#=GF ID   MCR_D
#=GF AC   PF02505.18
#=GF DE   Methyl-coenzyme M reductase operon protein D
#=GF AU   Mian N;0000-0003-4284-4749
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_2115 (release 5.4)
#=GF GA   25.00 25.00;
#=GF TC   25.00 46.60;
#=GF NC   23.20 23.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8863453
#=GF RT   Phylogeny of Methanopyrus kandleri based on methyl coenzyme M
#=GF RT   reductase operons. 
#=GF RA   Nolling J, Elfner A, Palmer JR, Steigerwald VJ, Pihl TD, Lake
#=GF RA   JA, Reeve JN; 
#=GF RL   Int J Syst Bacteriol 1996;46:1170-1173.
#=GF RN   [2]
#=GF RM   3170483
#=GF RT   Structure and comparative analysis of the genes encoding
#=GF RT   component C of methyl coenzyme M reductase in the extremely
#=GF RT   thermophilic archaebacterium Methanothermus fervidus. 
#=GF RA   Weil CF, Cram DS, Sherf BA, Reeve JN; 
#=GF RL   J Bacteriol 1988;170:4718-4726.
#=GF DR   INTERPRO; IPR003901;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Methyl coenzyme M reductase (MCR) catalyses the final step in
#=GF CC   methanogenesis. MCR is composed of three subunits, alpha 
#=GF CC   (Pfam:PF02249), beta (Pfam:PF02241) and gamma (Pfam:PF02240)
#=GF CC   [1]. Genes encoding the beta (mcrB) and gamma (mcrG) subunits
#=GF CC   are separated by two open reading frames coding for two proteins
#=GF CC   C and D [2]. The function of proteins C and D (this  family) is
#=GF CC   unknown.
#=GF SQ   88
#=GS A0A110A3F8_THEX5/15-140  AC A0A110A3F8.1
#=GS A0A1D3L4R9_9EURY/2-136   AC A0A1D3L4R9.1
#=GS B8GE90_METPE/8-149       AC B8GE90.1
#=GS M9SHS0_METAX/15-141      AC M9SHS0.2
#=GS L0HJW7_METFS/8-149       AC L0HJW7.1
#=GS A0A0Q4B5G7_9ARCH/13-139  AC A0A0Q4B5G7.1
#=GS D1YVW3_METPS/13-152      AC D1YVW3.1
#=GS A0A6B9T9X5_9ARCH/18-143  AC A0A6B9T9X5.1
#=GS A0A0Q4B337_9ARCH/4-130   AC A0A0Q4B337.1
#=GS A0A1F2P9G5_9EURY/49-128  AC A0A1F2P9G5.1
#=GS A0A1D2W9X6_9EURY/8-156   AC A0A1D2W9X6.1
#=GS D3E053_METRM/2-141       AC D3E053.1
#=GS F6BE94_METIK/3-148       AC F6BE94.1
#=GS W9DQG9_METTI/12-153      AC W9DQG9.1
#=GS D7DUH2_METV3/3-148       AC D7DUH2.1
#=GS A7I5U2_METB6/8-150       AC A7I5U2.1
#=GS A6UWG9_META3/3-148       AC A6UWG9.1
#=GS L0HF34_METFS/10-152      AC L0HF34.1
#=GS F1SVE8_METKA/13-163      AC F1SVE8.1
#=GS A0A062V6Q2_9EURY/13-163  AC A0A062V6Q2.1
#=GS A0A1D2WA08_9EURY/2-137   AC A0A1D2WA08.1
#=GS A0A8J8B542_9EURY/8-149   AC A0A8J8B542.1
#=GS A0A0X3BM21_9EURY/8-149   AC A0A0X3BM21.1
#=GS A0A483CQJ0_9EURY/8-149   AC A0A483CQJ0.1
#=GS A0A2V2MWE9_9EURY/8-150   AC A0A2V2MWE9.1
#=GS A0A1Q6DVN8_9EURY/3-126   AC A0A1Q6DVN8.1
#=GS A0A8J7YH42_9EURY/3-148   AC A0A8J7YH42.1
#=GS F0TCV3_METLA/8-156       AC F0TCV3.1
#=GS R9SP78_9EURY/2-142       AC R9SP78.1
#=GS A0A8J7S1T9_9EURY/1-137   AC A0A8J7S1T9.1
#=GS U6EC36_9EURY/2-136       AC U6EC36.1
#=GS A0A1Y3GAR2_9EURY/4-138   AC A0A1Y3GAR2.1
#=GS A2STS2_METLZ/8-150       AC A2STS2.1
#=GS A0A0E3L5N2_9EURY/13-154  AC A0A0E3L5N2.1
#=GS L0KYV7_METHD/13-154      AC L0KYV7.1
#=GS I7J9I9_METBM/8-151       AC I7J9I9.1
#=GS Q12TF5_METBU/13-154      AC Q12TF5.1
#=GS E3GZ54_METFV/2-135       AC E3GZ54.1
#=GS A0A1V6N4G6_METAZ/2-139   AC A0A1V6N4G6.1
#=GS A0A2Z4L887_9EURY/15-163  AC A0A2Z4L887.1
#=GS I7KD24_METBM/51-192      AC I7KD24.1
#=GS G7WN22_METH6/11-153      AC G7WN22.1
