#=GF ID MCR_gamma
#=GF AC PF02240.20
#=GF DE Methyl-coenzyme M reductase gamma subunit
#=GF AU Mian N;0000-0003-4284-4749
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_2713 (release 5.2)
#=GF GA 25.00 25.00;
#=GF TC 225.90 225.70;
#=GF NC 21.80 18.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0618
#=GF RN [1]
#=GF RM 9367957
#=GF RT Crystal structure of methyl-coenzyme M reductase: the key enzyme
#=GF RT of biological methane formation
#=GF RA Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK;
#=GF RL Science 1997;278:1457-1462.
#=GF DR INTERPRO; IPR003178;
#=GF DR SCOP; 1mro; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Methyl-coenzyme M reductase (MCR) is the enzyme responsible for
#=GF CC microbial formation of methane. It is a hexamer composed of 2
#=GF CC alpha (Pfam:PF02249), 2 beta (Pfam:PF02241), and 2 gamma (this
#=GF CC family) subunits with two identical nickel porphinoid active
#=GF CC sites [1].
#=GF SQ 90
#=GS W9DYL3_METTI/5-246 AC W9DYL3.1
#=GS Q6LWZ6_METMP/5-251 AC Q6LWZ6.1
#=GS A0A2V3J7I1_9EURY/2-250 AC A0A2V3J7I1.1
#=GS A0A315XPC1_9EURY/2-247 AC A0A315XPC1.1
#=GS A0A1F2P8S5_9EURY/6-251 AC A0A1F2P8S5.1
#=GS A0A1D3L4I3_9EURY/2-247 AC A0A1D3L4I3.1
#=GS A0A0X8V1S6_THEX5/6-251 AC A0A0X8V1S6.1
#=GS Q8TXL0_METKA/5-250 AC Q8TXL0.1
#=GS Q8PXH7_METMA/8-249 AC Q8PXH7.1
#=GS A0A1F2P510_9EURY/14-259 AC A0A1F2P510.1
#=GS MCRZ_METJA/5-251 AC Q60387.1
#=GS A0A8J8C9I0_9EURY/5-251 AC A0A8J8C9I0.1
#=GS D7DUH4_METV3/5-251 AC D7DUH4.1
#=GS A0A2V2MNB2_9EURY/5-249 AC A0A2V2MNB2.1
#=GS A0A166A6R3_9EURY/2-247 AC A0A166A6R3.1
#=GS U6EEZ4_9EURY/5-250 AC U6EEZ4.1
#=GS A0A1V6N552_METAZ/2-247 AC A0A1V6N552.1
#=GS A0A062V5Q9_9EURY/5-246 AC A0A062V5Q9.1
#=GS A0A0X3BMY4_9EURY/11-256 AC A0A0X3BMY4.1
#=GS A0A328PDU5_9EURY/2-247 AC A0A328PDU5.1
#=GS A0A366M9W2_9EURY/2-247 AC A0A366M9W2.1
#=GS L0HHU6_METFS/5-251 AC L0HHU6.1
#=GS L0KWQ4_METHD/5-247 AC L0KWQ4.1
#=GS A0A2V3JTG5_9EURY/5-246 AC A0A2V3JTG5.1
#=GS A0A166F2B1_9EURY/2-247 AC A0A166F2B1.1
#=GS A0A8J8B5S5_9EURY/5-250 AC A0A8J8B5S5.1
#=GS D3E051_METRM/2-247 AC D3E051.1
#=GS A2SSD0_METLZ/5-250 AC A2SSD0.1
#=GS A0B6N7_METTP/5-253 AC A0B6N7.1
#=GS F6BBJ1_METIK/5-250 AC F6BBJ1.1
#=GS A0A328S7M2_9EURY/5-250 AC A0A328S7M2.1
#=GS B8GE92_METPE/5-251 AC B8GE92.1
#=GS I7KZS5_METBM/5-250 AC I7KZS5.1
#=GS A0A498GYL8_9EURY/5-250 AC A0A498GYL8.1
#=GS A0A1D2W9X1_9EURY/5-250 AC A0A1D2W9X1.1
#=GS A0A1D2WB69_9EURY/2-247 AC A0A1D2WB69.1
#=GS A0A0Q4BF52_9ARCH/5-250 AC A0A0Q4BF52.1
#=GS Q12TF7_METBU/5-246 AC Q12TF7.1
#=GS A7I5U0_METB6/5-251 AC A7I5U0.1
#=GS Q0W340_METAR/5-249 AC Q0W340.1
#=GS MCRZ_METFV/5-250 AC Q49173.1
#=GS A0A1Y3GAS1_9EURY/5-250 AC A0A1Y3GAS1.1
#=GS MCRG_METJA/5-251 AC Q58255.1
#=GS D1YVW5_METPS/5-249 AC D1YVW5.1
#=GS A0A484F634_9EURY/5-246 AC A0A484F634.1
#=GS A0A1F2P3I3_9EURY/6-251 AC A0A1F2P3I3.1
#=GS A0A0A7LAF7_9ARCH/11-256 AC A0A0A7LAF7.1
#=GS A0A1F2P4X3_9EURY/8-253 AC A0A1F2P4X3.1
#=GS A0A483CSA4_9EURY/5-250 AC A0A483CSA4.1
#=GS MCRZ_METTH/5-250 AC P21112.5
#=GS A0A483CN68_9EURY/5-250 AC A0A483CN68.1
#=GS MCRG_METTH/2-247 AC O27233.3
#=GS A0A0E3L072_9EURY/1-225 AC A0A0E3L072.1
#=GS A0A4E0R287_9EURY/5-246 AC A0A4E0R287.1
#=GS A0A1Q6DVN5_9EURY/5-250 AC A0A1Q6DVN5.1
#=GS A0A2U1S6S0_9EURY/2-247 AC A0A2U1S6S0.1
#=GS A0A1F2PA65_9EURY/1-245 AC A0A1F2PA65.1
#=GS F0T8R2_METLA/2-247 AC F0T8R2.1
#=GS L0HFR7_METFS/6-251 AC L0HFR7.1
#=GS M4YNV7_THEXX/7-252 AC M4YNV7.1
#=GS A6UWH1_META3/5-251 AC A6UWH1.1
#=GS A0A2Z4L8Q4_9EURY/5-250 AC A0A2Z4L8Q4.1
#=GS A0A1F2P9Z1_9EURY/17-262 AC A0A1F2P9Z1.1
#=GS I7L043_METBM/5-250 AC I7L043.1
#=GS G7WN23_METH6/1-234 AC G7WN23.1
#=GS A2STS0_METLZ/5-250 AC A2STS0.1
#=GS D5EAD7_METMS/5-246 AC D5EAD7.1
#=GS F7XLI3_METZD/5-246 AC F7XLI3.1
#=GS A0A6B9TAS2_9ARCH/6-251 AC A0A6B9TAS2.1
#=GS Q8THH0_METAC/5-246 AC Q8THH0.1
#=GS A0A8J7RXU2_9EURY/5-250 AC A0A8J7RXU2.1
#=GS M9SFZ4_METAX/6-251 AC M9SFZ4.1
#=GS Q2FSN1_METHJ/5-249 AC Q2FSN1.1
#=GS H1YXI0_9EURY/5-249 AC H1YXI0.1
#=GS A0A166CF58_9EURY/2-247 AC A0A166CF58.1
#=GS E3GZ52_METFV/2-247 AC E3GZ52.1
#=GS A0A1F2P3C3_9EURY/5-250 AC A0A1F2P3C3.1
#=GS A0A8J7RBX9_9EURY/5-250 AC A0A8J7RBX9.1
#=GS F4BXY2_METSG/5-253 AC F4BXY2.1
#=GS U6EF24_9EURY/2-247 AC U6EF24.1
#=GS A0A0X3BM05_9EURY/5-250 AC A0A0X3BM05.1
#=GS R9T7E3_METII/5-250 AC R9T7E3.1
#=GS F6BE96_METIK/5-251 AC F6BE96.1
#=GS R9SN08_9EURY/2-247 AC R9SN08.1
#=GS E1RDX5_METP4/5-249 AC E1RDX5.1
#=GS F0TCV4_METLA/5-250 AC F0TCV4.1
#=GS A0A1F2PCA4_9EURY/25-273 AC A0A1F2PCA4.1
#=GS Q2NHZ9_METST/5-250 AC Q2NHZ9.1
#=GS D7E8X8_METEZ/6-247 AC D7E8X8.1
#=GS E1RJD6_METP4/4-249 AC E1RJD6.1
W9DYL3_METTI/5-246 ..l-QYYPGATSVAENRRKHM--SGKVEKLREISDDDLTLVLGHRAPGSDYPSTHPPLAEMGEPECSVREMVEPTPGAKAGDRVRYVQFVDSMYNGPSVPYVRSYSAAINFRGVDPGTLSGRQVVEARERDMEEVAKF.Q.METEMTCPALASLRGATVHGHSLRLPEDGVMFDMLDRCRK--EGDSIIMHKDQVGRPIDKKVNLGKPMSPEEAAKRTTIYR.VDNVAF........RD..DAEVIEWVHRVFDQRTTYGFK..
