMLAVDMAAIPLTGEDGLKDRTGLLEHRYD.....
A0A345Q930_9RHOB/4-173               .........LAYTPAYDPYHTVFRFLVLLTSSE..NQVL.T.YRSARAADFFFCFPWSLKDV...R.-AP..R..DI..EgfarT...R...N...AI.V....KK...YPKS...GYDNFPSARVVFERMEMIQATAVSALAGAKMIDANAATSERLVLNY.ENIPKE...LMN.S.VEN.ASQKTSDLVAFLAIDFPKMDELGKDGVLARSGLGEHSYD.....
A0A6L7G600_9RHOB/4-171               ........f-TYNEAFDPYHAVFRFARLHLACD.iSARM.P.FEMLRILDFYLLFPFRLQGM...R.FLE..H..DT..G....W...R...K...IS.K....NY...EKRT...PYGAMPEDNVVFLRMEPFQRAAAASLVHSGYLEGAAWNVEEVKFTP.EELPLD...FSS.R.CLA.ANEEMADFTNILCQIKSRYPLGGRDGLKDRTNLLEFRYD.....
A0A1E7R958_9GAMM/2-164               .........LIYHPAFDSSNCCYRLITIFNHLN.pRVTL.E.KDRLKIIDFYVVFPKKLSTT...R.-IP..N..EF..R....K...L...K...SE.L....KK...-IND...TYRPCSNPFFMAKKMGGIQEQVLKKLVSSKILSFDINSNSYG-RGE.NFSKLE...ING.D.LSP.FLSQENK--ELFLEYLTNYPLKGKDGIKHRTLLMEYRYD.....
A0A4Q5S2G9_9SPHN/4-163               .........RLWYPHLDVYDTVRRMLALIVAWP..ERDM.T.PERLYVSDFYLASPGLLHKT...R.MVS..D..MR..R....E...F...Q...AL.S....IM...RPEK...GFLSYPSPQMLFVKMEPVQKEALRTIVGKGFVAIEPLRQGRIEGGD.KLP--E...I-A.D.TVF.VTQAERRVVEFLVETFARIGADAPGELRLSTGL------rr...
A0A1H7XRN3_9BURK/2-164               .........LIYHPGYDAYHCIFRLLAVID--K..VQDL.E.IDKARILEFFLLYPSAVTQV...K.-IP..Q..GM..T....P...I...R...KE.A....KL...-LSN...QYHDPINIRTTFRDMRFIQDAALKCIAAASLIDLDRFEVGYVTRTK.LPIPDS...LNS.Y.IRS.FVKSHDNVSRFVLDELSTIPLLGVNGLKHRTELMEYRYD.....
A0A2A3CGE9_9HYPH/4-171               ........l-SYSSAYDPYHTVFRMICALRAAD..EQKI.D.YQKLRIVDFFLCFPWLIKEI...T.-AS..R..SI..K....N...F...A...KR.KnsilKA...YIAT...KYDVTPAPRTLFARMEPIQMAALGGLISAGVASGSR--DAAVRIDV.DALSSG...LNS.L.TAK.FNDNNRELVEFLSQELIKLPYAGDGGLKHRSGLDEYRYD.....
A0A6N6MAW1_9FLAO/1-138               ........m------------------------..----.E.VDKLRILDFYLAFPAELLEI...Q.-SF..R..GF..K....K...Y...R...KY.L....KA...-EMN...QYERVIDRKRLFFKMEQIQISAMKALVSYSLLDAREFKNGKIKRTD.IPLTEQ...LSL.R.IQE.EFKSNQNLLTLITGPLASLNLYGHLGLKVKTNLIEFKYD.....
A0A8H3J951_9LECA/208-365             .........LIYHPAFDINHARLRIIQLIDGLH..DKEI.S.FDLLRILDFYFLFPHLLADV...K.LTK..G..LV..R....T...K...R...EL.G....RG...--AN...KYNRVPAPKVLIRQMEGIHETAIRALQSSDLIELPSVNLAVVKRSS.VPLPDD...LKK.V.IAD.QPDQEKDLVQILSKEVATIPLNGSDGT------------gkstl
A0A0B6S255_BURPL/2-168               .........LIYNPALDPYHCAIRLMSLALASEklNVEL.T.TDLARIGDYFLAYPAKLARF...T.-LP..N..EF..R....G...L...R...AK.A....KE...-LEN...PYRNSAGDKIAFDRMHPIFFAALSGLVASGLVEVSAMKRGVVVRSE.GEIPGA...IAQ.A.VAD.FTARQTEVGEFILSEFMKIPTSGNNGIKHRSGLLEHRYD.....
