#=GF ID MCM2_N
#=GF AC PF12619.12
#=GF DE Mini-chromosome maintenance protein 2
#=GF AU Gavin OL;
#=GF SE Prosite
#=GF GA 23.60 23.60;
#=GF TC 23.70 23.70;
#=GF NC 23.50 23.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 16369567
#=GF RT The ATPase activity of MCM2-7 is dispensable for pre-RC assembly
#=GF RT but is required for DNA unwinding.
#=GF RA Ying CY, Gautier J;
#=GF RL EMBO J. 2005;24:4334-4344.
#=GF DR INTERPRO; IPR008045;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This domain family is found in eukaryotes, and is typically
#=GF CC between 138 and 153 amino acids in length. The family is found
#=GF CC in association with Pfam:PF00493. Mini-chromosome maintenance
#=GF CC (MCM) proteins are essential for DNA replication. These proteins
#=GF CC use ATPase activity to perform this function.
#=GF SQ 2311
#=GS A0A3B5ZW55_WHEAT/1-132 AC A0A3B5ZW55.1
#=GS MCM2_MOUSE/50-182 AC P97310.3
#=GS A0A6J1QER5_9HYME/26-159 AC A0A6J1QER5.1
#=GS A0A1B7N433_9AGAM/46-200 AC A0A1B7N433.1
#=GS A0A8H3U4V7_VENIN/18-156 AC A0A8H3U4V7.1
#=GS Q7K7J6_CAEEL/20-91 AC Q7K7J6.1
#=GS A0A090L9U3_STRRB/34-177 AC A0A090L9U3.1
#=GS A0A2T3ZYP4_TRIHA/1-121 AC A0A2T3ZYP4.1
#=GS A0A4W4HNF0_ELEEL/58-189 AC A0A4W4HNF0.1
#=GS A0A091HGD7_CALAN/37-169 AC A0A091HGD7.1
#=GS A0A226PTL0_COLVI/55-187 AC A0A226PTL0.1
#=GS A0A7K5EGZ2_POLCE/37-169 AC A0A7K5EGZ2.1
#=GS A0A7K5W8E2_9SYLV/35-167 AC A0A7K5W8E2.1
#=GS A0A8H7J462_9PLEO/53-198 AC A0A8H7J462.1
#=GS A0A2P8XD70_BLAGE/32-167 AC A0A2P8XD70.1
#=GS A0A0V0TM70_9BILA/42-197 AC A0A0V0TM70.1
#=GS A0A667XT31_9TELE/38-173 AC A0A667XT31.1
#=GS F7DDB3_HORSE/51-183 AC F7DDB3.2
#=GS A0A8B9YZE6_9AVES/36-168 AC A0A8B9YZE6.1
#=GS A0A2K6RAD1_RHIRO/51-185 AC A0A2K6RAD1.1
#=GS A0A0D2NB95_GOSRA/36-199 AC A0A0D2NB95.1
#=GS A0A4E0QY31_FASHE/39-180 AC A0A4E0QY31.1
#=GS A0A8H5LV11_9AGAR/63-213 AC A0A8H5LV11.1
#=GS A0A0D1YBK4_EXOME/50-200 AC A0A0D1YBK4.1
#=GS A0A091UYF5_PHORB/1-105 AC A0A091UYF5.1
#=GS A0A8J2IB94_9PLEO/44-190 AC A0A8J2IB94.1
#=GS A0A7L1J5M4_SMUAF/35-167 AC A0A7L1J5M4.1