#=GS Q0W5P0_METAR/19-159      AC Q0W5P0.1
#=GS A0A1F2P4Q0_9EURY/14-129  AC A0A1F2P4Q0.1
#=GS F4BXY3_METSG/11-152      AC F4BXY3.1
#=GS A0A1D2WB23_9EURY/2-137   AC A0A1D2WB23.1
#=GS MCRW_METTH/9-157         AC Q50485.2
#=GS A0A166CF39_9EURY/2-139   AC A0A166CF39.1
#=GS F0T8R0_METLA/2-136       AC F0T8R0.1
#=GS A0A0A7LAM9_9ARCH/16-140  AC A0A0A7LAM9.1
#=GS A0A328S3N1_9EURY/15-163  AC A0A328S3N1.1
#=GS A0B6N8_METTP/14-155      AC A0B6N8.1
#=GS A0A498GYM4_9EURY/8-150   AC A0A498GYM4.1
#=GS H1YXI2_9EURY/10-149      AC H1YXI2.1
#=GS A0A483CYB8_9EURY/8-149   AC A0A483CYB8.1
#=GS D1YW09_METPS/17-157      AC D1YW09.1
#=GS MCRD_METTH/2-135         AC O27235.1
#=GS A0A8J7S024_9EURY/8-150   AC A0A8J7S024.1
#=GS MCRD_METJA/5-153         AC Q58253.1
#=GS A0A484F515_9EURY/20-161  AC A0A484F515.1
#=GS E1RDX7_METP4/10-152      AC E1RDX7.1
#=GS A0A062V0J7_9EURY/13-163  AC A0A062V0J7.1
#=GS Q2FSN3_METHJ/8-150       AC Q2FSN3.1
#=GS Q8THG8_METAC/13-154      AC Q8THG8.1
#=GS Q2NI01_METST/20-168      AC Q2NI01.1
#=GS F6BBJ0_METIK/10-159      AC F6BBJ0.1
#=GS F7XL11_METZD/12-153      AC F7XL11.1
#=GS A0A0X3BPL7_9EURY/8-151   AC A0A0X3BPL7.1
#=GS Q8PXH5_METMA/13-154      AC Q8PXH5.1
#=GS A0A366M859_9EURY/2-139   AC A0A366M859.1
#=GS A0A4E0PYS3_9EURY/12-153  AC A0A4E0PYS3.1
#=GS A0A328PI59_9EURY/2-137   AC A0A328PI59.1
#=GS D7E8Y0_METEZ/14-155      AC D7E8Y0.1
#=GS A0A2U1S6W9_9EURY/2-141   AC A0A2U1S6W9.1
#=GS M4YM91_THEXX/1-123       AC M4YM91.1
#=GS U6EEL5_9EURY/8-156       AC U6EEL5.1
#=GS A0A315XKW4_9EURY/2-141   AC A0A315XKW4.1
#=GS A0A328S7V5_9EURY/9-157   AC A0A328S7V5.1
#=GS R9TBQ1_METII/13-137      AC R9TBQ1.1
#=GS D5EAD9_METMS/13-154      AC D5EAD9.1
#=GS Q0W342_METAR/13-153      AC Q0W342.1
#=GS MCRW_METJA/16-162        AC Q57582.1
#=GS A0A166F276_9EURY/2-139   AC A0A166F276.1
#=GS A0A2V3JKK1_9EURY/11-154  AC A0A2V3JKK1.1
#=GS A0A0W7TIG7_9ARCH/1-122   AC A0A0W7TIG7.1
#=GS Q6LWZ8_METMP/3-148       AC Q6LWZ8.1
#=GS A0A166A6P3_9EURY/2-139   AC A0A166A6P3.1
#=GS MCRW_METFV/11-160        AC Q49172.1
A0A110A3F8_THEX5/15-140             ..EVRVMTNRLLSAETTEKILNDID.VI.PNLRQINMSGESLPRTISSGPAKGLANNHTERKVIHVNGHEVELHCLVGAFYIELSvtdeaeMDKTVDEIKAAFDRTIP...DGYTIDVGR..YSKYRPSLHDY------.........------------------rs.............
A0A1D3L4R9_9EURY/2-136              ..DIEIFPHRLLSADTTERLLNDLE.KI.EGVERMVLHGQRLPQG----------SDNPDRRTIKINGEEVELQIKTGRVLMEID......SEETIDEVREICEEHLP...FGYNIHMGL..FIRKQKTVTDQIKYGEKl......eeVSEDMIGLTDQNAKLSE-r..............
B8GE90_METPE/8-149                  ..QCRIVPERLLNPSTVERLLNLLV.TI.ESIRKILIKGSSIPPAVPYGPARGALNPHSMRRTIMVGEQPVELTVHVGIIDMELE......DRDALPQIKAACEEVFT..qFTYSIKEGR..FMKTQASTSDYAKYGPD.........ADELLLGLADPKSRK---gp.............
M9SHS0_METAX/15-141                 ..EVRIMTNRLLSAESTEAVLNAID.KI.EHIRQVNMAGESLPATISSGPAKGLPNNHTERKIIHVDGREVELHCLVGAFYIELEvddsdmLEAVVKEIREACDKTIV...DGYTLDIGR..YSKYRPTLNDY------.........------------------rsa............
L0HJW7_METFS/8-149                  ..QCRIDSERFMNPETTERLLNQII.SV.PGVRRMVLNGPRLPATVPYGPSKGIANPHPMRKTIRVGDQEMELQVHVGTVLLELE......NRDIIPALKAAIEPVFK..dFSFHMKEGR..FMKTEPSLVDYCKYGPD.........ADKEILGLADPNSKS---rp.............
A0A0Q4B5G7_9ARCH/13-139             .e-VLIFPHRLLSADTTEKLLNRVY.EV.PHVRQINVSGEGLPAKVTSGPHAGLPVEHPQRKVITVKGKEVELTLQVGRIFVEIDdi..dnLQGALDEIEKICQEILT...FGFNLEVGR..YSKYRPTVTDYKK----.........------------------gkr............
