#=GF ID MCR_alpha_N
#=GF AC PF02745.19
#=GF DE Methyl-coenzyme M reductase alpha subunit, N-terminal domain
#=GF AU Mian N;0000-0003-4284-4749
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Griffiths-Jones SR;0000-0001-6043-807X
#=GF SE Pfam-B_2706 (release 5.2)
#=GF GA 27.00 27.00;
#=GF TC 28.40 33.60;
#=GF NC 24.30 19.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0618
#=GF RN [1]
#=GF RM 9367957
#=GF RT Crystal structure of methyl-coenzyme M reductase: the key enzyme
#=GF RT of biological methane formation
#=GF RA Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK;
#=GF RL Science 1997;278:1457-1462.
#=GF DR INTERPRO; IPR003183;
#=GF DR SCOP; 1mro; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Methyl-coenzyme M reductase (MCR) is the enzyme responsible for
#=GF CC microbial formation of methane. It is a hexamer composed of 2
#=GF CC alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma
#=GF CC (Pfam:PF02240) subunits with two identical nickel porphinoid
#=GF CC active sites [1]. The N-terminal domain has a ferredoxin-like
#=GF CC fold.
#=GF SQ 92
#=GS F4BXY1_METSG/7-276 AC F4BXY1.1
#=GS A0A1Y3GE24_9EURY/5-270 AC A0A1Y3GE24.1
#=GS M4YK22_THEXX/5-269 AC M4YK22.1
#=GS D1YVW6_METPS/7-275 AC D1YVW6.1
#=GS A0A1D3L4K2_9EURY/3-268 AC A0A1D3L4K2.1
#=GS A0A1F2P9A1_9EURY/5-276 AC A0A1F2P9A1.1
#=GS F0TCV5_METLA/5-270 AC F0TCV5.1
#=GS MCRX_METFV/6-272 AC Q49174.2
#=GS A0B6N6_METTP/7-276 AC A0B6N6.1
#=GS A7I5T9_METB6/10-278 AC A7I5T9.1
#=GS A0A484F5U2_9EURY/15-283 AC A0A484F5U2.1
#=GS A0A062V7W6_9EURY/16-283 AC A0A062V7W6.1
#=GS F6BBJ2_METIK/5-270 AC F6BBJ2.1
#=GS Q2FSN0_METHJ/8-277 AC Q2FSN0.1
#=GS A0A1V6N4K9_METAZ/3-268 AC A0A1V6N4K9.1
#=GS A0A1F2P3F1_9EURY/6-277 AC A0A1F2P3F1.1
#=GS A0A483CQ12_9EURY/8-278 AC A0A483CQ12.1
#=GS A0A8J7YI60_9EURY/3-42 AC A0A8J7YI60.1
#=GS F0T8R3_METLA/3-268 AC F0T8R3.1
#=GS A0A315XMC8_9EURY/3-268 AC A0A315XMC8.1
#=GS G7WN24_METH6/7-276 AC G7WN24.1
#=GS MCRX_METJA/5-271 AC Q60391.1
#=GS L0HD22_METFS/10-280 AC L0HD22.1
#=GS A0A166CHN2_9EURY/3-268 AC A0A166CHN2.1
#=GS A0A0W7TIP2_9ARCH/7-271 AC A0A0W7TIP2.1
#=GS L0HIJ7_METFS/11-279 AC L0HIJ7.1
#=GS MCRA_METTH/3-268 AC O27232.3
#=GS A0A498GZI7_9EURY/8-278 AC A0A498GZI7.1
#=GS MCRA_METKA/6-271 AC Q49605.2
#=GS M9SBG6_METAX/7-271 AC M9SBG6.1
#=GS A0A1F2P3I8_9EURY/2-269 AC A0A1F2P3I8.1
#=GS A0A8J7W8C2_9EURY/8-278 AC A0A8J7W8C2.1
#=GS Q12TF8_METBU/14-283 AC Q12TF8.1
#=GS Q6LWZ5_METMP/5-272 AC Q6LWZ5.1
#=GS E1RDX4_METP4/8-278 AC E1RDX4.1
#=GS D7DUH5_METV3/5-272 AC D7DUH5.1
#=GS A0A0X3BN07_9EURY/8-278 AC A0A0X3BN07.1
#=GS A2SSD1_METLZ/8-278 AC A2SSD1.1
#=GS L0L0H0_METHD/13-282 AC L0L0H0.1
#=GS B8GE93_METPE/8-277 AC B8GE93.1
#=GS U6EEP1_9EURY/3-268 AC U6EEP1.1
#=GS H1YXH9_9EURY/8-278 AC H1YXH9.1
#=GS A6UWH2_META3/5-271 AC A6UWH2.1
#=GS A0A1F2P8K6_9EURY/59-323 AC A0A1F2P8K6.1
#=GS A0A6B9TBW2_9ARCH/5-269 AC A0A6B9TBW2.1
#=GS U6EF81_9EURY/5-270 AC U6EF81.1
#=GS E3GZ51_METFV/6-271 AC E3GZ51.1
#=GS D5EAD6_METMS/14-284 AC D5EAD6.1
#=GS A0A059TIR1_THEX5/6-270 AC A0A059TIR1.1
#=GS Q8PXH8_METMA/14-282 AC Q8PXH8.1
#=GS A0A166CWD2_9EURY/3-268 AC A0A166CWD2.1
#=GS R9TAZ9_METII/3-268 AC R9TAZ9.1
#=GS A0A2Z4L8F8_9EURY/5-271 AC A0A2Z4L8F8.1
#=GS A0A1Q6DVQ2_9EURY/3-269 AC A0A1Q6DVQ2.1
#=GS A0A2V3JAG5_9EURY/7-280 AC A0A2V3JAG5.1
#=GS Q0W339_METAR/7-274 AC Q0W339.1
#=GS A0A1F2PC64_9EURY/2-269 AC A0A1F2PC64.1
#=GS D3E050_METRM/3-268 AC D3E050.1
#=GS A0A0A7LF46_9ARCH/7-271 AC A0A0A7LF46.1
#=GS MCRX_METTH/4-271 AC P21110.3
#=GS A0A1D2W9L6_9EURY/5-271 AC A0A1D2W9L6.1
#=GS D7E8X7_METEZ/15-284 AC D7E8X7.1
#=GS A0A366M976_9EURY/3-268 AC A0A366M976.1
#=GS A0A1F2P6A2_9EURY/2-269 AC A0A1F2P6A2.1
#=GS A0A483CX70_9EURY/8-278 AC A0A483CX70.1
#=GS I7KDB2_METBM/8-278 AC I7KDB2.1
#=GS A0A4E0Q940_9EURY/14-283 AC A0A4E0Q940.1
#=GS R9SLW2_9EURY/3-268 AC R9SLW2.1
#=GS I7LMP5_METBM/8-278 AC I7LMP5.1
#=GS A0A166A6T9_9EURY/3-268 AC A0A166A6T9.1
#=GS A0A0E3NU58_9EURY/14-282 AC A0A0E3NU58.1
#=GS F7XL13_METZD/14-283 AC F7XL13.1
#=GS A0A2V3JK07_9EURY/8-277 AC A0A2V3JK07.1
#=GS A0A2U1S6R5_9EURY/3-268 AC A0A2U1S6R5.1
#=GS A0A0X3BNP7_9EURY/11-281 AC A0A0X3BNP7.1
#=GS MCRA_METAC/14-282 AC Q8THH1.1
#=GS E1RJD5_METP4/8-278 AC E1RJD5.1
#=GS A0A8J7UNS3_9EURY/8-278 AC A0A8J7UNS3.1
#=GS W9DZJ0_METTI/14-283 AC W9DZJ0.1
#=GS A0A0Q4BCJ2_9ARCH/1-261 AC A0A0Q4BCJ2.1
#=GS A0A8J7RJF3_9EURY/8-278 AC A0A8J7RJF3.1
#=GS A0A2V2MZL0_9EURY/8-277 AC A0A2V2MZL0.1
#=GS F6BE97_METIK/5-271 AC F6BE97.1
#=GS MCRA_METJA/5-271 AC Q58256.2
#=GS Q2NHZ8_METST/5-271 AC Q2NHZ8.1
#=GS A0A1Y3GED3_9EURY/6-271 AC A0A1Y3GED3.1
#=GS Q8TVA5_METKA/8-59 AC Q8TVA5.1
#=GS A0A328PGC5_9EURY/4-269 AC A0A328PGC5.1
#=GS A0A1F2P729_9EURY/2-269 AC A0A1F2P729.1
#=GS A0A1F2PDF7_9EURY/167-444 AC A0A1F2PDF7.1
#=GS A2STR9_METLZ/8-278 AC A2STR9.1
#=GS A0A1D2WBA8_9EURY/3-268 AC A0A1D2WBA8.1
F4BXY1_METSG/7-276 .........KKLFVKALNKKFG.kD.fDLASQ.K.V.EY-KRLGPEQNARKREFMEYAKKL.EGKR..GMTGYNP-YVHA...gGIPLGQRQLVPYKLSST.EYV........VEGDDLHFVNNPAMQQFWDDIRRTIVVGLDMAHEVLQKRLGKEVTPETINNYLEILNHAMPGAAVVQEHMVETHPGLVDDCNVRVFSGDDALADEIDDQYKIDINKMFPE......D.QAETLKAAIGKTTWQAIHVPTIVVRTCDGGTTSRWSAMQLCMTFIDAYNMCAGEAAVADLAYAAKHAAVLQMSDMLP..............