#=GS A0A3P6T787_LITSI/10-167 AC A0A3P6T787.1
#=GS A0A7F8K695_DELLE/58-189 AC A0A7F8K695.1
#=GS A0A2U1KZ44_ARTAN/58-171 AC A0A2U1KZ44.1
#=GS A0A812IEX5_9DINO/10-174 AC A0A812IEX5.1
#=GS A0A5D2ZUZ2_GOSMU/36-201 AC A0A5D2ZUZ2.1
#=GS A0A7L2PQR5_9PASS/1-105 AC A0A7L2PQR5.1
#=GS A0A8E2F7F6_9PEZI/67-206 AC A0A8E2F7F6.1
#=GS A0A670Y648_PSETE/65-199 AC A0A670Y648.1
#=GS A0A0F4Z0Q2_TALEM/57-196 AC A0A0F4Z0Q2.1
#=GS A0A015KNS9_RHIIW/37-166 AC A0A015KNS9.1
#=GS A0A7L1BXA1_9PASS/37-169 AC A0A7L1BXA1.1
#=GS J4KNZ3_BEAB2/56-192 AC J4KNZ3.1
#=GS A0A8H7EKS9_9FUNG/43-184 AC A0A8H7EKS9.1
#=GS A0A668VGI8_OREAU/32-164 AC A0A668VGI8.1
#=GS A0A452Z5R2_AEGTS/80-254 AC A0A452Z5R2.1
#=GS A0A0A2VS76_BEABA/56-192 AC A0A0A2VS76.1
#=GS A0A0K9Q2T4_ZOSMR/31-198 AC A0A0K9Q2T4.1
#=GS A0A420YFU2_9PEZI/62-199 AC A0A420YFU2.1
#=GS A0A7H8QU58_9EURO/58-198 AC A0A7H8QU58.1
#=GS A0A2N3N4Z3_9PEZI/57-199 AC A0A2N3N4Z3.1
#=GS A0A0N1HUT8_9EURO/49-188 AC A0A0N1HUT8.1
#=GS A0A166CY20_9AGAM/57-214 AC A0A166CY20.1
#=GS A0A0D2AZD5_9EURO/52-192 AC A0A0D2AZD5.1
#=GS U5HJL8_USTV1/54-197 AC U5HJL8.1
#=GS A0A1B7P087_9EURO/59-196 AC A0A1B7P087.1
#=GS V7C891_PHAVU/36-198 AC V7C891.1
#=GS A0A4Q9M5W6_9MICR/9-117 AC A0A4Q9M5W6.1
#=GS A0A0N5CYV8_THECL/33-171 AC A0A0N5CYV8.1
#=GS A0A420HP57_9PEZI/45-184 AC A0A420HP57.1
#=GS A0A2J8A3I9_9CHLO/7-98 AC A0A2J8A3I9.1
#=GS A0A1V6YW98_PENNA/57-196 AC A0A1V6YW98.1
#=GS A0A5C3KLB1_9AGAR/50-203 AC A0A5C3KLB1.1
#=GS G3W5H9_SARHA/55-187 AC G3W5H9.2
#=GS A0A7L2FZU5_NYCGR/37-169 AC A0A7L2FZU5.1
#=GS A0A482WN63_LAOST/30-163 AC A0A482WN63.1
#=GS A0A8C4RAV0_EPTBU/35-166 AC A0A8C4RAV0.1
#=GS A0A093F010_GAVST/1-105 AC A0A093F010.1
#=GS A0A2T3ZG42_9HYPO/1-121 AC A0A2T3ZG42.1
#=GS A0A7R8UV44_HERIL/1-100 AC A0A7R8UV44.1
#=GS A0A452Z5P5_AEGTS/40-214 AC A0A452Z5P5.1
#=GS S8AK73_DACHA/43-183 AC S8AK73.1
#=GS E5R184_ARTGP/35-177 AC E5R184.1
#=GS A0A0A2L3H2_PENIT/57-196 AC A0A0A2L3H2.1
#=GS A0A7K6E2B7_9PASS/37-169 AC A0A7K6E2B7.1
#=GS A0A177DBS2_ALTAL/44-190 AC A0A177DBS2.1
#=GS A0A8C8CDG2_ONCTS/28-104 AC A0A8C8CDG2.1
#=GS A0A6I9N7G3_9TELE/35-169 AC A0A6I9N7G3.1