D1YVW3_METPS/13-152                 ..QLEIFPSRLLTVETAQKLLNELN.KI.SGITRMVVYGPGLPKDDPKDLLEGK--FEAQKRYLNILGEQVELTVQVGRVWVEVE......DIAVKDKIREACEKTLP...FSFDINEGL..YLRTRKTITDYVRKGGN.........VDDISLGMFDPKSRRK--ps.............
A0A6B9T9X5_9ARCH/18-143             ..EVQILTNRLLSAETTEKVLNALD.II.PNIRQINMTGESLPKTINSGPGKGLPNNHSERKVIHVGGQEVELRYLVGGFYIELDvedeetLDKRLEEIKEACNATIE...HGYTLQVGR..YSKYKPTLHDY------.........------------------rs.............
A0A0Q4B337_9ARCH/4-130              ..EIRITTKRLLGAESTEKVLNALS.AL.DNIRQITIKGENLPAKINSGPNKGLDNNHPERRMIRFGDKDILLTKLVGDFFLELEvenedmLSASVEEIDRICKEVIP...FGFTMDVGR..YSKYRPTLSDY------.........------------------klr............
A0A1F2P9G5_9EURY/49-128             fa-----------------------.--.--------------------------------RDLEIGDAKLKTTVKIGKLFVGIS......KASAEDEIRSICDDLFT...FPYHLHVGR..FSKDRPTIVDVLG----.........------------------kssykrigvlekrsn
A0A1D2W9X6_9EURY/8-156              ..DVKIFPHRLLKPKTTEKILNSII.DL.DGILRVLVNGKSLPRVVGYGPAKGTIVNHEDRKVIKVKEENFELLVSVGEIIVTVNh...ekLDSFKEELERILSDALN...FRYDVSVGI..FTKTNITVSDYMKYGIGfd.....ksIDPRLIGMVDPSAKSSE-t..............
D3E053_METRM/2-141                  ..DIEIFPHRILGTDTTEKVLNDLE.SL.DSVKRTVIQGPRLP------PQDEIDRIYGDRRIIVVNGEEVELKVKTGRIFVELY......DESGIEEIRAICDKHID...TGFDINTSKaqYIRKQKTVTDGLKYGENt.......eIPEELIGIADTRSKFNE-h..............
F6BE94_METIK/3-148                  ..EVEVFPHRYLKATTTEKFLNKVY.AL.ETTERIIIHGQPLPKTVYYGPAKGTPVNHSERKIISVGGVPVELTVMAGRFWITLK......DDSELDKLKEICEELFP...FGYNIKVGK..FLKDKPTVTDYIKYGERfv.....neIDKRLIGITDPRSKFES-a..............
W9DQG9_METTI/12-153                 ..QLEIFPSRLLKPETAQNLLSEIA.EV.EGIIRLFVHGPRLPQTVPYGPATGMPVNHPGNAVIEVAGQAIELAVSVGSIRMEVV......DVDVKEQVREVCEKVLT...VPFEFREGR..FIPTRQTVSDYARRGPN.........ADPLMTGMTDPKGKLKN-n..............
D7DUH2_METV3/3-148                  ..EIEVFPHRFLKATTTEKFLNSAY.KL.ETVQRVILHGESLPQKVGYGPAKGAPVNHSERKLINVNGVEVQLTLQVGRFWILLD......NENELSKIDEICNELFP...FGYRVSEGR..FIKDSPTVTDYLKYGESfv.....nsIDKRMLGVTDPRSRFEN-s..............
A7I5U2_METB6/8-150                  ..QCRIVTERLLNPETTELLLNRLV.DI.PGIRRMVLNGPRLPAIVTYGPAKGMPNPHSMRRAIHVGDQDMDLQVHVGTVLLEVE......SRDVIPALKAACEEVFT..hFAFRIQEGK..YMKTEPSLVDYCKYGPD.........ADKSVLGLADPSSKSR--pt.............
A6UWG9_META3/3-148                  ..EIEVFPHRFLKADTTEKFLNDIY.SI.ETVERVIVHGQPLPKTVYYGPARGTPVNHPERKEVLVNGVPVELTVMAGRFWILLE......NDNELNKIEEICKSLFP...YGYNLNVGK..FTRDSPTTTDYMKYGEKlv.....nsMDRKMIGLTDPRSKFAS-s..............
L0HF34_METFS/10-152                 ..QCRIVPMRLLSPDTTKRLLERIV.PV.PGIRRMLLNGQNIPVVVPYGPARGTANKTNLRKSIEIAGNTVDLHVQVGTITLEVE......DKSVIAAIRAICDNYFV..nFPCSVQEGR..FMKTRPSLVDYAKYGPE.........ADPSVIGLVDPKRKEK--pa.............
F1SVE8_METKA/13-163                 ..EVQIFPQRLLSADTTEKLLNELLeRV.EGIGRIVIHGPGLPKAVPFGPARGKPVKHPERRPIEVHGEKIPMKVQTGQIIVEIEde..drLDDIVEEIEKICREILP...CDFEVQVGR..FTRHKPTVTDYLKFGEEgv.....kkLDKRLLGLVEPRARLAD-r..............
A0A062V6Q2_9EURY/13-163             ..QIRIFPQRLLQPETTEKVLNDID.QV.KGVIRMLLNGKNLPRKVTSGPGTGADVNHPDRKIINVGDCAFELHIIVGEILVEVE......NEGAMEEVREACERTLP...FPFEFRRGH..FIKRKPTLTDYGKYGFRsrnderinlEDERIIGLTDPHAKTED-n..............
