#=GF ID   MCEL_GT_NTPase
#=GF AC   PF21004.1
#=GF DE   mRNA capping enzyme catalytic subunit, GTase, NTPase domain
#=GF PI   Pox_ATPase-GT_C;
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Karlin D
#=GF GA   27.00 27.00;
#=GF TC   62.00 61.80;
#=GF NC   23.20 22.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0179
#=GF RN   [1]
#=GF RM   8227060
#=GF RT   Identification of the vaccinia virus mRNA guanyltransferase
#=GF RT   active site lysine. 
#=GF RA   Niles EG, Christen L; 
#=GF RL   J Biol Chem. 1993;268:24986-24989.
#=GF RN   [2]
#=GF RM   8662635
#=GF RT   Domain structure of the vaccinia virus mRNA capping enzyme.
#=GF RT   Expression in Escherichia coli of a subdomain possessing the RNA
#=GF RT   5'-triphosphatase and guanylyltransferase activities and a
#=GF RT   kinetic comparison to the full-size enzyme. 
#=GF RA   Myette JR, Niles EG; 
#=GF RL   J Biol Chem. 1996;271:11936-11944.
#=GF RN   [3]
#=GF RM   17989694
#=GF RT   Structural insights into the mechanism and evolution of the
#=GF RT   vaccinia virus mRNA cap N7 methyl-transferase. 
#=GF RA   De la Pena M, Kyrieleis OJ, Cusack S; 
#=GF RL   EMBO J. 2007;26:4913-4925.
#=GF RN   [4]
#=GF RM   24607143
#=GF RT   Crystal structure of vaccinia virus mRNA capping enzyme provides
#=GF RT   insights into the mechanism and evolution of the capping
#=GF RT   apparatus.
#=GF RA   Kyrieleis OJ, Chang J, de la Pena M, Shuman S, Cusack S;
#=GF RL   Structure. 2014;22:452-465.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   mRNA-capping enzyme catalytic subunit from Vaccinia virus (MCEL,
#=GF CC   also known as mRNA-capping enzyme D1 subunit) catalyses the
#=GF CC   hydrolysis of the 5' triphosphate end of the pre-mRNA, the
#=GF CC   capping of the resulting diphosphate RNA end with GMP and the
#=GF CC   methylation of the GpppN cap [1-3]. It consists of an N-terminal
#=GF CC   RNA triphosphatase (TPase)-guanylyltransferase (GTase) module,
#=GF CC   and a C-terminal guanine-N7-methyltransferase (MTase) module
#=GF CC   (Pfam:PF03291) [4]. The N-terminal module comprises a TPase
#=GF CC   domain (Pfam:PF10640), followed by the GTase at the C-terminal,
#=GF CC   which consists of the nucleotidyltransferase (NTPase, this
#=GF CC   entry) and OB fold (Pfam:PF21005) domains [3,4]. The TPase and
#=GF CC   GTase modules stabilize their active conformations and their
#=GF CC   contacts also clamp the NTase and OB fold.