#=GS A0A851E9M4_9CORV/37-169 AC A0A851E9M4.1
#=GS A0A1V8UQE8_9PEZI/57-195 AC A0A1V8UQE8.1
#=GS A0A7J9BST6_GOSGO/36-192 AC A0A7J9BST6.1
#=GS R1E153_EMIHU/49-179 AC R1E153.1
#=GS A0A8H8S095_9HELO/75-215 AC A0A8H8S095.1
#=GS Q2UC60_ASPOR/56-192 AC Q2UC60.1
#=GS A0A226NAK4_CALSU/55-187 AC A0A226NAK4.1
#=GS A0A1G4B1G5_9PEZI/64-202 AC A0A1G4B1G5.1
#=GS A0A2S4W155_9BASI/44-195 AC A0A2S4W155.1
#=GS A0A5N5DPK9_9PEZI/54-192 AC A0A5N5DPK9.1
#=GS Q9XXI9_CAEEL/19-155 AC Q9XXI9.1
#=GS A0A4S4M5R1_9AGAM/51-203 AC A0A4S4M5R1.1
#=GS A7SMI2_NEMVE/1-106 AC A7SMI2.1
#=GS A0A484DDY0_PERFV/78-214 AC A0A484DDY0.1
#=GS A0A0L8HWR8_OCTBM/37-167 AC A0A0L8HWR8.1
#=GS A0A7L2H471_SAGSE/37-169 AC A0A7L2H471.1
#=GS A0A087Y1B3_POEFO/36-168 AC A0A087Y1B3.2
#=GS A0A7L3WQD4_9GRUI/37-169 AC A0A7L3WQD4.1
#=GS A0A8H4NTM5_9HYPO/43-177 AC A0A8H4NTM5.1
#=GS A0A0K9QAL5_SPIOL/41-205 AC A0A0K9QAL5.1
#=GS H0ET32_GLAL7/31-171 AC H0ET32.1
#=GS A0A8C4VQA6_9SAUR/1-107 AC A0A8C4VQA6.1
#=GS A0A8R1E5C8_CAEJA/21-159 AC A0A8R1E5C8.1
#=GS L8GYC9_ACACA/11-194 AC L8GYC9.1
#=GS A0A7J6ZTW8_9COLE/91-175 AC A0A7J6ZTW8.1
#=GS A0A162JGZ7_METRR/61-199 AC A0A162JGZ7.1
#=GS R0ILX8_9BRAS/38-196 AC R0ILX8.1
#=GS A0A8J4VAA1_9ROSI/40-206 AC A0A8J4VAA1.1
#=GS A0A7K5UVB5_9CORV/37-169 AC A0A7K5UVB5.1
#=GS A0A7K8AQC6_9CORV/37-169 AC A0A7K8AQC6.1
#=GS A0A673UQ04_SURSU/1-106 AC A0A673UQ04.1
#=GS A0A1B8DZC9_9PEZI/51-193 AC A0A1B8DZC9.1
#=GS A0A8R1Y7I2_ONCVO/39-169 AC A0A8R1Y7I2.1
#=GS A0A8H7XCG1_9HELO/50-191 AC A0A8H7XCG1.1
#=GS A0A167UT05_9PEZI/65-218 AC A0A167UT05.1
#=GS A0A2I3NGA5_PAPAN/51-182 AC A0A2I3NGA5.2
#=GS A7TRT0_VANPO/75-220 AC A7TRT0.1
#=GS A0A0S3R983_PHAAN/36-193 AC A0A0S3R983.1
#=GS A0A5N6NT55_9ASTR/439-559 AC A0A5N6NT55.1
#=GS A0A7K9JXC5_9PASE/37-169 AC A0A7K9JXC5.1
#=GS A0A812U838_9DINO/11-101 AC A0A812U838.1
#=GS A0A2K6LBD0_RHIBE/51-185 AC A0A2K6LBD0.1
#=GS A0A7L2X664_9PASS/37-169 AC A0A7L2X664.1
#=GS A0A8C8C689_ONCTS/37-113 AC A0A8C8C689.1
#=GS G0NBY3_CAEBE/13-169 AC G0NBY3.1
#=GS G0T1G7_RHOT2/19-165 AC G0T1G7.1
#=GS C5FCN5_ARTOC/64-204 AC C5FCN5.1