Q6LWZ6_METMP/5-251 ...PQFYPGATKVAENRRNHLNPNYELEKLREIPDEDVVKIMGHRQPGEDYKTVHPPLEEMDFVEDYARDLVEPLNGAKEGHRVRYIQFADSMYFAPAQPYDRSRSYMTRLRGVDAGTLSGRQVVECRESDLEEFSKNiL.MDTELFDPATSGVRGATVHGHSLRLDENGMMFDALQRCVFDEKTGHVMYVKDQVGKPLDAPVDVGEPIPEAKLREITTIYR.NDGVAM........RA..DPDVIEVVKRIHRARTLGGY-i.
A0A2V3J7I1_9EURY/2-250 ...PQFWPGSSFIAENRRKYMNPEYKYEKLRDIPEEDVVRLLAHRAPGEEYKSIHPPLEEMEEPECAVREMVEPTEGAKAGDRIRYNQFTDSMQFAPITPRQRAVAYYCRWRGIDVGVLSGRTIIEARERDVEKITKE.L.LDSETYDTARTGLRGRTVHGHAVRLDERGMMFDALRRWAIDESTGEVKYVKDMIGGAMDKEVVLGKPLPEDELRKRTTMYRnAQGGVWq......eAD..DPESMDVCSEIHWKRTVAGFQ..
A0A315XPC1_9EURY/2-247 ..v-QIYPGTSQVAQNRRNFTNPEYELEKLREISDEDVVKILGHKAPGEEYKSVHPPLDEMDEPDDSVRELVAPIDGAKAGDRIRYIQFVDSMYFAPAQPFLRARSYLSRFRGIDTGTLSGRQVVEARERDIEKLSKV.L.LETEYFDTARTGIRGGSVHGHSLRLDENGLMFDMLRRQVFNKETGKVEMVKDQIGKELDEPVILGEPLDEETLRAKTTIYR.IDGEAY........KD..DVDAVKVCQRIHVSRSFGAF-n.
A0A1F2P8S5_9EURY/6-251 anr---YPGNDPVGARRRELLSPESKFKRLREISDNDLVLLLGHRNPGEEYGSAHPPLDELEQKDDPIADLIEPSAGARAGDRIKYLQMTDSVYYSPSAPTFRGRMYHVRYPGIDTIVYSGRQLMETRERDLELYTRE.L.METELFDAARTSMRAITVHGSSLRLDENGLMFDARRRTRYDPETGEVSYVKNQMAIPMDRAVNLGKPMDEEELISISVRYG.GASIPY........RD..AKELWKLTGKILEQHVVGGFN..
A0A1D3L4I3_9EURY/2-247 ...AQFYPGTSQVAQNRRNLCNPDYELEKFREISDEDVVKILGHRAPGEEYPSVHPPLEEMDEPDDVIREMVEPVDGAKAGDRVRYIQFVDSMYFAPAQPYVRSRAYLCRYRGADAGTLSGRQIIEARERDLEKISKE.L.LETEFFDPARTGIRGASVHGHSLRLDEDGVMFDMLRRQVFNKETGKVEAVKDQIGEELDEPVVLGEPLDEATLRAKTTIYR.MDGEAY........RD..DKDAVEVLHRIHVTRSNGGY-s.
A0A0X8V1S6_THEX5/6-251 ...RQFFPGTTTPAKNRRRYLDPKVKLKQLRDVPMDDVVRIMGHRAPGEAYKSIHPPITEANEPECPIRKLVTPIEGAAAGDRVRYIQFTDSVYFAPISPYQRAWMYLSRYRGVDTGTLSGRQIIEMRERNLEQVAKE.L.IDNETFDPALTGIRGATVHGHSCRLDEHGLMFDGWQRYLWDDKKKEVMYVKDQVALPLDKKIYVGKPASMSDLKKRTTIFR.ADGVDM........RD..DKEVTDFYLRIHKLRTLGGFR..
Q8TXL0_METKA/5-250 ...AQFYPGETDVAENRRKYMNPNYELKKLREIPDEDIVRLMGHREPGEEYPSVHPPLEEMEEPECPIRELVEPTEGAKAGDRIRYIQFTDSVYFAPIHPYIRARMYMWRYRGVDTGSLSGRQIIEVRERDLEKIAKE.L.LETEIFDPARSGVRGATVHGHALRLDENGLMFDALRRYRLNEETGEVEYVKDQVGIELDEPIPVGAPADEDDLKERTTIYR.IDGTPY........RE..DEELLQVVQRIHELRTLAGYR..
Q8PXH7_METMA/8-249 ..s-QYYPGATSVGANRRKHM--SGKLEKLREISDEDLTAVLGHRAPGSDYPSTHPPLAEMGEPACSVREAVAPTPGAAAGDRVRYVQFADSMYNAPATPYFRSYFAAINFRGVDPGTLSGRQIVEARERDMEQCAKV.Q.METEMTDHALAGMRGATVHGHSVRLQEDGVMFDMLDRRRLE--GSTIIMDKDQVAIPLDRKVDLGKPMSSEEAAKRTTIYR.VDNVAF........RD..DAEVVEWVQRIFDLRTKYGFQ..
A0A1F2P510_9EURY/14-259 ...PQVYPGADKVSDRRRKAADPTKKLAKFRSIPDDNIVLLLGHRFKGESYVSVHPPLDELVEKYDPIKNIVEPTPGARAGDRIRYIQFADSIFYPPMAPWLRPRLYMSRLRGCDVMVYSGRQLLEQRERDIEASSKW.L.LETEVYDPARDAIRGITVHGHSLRLDEDGLMFDARRRYKLNKETGEVEYIKNMHAEVLDNPIPVGRPLTEREARGHDCTYR.WDVAAY........KS..RTEILTVIARYSRGRITGGFN..
MCRZ_METJA/5-251 ...PQFYPGNTLIAENRRKHMNPEVELKKLRDIPDDEIVKILGHRNPGESYKTVHPPLEEMDFEEDPIKDIVEPIQGAKEGVRVRYIQFADSMYNAPAQPYDRARTYMWRFRGIDTGTLSGRQVIEMRELDLEKISKNfL.IDTEFFDPATCGIRGATVHGHSLRLDENGLMFDGLQRYIYDEKTGHVLYVKDQVGRPLDEPVDVGEPLPHDYLAKITTIYR.KDNIGM........RE..DKEALEVVQIIHEARTKGGF-g.
A0A8J8C9I0_9EURY/5-251 ...PQYYPGKTKIAKNRRDHMNPNVELEKLREIPDDDIVKIMGQRQPGEDYKTVHPPLEEMDLPEDYVRDLVEPISGAKEGHRIRYIQFADSMYNAPAQPYDRARTYMWRFRGVDTGTLSGRQVIEMRESNLEEVAKN.FcMDTAFYDPAVCGIRGATVHGHSLRLDENGLMFDALQRYVYDEKTGHVLYVKDQVGKPLDEPVDVGEPLPNEKLVELTTIYR.KDGIPM........RE..DTELITVVKKIHRARTLGGYM..