A0A1D2WA08_9EURY/2-137              ..DIEIFPHRYLSADTTENLLKDLD.EI.GGVKRMVLQGQRLPP------AE---SGHPDRRIITLKGQEIDLQVKTGRILIEIE......AEPVIDELRDVCENHLP...FGFNIHVGT..YIRRQKTVTDKLKYGEKl......geIPDELIGLTDQNAQLSE-r..............
A0A8J8B542_9EURY/8-149              ..QIRIVPARFLTPDTAEDLLNEIL.AK.TGIRRIVLNGPRVPEIVPYGPARGTPNVVAQRREIEVQGETIKLQVQVGTILIELE......DASPIPEIRKACETVLT..nFPFTLQEGR..FMRSSMTMTDYAKYGVV.........EDERILGMVDPKSKT---rp.............
A0A0X3BM21_9EURY/8-149              ..QVRIVPLRMLKPETTERLLNTLA.GI.AGIRRMMIHGPGLPATVPYGPARGSPNPHSDRRAIHVGDAEIALRIQAGEVILEVE......DSSVIEEIRSHCDDFFT..eFPYQLQEGR..FMKTAPTLVDYAKFGPD.........ADTTLIGLADPRS-----gedp...........
A0A483CQJ0_9EURY/8-149              ..QCRIVPLRLLSPQTAEKFLGRCA.EV.PGIRRIVINGPGLPATVPYGPARGSANPNSNRRTIQVGGAAVEMKVQAGTFILEVD......DEGVIEEIRTVCDEFFT..aIPYRLQTGR..FMKSSPSLVDYAKYGPN.........VDEAVVGLVDPRKR----dgp............
A0A2V2MWE9_9EURY/8-150              ..QCRIVTERLLKPETVEKILNKLV.AI.EGIRRIVINGPSIPQLVPYGPARGLPNPHSGRVRIVVGGTDVDLRVQVGTILLELE......TRDIVPRIDEACREVFV..nFTYGLKEGK..FMRSTPTQTDYAKYGPG.........ADEMMIGIVDPKNKT---gpt............
A0A1Q6DVN8_9EURY/3-126              ..EVQIFPEKLLLAETTKELATKLS.KI.NEVEEILVHGPTLPKKVPYGPAKGKDNPHSERGKLQVRGEEVELNVQVGRVFVRVDes.kssLEDILEKLVDVCEETIS...CGFDIGQGR..FEKKESS----------.........------------------segnm..........
A0A8J7YH42_9EURY/3-148              ..EIEVFPHRYLKAKTTERFLNEVY.SL.STVDRVIIHGQSLPKTVYYGPARGTPVNHPERKIIDVHGVPVELTVMAGRFWITLE......DDSEVEKLENICKSMFP...YGYNLKVGK..FTRDKSTVTDYMKYGEIlv.....nrMDRSLIGLTDPRSKYES-s..............
F0TCV3_METLA/8-156                  ..DVKIFPYRRLKPQTTEKVLNGIM.EF.DGVLRVLVNGNSIPKVVNYGPAKGTPVNHEDRKVIGVKNENIELCVSVGELIITVNy...deLESFMEKLDTLLKETLT...MKYDVKTGI..FTKTDITVSDYIKIGLGle.....ngIDPSLIGLVDPNSKSSE-t..............
R9SP78_9EURY/2-142                  ..DIEIFPHRMLGPDTTEKILNDIE.SL.EDVNRTIIHGPRLPPDDPDLLPQ-----YKERREIVVKGQPITLKVKTGRILVELT......SESTINEIDKICSEYLP...FGYDINTSRreYIRKQRTVSDAIKYGPDd.......nLPDELVGMTDARRQMAD-d..............
A0A8J7S1T9_9EURY/1-137              ..----MPARFLNPETVERLLNRIL.EV.GGIRRLVLNGPRLPTTVPYGPARGTPNPHPMRKVIRVGDQDMELQVHVGTILLELE......DRSYIDPIRQACDEVFV..kFPYGFTEGK..FIKTQATVSDYAKYGPD.........ADTFILGMTDPKSR----gg.............
U6EC36_9EURY/2-136                  ..DIEIFPHRLLSADTTEKLLNNLE.GI.EGVKRMVIQGQRLPQT----------EDNPDRRVITILGEEIDLQVKTGRVLLEIE......DESVIEQVKSICEDQLP...FGYNIHVGT..FIRKQKTVTDDIKYGEAv......deIPDEMIGLTDQNAQLSE-r..............
A0A1Y3GAR2_9EURY/4-138              ..QVQIFPDRLLLGDTASEVITQLS.EI.DEVREIVVTGPRIPKRVPYGPAKGIENPHTERKKLKIMDKETDLEVKVGRIILDLDae.dddVDPIIGDITEICDIKIS...CDYNIETGQ..YTKPKPTVTEYMRYGKK.........PDKE--------------nk.............
A2STS2_METLZ/8-150                  ..QLRIVPTRFLNPETTEILLEKIY.TI.DGIRRLVLNGPNLPATVPYGPARGTVNDNSLRRIIKVCGEDYLLHVQVGAILLELE......DASVIPLVKAACDEVFAd.kFPYGITEGT..YMRSNMTTTDYAKYGIV.........DDKRILGMSDPKSKQ---rp.............
A0A0E3L5N2_9EURY/13-154             ..QIEIFPRRILSPETAQVLLAELY.KV.DGVIRVIVQGQRLPEKVSSGPGTGEKVEHPLRKPIQIGDQLIEMKVSVGRIQMELA......SPEAKEKVREVCDKVLS...FPFEFREGN..FMRRKATVSDYAKLGSD.........ADPTLLGMVDPKAKHED-n..............