#=GS A0A1A0H652_9ASCO/38-182 AC A0A1A0H652.1
#=GS A0A8H4VSK7_9AGAR/42-194 AC A0A8H4VSK7.1
#=GS A0A1Y1Y6E6_9FUNG/40-170 AC A0A1Y1Y6E6.1
#=GS A0A8H4PJV4_9HYPO/58-199 AC A0A8H4PJV4.1
#=GS A0A7C8MGJ7_9PLEO/52-188 AC A0A7C8MGJ7.1
#=GS A0A6A3Q8K2_9STRA/114-249 AC A0A6A3Q8K2.1
#=GS W1PEG8_AMBTC/63-194 AC W1PEG8.1
#=GS A0A8C6H1R6_MUSSI/50-182 AC A0A8C6H1R6.1
#=GS A0A1B9FYX6_9TREE/66-213 AC A0A1B9FYX6.1
#=GS A0A3N4ISI4_ASCIM/44-181 AC A0A3N4ISI4.1
#=GS A0A8K0DL48_9ROSA/42-209 AC A0A8K0DL48.1
#=GS A0A017S4S1_ASPRC/58-196 AC A0A017S4S1.1
#=GS A0A5N6JS26_MONLA/60-206 AC A0A5N6JS26.1
#=GS A0A852CGV6_9PICI/35-167 AC A0A852CGV6.1
#=GS A0A2H3BZJ7_9AGAR/49-203 AC A0A2H3BZJ7.1
#=GS A0A8J6LDL1_TENMO/117-244 AC A0A8J6LDL1.1
#=GS A0A0D2DM29_9EURO/48-192 AC A0A0D2DM29.1
#=GS G2Q8E3_MYCTT/59-201 AC G2Q8E3.1
#=GS W2R0J8_PHYPN/68-170 AC W2R0J8.1
#=GS M3D3C1_SPHMS/56-194 AC M3D3C1.1
#=GS A0A1M3T6K0_ASPLC/58-195 AC A0A1M3T6K0.1
#=GS A0A7J8LUN1_9ROSI/36-198 AC A0A7J8LUN1.1
#=GS A0A2J6QBD2_9HELO/51-194 AC A0A2J6QBD2.1
#=GS I3MUT7_ICTTR/12-130 AC I3MUT7.2
#=GS A0A4P9WJD9_9FUNG/1-76 AC A0A4P9WJD9.1
#=GS A0A6P5THY1_PRUAV/40-203 AC A0A6P5THY1.1
#=GS A0A2K5LCM6_CERAT/51-182 AC A0A2K5LCM6.1
#=GS A0A3Q2EEN4_CYPVA/27-160 AC A0A3Q2EEN4.1
#=GS A0A498SPZ6_ACAVI/39-168 AC A0A498SPZ6.1
#=GS A0A0V1I201_9BILA/51-199 AC A0A0V1I201.1
#=GS A0A0D2Q0W2_GOSRA/36-193 AC A0A0D2Q0W2.1
#=GS A5E191_LODEL/92-252 AC A5E191.1
#=GS A0A7K9S440_9PASS/37-169 AC A0A7K9S440.1
#=GS A0A2P5AGS1_TREOI/34-208 AC A0A2P5AGS1.1
#=GS A0A340Y170_LIPVE/138-271 AC A0A340Y170.1
#=GS A0A8C0AN53_9AVES/52-184 AC A0A8C0AN53.1
#=GS A0A3R7MZA9_9TRYP/9-130 AC A0A3R7MZA9.1
#=GS A0A8D2ISN6_VARKO/48-183 AC A0A8D2ISN6.1
#=GS A0A316VBA4_9BASI/2-147 AC A0A316VBA4.1
#=GS A0A0J7KL85_LASNI/12-141 AC A0A0J7KL85.1
#=GS A0A4U5LRI1_STECR/12-155 AC A0A4U5LRI1.1
#=GS A0A8B7XMM7_ACAPL/36-166 AC A0A8B7XMM7.1
#=GS A0A852KLP2_UROIN/37-169 AC A0A852KLP2.1
#=GS A0A8C5WAP5_MICMU/50-181 AC A0A8C5WAP5.1
#=GS A0A183T5Q6_SCHSO/17-163 AC A0A183T5Q6.1
#=GS A0A7K6CEL8_PTIVI/37-169 AC A0A7K6CEL8.1
#=GS A0A7L2ZRW1_9PASE/37-169 AC A0A7L2ZRW1.1