D7DUH4_METV3/5-251 ...PQFYPGATKVAENRRNHINPAFELEKLREIPDEDVVKIMGHRQPGEDYKTVHPPLEEMDLAEDYVRDLVEPISGAKEGHRIRYIQFADSMYFAPSQPYDRSRLYMSRFRGVDCGTLSGRQVVELRESNLEAISKNyL.VDTELFDPATTGIRGATVHGHSLRLDENGVMFDALQRYEFDEATGHILYVKDQVGRPLDEPVDVGEPVPQEKLKEITTIYR.KDGVAM........RD..DMEVVEVVKRIHRARTLGGY-c.
A0A2V2MNB2_9EURY/5-249 ...PQYGPGNSIVAENRRKQMNPGVKLEKIRDVTDEEIVLIMGHRAPGQAYPTAHPPLAEQGEPDCPIRKIVSPTEGAKAGDRVRYIQFADSMFNAPSQPYQRTYVEMYRYRGIDPGTLSGRQIVESRERDLEKIASD.L.INTNLFDPARVGIRGATVHGHSLRLAEDGMMFDMLQRCVLD--GGVVKYVKDQIGVPLDKKVPVGKPMDEAWLKANTTMFHsLVGTAF........RD..DPEYVEYVQRIHSLRTKYGFM..
A0A166A6R3_9EURY/2-247 ...AQYYPGTSQVAQSRRNFSDPEYELEKLREISDEGVVKILGHRAPGEEYKSVHPPLDEMDEPEDYIREIVEPIDGAKAGDRVRYIQFVDSMYFAPAQPFLRSRSYLNRYRGVDAGTLSGRQIIEARERDLERISKE.L.LETEYFDPARTGIRGKSVHGHSLRLDENGLMFDMLRRQVFNKETGKVESVKDQIGKELDEPVVLGEPLDEEKLKAITTIYR.VDGEAY........RD..DKDAVEILHRIHVSRSNGGF-c.
U6EEZ4_9EURY/5-250 ...PQYTPGETKIAQNRRNHLDPEFEMKKIRSINDEDIVRVLGHRNPGESYKSVHPPLDEMDFDEDMMKELVEPIPGAKEGGRTRYIQFTDSVYNAPAHPYDRARTYMSRFRGVDTGTLSGRQVIEIRELDLEKISKE.L.LETEFFDPAKCGLRGATVHGHSLRLDENGLMFDALQRYVYNEETGRVSYVKDQVGRPLDTPVDVGEPLDEDHLKEITTIYR.SDNVSM........RE..DKEALEAVLTIHQTRTDGGF-g.
A0A1V6N552_METAZ/2-247 ...AQYYPGTSQVAQNRRNFSDPDYELEKLREISDEGVVKVLGHRAPGEEYKSVHPPLDEMDEPEDIIRELVEPIDGAKAGDRVRYIQFVDSMYFAPAQPYLRSRSYLNRYRGVDAGTLSGRQIIEARERDLEKISKE.L.LETEYFDPARSGIRGKSVHGHSLRLDEDGVMFDMLRRQLLNKETGKIEMVKDQIGKELDEPVVLGEPLDEETLMKKTTIYR.VDGEAY........KD..DKDAVEILQRIHVSRSEGGF-c.
A0A062V5Q9_9EURY/5-246 ...PQYYPGNTSVAKNRRKHM--SDDLEKLRDIADEDLTAILGHRAPGSDYPSTHPPLSEMGEPDDPIREIVEPTPGAAAGDRVRYVQYADSMYNAPATPYFRSYHAAINFRGVDPGTLSGRQVNEMRERDLEEYTKR.Q.SETEITDWGLAGMRGCTVHGHSLRLQEDGVMFDMLDRRRLE--GGNIVMDKDQVGVPIDRKVNLGKPISEAEAAKRTSIYR.VDNISF........RS..DKEVVEHVQRVWELRTRYGFQ..
A0A0X3BMY4_9EURY/11-256 ...PQYGPGTSKVAENRRKQMNPNQKLEKMRDVTDEDIVMILGHRAPGAAYPTAHPPLAEQQEPDCPIRKIVTPTEGAKAGDRVRYIQFADSMFFAPSHPYQRTYTEAYRFRGIDPGTLSGRQIVECRERDLEKYAKE.L.INTELLDPARTGIRGATVHGHSLRLAENGMMFDMLQRSVLG-DDGIVRYVKNQIGEPLDRAVAIGKPMDEKWLKDHTTIFHsLGGIPY........RD..DKEYIEYVQRIHTLRTKYGF-l.
A0A328PDU5_9EURY/2-247 ...AQFYPGKTKIAENRRKFMNPEAELEKLREVSDEDVVWILGHRAPGEEYPSVHPPLEELDEPEDPIRELVEPLDGAKAGDRVRYIQFTDSMYNAPAQPYVRSRAYLWRYRGADAGTLSGRQIIETRERDLEKLSKE.L.IETEFFDPARSGIRGKTVHGHSLRLDENGMMFDMLRRQVYNPDTGRVEAVKNQIGDELDEPVDLGEPLDEETLKEKTTIYR.GDNIAY........RD..DEPVVEVTQRIHVLRSQAGF-l.
A0A366M9W2_9EURY/2-247 ...AQYYPGTSQIAQNRRNFSDPEYDLEKLREISDEGVVKVLGHRAPGEEYKSVHPPLDEMDEPDDIIRELVEPIDGAKAGDRVRYIQFVDSMYFAPAQPYLRSRSYLNRFRGVDAGTLSGRQIIEARERDLERISKE.L.LETEYFDPARSGIRGKSVHGHSLRLDENGVMFDMLRRQLLNKETGKIEMVKDQIGKELDEPVVLGEPLDEETLMKKTTIYR.VDGEAY........KD..DKDAVEILHRIHVSRSEGGF-c.
L0HHU6_METFS/5-251 ...PQYGPGQSVPAANRRKQMDPSRKLAKLRDVSDKDLVLVMGHRAPGSAYPSCHPPLSEQQEPACPIRKIVTPTDGAKAGDRVRYIQFADSMYNAPCQPYQRSYLEAYRFRGIDPGTLSGRQIVECRERDLEKYAKE.L.VGTELFDANLTGIRGCTVHGHSLRLDENGMMFDMLQRCVIDKKSGVVKYVKDQVGVPLDAEVKIGKAMDNKWLKANTTMFHsVSGVGF........RD..DPEYVEYIQRIHTLRVKYGFM..
L0KWQ4_METHD/5-247 ...PQYYPGATSVAANRRKHM--SGDVEKLREISDDDLTMILGHRPAGSDYRSTHPPLAEMGEPECSIRQTVEPTPGAKAGDRVRYVQFVDSMYNGPSVPYFRSYGAAIKFRGVDPGTLSGRQVVEARERDMEEVAKF.Q.IETEMFDPALSSLRGATVHGHSLRLQEDGVMFDMLDRARLE-EDGIVKMHKDQVGRPIDKKVQLGKPMSAKEAAKRTTIYR.VDNVAY........RS..DKEVIEWVHRVFDQRTKYGFK..
A0A2V3JTG5_9EURY/5-246 ...PQYYPGASHVAVNRRKHM--SGDVEKLRTVSDDDLVAALGHRAPGADYPSTHPPLAEMGEPDCPVRQMVEPTPGAAAGDRVRYSQFTDSMYSAPSIPYFRSYYAAINFRGVDPGTLSGRQIVEARERDMEAQCKA.A.IESEMTCPALAGLRGCTVHGHSLRLAEDGMMFDMLERTHLE--GGNVIEDKDQVGVPIDRKVNLGKPMSDAEAKKRTTIYR.TDGVKY........RS..EEEVLDHVHLVHHRRTMYGYR..
A0A166F2B1_9EURY/2-247 ...AQYYPGTSQIAQNRRNFSDPDYELEKLRDISDEGVVKILGHRAPGEEYKSVHPPLDEMDEPDDIVRELVEPIDGAKAGDRVRYIQFVDSMYFAPAQPYLRSRSYLNRYRGVDAGTLSGRQIIEARERDLEKISKE.L.LETEYFDTARTGIRGKSVHGHSLRLDEDGVMFDMLRRQIFNKATGKVEMVKDQIGKELDEPVVLGEPLDEETLKKKTTIYR.IDGEAY........KN..DKDAVEILHRIHVSRSEGGF-c.