A0A1Y3GE24_9EURY/5-270 .........EKRFIKALKNKFE..E..EPTDT.K.T.HFYDLGGYKQSERKKEFQERAAQI.AKER..GTPSLNEDI---....GVPLGQRVLMPYQLSHT.DTM........VEPDDLHIINNAAMQQAWDDIQRTVIVGLDTAHQVMEKRLGVEVTPETINEYLEVFNHTQPGGAVVQEHMAECNPGVTGDAYVKVFTGNDELADEIDDNLLIDINENFPE......D.QAEQLKEAIGDSLWQAIRAPTIVTRVMDGATIRRWAAMQSSMAFISSYSLCAGEAAIADFAYASKHSKVINMASAMP..............
M4YK22_THEXX/5-269 .........EKLFLEACKKKFK..E..EPTSM.E.T.KYYCYGGWKQSKSKVEFQKEAMEI.AKKR..GFPMMNEDV---....GVPLGQRSWMPYQLSHT.DIF........VEPDDLHCINNPAIQQAWDDIRRTVLVGLDSPHQTIEKRLGKEVTPETINAYLEAVNHTIPGGAIVQEHMAECNPALVYDSYVKVFSGNDELIDEIDPRFVIDINKNFPK......D.QAEKLKKAMGKTVMQAVRVPTMVGRVMDGATVSRHAAMQISMSFISSYKLAAGEAAIADFAYSAKHLS-INMGTMMP..............
D1YVW6_METPS/7-275 .........QKRFIKAMKKKFA.gE..DPTST.T.T.VY-KYEGYTQSKRKVEFKKAGDAI.AKKR..GISAYNP-MVHM...gGIPLGQRQLTPYVVSGT.DVV........VEGDDLHFVNNAAMQQFWDEIRRTVIVGLDTAHATLEKRLGKTVTPETISNYLAILNHAMPGAAVVQEHMVETNPALTDDCFVKVFTGDDELADSIDKQYVLDINKAFPK......D.QAAALKKAVGKSLYQAVHIPTTVVRTCDGGTTSRWSAMQIGMSFIDAYKMCAGEAAVADLAFAAKHASLVEMADILP..............
A0A1D3L4K2_9EURY/3-268 .........DKKFMEALNKKFK..E..APEEK.K.T.TFYSFGGWKQSERKREFVEAGKEV.AAKR..GIPQYNPDI---....GCPLGQRVLMPYQVSTT.DTF........VEGDDLHFVNNTAMQQFWDDIRRTVIVGLGTAHGVIEKRLGKEVSPETITNYLETVNHSMPGAAVVQEHMVETHPALVADSYVKIFTGNDEIADEIDSAFVIDINKMFPD......E.QAEVLKAEVGDGIWQAVRIPTIVSRTCDGGTTSRWSAMQIGMSMISAYKQCAGEAATGDFAFAAKHAEVIHMGTALP..............
A0A1F2P9A1_9EURY/5-276 ........k-KTHIKLLEETFK..V..SPTDIvD.K.KLYQHGGTRQSKRKTEYIEYANRI.AKER..GIPAYDPDHIALelevGVPLGQRYLEPVKISGT.DVM........CEYEDLHIMNNVAIEQMVDDIFRTAIVCIDLPHKVLVDRYGFEVTPESINTYLETINHTMVGGAVTQEHMCEMHPGPCADGYVKIFTGNDEVASSLDSRFVIDINKEFTP......E.KAAKLKEGVGDSLWQVSRVPTHALRTMDGAIIHRWNAMGQTMAFIASYHLCAGEAAISDFAYAAKHAQYIWMGT---p.............
F0TCV5_METLA/5-270 .........KKLFLKALKNKFN..E..DPNEH.Y.T.DYYCYGGWEQSPRKKEFNEFSKKL.EEER..GLPGYNPDI---....GVPLGQRKLMSYKVSGT.DSY........VEGDDLHFLNNSAIQQLSDDIKRTIIVGMDTAHAVLEKRLGVEVTPETINNYMETINHALPGGAVVQEHMVEVHPGLVGDCYAKLFSGDDDLIDELDSRFLVDINKEFPE......E.QAEQLKDYIGKKTYQISRVPTMVVRACDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVISMGSILP..............
MCRX_METFV/6-272 .........KKLFLEALEKKFK.gE..SPEEK.K.T.TFYCFGGWKQSERKREFVEYAKKL.AKKR..GIPFYNPDI---....GVPLGQRKLMAYRISGT.DAY........VEGDDLHFVNNAAIQQMVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPGLVDDCYAKIFTGNDELADELDKRVLIDINKEFPE......E.QAEMLKKYIGNRTYQVNRVPTIVVRCCDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSFAAKHADVIEMGTILP..............
A0B6N6_METTP/7-276 .........KKLFVRALTKKFG.kD.fDLSSQ.K.T.EY-KRLGPEQSARKREFMEYSKKL.EGKR..GISFYNP-YLHC...gGVPLGQRQLVPYKLSNT.EYI........VEGDDLHFVNNPAMQQMWDDIRRTVVVGLDMAHEVLEKRLGKEVTPETINNYLEILNHAMPGAAVVQEHMVETHPGLVEDCNVRVFTGDDDLADEIDPQYLIDINKLFPA......D.QAEQLKAAIGKTTWQAIHIPTIVVRSCDGGTTSRWSAMQLSMTFIDAYNMCAGEAAVADLAYAAKHAAVLQMSDMLP..............
A7I5T9_METB6/10-278 .........QKLFLKAMKEKFA..E..DPQAT.S.T.VF-ARAGLEQSPRKMEFLKEGQKV.ALDR..GISMYDPKRCHC...gGIPLGQRQLMTYEVSGT.GVF........VEGDDLHFVNNAAMQQMWDDIRRTIIVSLDLAHGTLQKRLGKEVTPETINEYLHVLNHAMPGAAVVQEHMVETHPALVDDCYVKIFTGDDEMADDIEPQFVLNLDKLFPA......K.QAAALKAAVGKSMWQAVHIPTTVSRTCDGGTTSRWSAMQIGMSFIGAYKMCAGEAAVSDLAFAAKHAGVIQMADILP..............
A0A484F5U2_9EURY/15-283 ........e-IKFAEDYGDNRQ.gG.tDITSK.T.E.KFY-RLGPEQSPRKREMIKAGKEI.AKKR..GLAGYNP-MMHT....GAPLGQRAITPYRISGT.DLV........CDPDDLHYVNNAAMQQMVDDIKRTNIVGLDMAHDTLEKRLGKEVTPETINNYLENLNHSLPGGAVVQEMMVECHPGLVDDCYVKMFTGNDDLADEIDKQFLIDINKMFPA......E.QAEQLKAAIGNTSWQALHIPTIVIRSTDGGQTSRWSAMQIGMSFISAYNMCAGEAAVADLSYAAKHAGSINMGEMLP..............
A0A062V7W6_9EURY/16-283 ..kewgtnk-------CGSTAK..S..KITDK.K.T.KY-LRLGYTQNPRKVEMTKCGAAI.TKKR..GLQAYDPK-LHL...aGIPMGQRQLTPYTISGT.DIV........CDGDDLHFVNNAAMQQEWDDIRRTCIVGLDLAHETLEKRLGKEVTPETINYYLEVLNHAMPGAAIVQEHMVETHPALVDDCYVKVFTGDETLQDEIDKQFVINIDNEFPA......E.QAKQIKAGIGKTSWQAVHIPTIVTRTEDGPGTSRWMAMQVGMTFISAYHMCAGEAAVGELAFTAKHAGLVEMSDMIP..............
F6BBJ2_METIK/5-270 .........KKLFLKALREKFE..E..DPKEK.Y.T.KFYVFGGWKQSARKREFYEYAQKI.AKER..GIPGYNPDI---....GVPLGQRKLMTYKISGT.DAF........VEGDDLHFCNNAAIQQLVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPGLVWDCYAKIFTGNDELADEIDKRFLIDINKEFPE......E.QAEMLKRYIGNRTYQVSRVPTLVVRCCDGATVARWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMGTLLP..............