#=GS A0A6P3GQC7_BISBI/22-152 AC A0A6P3GQC7.1
#=GS A0A319EUN8_ASPSB/58-195 AC A0A319EUN8.1
#=GS A0A6J1NVK8_BICAN/23-160 AC A0A6J1NVK8.1
#=GS H3AS78_LATCH/37-167 AC H3AS78.2
#=GS A0A2A9NUV1_9AGAR/1-83 AC A0A2A9NUV1.1
#=GS S7RWB7_GLOTA/1-85 AC S7RWB7.1
#=GS A0A177C7P3_9PLEO/47-185 AC A0A177C7P3.1
#=GS A0A2B7YXA5_9EURO/58-195 AC A0A2B7YXA5.1
#=GS A0A5C3NA96_9AGAM/47-204 AC A0A5C3NA96.1
#=GS A0A423TT33_PENVA/52-183 AC A0A423TT33.1
#=GS A0A0G4IM01_PLABS/2-102 AC A0A0G4IM01.1
#=GS A0A218VD52_9PASE/38-183 AC A0A218VD52.1
#=GS A0A851C0P7_CALVR/38-170 AC A0A851C0P7.1
#=GS A0A8C6Z665_NOTPE/37-169 AC A0A8C6Z665.1
#=GS A0A178F800_TRIRU/55-196 AC A0A178F800.1
#=GS A0A078BEG2_STYLE/53-197 AC A0A078BEG2.1
#=GS A0A7K9Q788_IRECY/37-169 AC A0A7K9Q788.1
#=GS A0A448ZB76_9STRA/118-276 AC A0A448ZB76.1
#=GS A0A194UUT4_9PEZI/62-199 AC A0A194UUT4.1
#=GS A0A7L4IYY0_9PASS/37-169 AC A0A7L4IYY0.1
#=GS A0A851YYE9_9AVES/37-169 AC A0A851YYE9.1
#=GS A0A8C8CFE0_ONCTS/37-157 AC A0A8C8CFE0.1
#=GS A0A068RF56_9FUNG/50-190 AC A0A068RF56.1
#=GS A0A1Y2D657_9FUNG/39-178 AC A0A1Y2D657.1
#=GS A0A452Z5M2_AEGTS/21-195 AC A0A452Z5M2.1
#=GS A0A673Z3C5_SALTR/50-178 AC A0A673Z3C5.1
#=GS A0A2T3B4J9_AMORE/57-197 AC A0A2T3B4J9.1
#=GS A0A7K5M802_CARCD/35-167 AC A0A7K5M802.1
#=GS A0A484B2R2_DRONA/35-166 AC A0A484B2R2.1
#=GS A0A6V7Y4G4_9BILA/17-163 AC A0A6V7Y4G4.1
#=GS A0A4W6DHG9_LATCA/38-172 AC A0A4W6DHG9.1
#=GS C1GZP9_PARBA/58-201 AC C1GZP9.2
#=GS A0A6G0U7F6_APHGL/28-166 AC A0A6G0U7F6.1
#=GS A0A135V679_9PEZI/56-197 AC A0A135V679.1
#=GS A0A7L2DAW1_CATFU/35-167 AC A0A7L2DAW1.1
#=GS A0A1S3CNN0_CUCME/43-207 AC A0A1S3CNN0.1
#=GS A0A0P7B6B1_9HYPO/58-198 AC A0A0P7B6B1.1
#=GS A0A8C9GRH7_9PRIM/51-182 AC A0A8C9GRH7.1
#=GS A0A8B7E2I0_HYDVU/2-109 AC A0A8B7E2I0.1
#=GS A0A3M6V6E2_POCDA/32-163 AC A0A3M6V6E2.1
#=GS A0A0U5GD16_ASPCI/53-192 AC A0A0U5GD16.1
#=GS A0A7K9BNE0_9PICI/37-169 AC A0A7K9BNE0.1
#=GS A0A317SZF8_9PEZI/1-107 AC A0A317SZF8.1
#=GS A0A8P0T425_CANLF/50-182 AC A0A8P0T425.1
#=GS A0A0V0TMC2_9BILA/42-197 AC A0A0V0TMC2.1
#=GS A0A2S4PYC0_9PEZI/45-184 AC A0A2S4PYC0.1