A0A8J8B5S5_9EURY/5-250 ...PQYGPGTSKVAENRRNQMNPEVKLEKIRDVTDEDVVLIMGHRAPGQAYPTAHPPLAEQGEPDCPIRKIVAPTEGAKAGDRVRYIQFADSMLNAPSQPYQRTYVEMYRFRGIDPGTLSGRQIVECRERDLEQIAKD.L.INTNLFDPARVGIRGATVHGHSLRLAEDGMMFDMLQRCVLE-ADGAVKYVKDQIGVPLDKKVAVGKPMDEKWLGENTTIFHvLGGNPY........RN..DAEYIEYIQRIHSLRTKYGYM..
D3E051_METRM/2-247 ...AQYYPGTSQVAENRRKFTNPDVELEVLREISDEDVVKLLGHRAPGEEYKSVHPPLDELDEPDDIIREIVEPIDGAKAGDRVRYIQFVDSMYFAPAQPFLRARSYVYRYRGIDTGTLSGRQIIEARERDVERISKE.I.LENEYFDTARTGIRGAGVHGHSLRLDENGLMFDMLRRQVLNKETGNVEMVKDQIGRELDEPVVLGEPLDEETLRAKTTIYR.CDGEAY........KD..DEDAVTVLRQIHVTRSQFGYN..
A2SSD0_METLZ/5-250 ...PQYGPGTSRVAEVRRNQMNPNVKLDKIRNITDEDLVLIMGHRAPGQAYPSAHPPLAEQGEPDCPIRKLVQPTEGAKAGDRVRYIQFADSMLNAPCQPYQRTYLEMYRYRGIDPGTLSGRQIVECRERDLEGYARE.L.VESSLFDPATVGIRGATVHGHSLRLAENGMMFDAVQRCILD-TDGVVKYVKDQVAIPLDRKVAVGKPMDAAWLKENTPMFHsLVGTPF........RA..DSEYVAYVQRIHALRTKYGFM..
A0B6N7_METTP/5-253 ...PQYYPGNTSVGANRRKHM--SGNLEKLRDIPEADVVAIMGHRAPGADYPSTHPPLKEMGEPDCPIRQLVEPTPGAAAGDRVRYSQFADSMYFAPSIPYWRSYWAAINCRGADPGTLSGRQIIEARERDIEAYTKK.L.MDSEMTDVARCSMRGCTVHGHSLRLEENGLMFDMLARTELG-ADGNVYYVKDQVGIPLDKKINVGKPMSEDELKKRTTIFR.YDNVSFggk..vgaRK..FDEALEALHHMWEYRTKWGFR..
F6BBJ1_METIK/5-250 ...PQFYPGETLIAENRRKHMNPNYELKKLREISDDDLVRVLGHRNPGESYKTVHPPLEEMDFEEDVIKEIVEPIPGAKEGIRVRYIQFADSMYNAPAQPYDRARTYMWRFRGVDTGTLSGRQVIEIRELDLERISKW.L.VETEIFDPATCGMRGATVHGHSLRLDENGLMFDGLQRYIYDEKTGHVIYVKDQVGRPLDEPVDVGEPLPQEYLAKITTIYR.KDNIGM........RE..DKEALEVVEIIHIARTEGGF-g.
A0A328S7M2_9EURY/5-250 ..v-QFYPGESVIAENRRKHLNPEYELKKLRTIADDDVVKLLSHRNPGEGYKTVHPPLDEMDFEEDAMKDFVEPIDGAKKGIRIRYVQFADSMYNAPAQPYDRARSYMRRFRGVDTGTLSGRQVVEMRESDLEETSKL.L.LESEFFDTAKTGLRGATVHGHSLRLDENGLMFDALQRYVYDEEKNHVVYVKNQVGVELDEPIDVGEPLPEDELKKITTIYR.TDNISL........RD..DEEVIKVVEEIHFARTDGGY-g.
B8GE92_METPE/5-251 ...PQYGPGTSVVAENRRKYMDPGHKLEKVRDITDEDIVLIMGHRAPGSAYPTAHPPLAEQQEPNCPVRKLVTPTEGAKAGDRVRYIQFADSMFNAPSQPYERTYLEMYRFRAIDPGTLSGRQIVECRERDLEKYAKE.L.LNTELFDPARVGVRGATVHGHSLRLDEDGMMFDMLQRCVFDKKDGIVKYVKNQIGEPLDRAVPVGKPMDEKWLKAHSTIFHsLDGVAF........RD..DPEYVEYIQRIHSLRTKYGFM..
I7KZS5_METBM/5-250 ...PQYGPGTSIVAENRRKQMNPSQKLEKVRSVTDEDIVLILGHRAPGSAYPTAHPPLAEQQEPNCPMRKLVKPTEGAKAGDRVRYIQFADSMFNAPSQPYQRTYAEMYRFRGIDPGTLSGRQIVECRERDLEKYSKE.L.LETEMFDPARVGIRGATVHGHSLRLAEDGMMFDMLQRCILD-EDGVVKYVKNQIGEPLDRAVAIGKPMDEKWLKAHTTIFHsLVGTPY........RE..DTEYIEYVQRIHSLRTKYGFM..
A0A498GYL8_9EURY/5-250 ...PQYGPGTTQVAENRRKQMNPGYNLEKMREITDEDVVLILGHRAPGSAYPTAHPPLAEQQEPDCPIRKIVTPTEGAKAGDRVRYIQFADSMFNAPSQPYQRTYAYCYRYRGIDPGTLSGRQIVECRERDLEKYSKE.L.LNTELFDPARCSVRGATVHGHSLRLAEDGMMFDMLQRCILG-EDGIVRYVKDQIGEPLDRAVEVGKPLDENWLKAHTTIYHsLVGTPY........RD..DKEYVEYVQRIHSLRTKYGFM..
A0A1D2W9X1_9EURY/5-250 ...AQYTPGKTKIAENRRNHMNPDYELKKIREVADEDIVKILGHRNPGEGYKTVHPPLEEMDFELDMMKELVEPIPGAKEGVRTRYVQFADSMYNAPAQPYDRARTYMWRFRGVDTGTLSGRQVVEIRELDLEKMSKT.L.IETELFDPAKTGIRGATVHGHSLRLDENGLMFDALQRYVYNEEDGQVSYVKDQVGRPLDEPVAVGEPLDDEHLAEMTTIYR.YDNVSM........RD..DEEAIEVVETIHDARTKGGY-g.
A0A1D2WB69_9EURY/2-247 ..a-KYYPGTSKVAQNRSNFQDPEYELEKLREVSDEDVVSILGHRAPGEEYPSAHPPLEEMDEPEDPIRELVEPVDGAKAGDRVRYIQFTDSMYFAPAQPYLRSRAYLCRYRGADAGTLSGRQIIEARERDLEKISKE.L.LETEFFDPARSGIRGKSVHGHSLRLDEDGMMFDMLRRQILNKETGQVEAVKNQIGDELDEPVALGAPLDEETLKDKTTIYR.KDGEAY........RD..DKDAVEVCQRIHVLRSQGGF-y.
A0A0Q4BF52_9ARCH/5-250 ...RQFYPGESQVAKNRRRYMDPSEKLKKLRDVAMDDVIRILGHRAPGEDYKSIHPPLAEGNEPEDLIRKLVVPIEGAKAGDRIRYIQFTDSVYFAPMVPYLRAWMYMTRIRGFDTGTLSGRQIIEMRERDLEKVSKE.F.IDNETFDPAKTGIRGATVHGHACRLDENGLMFDAWQRYRWNAKKGEVEYVKDQVALPLDKPISVGKPLPEADLKKMTTIFR.ADGVDM........RD..DPEVMAINLRIHRLRTLCGYQ..