Q2FSN0_METHJ/8-277 .........QKLFLKALKTKFE..G..DVADT.K.T.GFYNFGGLNQSPRKKEFMEASKKV.ELRR..GISMYDPNRCHL...gGLPMGQRQLMTYEVSGT.GTF........VEGDDLHFVNNPAMQQMWDDIRRTIIVNMDLAHQTLQKRLGKEITPETINEYLHILNHAMPGGAVVQEHMVETHPSVVDDCYVKVFTGDSELADQIEKQFVLDVNKLFPA......K.QAEQLNEAVGKSLWQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFITAYRMCAGEAAVADLSFAAKHAGVIQMASHLP..............
A0A1V6N4K9_METAZ/3-268 .........DKKFIEALNKKFK..E..DPEEK.T.T.TFYNLGGWKQSERKTEFANAGKEI.AEKR..GIPQYNPDV---....GSPLGQRALMPYQVSTT.DTY........VEGDDFHFVNNAAIQQMWDDIRRTVIVGLNTAHNVLEKRLGMEVTPETITEYLETVNHAMPGAAVVQEHMVETNPSLVADSYVKVFTGDDELADEIDSAFVLDINKEFPE......D.QAEALKAEVGDKVWQAVRIPTIVGRVCDGGTTSRWSAMQIGMSMISAYNQCAGEGATGDFAYASKHAEVIHMGTYLP..............
A0A1F2P3F1_9EURY/6-277 .....tkeh----IKWLEETYK.vE..ATDII.D.K.KLYQHGGTRQSKRKTEYIEYANKI.AKER..GIPSYDPDHIALeleiGVPLGQRYLEPVKISGT.DVF........CEYEDLHMLNNAAIQQMIDDIFRTAIVCLDLPHRVLIDRYGFEVTPESINRYLETINHTMVGGAVAQEHMCELHPGLCPDGYVKVFTGDDDVANSLDKRFVIDINREFPE......E.KAAKLKEGVKRSLWQVSRIPTHALRSMDGGMVHRWNAMGQTMAFISSYHLCAGEAAISDFAYAAKHAQYIWMGT---p.............
A0A483CQ12_9EURY/8-278 .........QKLFLKALKEKFE.gQ..DVQSE.K.A.EFYKFGGLKQSPRKQEFLKESRAI.EMQR..GISMYDPERCHL...gGIPMGQRQLMTYEVSGT.GVF........VEGDDLHFVNNAAMQQFWDDIRRTVIVGMDLAHATLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPALTDDCYVKVFTGDDELADDIEPQFLLNIEKLFPA......K.SAEALKAAVGKSMWQSIHIPTSVSRTCDGGTTSRWSAMQIGMSYIAAYRMCAGEAAVADLSFAAKHAGVIQMADILP..............
A0A8J7YI60_9EURY/3-42 .........KKLFLKALKEKFE..D..DPKEK.Y.T.KFYTFGGWKQSKSLR---------.----..------------....-----------------.---........--------------------------------------------------------------------------------------------------------------......-.-----------------------------------------------------------------------------knyf..........
F0T8R3_METLA/3-268 .........EKMFIDALKKAFK..E..DPTDD.K.T.TFYNKGGWKQSERKREFVAAGKDI.AAKR..GIPMYDPDV---....GTPLGQRVLMPYQVSTT.DTF........VEGDDLHFVNNAAMQQFWDDIRRTVIVGMNTAHMVIEKRLGKEVSPETITNYLETVNHAMPGAAVVQEHMVETNPYLVADSYVKTFTGNDEIADEIDPAYVLNINKMFNE......E.QAEVLKAEVGDGIWQVVRIPTIVSRTCDGGTTSRWSAMQIGMSMISAYKQAAGEAATGDFAYAAKHAEVVHMGTALP..............
A0A315XMC8_9EURY/3-268 .........DKKFLDAMKKKFT..E..DPTEK.R.T.QFYNMGGWTQSERKTAFVNEGKEI.AAKR..GIPMYNPDI---....GSPLGQRALMSYQLSTT.DTF........VEGDDLHYINNAAIQQAWDDIRRTVIVGLNTAHNVLEKRLGIEVTPETITNYLETVNHAMPGAAVVQEHMVETDPLVVQDSYVKVFTGDDELADEIDSAFVLDINKEFPE......E.QAEALKAEVGGAIWQAVRIPSIVGRVCDGGNTSRWSAMQIGMSMISAYNQCAGEGATGDFAYASKHAEVIHMGTYLP..............
G7WN24_METH6/7-276 .........KKLFVKALNKKFG.rD.fDLSGT.K.T.VY-ERLGPEQNARKREFMEASKKL.EGKR..GISMYNP-YLHA...gGVPLGQRQLVPYKLSTT.EYI........VEGDDLHFVNNPAMQQMWDDIRRTIVVGLDMAHEVLEKRLGKEVTPETINNYLEILNHAMPGAAVVQEHMVETHPALVDDCNVRMFTGDDDLADEIDDQYLIDVNKLFPA......E.QAEEIKAAMGKTSWQAIHIPTIVSRTCDGGTTSRWSAMQLSMTFIDAYNMCAGEAAVADLAFAAKHAAVIQMADMLP..............
MCRX_METJA/5-271 .........KKLFLKALKEKFE..E..DPKEK.Y.T.KFYIFGGWRQSARKREFVEFAQKL.IEKR.gGIPFYNPDI---....GVPLGQRKLMTYKISGT.DAF........VEGDDLHFCNNAAIQQLVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPGLVWDCYAKIFTGNDELADEIDKRFLIDINKEFPE......E.QAEQIKKYIGNRTYQVSRVPTIVVRCCDGGTVSRWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMGMILP..............
L0HD22_METFS/10-280 .........QKQFLKALKEKFK.gQ..DVESQ.K.T.GFYKFGGVQQSPRKREFMAATKKI.EADR..GISMYDPEHCHL...nGIPMGQRQLMTYEVSGT.GTF........VEGDDLHYVNNSAIQQMSDEIKRTIIVGMDIAHNTLQKRLGKEVTPQTINEYLHILNHAMPGGAVVQEHMVETNPGLVDDCYVKIFTGNDEVADDIEPQYLLNIEKLFPK......K.QAEALKAEIGKSMYQAIHVPTIVVRTCDGGTTSRWSAMQIGMSFIAAYRTCAGEAAVADLSFAAKHAGVIQMGSHLP..............
A0A166CHN2_9EURY/3-268 .........DKKFIDALNKKFK..E..DPTEK.S.T.TFYNLGGWTQSERKTEFANAGKEI.AEKR..GIPQYNPDV---....GSPLGQRALMPYQVSTT.DTY........VEGDDFHFVNNAAIQQMWDDIRRTVIVGLNTAHNVIEKRLGMEVTPETITHYLETVNHAMPGAAVVQEHMVETNPLLVADSYVKIFTGDDELADEIDKAYVLDINKEFNE......E.QAAALKAEVGDNIWQVVRIPSIVGRVCDGGTTSRWSAMQIGMSMISAYNQCAGEGATGDFAYASKHAEVIHMGTYLP..............
A0A0W7TIP2_9ARCH/7-271 .........EKLFLEACKKKFK..E..APTDI.E.T.KYYCYGGWHQSKSKVEFQKEAMEI.AKKR..GFPMMNEDI---....GVPLGQRAWMPYQLSHT.DIF........VEPDDLHCINNPAIQQAWDDIRRTVLVGLDSPHNTIQKRLGKEVTPETINAYLETVNHTMPGGAVVQEHMAECNPALVYDSYVKVFSGDDELIDELDPRFVIDINKNFPK......D.QAEQLKKAMGKTVMQAVRVPTMVGRLMDGATVSRHAAMQISMAFISSYKLAAGEAAIADFAYSAKHQS-ITMGSMMP..............
L0HIJ7_METFS/11-279 .........QKLFLKAMKEKFA..E..DPQAQ.A.T.VF-KREGLSQSPRKMEFVKAGKAA.EMDR..GISMYDPARCHC...gGIPLGQRQLMTYEISST.GVF........VEGDDCHFVNNAAMQQMWDDIRRTIIVGLDLAHGTLQKRLGKEVTPETINEYLHVLNHAMPGAAVVQEHMVETHPSLVDDCYVKVFTGDDEMADDLEPQFVLNVDKLFPA......K.QAAQLKAAVGKSMWQAVHIPTIVSRTCDGGTTSRWSAMQIGMSFIGAYKMCAGEAAVADLAFAAKHAGVIQMADILP..............