A0A654DYF4_9BACT/2-171               ........i-VYQKAYDLYHTVYRLIKLLAHFR.gDGDI.E.IDRLRIWDYYVLFPNRMRAI...K.-HK..K..SE..K....D...I...K...AI.I....HQyilRPEN...PYEPLHNDRKTFEKIKPYQLTAIKCLASYGMINKDYLNNNRITSIS.RDFFSK...YDE.D.FKN.LSIQEENAIKLLTSHYYKISLFGPYGLKAKTGLLESKYD.....
A0A327LN72_9RHOB/1-120               .........------------------------..----.-.---------------MIGDI...K.MTN..T..YR..N....R...Y...G...EL.G....LP...KKKD...EFVVFPPATLLFHSMTPIQKRALVSLVAKEILSKESYDVGAVALTN.IGRRTA...SDL.S.NVH.QGETETIALDFMVSLMATDEFASNSDLRSRTGL---RY-y....
A0A427U106_9VIBR/2-143               qdledfdsv------------------------..----.-.--RLRIYDLFYLFPHLVKDI...E.-FP..R..ARgiA....A...L...K...RS.F....GS...-IEQ...PYEILPDKKRLFSEMGDYHIQALQILKAKGLFEEE---NGKLRISE.GFYSPS...IRR.L.IND.NSNESTELFCKLFQTLNTIEVVGESGLKKRTGLMEYRYD.....
A0A7Y3RYG6_9SPHI/1-143               ........m-----------------------E..RDSI.E.LERIRIWDFYLTFPNEARKI...K.-FP..M..QL..A....E...L...K...KI.F....KD...KAAN...PYEDLIDPRRILQRMQSFQMAALRCPASYGLIDGELLIKKMVKRTD.KPIPDA...IKV.N.FQK.NSPERDNIIKLVIG-FADLPLYGAVGLKERSGLLDFKYD.....
A0A1M4N0E5_9RHOB/4-171               ........l-SYQPAFDPFNAVFRGLQITQGL-..EGSV.S.FDAFRICDFFLAFPFFMAGT...EnRYK..K..GH..Q....W...L...R...SV.G...rKY...ADRK...PYGKIPDRKLLFQRVLPFQVAAISSLAKNELIDHDAWVGGEVKRTD.KQVPCA...LLK.R.IEL.ENERNGDLVRAIRTLIAEYDLQGENGLKHRTGLLEYRYD.....
A0A4U1BKH8_9GAMM/2-164               ........i-LYHPTKDIYHTQYRIISILL--S..TKEL.P.KEKLRLLDFYYNFPHFISEI...Q.PWP..S..DI..K....E...Y...K...IK.K....GA...-IPE...PFEKISNKKRVFFQMTEVFNTAVGLLVAKDIVKV-SGENRNISLKQ.ENIPSQ...LIH.E.ISE.DLFIKTSAFKTIVSGLAKTNWSGPQGLKKRSGLLEFKYD.....
A0A180FGA9_9BACT/2-166               .........LVYHPAFDIYNCVFRMLQLLAAMK..QQEV.E.LDRLRIWDFYLTFPNEARKI...K.-YP..T..TL..S....E...L...K...KI.F....KK...KEEN...PYEDLIDAKRIIERMKPYQMSALHCIASYGLIDAKLLSKNCVARTE.KGLPQE...LLS.K.FED.ISVEKANVIKLVIG-FSELPLYGQMGLKCRTGLIEFKYD.....
A0A4V3YX18_9BURK/2-167               .........LIYHPAFDANHCLYRIVSILHATN..YTPV.S.WSLLRILDFYYLFPGQLKNI...K.PWP..R..EI..Q....K...F...K...TH.A....TK...-IPD...QFEDITNPARTFFELQSFQKTAMLELISKGIISKTSFDNDIIELEP.NSIATA...YIE.L.LET.DDFLKSDIFKLITMGLPKVKFSGANGLKSRSGLMEYVYD.....
A0A021XEQ0_9HYPH/4-161               ........l-SYNEAFDPYHAVFRFLRLFFGCK.lREPV.P.YDKFRILDFYLLYPFRLQNL...Q.LFA..D..DT..R....W...R...A...VS.R....SY...ARLK...PYGELPDDNSLFERMGSFQKAAVSSMARAGIISDDEWTRNRILFLP.DRIPGD...AEK.R.CQE.LNDTMAEIIEILSEINARYELNANS--------------eair.