Q12TF7_METBU/5-246 ...AQYYPGATSVAENRRKHM--SGKVEKLREVSDDDLTLVLGHRAPGSDYPSTHPPLAEMGEPECSVREMVEATPGAKAGDRVRYVQFVDSMYNAPSTPYFRSYAVAINHRGVDPGTLSGRQVVEARERDMEEVAKF.Q.LETEMTCPALASLRGATVHGHSLRLPEDGIMFDMLDRCRLE--NGVVIMHKDQVGRAIDKKVDFGKPMSEEEAAKRTTIYR.VDNIAF........RD..DAEVIEWVHTIFEKRTAYGFK..
A7I5U0_METB6/5-251 ...PQYCPGQTQVAENRRKQLDPNHKLEKIRDVTDKDLVLIMGHRAPGSAYRAVHPPLSEQQEPACPIRKIVTPTDGAKAGDRVRYIQFSDSMYNAPCQPYQRSWLESYRYRGIDPGTLSGRQIIECRERDLEKYAKE.L.VNTELFDPALTGVRGCTVHGHSLRLDENGLMFDMLQRCILDKKSGVIKYVKDQVGVPLDSEVKVGKAQDEKWLKSHTTMYHsLVGTGF........RD..DAEYVEYIQRIHALRVKYGFM..
Q0W340_METAR/5-249 ...PQFYPGKTSVAQNRKKFMDPSYKMEKLRSLSDDDIVIMLGHRAPGSAYKTIHPPLTESNEPDCPIRKLVEPTPGAKAGDRIRYNQYADSMYFAPMVPYLRSWMAVTRYRGVDPGTLSGRQIIEARERDLEKITKE.T.FETEMFDPARTSLRGCTVHGHSLRLNENGMMFDMLQRQVLD-KDGTVKAVKDQVGDPLDRKVNLGKPMSEAELKKRTTIYR.IDGVSF........RS..DDEVVGWVQRIFTLRTKCGF-y.
MCRZ_METFV/5-250 ...PQFNPGETKIAENRRKHMNPNYELKKLREIADEDIVRVLGHRSPGESFKTVHPPLEEMDFEEDPMKDIVEPIEGAKQGTRIRYIQFADSMYNAPAQPYDRARTYMWRFRGVDTGTLSGRQVIEMRELDLEKVSKI.L.LETEIFDPARCGIRGATVHGHSLRFDENGLMFDALQRYIYDEDSGHVVYVKDQVGRPLDQPVDMGEPLPEDELKEITTIYR.KDNIGM........RE..DEELLEVVNKIHEARTIGGF-g.
A0A1Y3GAS1_9EURY/5-250 ..a-QRYPGSTTPAENRRKYMDPDYELEKLREISDDDVTILLSHREPGEAFKSVHPPLDELDEPDCPIREMVEPTEGAKAGDRIRYVQFTDSVYNAPLPPFMRAYMYMTRYRGIDTGTLSGRQVIEARERDVEKISKE.L.LTTEVFDPAKTGLRGATVHGHAVRLDENGLMFDALQRYQFNEDTGEVEYVKDQIGVPLDQPISFGKPMSEEDLLERTCIFR.EDGKPF........SE..DEEVVEFTQRVHKLRTLAGYN..
MCRG_METJA/5-251 ...PQFYPGQTKIAQNRRDHMNPDVQLEKLRDIPDDDVVKIMGHRQPGEDYKTVHPPLEEMDLPEDYVRDLVEPLNGAKEGHRIRYIQFTDSMYFAPAQPYDRARTYMWRFRGVDTGTLSGRQVIEMRESDLEALSKNfL.IDTAFFDPARIGIRGATVHGHSLRLDENGLMFDALQRYVYDEKTGHVLYVKDQVGRPLDEPVDVGEPLPEEKLKEITTIYR.IDGVPM........RE..DEELLTVVKRIHRARTLGGF-l.
D1YVW5_METPS/5-249 ...AQYYPGKTSVAQNRKKFMDPSYKLEKIRSLSDDDVVIMLGHRAPGSAYKTIHPPLKEGGEPDDPIRKIVEPTAGAAAGDRIRYCQFTDSMFYAPAVPYLRSWMAATRYRGVDPGTLSGRQIVEARERDVEKITKE.L.METEVYDAARSGLRGCTVHGHSLRLNENGMMFDMLQRVVLD-KNGNVYAVKDQVGDPLDRKVNLGKPMSDAELKKRTTIYF.IGGVPF........RS..DAEVVGWVQRIHNERTKCGF-a.
A0A484F634_9EURY/5-246 ...AQYYPGTTSVAANRRKHM--GHDLEKLREISDEDLTAILGHRAPGQDYPSTHPPLAEMEEPPCPIRELVEPTPGAKAGDRVRYVQFVDSMYNAPSVPYVRSYYAAINFRGVDPGTLSGRQIVEARERDMEVVAKD.Q.IETEMTCPARSSLRGATVHGHSVRLQEDGVMFDMLDRARLE--GDVIIMDKDQVAIPLDRKVNLGKPMSEDELAKRTTIYR.VDNVSF........RS..DAEAVEWVQRVYLQRTQYGFR..
A0A1F2P3I3_9EURY/6-251 vnr---YPGTDSVAERRRTLFSPESKFKQLREISDDDLVLLLGHRNPGEVYGSIHPPLDEMELPYDPISELIEPSPGARAGDKIRYLQITDSVYFSPLFPAFRGRMYHIRYPGIDTIVYAGRQLIEARERDLERYAKE.L.IETELFDPARTSIRGITVHGSSLRLDEDGMMFDARRRTRYDPASGEVTYIKNQMAVPLDRPVNVGKPMSDEDLLSISARYG.GGSVPY........RD..AKELWELTGRILRQHVEGGF-d.
A0A0A7LAF7_9ARCH/11-256 ...RQFYPGASSPAKNRRRYMDPKVKLKKIRDVSMDDVVRLMGHRNPGEDYKSIHPPIQEGKEPNCPIRKLVEPIDGAKHGDRIRYIQFTDSVYFAPISPYQRAWMYLSRERGVDTGTLSGRQIIEVRERDLERMAKE.L.IDNETFDPALTGIRGATVHGHACRLDENGLMFDAWQRYVWDDKKKEVVYVKDQVAVPLDRKIYVGKPASMADLKKRTTIFR.ADGVDM........RD..DKEVTAYGLRIHKLRTLGGYQ..
A0A1F2P4X3_9EURY/8-253 .ln--IYPGADRVAERRRTILDKNTKFRELREIPDEDLILLLGHRNPGERYTSVHPPLDELKEPADPIRELIEPTPGARGGDRIRYVQFTDSVYHSPVTPVFRGRMYHIRYRGVDTISYSGRELMEVRERDLELYTKE.L.IETELFDPARTAIRGITVHGSAMRLDEDGLMFDARRRYMYDREKGLVIYTKNQMAIPIDKSIPVGSPRSDEELKSDSIIYG.LDTVRC........RD..AEEVWEVTGKLMEANVKGGFN..
A0A483CSA4_9EURY/5-250 ...PQFGPGTSAVAENRRKQMNPGYQLSKIRDVTDEDVVLILGHRAPGAAYPTAHPPLAEQQEPDCPVRKLVTPTDGAKAGDRVRYIQFADSMFNAPSQPYQRTYMECYRFRGIDPGTLSGRQIVECRERDLESYSKE.L.INTEVFDPALVSCRGATVHGHSLRLAEDGMMFDMLQRCVLG-ADGVVKYVKNQIGEPLDRAVEVGKPMDAEWLKANTTIFHsLAGTAF........RD..DQEYVEYVQRIHSLRTKYGFM..
MCRZ_METTH/5-250 ...AQYTPGETQIAENRRKHMDPDYEFRKLREVSDEDLVKVLGHRNPGESYKSVHPPLDEMDFEEDIVRDMVEPIQGAKEGVRVRYIQFADSMYNAPAQPYDRARTYMWRYRGVDTGTLSGRQVIEMRELDLEGVSKE.L.VETELFDPATTGIRGATVHGHSLRLDENGLMFDALQRYVFDEEKGHVVYVKDQVGRPLDEPVDMGQPLGEDELKKITTIYR.KDNIAM........RD..DKEAIEVVENIHTGRTMGGF-g.