MCRA_METTH/3-268 .........DKLFINALKKKFE..E..SPEEK.K.T.TFYTLGGWKQSERKTEFVNAGKEV.AAKR..GIPQYNPDI---....GTPLGQRVLMPYQVSTT.DTF........VEGDDLHFVNNAAMQQMWDDIRRTVIVGLNHAHAVIEKRLGKEVTPETITHYLETVNHAMPGAAVVQEHMVETHPALVADSYVKVFTGNDEIADEIDPAFVIDINKQFPE......D.QAETLKAEVGDGIWQVVRIPTIVSRTCDGATTSRWSAMQIGMSMISAYKQAAGEAATGDFAYAAKHAEVIHMGTYLP..............
A0A498GZI7_9EURY/8-278 .........QKLFLKALKEKFQ.gQ..DVESE.T.A.EFYKFNGVRQSPRKQEFMKASRAI.EMDR..GISMYEPERCHL...gGIPMGQRQLMTYEVSGT.GVF........VEGDDLHFVNNAAMQQMWDDIRRTVIVGMDMAHQTLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDDEMADDIEPQFLINIEKQFPA......Q.QAEALKAAVGKSMYQAIHIPTSVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSYAAKHAGVIQMGSHLP..............
MCRA_METKA/6-271 .........EKLFMKALKEKFE..E..SPEEK.Y.T.KFYIFGGWKQSERKKEFKEWADKI.VEER..GVPHYNPDI---....GVPLGQRKLMSYQVSGT.DVF........VEGDDLHFVNNAAMQQMWDDIRRTVIVGMDTAHRVLERRLGKEVTPETINEYMETLNHALPGGAVVQEHMVEIHPGLTWDCYAKIITGDLELADEIDDKFLIDIEKLFPE......E.QAEQLIKAIGNRTYQVCRMPTIVGHVCDGATMYRWAAMQIAMSFICAYKIAAGEAAVSDFAFASKHAEVINMGEMLP..............
M9SBG6_METAX/7-271 .........EKLFLEACKKKFK..E..DPTSM.E.T.KYYCYGGWKQSKSKVEFQKEAMEI.AKKR..GFPMMNEDI---....GVPLGQRSWMPYQLSHT.DIF........VEPDDLHCINNPAIQQAWDDIRRTVLVGLDSPHQTIERRLGKEVTPETINAYLETVNHTMPGGAVVQEHMAECNPALVYDSYVKVFSGDDELIDELDPRFVIDINKNFPK......D.QAEKLKKAIGKTVMQAVRVPTMVGRVMDGATVSRHAAMQISMAFISSYKLAAGEAAIADFAYSAKHMS-INMGSMMP..............
A0A1F2P3I8_9EURY/2-269 ......dee---ILEKFKEIFR.eD..DPTRR.K.T.RFYEFGGRMQSKRKREFIEASKRI.AEER..GIPGYQGDREDL....GVPLGARYLEPYYISGT.DTI........CDMDDIHQINNAAIQQLGDDIKRTAINGLDLPHRILQQKVGVTVTPETINRYLESINHSLVGGALAQEHMAEINPLMTRDGYAKVITGDDELADALDKRFLIDINREFPE......E.MAEKLKDKIGNHLYQVSRIPTIGVRIADGSIVHRWNGNQSALAFVSAYKLGGG-SILAEFTITVKHMAYMLLG----tqt...........
A0A8J7W8C2_9EURY/8-278 .........QKLFLKALKEKFP.gQ..DVESQ.K.A.KFYAFDGVNQSPRKKEFKAANEKI.VKER..GIDMYDPERCHL...gGVPMGQRQLMTYEVSGT.GTF........VEGDDLHFVNNAAMQQFWDDIRRTVIVNMDLAHQTLQKRLGKEVTPETINEYLHVVNHAMPGAAVVQEHMVETHPALTDDCYVKVFTGDSELADDIEPQFLINVEKLFPK......K.QAESLMNAVGKSMWQCVHIPTSVSRTCDGGTTSRWSAMQIGMSFIGAYRMCAGEAAVADLSYAAKHAGVIQMSSHLP..............
Q12TF8_METBU/14-283 ........e-IKFTKAHGDNKM..EggEITDK.K.V.TYY-RLGVDQNPRKVEMRKAGQEI.ADKR..GLVGYNP-MMHC...gGIPLGQRALTPSFISGT.DIM........VESDDLHYVNNAAMQQMWDDIRRTTIVGMDMAHETLEKRLGIEVTPETINHYLEVLNHALPGGAVVQEHMVETHPALVDDCYCKIFTGDDELADEIDDQFLININKQFPE......E.QAEALKAAIGKTTWQAAHIPTIVSRTTDGAQTSRWMAMQVGMSFIAAYNMCAGEAAVADLSYAAKHAGVISMGDMLP..............
Q6LWZ5_METMP/5-272 .........KRLFLKALKEKFE..E..DPKEK.Y.T.KFYTFGGWEQSARKREFVEANEKI.VSEKrqGIPLYNPDI---....GVPLGQRKLMPYKLSNT.DDY........CEGDDLHFLNNAAIQQLWDDIRRTVIVGMDTAHSVLEKRLGVEVTPETINEYMHTINHSLPGGAVVQEHMVEVHPSLAWDCYARIFTGDDELADELDSRFLIDINKLFPE......E.QAETLKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFITAYKLCAGEAATADFSYASKHADVIQMGNALP..............
E1RDX4_METP4/8-278 .........QKLFLNALKEKFQ.gE..DPESV.K.T.TFYNFDGVRQSPRKREFMAEAKKV.EMKR..GISMYDPEHCHL...gGLPMGQRQLMTYQVSQT.DVF........VEGDDLHFVNNAAMQQMWDDIRRTVIVGMDLAHATLQKRLGKEVTPETINEYLHILNHAMPGGAVVQEHMVETHPGIVDDCYVKVFTGDDEMADDIEPQFLLNVDKLFNA......E.QAEVLKKQVGKSMYQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVIQMATHLP..............
D7DUH5_METV3/5-272 .........KRLFLKALKEKFE..E..DPKEK.F.T.KFYTYGGWQQSERKKEFFAENERIvAEKR.dGIPMYNPDI---....GVPLGQRKLMPYKVSNT.DSY........VEGDDLHFMNNAAIQQLWDDIRRTVIVGMDTAHMVLEKRLGVEVTPETINEYMHTINHSLPGGAVVQEHMVEVHPSLAWDCYAKIFTGDDELADELDDRFVININKLFPE......E.QAEELKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMGNALP..............
A0A0X3BN07_9EURY/8-278 .........QKLFLKALKEKFQ.gQ..DVQSD.T.A.EYYKYNGVRQSPRKMEFMKASRAI.EMDR..GISMYDPERAHL...gGIPMGQRQLMTYEVSGT.GVF........VEGDDLHFVNNAAMQQFWDDIRRTVIVNMDLAHQTLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDQELADDLEPQFVLDVEKLFPA......K.QAEALSAAVGKSLWQAIHIPTAVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVIQMASLLP..............
A2SSD1_METLZ/8-278 .........QKLFLDALKQKFP.kQ..DVASV.Q.T.EFYKFNGVQQSPRKREFMAENKKI.EAAR..GISMYDPEHCHL...gGIPMGQRQLMTYEVSGT.GTF........VEGDDLHFVNNAAMQQMWDDIRRTVIVSMDMAHQTLQKRLGKEVTPETINEYLHVVNHAMPGGAVVQEHMVETHPGLTDDCYVRVFTGDQELADNLEPQFVIDVEKLFPK......K.QAEALQAAVGKSLWQCVHMPTIVGRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVINMAHHLP..............
L0L0H0_METHD/13-282 .......ei--KFTKEHGANKM..EggKITDM.V.G.KYY-RLGVDQNPRKVEMKKAGQEL.AKKR..GLVGYNP-MMHC...gGIPLGQRALTPSFISGT.DMM........VEVDDLHYVNNAAMQQMWDDIRRTCIVGIDLAHETLEKRLGIEVTPETINFYLETLNHALPGGAVVQEHMVETHPALVDDCYCKIFTGDDELADEIDKQFLIDINKEFPE......E.QAAQIKAAIGKTTWQAAHIPTVVSRVTDGAQTTRWMAMQVGMSFISAYSMCAGEAAVADLSYAAKHAGVISMGEMLP..............
B8GE93_METPE/8-277 .........QKLFLKALKEKFA.gE..DPAGE.H.T.HF-ARAGLEQSERKREFMKEGKKV.EMER..GISQYDPKRCHL...gGIPLGQRQLMTYEISGT.GTF........VEGDDLHFVNNAAMQQMWDDIRRTIIVGMDLAHNTLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPSLVSDCYVKVFTGDDEVADQIEPQYLLNIEKLFPA......K.SAEKLKAAVGKSMFQAIHIPTTVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSYAAKHAGVIQMADILP..............
U6EEP1_9EURY/3-268 .........EKMFINALKKAFE..E..DPSDK.T.T.TFYKFGGWRQSERKREFVEAGKEV.AAKR..GIPQYDPDV---....GTPLGQRVLMPYQVSTT.DTF........VEGDDLHFVNNAAMQQFWDDIRRTVIVGLNTAHSVIEKRLGKEVTPETITHYLETVNHAMPGAAVVQEHMVETHPLLTADSYVKVFTGNDEIADEIDQRYVLDINEEFPE......H.QAEVLKAEVGDGMWTVVRIPTIVSRTCDGGTTSRWSAMQVGMSMISAYKQAAGEAATGDFAYAAKHAEVIHMGTYLP..............
H1YXH9_9EURY/8-278 .........QKLFLDALKQKFQ.gE..DVESV.K.T.TFYNFDGVRQSPRKREFMEATKAV.EAKR..GMAMYDPEHCHL...gGLPMGQRQLMTYEVSGT.GTF........VEGDDLHFVNNAAMQQFWDNIRRTVIVGMDLAHATLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDDEMADDIEPQFLINVEKLFPA......E.QAEVLKAEVGKSMYQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVVQMASHLP..............
A6UWH2_META3/5-271 .........KKLFLKALKEKFD..E..DPKEK.Y.T.KFYTYGGWKQSKRKTEFVEAAKDI.ADKR.gGMPGYNPDI---....GVPLGQRKMMSYKLSGT.DDY........VEGDDLHFMNNAAIQQLHDDIRRTVIVGMDTGHMVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVDPALAWDSYAKIFTGDDELADELDKRVLVDINKLFPE......E.QAEELKAAIGKKTYQISRVPTLVGRVCDGGTIARWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIGMGTALP..............
A0A1F2P8K6_9EURY/59-323 ........q-REMYKALHTLFE..G..EPMDT.VdK.QSYRHGGVQQSRSKRMWVEWGKKI.AIER..GIPQYNREM---....GIPLGQRYYEPVLVSNT.DYI........VDYDDFSVYNNCAIQQMMDDMRKTVIMGLDVPHRVIQLRLGKEISPESMNLYMETIQHVLAGGAVVQEHMAETHPGLVTDAYAKIITGNPDLRDQFDRRWVLNIDKEFHP......T.RAEPLNEMIGNRLFNTIRTHTLRVRMTNGAAVIRSAAIAVTMSFVAAYKL-TGESVLSDISFATRHAQAIHMG----lat...........
A0A6B9TBW2_9ARCH/5-269 .........EKLFMEACKKKFK..E..EPTDM.T.T.KYYCYGGWKQSKSKVEFQNSAMEI.AKKR..GIPMMNEDI---....GVPLGQRSWMPYQLSHT.DIF........AEADDLHCVNNCAIQQAWDDIRRTILVGLDSPHQTIERRLGKEVTPETINTYLETVNHTMPGGAVVQEHMAEVNPALVWDSYVKVYSGDDELIDEIDPRFVIDINKLFPA......E.QAEQLKKAIGKTLMQAVRVPTIVGRLMDGATVSRHAAMQISMAFISAYKLAAGEAAIADFAYSAKHQS-LAMGTMMP..............
U6EF81_9EURY/5-270 .........KKLFLKALQNKFD..E..DPKQN.H.T.NFYCFGGWKQSPRKKEFDEFAKKI.EEDR..GIPFYNPDI---....GVPLGQRKLMAYKVSGT.DTY........VEGDDLHFCNNAAIQQLNDDIKRTIIVGMDTAHSVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPGLVGDCYAKLFTGDDSLADELDSRYLIDINKEFPE......E.QAKQLKEYIGNKTYQISRVPSLVVRVCDGGTVSRWSAMQIGMSFIAAYKLCAGEAAIADFSYAAKHADVISMGSILP..............
E3GZ51_METFV/6-271 .........KKLFVDALRKKFK..E..EPKER.K.T.TFYTLGGWKQSERKKEFVEYGKKV.AKER..GIPAYNPDI---....GTPLGQRVLMPYQVSTT.DTF........VEGDDLHFVNNAAMQQFWDDIRRTVIVGLNHAHRILERRLGKEVTPETINHYLETVNHAMPGAAVVQEHMVETHPGLTADSYVKVFTGNDELADEIESCYLIDINKQFPE......H.QAEQLKKAIGDSIWQAVRIPTIVSRTCDGATTSRWSAMQIGMSMISAYKQAAGEAATADFAYAAKHAEVIHLGTFLP..............
D5EAD6_METMS/14-284 ........e-VKFTKEHGTNKM..EggDITDM.R.I.PYY-RLGVDQNPRKLEMKKVGKDI.AEKR..GLAGYNP-MMHC...gGIPLGQRALTPSFISGNdDMM........VENDDLHYVNNAAMQQMWDDIRRTCIVGMDMAHETLEKRLSIEVTPETINHYLEVLNHALPGGAVVQEHMVESHPALVDDCYVKIFTGDDELADEIDDQFLIDIDKQFPA......E.QAEQLKASIGNTTWQAAHIPTIVSRTTDGGQTTRWTAMQIGMSYIAAYGMCAGEAAVADLSYAAKHAGVVNMGDMLP..............
A0A059TIR1_THEX5/6-270 .........QKLFLEACKKKFK..E..EPTQM.D.T.KYYCYGGWKQSKRKVELQATAAEI.AKKR..GFPMMNEDI---....GVPLGQRSWMPYQLSHT.DIF........VEPDDLHCINNPAIQQAWDDIRRTVLVGLDFPHQTIEKRLGKEVTPETISNYLEVVNHTMPGGAVVQEHMAECNPALVADSYVKVFSGNDDLIDEIDPRFVIDINKNFPK......E.QAAQLKKAIGNTFMQAVRVPTMVGRLMDGGTVSRHAAMQISMAFISAYKLAAGEAAIADFAYSAKHQS-ITMGSMMP..............
Q8PXH8_METMA/14-282 ........e-VKFTQEYGSNQQagG..DITGK.T.A.KF-LRLGPEQDARKAEMIKAGKEI.AEKR..GIAFYNP-MMHS....GAPLGQRAITPYTLSGT.DIV........AEPDDLHYVNNAAMQQMWDDIRRTCIVGLDMAHETLEKRLGKEVTPETINHYLEVLNHAMPGAAVVQEMMVETHPALVDDCYVKVFTGDDELADEIDKQYVININKMFSE......E.QAAQIKASMGKTTWQAIHIPTIVSRTTDGAQTSRWAAMQIGMSFISAYAMCAGEAAVADLSFAAKHAALVSMGEMLP..............
A0A166CWD2_9EURY/3-268 ........n-KKFIEALNKKFK..E..SPEEK.T.T.TFYNLGGWKQSERKSEFAKEGKEI.ATKR..GIPQYNPDV---....GSPLGQRALMPYQVSTT.ETF........VEGDDFHFVNNAAIQQMWDDIRRTVIVGLNTAHTVLEKRLGIEVTPETITEYLETVNHAMPGAAVVQEHMVETNPALVADSYVKIFTGDDEVADEIDSAFVLDINKEFSK......E.QAEALKAEVGDKIWQVVRIPSIVGRVCDGGTTSRWSAMQIGMSMISAYNQCAGEGATGDFAYASKHAEVIHMGTYLP..............
R9TAZ9_METII/3-268 .........DKLFMDAMKKKFK..E..DPTDE.Y.T.SYYTFGGWKQSKRKREWVEQANAI.AKAR..GIPMMNQDI---....GVPLGQRVLMPYQLSHT.DMY........AEADDLHFVNNAAIQQAWDDIRRTVIVGLDTAHTVIEKRLGKEVTPETINNYLETVNHAMPGGAVVQEHMAECSPALTADCYVKVFSGNSELIDQLDKRFVIDINKEFPE......D.QAKQLNDAIGKSLYQVVRCPTIVGRVCDGGTMSRWSAMQISMSFISAYRLAAGEAAIADFAYAAKHASVVEMGTMMP..............
A0A2Z4L8F8_9EURY/5-271 .........KKLFLKALQEKFD..E..DPEEQ.N.T.KYYCYGGWEQSARKREFNEQAEKA.MEAR.gGLPFYNPDI---....GVPLGQRKLMAYQVSGT.DTY........VEGDDLHFCNNSAIQQLVDDIKRTVIVGMDTAHGVLEQRLGVEVTPETINEYLETINHALPGGAVVQEHMVEVDPGLVVDSYAKIFTGDDDLLDQLDQRFVIDINKEFPE......E.QAEMLKKYIGKKTYQVSRVPTLVVRACDGGTTSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVVSMASAMP..............