L0KYV7_METHD/13-154                 ..QLEIVPQRLLRPETAQDLLNKIL.DL.EGVIRLFIHGPRLPGTVPYGPAKGTALVHDSRRLIEIEGKAVELMVSVGSIRLEVT......DADVKEQVHEICEKILP...FPFEFREGN..FMLRRQTVSGYARFGPD.........QDPLLVGMTDPKGKLKD-q..............
I7J9I9_METBM/8-151                  ..QVRIVSARFLRPDTVEQLLNRLV.QV.GGIRRMSINGPSLPATVPYGPARGKPNPHPDRKAIRVGNQDVQLQVQVGTIILELE......DESYIPAIGEAVDEVFAekdFSCTVQQGR..YMKTRPSMSDYARYGPD.........ADREILGIVDPRRK----dgp............
Q12TF5_METBU/13-154                 ..QIEICPARFLSPETAQRLLNELS.NI.EGITRAFVHGPRLPKTVPYGPATGHDVDHKFSKNIQIGETDMDLAVIVGRIRLEIL......NEEIRENIREVCERTLP...MGYEFRQGL..FIQRRQTVSDYAKRGPG.........ADPTTLGLADPKGKVG--nr.............
E3GZ54_METFV/2-135                  ..DVEIFPHRLLSAETTEKLLNKLG.EI.EGIKRMIIQGQRLPAG-----------EHPDRRVINVKGQDIELKVKTGRIFVEIE......DKKTMEKIKEVCDEVFP...FKYELIPGT..FFRRQKTVTDAIKFGKDv......dkLPTELVGMTDQSARLKD-r..............
A0A1V6N4G6_METAZ/2-139              ..DIEVFPHRVLGADTTEKLLNGIE.SL.DDVKRTVIQGPRLPPE---DPNED--PRYVDRRKITVNGKELELKVKTGRIFVEIS......NESTIDDIREICNEYLP...FGFDINIGK..YIRTQKTVSDNIKYGDA........dIPEELIGMTDQSAKLAD-r..............
A0A2Z4L887_9EURY/15-163             ..DVKIFPYRILKPETAESILNEVM.VL.DGVLRVLINGESLPTVVNFGPARGLPVNHTDRKTINVKGNDVPLRVSVGEIILTVQl...dnLEDFVEKVDEILENTLS...FGYDLKVGV..FTKTQTSVSDYMKYGKGfe.....dkIDSRLIGLVDPNAKSSE-t..............
I7KD24_METBM/51-192                 ..QVRIVPLRMLKPETTERLLNTLA.GI.AGIRRMMIHGPGLPATVPYGPARGSPNPHSDRRAIHVGDAEIALAIQAGEVILEVE......DSSVIEEIRSHCDDFFT..eFPYQLQEGR..FMKTAPTLVDYAKFGPD.........ADTTLIGLADPRS-----gedp...........
G7WN22_METH6/11-153                 ..QIEIFPQRFLKPDTAQRLLEEIY.SS.GGILRIMIQGPNLPKSVPYGPGKGIPIEEHLNMLLELGDSALELRVKVGRIWLELD......SEERIEGVKAACERVLP...CTFSIKRKQ..LFHTKPTVSDYAKYGSE........vEDKRILGLVDPKAKRE--rd.............
Q0W5P0_METAR/19-159                 ..QIEVFPLRVLNVETAQKLIDELN.KI.DGITRMVVHGPRLPRENPDDLLEGK-FGATDKKYLNIKGEQVELTVQVGRIWIEIT......DTPVIEQVRAAAEKTLP...FPFEMYEGV..YIRTKKTLSDYVRKGGN.........VDDISVGLFDPKAKARS-s..............
A0A1F2P4Q0_9EURY/14-129             .e-VVIIPERLLGDETTEKLLERFQ.AI.DGIVNIILQGPNY-----------------LSRHLRVGEQKIHTTVKVGKIFIGIS......KESTIDEIKGVCDDILA...FPYDLAVGR..FSKTRPTVSDALGKSS-.........------------------yrdigildrk.....
F4BXY3_METSG/11-152                 ..QVEITPQRYLMPATAQKLLNAIY.EN.GGITRIMIHGPNLPRTIPYGPGKGTPIDEHKDLLIEVAGQVFELGVKVGRVRLELE......SEKYMPGLEAACERALP...FSFQIKRGR..FFRNSPTLSDYAKYGDV.........EDKRLLGLIDPKARKE--kl.............
A0A1D2WB23_9EURY/2-137              ..DIEIFPHRLLNVDTAERLLNDLD.SI.EGIKRMIIHGPRLPPV------R---EGHPDRRIIVVSGEEVEVQVKPGRILLEIE......SEDVIEDVKEVCEDHLP...FGYNIHIGH..FIRKQKTVSDQLKYGEEl......dnIPDEMVGLTDQNAQLSE-r..............
MCRW_METTH/9-157                    ..DVKIFPQRLLKPETAEKLLNRIY.EL.EGIVRVLVHGPSIPDRVYYGPARGTEVNHSDRRKITVRGEEFELRVKVGEIIVGMLp...etLEEKMETIEEILDEVLP...CSYKVFIGA..FTKKDITISDYLKYGLKfe.....ekIDPRVIGMVDPSSRMKD-t..............