#=GF SQ   41
#=GS MCEL_VACCW/225-338        AC P04298.1
#=GS Q6TUT6_YMTV5/224-336      AC Q6TUT6.1
#=GS MCEL_VACCT/225-338        AC Q9JFA8.1
#=GS F1AX59_ORFV/221-335       AC F1AX59.1
#=GS A0A097IVV1_9POXV/237-350  AC A0A097IVV1.1
#=GS D3IZL1_9POXV/221-335      AC D3IZL1.1
#=GS A0A3F2YKN2_SHEVT/224-337  AC A0A3F2YKN2.1
#=GS MCEL_VAR67/225-338        AC P0DSX5.1
#=GS Q98257_MCV1/329-443       AC Q98257.1
#=GS A0A7H0DN85_MONPV/225-338  AC A0A7H0DN85.1
#=GS A0A385HBA1_FOWPV/231-343  AC A0A385HBA1.1
#=GS MCEL_FOWPN/231-343        AC Q9J584.1
#=GS A0A2U9QHS7_9POXV/227-342  AC A0A2U9QHS7.1
#=GS Q6TVQ6_ORFSA/221-335      AC Q6TVQ6.1
#=GS A0A1V0S7Z3_CNPV/230-343   AC A0A1V0S7Z3.1
#=GS A0A223FND9_9POXV/224-336  AC A0A223FND9.1
#=GS MCEL_CAMPS/225-338        AC Q775U0.1
#=GS A0A1B3B692_LSDV/224-337   AC A0A1B3B692.1
#=GS MCEL_VACCC/225-338        AC P20979.1
#=GS R4JNM0_9POXV/226-340      AC R4JNM0.1
#=GS Q0GNX8_HSPV/225-338       AC Q0GNX8.1
#=GS A0A2C9DT55_9POXV/242-356  AC A0A2C9DT55.1
#=GS A0A0M3ZRQ5_9POXV/230-342  AC A0A0M3ZRQ5.1
#=GS U3UBK1_9POXV/223-337      AC U3UBK1.1
#=GS Q08FR4_DPV83/225-337      AC Q08FR4.1
#=GS Q08F94_DPV84/225-337      AC Q08F94.1
#=GS Q9Q8M4_MYXVL/220-332      AC Q9Q8M4.1
#=GS G3EIG4_9POXV/224-336      AC G3EIG4.1
#=GS Q070E2_CPRVZ/226-341      AC Q070E2.1
#=GS A0A1L3IZK0_9POXV/225-337  AC A0A1L3IZK0.1
#=GS MCEL_RFVKA/221-333        AC P25950.1
#=GS Q6VZF5_CNPV/229-341       AC Q6VZF5.1
#=GS Q0NPA3_9POXV/225-338      AC Q0NPA3.1
#=GS A0A6B9R1L8_9POXV/228-340  AC A0A6B9R1L8.1
#=GS A0A223FMV0_9POXV/224-336  AC A0A223FMV0.1
#=GS Q9EMR4_AMEPV/229-343      AC Q9EMR4.1
#=GS A0A1B1MRC8_9POXV/226-341  AC A0A1B1MRC8.1
#=GS Q9DHN4_YLDV/224-336       AC Q9DHN4.1
#=GS Q8V3L9_SWPV1/224-336      AC Q8V3L9.1
#=GS B2CWI3_9POXV/220-332      AC B2CWI3.1
#=GS H6TA69_9POXV/237-350      AC H6TA69.1
MCEL_VACCW/225-338                   .ENVILSP..PINAPIKTFMLPKQDIVGLDLENLYAVTKTD....................................GIPITIRVTS.NGLY.CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAINDRLEESKYVESKL.......
Q6TUT6_YMTV5/224-336                 .ENVFLVP..NFKNPLKTYMLKKQDISGISLDNLYATTKTD....................................GIGAIVKIKQ.NKIY.CHFSHINYCIKYLANRTME.N.EIVIYGEALK..YNGKWNIYLIKLINP..NLENRIMEKDFVDEEL.......
MCEL_VACCT/225-338                   .ENVILSP..PINAPIKTFMLPKQDIVGLDLENLYAVTKTD....................................GIPITIRVTS.NGLY.CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAINDRLEESKYVESKL.......
F1AX59_ORFV/221-335                  .DAVFLAP..PAEMPVRTLMLQKQEIPALDLDGLFAVSKTD....................................GVSASVRVDE.DGVF.CAFSHLAYTIRYPLAREVQ.G.RYRLWCEAVRpvGERVWSMFVLVVEEP..AGDDRVAAVAGAVEAL.......
A0A097IVV1_9POXV/237-350             .KNIFLKR..QLSYPIHTYMLKKQDISGISLDDLYITNKTD....................................GVGTYITILD.SGIY.CYFSHLNYTIRYDINKKIN.TtTVKLYGEGLK..YDGKWSIYLIKLITP..SFDDRFKEKEFVSNEL.......