A0A1Q6DVQ2_9EURY/3-269 ........e-EKFIESLKNKFE..E..DPTSK.N.QkSLYQLGGYKQSKRKKEFQEAGQQI.AKER..GTSSFNEDI---....GVPLGQRVLMPYQLSHT.DMT........VEPDDLHVLNNAAMQQAWDDIQRTVIVGLDMSHKVLEKRLGKDVTPETINQYLETYNHTQPGGAVVQEHMAECNPGVTGDAYVKVFTGDDELKDEVDDQFLLDIDEKFPE......D.QAEQLKDAIGETTWQILRVPTIVVRTMDGATVRRWAAMQSCMAFISAYNLCAGEAPVSDFVFAAKHQSVVNMGSAMP..............
A0A2V3JAG5_9EURY/7-280 ........q-HNFLKAMSNKFA..E..KPDST.K.T.KFYVYGGWTQSKRKTEFVEEGKKL.AMARssRTPGYNPDV---....GMPQGQRYLMPYMLNHT.DIM........VEADDLHWINNAAMQQCWDDMKRCIILGLDDAHGLLEARLGKEVTPDTISHYMEVLNHALPGAAVIQEHMVETKPMLVNDCYAKVFTGDDDLADALDRRFVLDINKEFPAgwtrpgE.QSDQLKEAIGKKIWQVLWMPTVVGRMCDGETMFRWVGMQVGMTMINAYKMCAGESATGEFAYYAKHAAVVQLAGKMP..............
Q0W339_METAR/7-274 .........QKRFIKAMKKKFA..E..EPTAQ.V.T.KF-KYEGYTQSKRKVEFKKTGDAI.AKKR..GISMYNP-MVHM...gGIPLGQRQLMNYVVSGT.DIA........VEGDDLHFVNNAAMQQFWDEIRRTVIVGLDTAHATLEKRLGKTVTPETISNYLAVLNHAMPGAAVVQEHMVETHPGLTDDCFVKVFTGDDELADSIDKQYVLDINKAFPK......E.QAAQLKKAIGKQLFQAVHIPTIVVRTCDGGTTSRWSAMQIGMSFIDAYKMCAGEAAVADLAFAAKHASVVEMGNLLP..............
A0A1F2PC64_9EURY/2-269 ........k-KKAIDLLMATFD.eD..DATRE.Y.T.TFFQFGGWKQSKRKQEYVKLAKEL.LKER..GLTGYQGDRDDM....GVPLGQRFIEPYYISGT.ETM........CEAEDLHQINNAAMQQLGDDIKRTAIAGLDMAHKMLEVRIGATVTPETINRYLEVANHTIVGGAVAQEHMPEINPAMTKDASVKLMSGNDELLDHIDDQYIIDIDKEYPE......K.QAEDLKEGIGKRLFQATRIPTIAVRISDAGIVHRWAANQTTLAFITAYALG-GGAVLADFSLTSKHMQYVLLG----tps...........
D3E050_METRM/3-268 .........DKKFLDAMTKKFK..E..APEEK.T.T.TFYNMGGWTQSERKTEFVNEGKAI.AEAR..GIPMYNPDI---....GNPLGQRALMSYQLSGT.DTF........VEGDDLHFINNAAMQQAWDDIRKTVIVGLNTAHNVLEKRLGMEVTPETITNYLEVVNHAMPGAAAVQEHMVETNPLLVDDSYVKVFTGDDDLAAEIDPAFVLDINKEFPE......E.QAEALKAEVGGAIWQIVRVPSVVGRVCDGGTTSRWSAMQIGMSMISAYGQCAGEGATGDFAYASKHAEVIGMGTYLP..............
A0A0A7LF46_9ARCH/7-271 .........DKLFMDAVKKKFK..E..DPTDM.E.T.KYYCYGGWRQSKSKVEFQKAAQAI.AKKR..GFPMMNEDI---....GVPLGQRAWMPYQLSHT.DIY........VEVDDLHCINNPAIQQAWDDIRRTILVGLNSPHETIEKRLGKEVTPETINNYLEAVNHTMPGGAIVQEHMAECNPALVSDSYVKVYSGDDELIDEIDKRFVIDINKLFPK......A.QADQLKKAIGKNLMQAVRVPTMVGRLMDGATVSRHAAMQISMAFISSYKLAAGEAAIADFAYSAKHLS-INMGTMMP..............
MCRX_METTH/4-271 .........KKLFLTALKKKFE.vE..DPDEK.Y.T.NFYCFGGWEQSARKKEFTEYAKKA.AEKR.gGIPFYNPDI---....GVPLGQRKLMAYRVSGT.DAY........VEGDDLHFVNNAAIQQMVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMEAINHALPGGAVVQEHMVEVHPGLVEDCYAKIFTGDDNLADELDKRILIDINKEFPE......E.QAEQLKSYIGNRTYQVNRVPTIVVRTCDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVIEMGTIMP..............
A0A1D2W9L6_9EURY/5-271 .........KKLFAKALKGKFD..E..DPNEN.H.T.NFYCFGGWEQSARKKEFNAEAEKL.MEER.gGVPFYNPDI---....GVPLGQRKLMAYKVSGT.DSY........VEGDDLHFLNNAAIQQLLDDIKRTVIVGMDTGHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVNPGLVGDCYAKIFTGDDNLADELDKRVLIDINKEFPE......E.QAEMLKKYVGKKTYQVSRVPTAVVRSCDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVIGMGAILP..............
D7E8X7_METEZ/15-284 .........ERKFTQEFGDNKQsgG..EITDK.K.T.EY-QRMGVAQSPRKMEMLKAGQEL.SKKR..GLVGYNPDL-HA...gGVQLGQRALTPSYLSGT.DML........TEMDDLHYVNNAAMQQMWDDIRRTCIVGMDSAHETLEKRLGIEVTPETINHYLEVLNHAIPGGAVVQEHMVETHPGLTEDCYVKIFTGDDDLADEIDDQFLIDIDKEFPE......D.QAQQLKESIGKTTWQVAHIPTVVSRTTDGGQTRRWMAMQLGMSFINAYHMCAGEAAVADLSYAAKHASVINMGEMLP..............
A0A366M976_9EURY/3-268 .........DKKFIEALNKKFK..E..NPEEK.T.T.TFYNLGGWKQSERKTEFANAGKEI.AAKR..GIPQYNPDV---....GSPLGQRALMPYQVSTT.DTY........VEGDDFHFVNNAAIQQMWDDIRRTVIVGLNTAHNVLEKRLGMEVTPETITEYLETVNHAMPGAAVVQEHMVETNPSLVADSYVKVFTGDDELADEIDSAFVLDINKEFSE......E.QAEALKAEVGDKVWQAVRIPTIVGRVCDGGTTSRWSAMQIGMSMISAYNQCAGEGATGDFAYASKHAEVIHMGTYLP..............
A0A1F2P6A2_9EURY/2-269 ........e-KKSIDIIKEIFG.eE..DAESK.H.T.SFYEFGGWRQSRRKREYVEIARDL.VKKR..GVTGYQGDRDDM....GVPLGQRFIEPYYISGT.DIL........CDAEDLHQINNAAIQQMGDDIKRTAISGLDMAHRMLEVRIGATVTPETINRYLEVANHTIVGGAVAQEHMAEINPAMTRDGYVKITTGNEDLTDHIDKQYLIDINMEYPE......D.QADALKEGVGSSLYQVVRVPTIAVRNADGGITHRWAANQCTLAFITAYALGGG-SVLADFSLTSKHMQYVTLGT---pt............
A0A483CX70_9EURY/8-278 .........QKLFLKSLKEKFQ.gQ..DVQSE.K.T.EFYKFGGVRQSPRKLEFMKESRAI.EMQR..GISMYDPERCHL...gGIPMGQRQLMTYEVSGT.GVY........VEGDDLHFVNNAAMQQMWDEIRRTVIVGMDMAHATLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPALTDDCYVKVFTGDDELADDIEPQFLLNIEKLFPK......K.QAEELKAEVGKSMYQSIHIPSIVSRTCDGGTTSRWSAMQIGMSYIAAYRMCAGEAAVADLSFAAKHAGVIQMGSILP..............
I7KDB2_METBM/8-278 .........QKLFLKALKEKFQ.gQ..DVQSD.T.A.EYYKYNGVRQSPRKMEFMKASRAI.EMDR..GISMYDPERAHL...gGIPMGQRQLMTYEVSGT.GVF........VEGDDLHFVNNAAMQQFWDDIRRTVIVNMDLAHQTLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDQELADDLEPQFVLDVEKLFPA......K.QAEALSAAVGKSLWQAIHIPTAVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVIQMASLLP..............