A0A483CN68_9EURY/5-250 ...PQYGPGTSVVAQNRRNQMNPNFELAKLRSITDEDVVLILGHRAPGAAYPTAHPPLAEQQEPADPMRKLVKPTEGAKAGDRVRYIQFADSMFNAPSQPYQRTYMECYRFRGIDPGTLSGRQIVECRERDLDQYSKM.L.IETEVFDPATVSCRGATVHGHSLRLAEDGMMFDALQRCVLG-DDGVVKYVKDQIGVPLDRAVEVGKPMDEAWLKEHSTIFHsLAGTSL........RE..DPEYIEYIQRIHSLRTKYGFM..
MCRG_METTH/2-247 ...AQYYPGTSKVAQNRRNFCNPEYELEKLREISDEDVVKILGHRAPGEEYPSVHPPLEEMDEPEDAIREMVEPIDGAKAGDRVRYIQFTDSMYFAPAQPYVRSRAYLCRYRGADAGTLSGRQIIETRERDLEKISKE.L.LETEFFDPARSGVRGKSVHGHSLRLDEDGMMFDMLRRQIYNKDTGRVEMVKNQIGDELDEPVDLGEPLDEETLMNKTTIYR.VDGEAY........RD..DTDAVEIMQRIHVLRSQGGYN..
A0A0E3L072_9EURY/1-225 .ms---------------------GDLEKIREISDEDLTAVLGHRAPGSDYPSTHPPLAEMGEPACSVREAVEATPGAKAGDRVRYVQFADSMYNAPATPYFRSYFAAINFRGVDPGTLSGRQIVEARERDMEECAKV.Q.METEISCPGLSGMRGATVHGHSVRLQEDGVMFDMLDRRRLE--NGTIIMDKDQVAIPIDRKVDLGKPMSEEEAAKRTTIYR.VDNVPA........RS..DAEVIEWIHRVFDQRTSFGFQ..
A0A4E0R287_9EURY/5-246 ..l-QYYPGATSVAENRRKHM--SGKVEKLRDISDEDLTLVLGHRAPGSDYPSTHPPLAEMGEPEDSIRELVEATPGAKAGDRVRYVQFVDSMYNAPATPYFRSYNAAINFRGVDPGTLSGRQVVEARERDMEELAKF.Q.IETEMTDPALAGLRGATVHGHSLRLPEDGVMFDMLERVRK--EGDVIVMHKDQVGRPIDRKVSLGKPMSEEEAAKRTTIYR.ADNVAF........RD..DAEVIEWVHRVFDQRTIYGFK..
A0A1Q6DVN5_9EURY/5-250 ...PNFYPGTTKVSESRKHYMDPEEDLEKIREISDDEVTRLLHHREPGEAFGSVHPPLEEMDEPDCPIRELVEPTEGAKAGDRIAYVQFTDSVYFAPTAPYIRAWMYMNRFRGLDTGTLSGRQIIEGRLRDVEEMSKK.L.LTTEVFDPARTGIRGATVHGHAVRLDENGMMFDALQRYKFNEETGEVEYVKNQVGEPMDEPVNFGKPLSEEELIERSPIFR.EDGISF........SD..DEEVVKMVQRIHKLRTLAGYK..
A0A2U1S6S0_9EURY/2-247 ..v-QLYPGTSQVAQNRRNFTDPDYELEKLREISDEDVVKILGHRAPGEEYKSVHPPLDEMDEPDDIVRELVAPIDGAKAGDRIRYIQFVDSMYFAPAQPYLRARSYLYRFRGIDTGTLSGRQVIEARERDIERISKI.L.LETEYFDTARTGIRGAGVHGHSLRLDENGLMFDMLRRQVFNKETGNVEMVKDQIGTDLDEPVVLGEPLDEEILKEKTTIYR.IDGEAY........KD..DEQAVEVLRNIHVSRSFGAF-n.
A0A1F2PA65_9EURY/1-245 .mi---YPGTDRVAERRRMILDKDTKLRRLREVSDDDLVVLLGHRNPGEQYRSVHPPLDELKEIEDPIRDLIEPTPGAQSGDKIRYIQFTDSVHHSPITPVFRGRMYHTRYRGVDTICYSGRELMEARERDLEKYAKE.L.IETEVFDTARTAIRGITVHGSAMRLDEDGLMFDARQRYRYDRANNTVLYTKNQMAIPINRPIPIGAPGEEKDLIANSIIYG.ISTVGY........RD..AEELWEVTGKLMEENVKGGL-n.
F0T8R2_METLA/2-247 ...AQYYPGTTKVAQNRRNLCNPDYDLEKLREISDEDVVKILGHRAPGEEYPSVHPPLEEMDEPEDAIREMVEPVDGAKAGDRVRYIQFADSMYFAPAQPFARSRAYLCRYRGSDAGTLSGRQIIEARERDLEKISKE.L.LETEFFDPARTGIRGKSVHGHSLRLDEDGMMFDMVRRQVLNKATGNVEMVKNQIGDELDEPVILGEPLEEAVLKEKTTIYR.KDGEAY........KD..DTDAVEVLHRIHVTRSNGGY-g.
L0HFR7_METFS/6-251 ...PQYGPGTSVVAANRRKQMDPGQVLTKMRSITDEDIVLLLGHRAPGERFRNVHPPVTEQTEPACPMRKLVRPTEGAKNGDRVRYVQFADSMFNAPCQPYQRTYAEMYRFRGIDPGTLSGRQIVECRERDLEQYCRL.L.IETEMFDPALVSLRGATVHGHSLRLAEDGMQFDALQRCVLG-TDGMVRYVKDQIGLPLNRPVEVGKPLGQPWLKEHSTIFHcLVGTAL........RD..DAEYVEYLKRIHTLRTRYGFM..
M4YNV7_THEXX/7-252 ...RQFYPGQSIPAQNRRRYLDPKVKLKKLRDVPMDDVVRLMGHRAPGEAYKSIHPPIEEGKEPKCPIRELVVPIEGAKHGDRVRYIQFTDSVYFAPISPYQRAWMYMSRWRGVDTGTLSGRQIIEVRERDLEVYAKE.L.IDDETFDPALTGIRGSTVHGHACRLDENGLMFDGWQRYVWDAKKKEVVYKKDQVALPLDKDIYVGKPASMENLKKRTTIFR.ADGVDM........RD..DKEVTDFYIRVHWLRTLGGYR..
A6UWH1_META3/5-251 ...PQFCPGSTTVAQNRRDHMNPDVQLEKLREIPDDEIVKVMGHRQPGEDYKTVHPPLEEMDMPEDFVRDIVEPMSGAKEGHRIRYIQFADSMYNAPAQPYDRARTYMWRFRGVDTGTLSGRQVIEMRESNLEEMSKN.FcIDTAFFDPATCGMRGATVHGHSLRLDENGLMFDALQRYVFDEKTGHVLYVKDQVGRPLDEPVDFGEPLSTEKLKEITTIYR.KDSIAM........RD..DEEIVTVVKRIHRARTLGGYM..
A0A2Z4L8Q4_9EURY/5-250 ..v-QFYPGESKIAENRKKHLNPDYELEILRSIADDDIVKLLSHRNPGEGYKTVHPPLDEMDFEADDMKDFVEPIDGAKKGIRIRYVQFADSMYNAPAQPYDRARSYMRRFRGVDTGTLSGRQVVEMRESDLEETSKL.L.IESEFFDPAKTGLRGATVHGHSLRLDENGLMFDALQRYVFDEDEGVVKYVKDQVGVELDEPISVGEPLPEDKLKEITTIYR.SDNISL........RD..DPEVIKVVEEIHFARTDGGY-g.