D3IZL1_9POXV/221-335                 .DAVFLTP..PADMPVRTLMLQKQEIPALELEGLFAVSKTD....................................GVSASVRVDA.GGVF.CAFSHLGYTIRYPLAREVK.G.VFRLWCEAVRpvGERVWSLFVLFVEEP..AGEDRVAAVAAAVEA-l......
A0A3F2YKN2_SHEVT/224-337             .KNVFLPT.vIFTSPVKTIMLKKQEIHNIELDKLYITTKTD....................................GVGTLIKINK.NGIF.CYFTHLNYIIKYNLSRKFD.D.TVILYGEAIK..QNQKWFIYLIKLLKP..ELSNRFKERDFLIEKL.......
MCEL_VAR67/225-338                   .ENVILSP..PINAPIKTFMLPKQDIVGMDLENLYAVTKTD....................................GIPITIRVTS.KGLY.CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.......
Q98257_MCV1/329-443                  .EHVFLMP..APKEPLTTHMLKKQDLLTLELRDLYVTGKTD....................................GVPTFVHVAG.ASVY.CFFSHLGYAIRYPARVTLP.A.PVALFGEAVRdaQSKQLTVYLIKLMAP..ALEDRLEEREFVLRRL.......
A0A7H0DN85_MONPV/225-338             .ENVILSP..PINAPIKTFMLPKQDIVGLDLENLYAVTKTD....................................GIPITIRVTS.KGLY.CYFTHLGYIIRYPVKRTID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.......
A0A385HBA1_FOWPV/231-343             .KYIRLCP..SINPILRTHLLKKQDIININTDDLYITSKTD....................................GIFSHVYIEK.KSIF.CYFSHLGYIKEYTASREIE.E.TIYLYAEMRK..EESILYLTVIKVLKP..CMEDRLSELAFVKNHL.......
MCEL_FOWPN/231-343                   .KYIRLCP..SINPILRTHLLKKQDIININTDDLYITSKTD....................................GIFSHVYIEK.KSIF.CYFSHLGYIKEYTASREIE.E.TIYLYAEMRK..EESILYLTVIKVLKP..CMEDRLSELAFVKNHL.......
A0A2U9QHS7_9POXV/227-342             n-NVFLYS.pYPKMIPNTIMLKKQDITTLDLDELYIVGKTD....................................GVQVNIVIEH.TNIY.CFFNHLGYGIRYVCNVKKH.T.TIELVGEAVKnpDENIWTIYVIKVISP..CLSSRLDELDYVSKEL.......
Q6TVQ6_ORFSA/221-335                 .DAVFLLP..PAEMPVRTLMLQKQEIPALDLDGLFAVSKTD....................................GVSASVRVDE.NGVF.CAFSHLAYTIRYPLAREVQ.G.RYRLWCEAVRpvGERVWSMFVLVVEEP..AGDDRVAAVAGAVEAL.......
A0A1V0S7Z3_CNPV/230-343              .DKIRLCP..RIKLVLQTHLIKKQEIINLNTDNLYVTSKTD....................................GVFTYVLIKD.KSIF.CYFSHLGYIKEYTANRKLEiD.EVYLYAEMRK..DDNILYFIVIKVLTP..EIEDRLDELKFVNDNL.......
A0A223FND9_9POXV/224-336             .ENVFLSP..IMKIPVNTYMLHKQDIPGLELENLYAVTKTD....................................GIPVTVKINS.TGIY.CYFTHIGYIIRYPAKKILD.T.TVVLFGEAIK..DKNQWTIYLIKLLEP..VINDRLEERSYIESKL.......
MCEL_CAMPS/225-338                   .ENVILSP..PINAPINTFMLPKQDIVGLDLENLYAVTKTD....................................GIPITIRVTS.KGLY.CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.......
A0A1B3B692_LSDV/224-337              .KNVFLPT.vIFTSPVKTIMLKKQEIHNIELDKLYITTKTD....................................GVGTLIKINK.NGIF.CYFTHLNYIIKYNLLRKFD.D.TVILYGEAIK..QNQKWFIYLIKLLKP..ELSNRFKERDFLIEKL.......