A0A4E0Q940_9EURY/14-283 ........e-IKFTKEHGSNKM..EggEITDK.N.V.TYY-RLGVDQNPRKVEMKKAGQEI.SKKR..GLVGYNP-MMHC...gGIPLGQRALTPSFLSGT.DMM........VEMDDLHYVNNAAMQQMWDDIRRTCVVGMDMAHETLEKRLGIEVTPETINHYLETLNHALPGGAVVQEHMVETHPALVDDCYVKIFTGDDELADEIDKQFLIDINKEFPA......E.QAEQLKAAIGKTSWQAAHIPTIVSRTTDGAQTTRWMAMQVGMSFISAYSMCAGEAAVADLSYAAKHAGVIQMGEMLP..............
R9SLW2_9EURY/3-268 .........DKKFYEALNKKFK..E..SPEDK.T.T.TFYNLGGWKQSERKTQFYEAGKEI.AEER..GIPMYNPDI---....GSPLGQRTLMPYQLSTT.DTF........VEGDDLHFINNAAIQQLWDDIRRTVLVGLNTAHNVLQRRLGMEVTPETITNYLETVNHAMPGAAVVQEHMVETNPYLVSDSYVKIFTGDDELADEIDQCYVLDINKEFPD......D.QAAQLKAEVGDKIWQVVRVPSLVGRVCDGGTTSRWSAMQIGMSMISAYNQCAGEGATGDFAFATKHAEVIQMGAPLP..............
I7LMP5_METBM/8-278 .........QKMFLKALKEKFQ.gQ..DIESE.T.A.EFYKFNGVRQSPRKMEFMKASRAI.EMDR..GISMYDPERCHL...gGIPMGQRQLMTYEVSGT.GVF........VEGDDLHYVNNSAMQQFWDDIRRTVIVGMDLAHQTLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDDDVADDIEPQFLLNIEKLFPA......K.QAEELKAEVGKGMYQAIHIPTAVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVVQMASLLP..............
A0A166A6T9_9EURY/3-268 .........DKKFIQALDKKFK..E..APEDK.T.T.TFYNLGGWKQSERKTEFYNAGKEI.AEKR..GIPQYNPDV---....GSPLGQRTLMPYQVSTT.DTY........VEGDDFHFVNNAAIQQMWDDIRRTVVVGLNTAHTVLEKRLGIEVTPETITNYLETVNHAMPGAAVVQEHMVETNPLLVADSYVKVFTGDDELADEIDSAFVLDINKEFPE......D.QAAVLKEEVGDKIWQVVRIPSIVGRVCDGGTTSRWSAMQIGMSMISSYNQCAGEGATGDFAYASKHAEVIHMGTYLP..............
A0A0E3NU58_9EURY/14-282 .......ev--KFAQDYGTNQLggS..DIEAK.T.S.KF-LRLGPEQSPRKVEMIAAGKEI.AEKR..GIVGYNPNM-HM....GAPLGQRAITPYTLSGT.DIV........AEPDDLHYVNNAAMQQMWDDIRRTCIVGLDMAHETLEKRLGKEVTPETINHYLETLNHAMPGAAVVQEMMIETHPALVDDCYVKIFTGDDALADEIDSQFVININKMFPE......E.QAEQIKASIGKTTWQAIHIPTIVSRTTDGAQTSRWAAMQIGMSFISAYAMCAGEAAVADLSFSAKHASLVSMGEMLP..............
F7XL13_METZD/14-283 ........e-IKFTKEFGDNKQsgG..SITDT.R.N.KY-HRLGVDQDPRKREMREAGQKV.AKER..GLVGYNP-MMHC...gGIPLGQRAITPSFVSGT.DIM........VEPDDLHYVNNAAMQQMWDDIRRTCIVGLDMAHETLEKRLGMEVTPETINHYLEVLNHALPGGAVVQEYMVETHPALVDDCYVKIFTGDDDLADEIDKQFLIDINKEFPE......E.QAEQLKKSIGKTTWQAAHIPTIVSRTTDGGQTSRWIAMQVGMSFISAYNMCAGEAAVADLSYSAKHAAVVSMGDMLP..............
A0A2V3JK07_9EURY/8-277 .........EKLFVEALKAKFA..G.iDLADQ.T.T.KY-VRAGYVQNARKREFQAAGERV.AEQR..GIQQYDVNV-HL...gGMTLGQRQLVPYKLSTR.PDI........VEGDDLHYVNNPAMQQMWDDMKRTIIVGMDLAHETLEKRLGKEVTPESIAGYMEAVNHTMPGAAIVQEHMVETHPGLVDDCYVKMFTGDDELADEIDSQYVININDLFDK......EgQNEKIKAAIGKTTWQAIHIPTIVVRCCDGGNTSRWSAMQLGMSYIAAYNMCAGEAAVADLAFAAKHAAAVQMAEMLP..............
A0A2U1S6R5_9EURY/3-268 .........DKKFLDAMKQKFS..E..DPTDD.R.T.TFYNMGGWKQSERKSAFVKEGQEI.AEKR..GIPMYNPDI---....GTPLGQRALMSYQLSTT.DTF........VEGDDLHFINNSAIQQAWDDIRKTVIVGLNTAHNVLEKRLGIEVTPETITEYLETVNHAMPGAAVVQEHMVETDPLVVSDSYVKVFTGDDELADEIDSAFVLDINKEFPE......E.QAEALKAEVGGSIWQAVRIPGIVGRVCDGGTTSRWSAMQIGMSMISAYNQCAGEGATGDFAYASKHAEVIHMGTYLP..............
A0A0X3BNP7_9EURY/11-281 .........QKMFLKALKEKFQ.gQ..DIESE.T.A.EFYKFNGVRQSPRKMEFMKASRAI.EMDR..GISMYDPERCHL...gGIPMGQRQLMTYEVSGT.GVF........VEGDDLHYVNNSAMQQMWDDIRRTVIVGMDLAHQTLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDDEVADDIEPQFLLNIEKLFPA......K.QAEELKAEVGKGMYQAIHIPTAVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVVQMASLLP..............
MCRA_METAC/14-282 ........e-VKFTQEYGSNKQagG..DITGK.T.E.KF-LRLGPEQDARKQEMIKAGKEI.AEKR..GIAFYNP-MMHM....GAPLGQRAITPYTISGT.DIV........AEPDDLHYVNNAAMQQMWDDIRRTCIVGLDMAHETLEKRLGKEVTPETINHYLETLNHAMPGAAVVQEMMVETHPALVDDCYVKIFTGDDELADEIDKQYVINVNKMFSE......E.QAAQIKASIGKTTWQAIHIPTIVSRTTDGAQTSRWAAMQIGMSFISAYAMCAGEAAVADLSFAAKHAALVSMGEMLP..............
E1RJD5_METP4/8-278 .........QKLFLNALKEKFQ.gQ..DIESE.R.T.TFYNFDGVRQSPRKREFMAETVEI.EKKR..GISMYDPERCHL...gGIPMGQRQLMTYEVSGT.NTF........VEGDDLHFVNNAAMQQMWDEIRRTVIVGMDMAHATLQKRLGKEVTPETINEYLHILNHAMPGGAVVQEHMVETHPALTDDCFVKVFTGDDELADDIDPQYLINIDKLFPE......N.QAAELKEEVGKSIFQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVIQMGTILP..............
A0A8J7UNS3_9EURY/8-278 .........QKLFLKSLKEKFQ.gQ..DVQSE.K.T.EFYNFDGVRQSPRKREFMEATKAI.EAKR..GISMYDPERCHL...gGIPMGQRQLMTYEVSGT.GTF........VEGDDLHFVNNSAMQQFWDDIRRTVIVGMDMAHATLQKRLGKEVTPETINEYLHTLNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDDDLADDIEPQFLLNIEKLFPA......K.QAEELKAEVGNSMYQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVVQMGTILP..............
W9DZJ0_METTI/14-283 ......eik---YTKEHGTNKMegG..KITDK.T.V.EYY-RLGVDQNPRKLEMKKAGQEL.AKKR..GLVGYNP-MMHC...gGIPLGQRALTPSFLSGT.DDM........VEIDDLHYVNNAAMQQMWDDIRRTVIVGLDMAHETLEKRLGIEVTPETINHYLETLNHALPGGAVVQEHMVETHPALVDDCYVKMFTGDDELADEIDSQFLIDINKAFPE......E.QAEQLKAAIGKNSFQAAHIPTIVSRTTDGGQTSRWMAMQVGMSFISAYSMCAGEAAVADLSYAAKHAGVVQMGEMLP..............
A0A0Q4BCJ2_9ARCH/1-261 ........m-----AAVKKKFK..E..DPTDE.Y.T.SYYKFGGWRQSKRKVEFVEAANKI.AKER..GIPMMNQDI---....GVPLGQRSWMPYQLSHT.DIY........VEPDDLHCINNPAIQQAWDDIRRTILVGLDAPHQTIEKRLGKEVTPETINEYLEAVNHTMPGGAVVQEHMAEINPALAYDSYVKVYSGNDELIDELDKRFVIDINKLFSK......D.HAAQLKKAIGSTLMQAVRVPSIVGRVMDGATTSRHAAMQISMAFITSYRLAAGEAAIADFAYSAKHQS-LPMGTMMP..............