A0A1F2P9Z1_9EURY/17-262 qip---YPGDDPVANNRKKWMNSEFTPRKLREISDDDIVSLLGHRKPGTAYSSVHPPLDEMKEAADPIKELVVPTDGAKAGDRIRYIQFADSMHFAPLPPWMRFRMYGARLRGFDSLAYSGRTLLEMRERDLDETAKF.L.VETEIFDASRVAMRSVTVHGFSLRLDEDGLMFDARRRYVFNKETGEVEYVKTQRATPLDRRISVGKPLPEDELKTLTTRYH.TALTSP........RD..ADELIKVVKRVGELRVLGGL-r.
I7L043_METBM/5-250 ...PQYGPGTSKVAENRRKQMNPNQKLEKMRDVTDEDIVMILGHRAPGAAYPTAHPPLAEQQEPDCPIRKIVTPTEGAKAGDRVRYIQFADSMFFAPSHPYQRTYTEAYRFRGIDPGTLSGRQIVECRERDLEKYAKE.L.INTELLDPARTGIRGATVHGHSLRLAENGMMFDMLQRSVLG-DDGIVRYVKNQIGEPLDRAVAIGKPMDEKWLKDHTTIFHsLGGIPY........RD..DKEYIEYVQRIHTLRTKYGF-l.
G7WN23_METH6/1-234 .ms---------------------SDLEKLRDISDADVVTIMGHRAPGADYPSTHPPLAEMGEPDCPIRQLVTPTPGAAAGDRIRYSQFADSMYNAPAIPYFRSYWAAINCRGSDPGTLSGRQIVEARERDIEQYTKI.M.MDTEMCDPALATMRGCTVHGHSLRLDEDGMMFDMLARTELG-SDGNVYYVKDQVGIPLDRKVNAGKPMSEAEAKKRTTIFR.CDNVSFggpctadkRT..FDEGLVTLHHMWERRSKWGFR..
A2STS0_METLZ/5-250 ...PQYGPGTSKVAEVRRNQMNPNVKLEKIRSVTDEDIVLIMGHRAPGQAYPSAHPPLAEQGEPDCPIRKLVKPTEGAKAGDRVRYIQFADSMLNGPSQPYQRTYLECYRFRGIDPGTLSGRQIVECRERDLEGYARE.L.IETSIFDPATTGIRGATVHGHSLRLAENGMMFDMLQRCILD-TDGVVKYIKDQVGVPLDRKVAVGKPMDAAWLKANTPMFHsLVGTAF........RS..DSEYVAYVQRIHALRTKYGFM..
D5EAD7_METMS/5-246 ...AQFYPGATSVAENRRKHM--SGKVEKLREISDDDLTIILGHRVPGTDYPSTHPPLAEMGEPECSIREMVEPTDGAKAGDRIRYVQFVDSMYNAPSTPYFRSYNTAINFRGVDPGTLSGRQVVEARERDMEELAKF.Q.LETEMTCPALACLRGASVHGHSLRLQEDGVMFDMLERVRLE--NGTIIVQKDQVGRPIDKKVDLGKPMSDEEAAKRTTIYR.VDNVPY........RE..DKEVLEWVHRVFEQRTMYGYK..
F7XLI3_METZD/5-246 ...PQFYPGNTIVAENRRKHM--SGKLEKLREISDEDLTLILGHRAPGSDYPSTHPPLAEMGEPECSIRELVEPTEGAKAGDRVRYVQFVDSMYNAPATPYFRSYFAAINFRGVDPGTLSGRQVVEARERDMENVAKV.S.LETEISCPALSGLRGATVHGHSLRLQEDGVMFDMLDRRRLE--NGTIIMDKDQVGRPLDKKVDLGKPMSEDEAAKRTTIFR.ADNVAF........RD..DEEVVEWVHRVWSQRTKYGFQ..
A0A6B9TAS2_9ARCH/6-251 ...RQFYPGTTTPAKNRRRYMDPKVKLKKLRDVAMDDVVRIMGHRNPGEDYKSIHPPIEEGKEPDCPIRKLVVPIEGAKHGDRVRYIQFTDSVYFAPISPYQRAWMYLSRYRGVDTGTLSGRQIIEVRERDLEVMAKE.M.IDNETFDPALTGIRGATVHGHACRLDEHGLMFDGWQRYVWDDQKKEVVYVKDQVAIPLDRRISVGKPAAMSDLKKRTTIFR.ADGVDM........RD..DKEVTMYGLRIHKLRTLGGYQ..
Q8THH0_METAC/5-246 ...AQYYPGATSVGANRRKHM--SGKLEKLREISDEDLTAVLGHRAPGSDYPSTHPPLAEMGEPACSIREAVAATPGAAAGDRVRYVQFADSMYNAPATPYFRSYFAAINFRGVDPGTLSGRQIVEARERDMEQCAKV.Q.METEMTDPALAGMRGATVHGHSVRLQEDGVMFDMLDRRRLE--GGVIIMDKDQVAIPLDRKVNLGKPMSSEEAAKRTTIYR.VDNVAF........RD..DAEVIEWVHRVFDQRTSYGFQ..
A0A8J7RXU2_9EURY/5-250 ...PQFGPGTTVVAENRRKQMNPDYQLEKLREVTDEDIVLILGHRAPGAAYPTAHPPLAEQQEPACPIRKIVEPTEGAKAGDRVRYIQFADSMFNAPCQPYQRTYSECYRFRGIDPGTLSGRQIVECRERDLEGYSKE.L.INTEVFDPARTGIRGATVHGHSLRLAEDGMMFDMLQRCVLG-DDGVVRYVKNQIGEPLDRAVEVGKPMDEAWLKTHTTMFHsLAGTGF........RE..DQEYVEYVQRIHSLRTKYGFM..
M9SFZ4_METAX/6-251 ...RQFYPGESVPAKNRRRYMDPKVKLKKLRDVPMDDVVRIMGHRAPGEAYKSVHPPIEEGKEPKCPIRELVEPIEGAKYGDRVRYIQFTDSVYFAPISPYQRAWMYMSRYRGVDTGTLSGRQIIEVRERNLEQIAKE.L.VDDETFDPALTGIRGATVHGHACRLDENGLMFDGWQRYVWDDQKKEVVYVKDQVALPLDRRVSVGKPASMSDLKKRTTIFR.ADGVDM........RD..DKEVTDFYIRIHKLRTLGGYR..
Q2FSN1_METHJ/5-249 ...PQYGPGQSIVAENRRKQMNPNVKLEKIRNVTDEDIVLILGHRAPGQAYPTAHPPLAEQGEPDCPIRKIVTPTDGAKAGDRVRYIQFADSMFNAPSQPYQRTYTECYRYRGIDPGTLSGRQIVECRERDLEKISAD.L.INTNLFDPARVGIRGATVHGHSLRLAEDGMMFDMLQRCILE--GGTVKYVKDQIGTPLDKKVDVGKPMDDAWLKANTTMFHsLVGTPY........RS..DAEYIEYIQRIHSLRTKYGFM..
H1YXI0_9EURY/5-249 ...PQYGPGTSIVAENRRKQMNPAVQLEKVREVTDEDIVLILGHRAPGSAYPTAHPPLAEQQEPDCPIRKIVAPTEGAKAGDRVRYIQFADSMFNAPSQPYQRTYSECYRFRGIDPGTLSGRQIVECRERDLEQYSKL.L.METEMFDPALVSCRGATVHGHSLRLAEDGLMFDMLQRCIL--KDGSVKYVKDQIGEPLDREVDVGKPMDEEWLKAHSTIFHsLVGVAY........RD..DAEYVEYIQRIHALRTKYGFM..
A0A166CF58_9EURY/2-247 ...AQYYPGTSQVAQNRRNFSDPDYELEKLREISDEGVVKILGHRAPGEEYKSVHPPLDEMDEPEDYIREIVTPIDGAKAGDRVRYIQFVDSMYFAPAQPFLRSRSYLNRFRGVDAGTLSGRQIVEARERDLERISKE.L.LETEYFDPARTGIRGKSVHGHSLRLDENGVMFDMLRRQLYNKETGKVEAVKDQIGKVLDEPVVLGEPLDEETLKAKTTIYR.VDGEAY........KD..DKDAVEILHRIHVARSEGGF-c.