MCEL_VACCC/225-338                   .ENVILSP..PINAPIKTFMLPKQDIVGLDLENLYAVTKTD....................................GIPITIRVTS.NGLY.CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAINDRLEESKYVESKL.......
R4JNM0_9POXV/226-340                 .ENIFIPQ.qILHMPIKTIMLKKQDIINLDVEDLYATTKTD....................................GVPTIVNIIN.NNIY.CYFSHLNYIIKYESIHNFD.K.SITLFGEAIK.nSNKQWIIYLIKLLTP..TFNTRFEEKEFIDKTL.......
Q0GNX8_HSPV/225-338                  .ENVILSP..PINAPIKTFMLPKQDIVGLDLENLYAVTKTD....................................GIPITIRVTS.NGLY.CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAINDRLEESKYVESKL.......
A0A2C9DT55_9POXV/242-356             .DNVFFVP..VPKPPVTTHLVRKQDVLALEIEHLYLTEKTD....................................GVATFVYANG.SDLY.CYFSHLGYVIRYDTKRVLE.E.PIYLFGEMVRpvGAGMVTVSVIKLIQP..EVGDRLAGAEFADDT-m......
A0A0M3ZRQ5_9POXV/230-342             r-HVRLCP..YLQPKLKTYLLKKQELINIDTDNLYITGKTD....................................GIFSYVYIYH.RSIF.CYFNHLGYIKDYDISVDVE.E.PIYLYAEMRK..ENNIIYFTVIKVLLP..ELDDRLAELEFVNSNL.......
U3UBK1_9POXV/223-337                 .DNVFLVP..PVRDPIRTHMLKKQNILSLELQGLYATSKTD....................................GVAATVRVDA.SGVY.CFFNHLGYVIRYPALREVE.E.PVVLFGEAVRsaEDRRWHVHLIKLVAP..TLESRLEEHEFVERR-m......
Q08FR4_DPV83/225-337                 .KNIFMTP..EQKNPIKTRMIKKQDLTGLELDNLYITTKTD....................................GVGSLIKINK.NGIF.CYFSHLNYSIRYNLLKPID.K.QIVLYGEALK..HGKMWNIFLIKLIEP..ILDDRIKEKDFINDEL.......
Q08F94_DPV84/225-337                 .KNIFMTP..EQKNPIKTRMIKKQDITGLELDNLYITTKTD....................................GVGSLIKINK.NGIF.CYFSHLNYSIRYNLLKPID.K.QIVLYGEALK..HGKMWNIFLIKLIEP..ILDDRIKEKDFINDEL.......
Q9Q8M4_MYXVL/220-332                 .DNIILDG..ILKPPVQTVMLKKNDLPGIDLTNLYVTTKTD....................................GVGVLITVTN.KGIY.CFFTHLQYTIRYDTTFKSD.N.PVTLYGEAIK..QNNVWHVYLIKLMTP..KLSDRFKEKDYVEEHL.......
G3EIG4_9POXV/224-336                 .ENVYLSP..IIKIPVNTFMLHKQDIPALELENLYAVSKTD....................................GIPVTVKLKS.TGIY.CYFGHIGYIIRYPIKKNLD.T.DIILFGEAIK..DKNQWIIYLIKLLEP..VIHDRLDERNYIESRL.......
Q070E2_CPRVZ/226-341                 .DSVFLVQggGPRPPVPTNMLKKYQLQTLETADLYVTEKTD....................................GVLTYVLLRD.KDIF.CHFAHLGYFIRYRGRRKFA.E.PVSLMGEMTR.aGSGEKVVHFIKLQTP..ALPDRLEERAFVEERL.......
A0A1L3IZK0_9POXV/225-337             .KNIFLKR..ECGYPIRTHMLKKQDINSISLDDLYITNKTD....................................GIGTFISILK.DGIY.CYFSHLNYTIRYDVNKKVD.N.PIKLYGEGLK..YDGKWSIYLIKLVTP..EFNDRFKEKEFVTNEL.......