A0A8J7RJF3_9EURY/8-278 .........QKLFLKSLKEKFQ.dQ..DVQSE.K.T.EFYKFGGIRQSPRKLEFMKASQAV.EMQR..GMAMYDPERCHL...gGLPMGQRQLMTYEVSGT.GVY........VEGDDLHFVNNSAMQQMWDDIRRTVIVGMDLAHATLQKRLGKEVTPETINEYLHILNHAMPGAAVVQEHMVETHPGLVDDCYVKVFTGDDELADDIEPQFLLDVEKLFPA......K.SAEALKAAVGKSMWQAIHIPTIVSRTCDGGTTSRWSAMQIGMSYIAAYRMCAGEAAVADLSFAAKHAGVIQMADILP..............
A0A2V2MZL0_9EURY/8-277 .........QKLFLKALKEKFE..G..DVQDT.K.T.SFYNFDGVNQSPRKREFMAASKKV.ELRR..GISMYDPNRCHL...gGLPMGQRQLMTYEVSGT.GTF........VEGDDLHFVNNPAMQQMWDDIRRTIIVSMDLAHNTLQKRLGKEITPETINEYLHILNHAMPGAAVVQEHMVETHPSVVDDCYCKVFTGDSELADQLEKQFVLDVDKLFPA......K.QAEELKAAVGKSLWQAIHIPTIVSRTCDGGTTSRWSAMQIGMSFITAYRMCAGEAAVADLSYAAKHAGVIQMGSHLP..............
F6BE97_METIK/5-271 .........KKLFLKALKEKFE..E..DPKEK.Y.T.KFYVFGGWKQSARKREFVEAAEKL.LEKR.gGIPFYNPDI---....GVPLGQRKLMPYKLSGT.DYI........VEGDDLHFMNNAAMQQMWDDIRRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPALAWDCYAKIFTGDDELADEIDKKFLIDINKLFPE......E.QAEQIKKAIGKRTYQVNRVPTLVGRVCDGGTIARWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMGTLLP..............
MCRA_METJA/5-271 .........KRLFLKALKEKFE..E..DPREK.Y.T.KFYVFGGWRQSARKREFVEAAQKL.IEKR.gGIPFYNPDI---....GVPLGQRKLMPYKVSNT.DAI........VEGDDLHFMNNAAMQQFWDDIRRTVIVGMDTAHAVLEKRLGVEVTPETINEYMETINHALPGGAVVQEHMVEVHPALVWDCYAKIFTGDDELADEIDKRFLIDINKLFPE......E.QAEQIKKAIGKRTYQVSRVPTLVGRVCDGGTIARWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMASFLP..............
Q2NHZ8_METST/5-271 .........KKLFLKALKEKFD..E..DPEEE.N.T.KFYCYGGWEQSARKREFAEEAEKA.VEAR.gGLPFYNPDI---....GVPLGQRKLMAYQVSGT.DTY........VEGDDLHFCNNSAIQQLVDDIKRTVIVGMDTAHGVLEQRLGVEVTPETINEYLETINHALPGGAVVQEHMVEVDPGLVTDSYAKIFTGDDDLLDQLDQRFVIDINKEFPE......E.QAEMLKKYIGKKTYQVSRVPTLVVRACDGGTTSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVISMASAMP..............
A0A1Y3GED3_9EURY/6-271 ........s-KRFIKALKNKFE..E..EPTDT.K.T.HFYDLGGYKQSERKKEFQERAAQI.AKER..GTPSLNEDI---....GVPLGQRVLMPYQLSHT.DTM........VEPDDLHIINNAAMQQAWDDIQRTVIVGLDTAHQVMEKRLGVEVTPETINEYLEVFNHTQPGGAVVQEHMAECNPGVTGDAYVKVFTGNDELADEIDDNLLIDINENFPE......D.QAEQLKEAIGDSLWQAIRAPTIVTRVMDGATIRRWAAMQSSMAFISSYSLCAGEAAIADFAYASKHSKVINMASAMP..............
Q8TVA5_METKA/8-59 ........e-ALFIKALKEKFE..E..DPEEK.H.T.KFYVYGGYRQSPRKE-FA------.----..------------....-----------------.---........--------------------------------------------------------------------------------------------------------------......-.-----------------------------------------------------------------------------kgalrefepagerd
A0A328PGC5_9EURY/4-269 .........EKLFMKALKRKFE..E..DPEER.Q.T.SFYKFGGWKQSERKREFVEAGKEI.AKKR..GIPGYNPDI---....GTPLGQRVLMPYQVSTT.DTF........VEGDDLHFVNNAAMQQFWDDIRKTVIVGLNHAHAVIEKRLGKEVTPETINHYLETVNHAMPGAAVVQEHMVETHPALTADSYVKVFTGNDEIADEIDDAFLIDINKQFPE......D.QAEQLKAEVGDGIWQAVRIPTIVSRTCDGGTTSRWSAMQIGMSMISAYKQCAGEAATGDFAYAAKHAEVIHMATYLP..............
A0A1F2P729_9EURY/2-269 .......de--KILDDFKRIFK.eE..DPTKR.E.T.QFYNFGGRTQSKAKREFIESAKRI.AETR..GIPGYQGDREDF....GVPLGSRYLEPYHIAGT.DTF........CEMDDIHQINNAAIQQMGDDIKRTAINGLDLPHRVLQQKVGIAVTPETINRYLEAVNHSIVGGALAQEHMAEINPNMSKDGYAKIITGDDELVDRIDSRFVIDINKEYPK......E.MAEKLKSKIGNHLYQVARIPTIGVRIADGSVVHRWNGNQSALAFVSTYNLGGG-SILAEFSLTVKHMAYMLIG----tpt...........
A0A1F2PDF7_9EURY/167-444 qramnesvl--------AKGFG.vE..DVREE.T.T.EY-PAGGISQVPEKLEYVKVSKEI.EKQR..GISLYRPHL-HW...hGIELGQKPYVKWKITAT.HMQrpcrtfdgLSMEQINFLNNAACHQWMADVQRTHIFGLDLAHRTVERRFGKEVTPDSINLYMEMHNHNIAAGSLIMEHIGETDPRLVADSYVKIITGNEAMLEVLDPQYIIDVRQLFPE......Y.QASQIMNQIGDKLFEVARIPTLITMIGDHGTTRGWTGQQASLAFLSAYRIPAGEAVTSDFVYTVKHGDNIFMGNRLP..............
A2STR9_METLZ/8-278 .........QKLFLDALKQKFP.kQ..DVAST.T.A.EFYKFNGLEQSPRKREFMAENKKI.EAAR..GISMYDPNRCHL...gGIPMGQRQLMTYELSGT.GTF........VEGDDLHFVNNAAMQQMWDDIRRTVIVSMDMAHQTLQKRLGKEVTPETINEYLHVVNHAMPGGAVVQEHMVETHPGLTDDCYVRVFTGDQELADNLEPQFVIDVEKLFPK......K.QAEALQAAVGKSLWQCVHMPTIVGRTCDGGTTSRWSAMQIGMSFIAAYRMCAGEAAVADLSFAAKHAGVINMAHHLP..............
A0A1D2WBA8_9EURY/3-268 .........DKKFMEALKKKFE..E..APEES.K.T.HFYDLGGWKQSERKTEFVKAGKEI.AEKR..GIPMYNPDV---....GTPLGQRVLMPYQVSTT.DTY........VEGDDLHFVNNAAMQQFWDDIRRTVIVGLNTAHNVIEKRLGKEVTPETITTYLETVNHAMPGAAVVQEHMVETNPSLVYDSYVKIFTGNDEIADEIDPAFVININKMFPE......E.QAEVLKAEVGDAMWQVVRIPTIVSRTCDGGTTSRWSAMQIGMSMISAYKQAAGEAATGDFAYAAKHAEVVHMGSYLP..............
#=GC seq_cons .........pKhFlcALKcKFp..E..Dspcc.p.T.pFYpaGGhcQStRKpEFhctuccI.sccR..GIshYNP-h.......GlPLGQRtLMsYplSsT.Dsa........VEGDDLHFVNNAAhQQhWDDIRRTVIVGhDhAHpsLEKRLGhEVTPETINcYLEslNHAMPGuAVVQEHMVETHPuLVsDsYVKlFTGDDELAD-IDspFlIDINK.FPc......-.QAEpLKstlGcshaQsl+lPTlVuRsCDGGTTSRWSAMQIGMSFIoAY+hCAGEAAlADhuaAAKHAsVIpMGshLP..............
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