A0A166CF39_9EURY/2-139              ..DIQIFPHRILSADTTELVLNKIE.AL.DDVHRTVINGPRLPPEDLDLPPQ-----YREKRTINVQGKEIDLKVQTGRIFVEIS......QESTIDEVKNICQDAFP...FGFEINIGK..FMRTQKTVTDHMKYGDE........kIPDEYIGMTDQSAKLSD-r..............
F0T8R0_METLA/2-136                  ..DIEIFPHRLLNPETTESLLNALD.EI.DGVKTIVLQGQRLPPE----------AINSDHTTITVKGEEVDLQVKTGRVLMEID......TEDTIELVRQKCEENLS...FGFNVHVGT..FIRKQKTVSDKIKYGEAl......enVPDEMVGLTDQNALL---ser............
A0A0A7LAM9_9ARCH/16-140             ..EVEVFSNVLLSHGTTEKVLNALD.PI.KHIRQINMTGESLPKNLNSGPAKGLPNDHSERKVIKVGGRDVELRFLVGAFYIELDveneamLDEAVKKIKAACDATLP...RGFSLTVGR..YSKYRKTLRDY------.........------------------r..............
A0A328S3N1_9EURY/15-163             ..DVKIFPHRILKPTTTEKILNQIL.QL.DGLLRVLINGKSLPAIVTFGPAKGLPVNHTDRKTINVKGNDVPLRVSVGEIILTVQl...dnLEDFVEKVDEILNETLS...FGYDVKVGI..FNKTQTSVSDYMKYGEGfe.....dkIDSRLIGLVDPNAKSSE-t..............
A0B6N8_METTP/14-155                 ..QVEIFPSRFLSPETTQKLLNELY.KS.GGIVRMMIQGPNLPRTVTYGPGKGLPIEEHRNLLVEVGGEVLELRVKVGRIRLELE......GEEFLPGIEAACERALP...FSFQIKRGK..FFRDISTISDYAKYGKD.........ADKRILGLVDPRAKKES-a..............
A0A498GYM4_9EURY/8-150              ..QCRIVSARFLKPDTAERLLNRIV.EV.GGIRRMSINGPSIPATVPYGPARGKPNPHPDRKAIHVGDQEIQLRVQVGTIVLELE......DESIIPAMKEACDEIFAdlgFSYTFQQGR..FMKTQPSLSDYVKYGPD.........AEDQILGLVDPKRK----dg.............
H1YXI2_9EURY/10-149                 ..QCRVVPLRMLSPDTTEIFLDKVV.KV.KGIRRMTINGPSLPKTVPYGPARGKPNPNTNRRTIQVGDSEVELRVQAGMFVFELE......DEGVTENIRAVCDEVFT..kFPYQLQVGK..YMKTSPTLSDYCKYGPD.........ADEKMVGLSDPRK-----dg.............
A0A483CYB8_9EURY/8-149              ..QCRIVPARFLNPETVENLLNRFL.EV.GGIRKLVLNGPRLPTTVPYGPARGQPNPHQMRRVIRVGDQDVELQVQVGTILLELE......DRSYIDGIKKACEEVFV..kFPFGFSEGK..YMKTEATVSDYAKYGPD.........ADKMFLGTTDPKSRS---gp.............
D1YW09_METPS/17-157                 ..QIEVFPQRLLNIGTAQKLLNELN.TI.EGIIRMVVYGPGLPRDDPDDLLEGK-FGVAEKKYFNIMGEMVELSVQVGRIWIEIE......DTKAIEKIREACEKALP...FPFELNEGL..YLRRKKTVSDYARRGPN.........VDDMSLGMFDPKVKRE--pa.............
MCRD_METTH/2-135                    ..DVQIFPHRLLGADTTEKLLNRLE.DI.SGVKRMVIHGQRLPPE-----------DHPDRRIISVKGHEFELQVKTGRVLLEIE......DEDTIADIKRVCEDLLP...FGYDVTPGK..YIRTQKTVTDEIKYGEDl......dkVPEELIGLTDQNARLSE-r..............
A0A8J7S024_9EURY/8-150              ..QCRIVPLRLLSPATTERLLNQIA.GI.PGVRRAVINGPSLPVTIPYGPARGAANPNTNRQTIQVRGTEFEMRVQTGMVTLEVR......DDTVIEAVRNACDEIFT..aFPYTLQTGR.qFMKSQASLVDYTKYGPN.........ADEFIIGLTDPRRH----dsp............
MCRD_METJA/5-153                    ..EVEIFPHRYLKASTTEKFLNKIY.DL.KTVERVVIHGQPLPKVITYGPARGLPVNHTERKIIHVKGVPVELTVMAGRFWITLS......DDSELDKLDEICKEMFP...FGYNLRVGK..FLKDRPTVTDYIKYGEDgvf..lineMDRRLIGMVDPRSRMAN-s..............
A0A484F515_9EURY/20-161             ..QIEIVPQRILSPDTSEILLGRIY.DC.DGIIRVMVQGSRLPDKVGYGPGTGEKVDHPLKKSIEVEGQQVNMRVTLSRLLIEVD......SDRTADEIKKICDETFS...FPFEFYKGV..FFKKYSTVVDYAKMGPE.........PDERLLGMTDPKGKLD--qi.............
E1RDX7_METP4/10-152                 ..QCKIVPIRMLSPETAEKFLNLIV.RV.KGIRRFVINGPSLPKTVPYGPARGKPNPNSNRRVIQIGDTETELRVQVGVIILEVE......ERSVIDEIRKVTSEFFEg.kFSCQVMEGK..FMKTEPTTSDYAKYGPN.........ADEMILGLVDPRKKE---gp.............