MCEL_RFVKA/221-333                   s-NIILDV..VFKNPVQTILLKKNELPGIDLTNLYVTTKTD....................................GVGVLITVTN.KGIY.CFFTHLQYTIRYDTTFESN.E.SVTLYGEAVK..QNNVWQIYLIKLITP..KVSDRFKEKEYVEERL.......
Q6VZF5_CNPV/229-341                  .DKIRLCP..RIKLVLKTYLLKKQEIINLNIENLYITSKTD....................................GVFTYVLLQN.KSIY.CYFSHLGYIKEYTANREID.E.KVYLYAEMRK..ENGILYFTVIKVLNP..RMKNRLDELKFVNKNL.......
Q0NPA3_9POXV/225-338                 .ENVILSP..PINAPINTFMLPKQDIVGLDLENLYAVTKTD....................................GIPITIRVTS.KGLY.CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.......
A0A6B9R1L8_9POXV/228-340             .ENVLLNI..SKTDIIKTHMLRKQDILGLDVNNLYATSKTD....................................GVPSIIKINK.SGVY.CFFKHLNYTIKYPVKN-FC.N.NIVIYGEAVRhvNDKQWKIYLIKLIEP..VVHDRLEEIKYVEK--i......
A0A223FMV0_9POXV/224-336             .ENVFLSP..IMKIPVNTYMLHKQDIPGLELENLYAVTKTD....................................GIPVTVKINS.TGIY.CYFTHIGYIIRYPAKKILD.T.TVVLFGEAIK..DKNQWSIYLIKLLEP..VINDRLEERSYIESKL.......
Q9EMR4_AMEPV/229-343                 s-NISLVT.iKNKPKIKTHMIQYNKLNTIDKESYIMAIKIDgdvvefnvmngicniiiydmvyknfscnidkniqmiGMGEYIKVDNvKKIYpFYFSKLSYNNKKIINNI--.-.----------..---------------..----------------ldrykqi
A0A1B1MRC8_9POXV/226-341             d-NIFFYY.qSPKMYPKTIMLKKQELLTLQLENLYIVGKTD....................................GVTTHVLVDQ.SGIL.CYFKHLGYAIKYKCNKKLT.G.VIELVCEAVKnqSNNTWTLYVIKVIKP..SMNDRLSELEFVNEEL.......
Q9DHN4_YLDV/224-336                  .ENVFLVP..SFKNPLKTYMLKKQDIAGLHLENLYATTKTD....................................GIGTIVKIKQ.NEIY.CHFSHINYCIKYLANRTIE.N.EILLYGEALK..HKGKWSIYLIKLMKP..KLENRIKEKDFVDENL.......
Q8V3L9_SWPV1/224-336                 .KNIYLYS..RFKNPIKTHMLKKQDITSIDLENLYITTKTD....................................GVGVLVKINK.NGIY.CYFQHLMYTIRYTLIKVLD.N.DVTIYGEAIK..QNNVWNIYLIKMIQP..VLVDRFNERDYVVSYL.......
B2CWI3_9POXV/220-332                 .DNIILDG..ILKPPVQTVMLKKNDLPGIDLTNLYVTTKTD....................................GVGVLITVTN.KGIY.CFFTHLQYTIRYDTTFKSD.N.PVTLYGEAIK..QNNVWHVYLIKLMTP..KLSDRFKEKDYVEEHL.......
H6TA69_9POXV/237-350                 .KNIFLKR..QLSYPIHTYMLKKQDISGISLDDLYITNKTD....................................GVGTYITILD.SGIY.CYFSHLNYTIRYDINKKIN.TtTVKLYGEGLK..YDGKWSIYLIKLITP..SFDDRFKEKEFVSNEL.......
#=GC seq_cons                        .-NVhLsP...hpsPl+TaML+KQDIsuL-L-sLYssoKTD....................................Glsshl+lss.sGIY.CYFoHLuYhIRYssp+pl-.s.plhLaGEAlK..tsphWslYLIKLlpP..slsDRlcEpcaVppcL.......
//