A0A7D5IT81_9PSED/2-164               .........LLYNKAFDPIHTILRLAAICQNSR..TDQI.E.LERLQIFNFLLAFPAHIADM...P.-LP..R..EL..L....Q...A...K...NK.F....KK...-YRS...PYNNF-EPYTLFNRMNPTFFASLQMAENIGFLHVQ--DNGTIQLNK.ELIPTE...LNSiT.RAE.VSSISREALDFEIGHLSKMPILGKTGLKAASKLMDYKYD.....
A0A246JSA2_9SPHN/4-171               .........LTYNEAFDAYHAVFRFLRLHLACD.mGTKL.P.FDTLRILDFYLLFPFRLQAM...K.FFA..D..DM..G....W...R...K...IS.K....RY...EDCA...PYGEMPEDSTVFARMEPFQRAAAASLVHSGYLSAEAWDASEVQFTL.EMLPPG...FAE.R.CSV.VNTQMTDIIEILCQIKSRYPLGGRDGLKDRTGLLEYRYD.....
Q6AKU1_DESPS/2-166                   ........i-IYHPYKDANHCAYRLISIMY-GT..NNAV.S.RDFLNIADFYYLFPSKLKEI...N.NWP..R..KN..S....N...D...Y...RA.V....KA...-IEN...CHENLDNAKMIFYEIKEIRHNTFLNLISRGIVIERNKHNQLYTMEQ.SLLPDS...LIE.L.LKK.DEFRESEAYRIITQKMSKIPLNGDTGLKAKTSLLEHRYD.....
A0A244CUL6_PSEDV/2-165               .........LVYHPKNDIYNCMYRFLSIIKLAN..KNSI.E.FNRLRIFDFFFLFPHLADGI...V.YPK.lK..GV..S....N...V...R...KL.S....RS...-FNE...PYENLPDNKRLFSEISDYHIQAIQILCSKGILR---LDNDLVFIGE.NFENFN...IQQ.L.LID.NKYLEGLFYQKFVMLLMEVKLTGENGLKQRTGLMEYRYD.....
C6BWE7_MARSD/2-166                   .........LVYNSAFDIYHCMFRIILLLNACP..QNKI.E.YERARIFDYFFAFPQRAQEI...K.-LQ..R..GC..G....F...T...K...KT.F....KL...-ETT...HYQEIQDDKQIFFEMSKIFEGAVRCLAAYGEIEPTKLSVGTIVQKN.NSLSEK...INA.H.FGE.IDPLRQSILELFSGPFYNLELTGANGLKARSGLMEFRYD.....
I4YS85_9HYPH/4-173                   .......is--YSAAQDPFHAVFRMLSLLKEPV..PITY.E.VERVYIYDFYICFPWQIGKIegvR.SIP..D..FI..R....D...R...N...AL.K....RI...YVQN...EYEQIPEPRIMLQRMRPAQLAALNSLSSYGFLVPEHLKCGNVTRTD.EPLPQS...LEG.K.VNA.FSEANRALFDFIKKKLSTLPLSGPNGLKAKTGLEEYRYD.....
A0A2U2DKA8_9HYPH/4-171               ........l-SYNEAFDPYHTVFRFLRLFFGCK.lERAV.P.YDKFRILDFYLLHPYRLQNL...H.FFA..D..DT..R....W...R...A...VS.R....RY...TRLK...PYGELPDDNSLFERMAVFQKAAAGSLARVGIISEEEWTRNQVLFVA.DPVSDE...VEQ.R.CQE.LNGTMPDIIGILREINERYALNGRDGLKARSGLLEYRYD.....
A0A6J5DRC9_9BURK/2-164               .........LIYHPAYDAYHCVFRMLLIAE--H..VKDL.E.IEKARLLDFYLLFPGMLVHA...R.-LP..D..EL..R....A...L...R...SQ.A....KS...-LAN...VYRDPVSGLSTFRDMRHIQEAALKSVAASGLIDVKQFERGFVKRTE.MLLAPG...LKE.K.LDA.FTLANGPVVDGVLAGLSKLPLLGHNGLKHRSELMEYRYD.....
#=GC seq_cons                        ..........lYpsAhD.YHslaRhltllp.hp..pptl.p.h-+lRIhDFYlhFPttlppl...c..hs..c..sh..p....p...h...+...ph.h....tt.....ps...sYpshssspplFpcMcshQpsAlpsLsutGllstpphppshlphsp.ptlspp...ltp.p.hpp.hstpcsslhphlsphhsplshhGpsGLKpRouLhEa+YD.....
//