A0A062V0J7_9EURY/13-163             ..QIRVFPKRLLQPETAEKLLNEID.QT.KGVIRMLLNGKNLPRKVTCGPGTGADVNHPDRMIINVGGCAFELHIIVGEVIVEVE......NESAMEDVKKACERALP...FPFEFKRGH..FIKRRPTLTDYGKYGFRsktderinlEDERILGLIDPHAKAE--tn.............
Q2FSN3_METHJ/8-150                  ..QCRIVTERLLKPETVEKILNKLA.VI.PGIRRIVINGPSIPQKVPYGPARGLDNPHSGKATIRVGVTDVDLRVQVGTFLLELE......TRDIVSQVEEACKEVFT..nFSYSVKEGK..FMRSTPTQVDYAKYGPN.........ANEIMLGLVDPKNKT---gpt............
Q8THG8_METAC/13-154                 ..QIEIFPSRILSPETAQKLISELY.QV.DGIIRVMVQGPRLPERVSAGPGTGEKVEHPLRKPIQIGDQVIELKISVGRIRLEIE......NAETKEKVRSVCDKMLP...FSFEFREGH..FLRRKPTVTDYAKLGPE.........TDPRLLGMVDPKAKVN--ql.............
Q2NI01_METST/20-168                 ..DVKIFPDRILKPETTETILNKVM.KL.EGVLRILINGERLPTVVTMGPARGAPVNHTDRKTINVKGNDVPLRVSVGEIILTVQl...dnLEDFVTEVNNILDETLK...FGYNVSVGV..FTKTNTTVSDYMKYGQGfe.....dkIDSRLIGLVDPNAKSSE-t..............
F6BBJ0_METIK/10-159                 ..DIKIFPHRYLKPETSEKVLNAIY.DLgDDIIRVIVHGPSLPKYVYYGPARGMPVNHSDRKVIKIKGEEVELTVKVGEIIVTVPf...ekAMEIEKKLHKICKENFP...YGYDIYVGA..FTKVRPTVTDYLKYGERfv.....neVDKRLIGITDPRSKFES-a..............
F7XL11_METZD/12-153                 ..QVEIFPKRLLGPEKAQKLLNELS.NI.DGILRAVIQGPRLPLKVPYGPATGEDVHHPDRKVVQIANTTFELSIMVGRIRLELA......NTDVKEKVRQVCEKMIP...FGFEFREGT..FIAKRSTVTDYAKRGPD.........ADPTLRGLFDPKAKIDE-q..............
A0A0X3BPL7_9EURY/8-151              ..QVRIVSARFLRPDTVEQLLNRLV.QV.GGIRRMSINGPSLPATVPYGPARGKPNPHPDRKAIRVGNQDVQLQVQVGTIILELE......DESYIPAIEEAVDEVFAekdFSCTVQQGR..YMKTRPSMSDYARYGPD.........ADREILGIVDPRRK----dgp............
Q8PXH5_METMA/13-154                 ..QIEIFPSRILSPETAQKLLVELS.QV.DGILRVMIQGNRLPEKVGYGPGTGEKVEHPLRKPIQIGGQVIELRVSVGRIRLEVL......NAEVKENVRAVCEKMLP...FSFEFREGH..FLRRKPTVTDYAKLGPE.........ADPRLLGMVDPKAKIN--ql.............
A0A366M859_9EURY/2-139              ..DIEVFPHRVLGADTTEKLLNGIE.GL.DDVKRTVLQGPKLPPA---DPNED--PKYADRGIIIVNGKEIELKVKTGRIFVEIS......NESTIDDIREVCDEYLP...FGFDINIGK..YIRTQKTTSDNIKYGDA........dIPDELIGMTDQSAKLAD-r..............
A0A4E0PYS3_9EURY/12-153             ..QLEIFPSRLLRPETAQNLLNEIA.EI.EGVTRLFVHGPRLPQNVPYGPAKGEPVQHPGNKVIEVAGQAMELAVCVGGIRMEVI......NVDVKEQVREVCEKILP...VSFEFRQGH..FIPTKQTVTDYAKRGPG.........ADPLMIGMTDPKGKLKD-y..............
A0A328PI59_9EURY/2-137              ..DIEIFPHRLLGADTTEKLLNDLE.EI.ESIKRMVIQGQRLP------PAE---EGHPDRRMIKISGQEVELQVKPGRVLLEVE......DESAIDDIKKVCEEHLP...FGFEVHIGK..FIRTQKTVTDELKYGELl......deIPDELIGLTDPNARLTE-r..............
D7E8Y0_METEZ/14-155                 ..QIELFPTRLLKPETTQNLLEELS.EV.DGIIRAFIHGPRLPLTVPSGPATGQDVEHPHRKVIQIGDTAIELSISVGRIRLEIT......DEDVEEEIETIAEKVLP...CKYELREGY..FIPKESTVTDYAKRGPN.........ADPKRRGLSDPKASEES-q..............
A0A2U1S6W9_9EURY/2-141              ..DIEIFPHRVLGSDTTEKLLNEIE.AL.NDVKRTVIHGPRFPANEETLPPK-----FRERRVININGEDVILKVKTGRIFVELT......MESTIKQIDEICKKHIP...YGYDINQDKsnYIRKERTVSDRIKYGEA........dLPDELIGMTDQYSSFED-h..............
M4YM91_THEXX/1-123                  .m-----TNRLLSAQSTEAVLNAID.DI.EHIRQVNMSGENLPATINSGPAKGMSNNHTERQIIHVGQQEVELHCLVGAFYIELEvddkdmLEATVDKIKAACDEHIK...DGYSLEIGR..YSKYRPSLTDY------.........------------------rsa............