#=GS A0A852FH04_PEUTA/35-167 AC A0A852FH04.1
#=GS A0A1B8CKH4_9PEZI/48-200 AC A0A1B8CKH4.1
#=GS A0A093RCB4_PHACA/2-126 AC A0A093RCB4.1
#=GS A0A8B8AXB8_CRAVI/40-170 AC A0A8B8AXB8.1
#=GS S8ECA7_FOMPI/1-120 AC S8ECA7.1
#=GS A0A8C6E899_MOSMO/1-106 AC A0A8C6E899.1
#=GS A0A8C8WN11_PANLE/50-182 AC A0A8C8WN11.1
#=GS A0A420U7Z5_FUSOX/55-189 AC A0A420U7Z5.1
#=GS A0A2P4T0C9_BAMTH/36-167 AC A0A2P4T0C9.1
#=GS A0A2Y9MMB1_DELLE/52-183 AC A0A2Y9MMB1.1
#=GS A0A409WN59_PSICY/44-196 AC A0A409WN59.1
#=GS A0A8H4XFJ8_9HYPO/24-163 AC A0A8H4XFJ8.1
#=GS A0A8C8HRQ7_ONCTS/36-165 AC A0A8C8HRQ7.1
#=GS A1CL94_ASPCL/58-195 AC A1CL94.1
#=GS W7MG18_GIBM7/55-189 AC W7MG18.1
#=GS A0A2T6ZBQ0_TUBBO/55-194 AC A0A2T6ZBQ0.1
#=GS A0A4Q1BW74_TREME/58-208 AC A0A4Q1BW74.1
#=GS A0A067R1R5_ZOONE/29-163 AC A0A067R1R5.1
#=GS A0A4W2C818_BOBOX/1-63 AC A0A4W2C818.1
#=GS A0A0F8A2X4_9HYPO/62-199 AC A0A0F8A2X4.1
#=GS Q6C2W1_YARLI/31-166 AC Q6C2W1.1
#=GS A0A6A3JCG6_9STRA/138-260 AC A0A6A3JCG6.1
#=GS L2GB05_COLFN/56-198 AC L2GB05.1
#=GS A0A0V1CD84_TRIBR/42-197 AC A0A0V1CD84.1
#=GS A0A6J3KAB2_9HYME/25-155 AC A0A6J3KAB2.1
#=GS A0A1F7ZYI5_9EURO/57-193 AC A0A1F7ZYI5.1
#=GS A0A2G5DBN9_AQUCA/36-199 AC A0A2G5DBN9.1
#=GS A0A2G3CEJ8_CAPCH/56-213 AC A0A2G3CEJ8.1
#=GS Q4Q8I2_LEIMA/30-178 AC Q4Q8I2.1
#=GS A0A4Z1PGC5_9PEZI/50-194 AC A0A4Z1PGC5.1
#=GS F6XZD4_ORNAN/54-186 AC F6XZD4.3
#=GS K7UQQ7_MAIZE/41-217 AC K7UQQ7.1
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#=GC seq_cons .......................................................................................-E-E...-GE-Lhu.-s...h....E........c.............DY......Rs..h.s.......E.....LDpY.E.u......cs..l-....D...-...p...D..h.-..E...l..s....h.usRcAAEtthcpRDRchs......................ttcp+.............uh........L....D...sD...D-p....................t...st.p....+R...+.....Rcth..........tts....................ts.t.t.h.--........................t....t-.......SlEsLpDhKuts.h.................................................................................................
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