U6EEL5_9EURY/8-156                  ..DVRIFPHRRLKPETTEKILNALL.DL.EGVLRFLVNGESLPKIVGYGPARGTSVDHPDRKIITVKGKEVELLVSVGEIIVTIRq...enLEEFVEKTKAILEETLD...FGFDVQVGI..FTRQQATVSDNLKVAYGie.....edFDPRLIGLVDPKDNSNE-t..............
A0A315XKW4_9EURY/2-141              ..DIEIFPYRVLGSDTTEALLNDLE.SL.EDVKRTVIHGPRFPKGEATLPPK-----YRERRVININGEDVVLQVKTARIFLEIT......MESTIDEIEEICKEHIP...YGFDINQDRsnYIRKQQTVTDRIKYGDK........eLPDELVGMTDQYSTFD--dh.............
A0A328S7V5_9EURY/9-157              ..DVKIFPHRILKPQTTENILSQIL.EL.DGVLRVLINGKSLPTMVNFGPAKGLPVNHTDRKTINVNGNEVPLRVSVGEIILTVQl...dnLEDFVTQVDRILEESLN...FGYDLDVGI..FTKHATSVSDYMKYGEGfe.....dkIDSRLIGLVDPSAKSSE-t..............
R9TBQ1_METII/13-137                 .e-ILIFPARMLSAGTTEKLLNNIY.EV.PNVRQVNISGEALPAVVGNGPAKGTLVNHPERKVINVKGREYELNLLVGRVFVEINdi..dnVDKAVEEIKKICDDLLP...FGYNLEVGR..YSKFQPTITDYKK----.........------------------m..............
D5EAD9_METMS/13-154                 ..QIEIFPKRMIKPDTVEGLLNKLC.SL.EGIQRAFIQGPRLPTKVPFGPAVGTPVHHPSRTNVHFGKTEMGLEVLVGRITLELA......GKEIMEEINAICEDTLP...CGYDIREGR..FIQTRQTVSDYAKRGPT.........ADPALYGLYDPKSKVES-q..............
Q0W342_METAR/13-153                 ..QIEIFPERLLNIETAQALLNELN.KI.GGITRMIVYGPRLPKDDPKDLLDGK-FDAREKKFLDIMGEKIELTVQVGRIFVEIE......NPGVKDKINEACRKTLP...FPFEINEGL..YIRTQKTLTDYVRKGGK.........VDDISVGMSDPGAM----qkys...........
MCRW_METJA/16-162                   ..DVKIFPHRYLKAETTEKVLNEIY.DL.DGIVRVIVHGQPLPKTVPFGPARGLPVNHQDRKVIKVKGEEMELRVKVGEIIITVEg...ekLEKIMDGIEEICKRNFP...FGYDIYVGA..FTKIKPTVTDYMKYGDIs.......sIDPRLIGMVDASARLKD-s..............
A0A166F276_9EURY/2-139              ..DIEIFPHRVLGADTTEKLLNGIE.SL.VDVKRTVLQGPRLPPE---DPNED--PRYFDRRRITVNGKEIELKVKTGRIFVELS......TEETIDEIKVICEQHLP...FGFDINIGK..YIRDQKTVTDNIKYGDA........dIPDELIGMTDQSAKLKD-r..............
A0A2V3JKK1_9EURY/11-154             ..QYEIFPQRMLDPSSAQELLNRLE.QI.EGVTRVLVQGPRLPLTVPSGPGKGVPVDHQAREVIRVGDQVMELQVKVGRIRLEAE......-NDVMEEVRALCEELFP...FPFELKEGL..FLRRKATVTDYAKYGPDe......mvEDKDIYGMTDPNM-----sptak..........
A0A0W7TIG7_9ARCH/1-122              .m-----TNRLLSAETTEKVLNAID.SI.EHIRQINMGGESLPKTISSGPAKGAENNHSERRIINVNGHEVELRCEVGAFYIELEvddkdmLEATVEKIKDAFDATVP...FGYTIEIGR..YTKYRPSLHDY------.........------------------rs.............
Q6LWZ8_METMP/3-148                  ..ELEVFPHRYLKAETTEKFLNRAY.SL.SKVQRVVIHGESLPNKVGYGPAKGTPVNHSEKKEITVKGVPVELMLQVGRLWVLLD......DESEIEKIEEICKDLFP...FGYRLTKGK..FLRNDPTVSDFIKYGESav.....ddIDKRLLGATDPRSKFDS-s..............
A0A166A6P3_9EURY/2-139              ..DIEIFPHRILGSDTTERLLNEIE.GL.EDVNRTILQGPRLAPESPDDDP-----RYAERRIITVQGKEIELKVKAGRIFVDLS......EESTIDQIREICNEILT...FGFDINIGT..YIRTQKTVTDSIKYGNA........eLPDELIGMNDQYSMLE--dr.............
MCRW_METFV/11-160                   ..DVKVVPYRLLNPQTVETILNKIY.DL.DGIVRVLVHGPSIPKEIPYGPAKGIKVNHKDRQVIKVKGEEVELKVKVGEIIVGVLcd..dkMDENIGKIEKIMDENLP...CSYQMWVGT..YTKRDVTVTDWMKYGPKfe.....kkLDPRYIGLVDPNSKVKE-n..............
#=GC seq_cons                       ..plcIFPpRlLss-ToE+LLNcl..pl.cGlpRhllpGspLPtpVshGPA+GhsssHs-R+hIpVsGp-lELpVpVGcIhlElc......s-ssl-cl+clC--hls...Fuaslp.G+..Fh+ppsTloDYhKYG.s.........hDppllGhsDPpu+.t..p..............
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