E3GZ52_METFV/2-247 ...AQFYPGSTKIAENRRKFMNPDAELEKLREISDEDVVRILGHRAPGEEYPSVHPPLEELDEPEDPIKDIVEPTEGAKAGDRVRYVQFTDSVYFAPAQPYIRSRAYLWRYRGADAGTLSGRQIIEARERDVEKIAKE.L.IETEFFDPARTGIRGKSVHGHSLRLDENGMMFDMLRRQVYDEETGRVKMVKNQIGDEFDEPIDLGEPLDEETLKEKTTIYR.IDNIPY........RE..DKDLLEIVQRIHQLRSEAGF-s.
A0A1F2P3C3_9EURY/5-250 qip---YPGDDPVVNKRKEWLSSRYEPRKIREISDEDIVRLLGHRKPGTAYSSVHPPLDELKEARDPIKELVEPTPGAKAGDRIRYIQFADSRHLAPLPPWMRFRMYGVRLRGFDSLAYSGRTLLEQRERDLDRTAKF.L.LETEIFDPARVALRSITVHGFSLRLDEDGLMFDARRRYRLNKETGEVEYTKTQQSVPLEQRISVGKPMDEEDLKQIATIYR.FGMVSP........RD..SEELLKVMKRVGELRVLGGL-r.
A0A8J7RBX9_9EURY/5-250 ...PQYGPGTSIVAQNRRNQMNPGYELQKLRSVTDEDVVLILGHRAPGAAYPTAHPPLAEQQEPEDPMRKIVKPTDGAKAGDRVRYVQFADSMFNAPSQPYQRTYSECYRFRAIDPGTLSGRQIVECRERDLDQYAKF.L.IETEMFDPATVGIRGATVHGHSLRLAEDGMMFDALQRCVLG-DDGVVKYVKDQVGVPLDRPVEVGKPMDEKWLKEHTTMFHsLAGTGF........RE..DQEYIEYIQRIHTLRTKYGFM..
F4BXY2_METSG/5-253 ...PQFYPGSTSVGINRRKHM--SGNVEKLRDIPEADVVAVMGHRAPGADYSSTHPPLKEMGEPDCPIRQIVAPTAGAAAGDRVRYSQWTDSMYFAPSIPYFRSYWGAINCKGCDPGTLSGRQIIEARERDIEDYTKA.Q.YDSEMTDVALCSMRGCTVHGHSLRLEENGMQFDMLARTELG-SDGNVYGVKDQVGIPLDKKVNLGKPMSEAEAKKRTTIFR.FDGVPMggk..vgaRQ..FDEAIEMTHHMWERRSKWGYR..
U6EF24_9EURY/2-247 ...AQYYPGTSKVAENRRRFCDPNVELEKLREISDEDIVKILGHRAPGEEYPSVHPPLEEMDEPDDAIREMVEPLDGAKAGDRVRYIQFADSMYFAPAHPFLRSRAYLCRYRGADAGTLSGRQIIETRERDLEKVSKE.L.LETEFFDPARTGFRGKTVHGHSLRLDEDGMMFDMLRRQVFNKSTGKVEGVKNQIGDELDEPVILGEPLDEATLKEKTTIYR.KDGEAY........RD..DTDAVEVLHRIHVSRSKGGF-c.
A0A0X3BM05_9EURY/5-250 ...PQYGPGTSIVAENRRKQMNPSQKLEKVRSVTDEDIVLILGHRAPGSAYPTAHPPLAEQQEPNCPMRKLVKPTEGAKAGDRVRYIQFADSMFNAPSQPYQRTYAEMYRFRGIDPGTLSGRQIVECRERDLEKYSKE.L.LETEMFDPARVGIRGATVHGHSLRLAEDGMMFDMLQRCILD-EDGVVKYVKNQIGEPLDRAVAIGKPMDEKWLKAHTTIFHsLVGTPY........RE..DTEYIEYVQRIHSLRTKYGFM..
R9T7E3_METII/5-250 ...RQFYPGISQVAKNRRRFMDPSQELKKLRDVSLDDVVRIMGHRSPGEEYKSIHPPLEEGNEPDDLIRQLVTPIEGAKKGDRVRYVQFADSVYFAPMVPYVRAWAYMSRIRGFDTGTLSGRQIIEMRERDLEKVAKE.F.IDNETFDPARCGIRGATVHGHACRLDENGLMFDAWQRYVWNEKTGEVDYVKDQVAIPLDKPISVGKPIPEADLKKMTTIFR.IDGDDM........NA..DKEVLDMNLRIHTLRTLCGYQ..
F6BE96_METIK/5-251 ...PQFYPGETKIAQNRRNHMNPDVELEKLREIPDEDVVKIMGHRQPGEDYKTIHPPLEEMDLPEDYVRDLVEPINGAKEGHRIRYIQFADSMYFAPAQPYDRARTYMWRFRGVDTGTLSGRQVIEMRESDLEALSKNfL.IDTAFFDPARCGIRGATVHGHSLRLDENGLMFDALQRYVYDEKTGHVVYVKDQVGRPLDEPVDVGEPLPEEKLREITTIYR.KDGIPM........RE..DKELLTVVKRIHRARTLGGF-c.
R9SN08_9EURY/2-247 ...AQYYPGTSQVSENRRHFADPEQKLEKLREISDEDVVKILGHRAPGEEYKHVHPPLDEMDEPDDIVRELVTPIDGAKAGDRVRYIQFADSMYFAPVQPYVRARSYMNRYRGIDTGTLSGRQVIEARERDLEKLSKE.L.LETEYFDPARTGIRGKSVHGHSLRLDEDGIMFDMLRRQLKNKETGHIEMVKNQIAIPLDEPIDIGEPLDEEKLKSITTIYR.VDGDKY........RD..DKDAVEVLHKIHLTRTQGGYN..
E1RDX5_METP4/5-249 ...PQYGPGTSNVAANRRKQMNPAVQLDKVRDVTDEDVVLILGHRAPGSAYPTAHPPLAEQQEPDCPIRKIVEPTEGAKAGDRVRYIQFADSMFNAPSQPYQRTYTECYRFRGIDPGTLSGRQIVECRERDLEQYAKW.L.IETEMFEPALVSCRGATVHGHSLRLAEDGMMFDMLQRCILE--DGVVKYQKDQIGEPLDRAVEVGKPMDDAWVKDHSTIFHsLVGTAY........RD..DAEYVEYIQRIHSLRTKYGFM..
F0TCV4_METLA/5-250 ..v-QYTPGNTKIAENRRKHMDPDFELKKIREIADEDIVKILGHRNPGEGYKSVHPPLEEMDFEEDLMKEMVEPIEGAKEGNRTRYVQFTDSMYNAPAQPYDRARTYMWRFRGVDTGTLSGRQVIEIRERDLEKISKT.L.VETELFDPAKTGIRGATVHGHSLRLDENGLMFDALQRYVFDEKTGSVSYIKDQVGRPLDEPVDMGAPLDEENLKEITTIYR.SDNISM........RD..DPEAIETVEAIHAARTDGGF-g.
A0A1F2PCA4_9EURY/25-273 ...RQYYPGSTMVPENRRKFYDPIRPLEVLRTLTDEDFQNLLGFRALGQRYLSVHPPLEEIGEPDDPIRELVPADAGAKAGDRITTMVMSDSLTHPLIGPYTRIWMYLNRFRGIDGASYSARTTLEMREREMEGVSRV.I.IEAECFDPARDAFRQFGCTGASSRLDKNGLFFDPMARIEYDPSTGHYMQVKDGFGIPLDKPVDLGPTLPEEEKAKRNVMYMnTDGNPV........LAgpEWEVLVVKRRIQALRFLAG--mg
Q2NHZ9_METST/5-250 ..v-QYYPGESVIAENRKKHMNPDHELKKLRNIADDDIVKLLSHRNPGEGYKTVHPPLDEMDFEEDTMKDFVEPIDGAKKGIRIRYIQFADSMYNAPAQPYDRARSYMRRFRGVDTGTLSGRQVIEMRESDLEETSKL.L.LESEFFDSAKTGLRGATVHGHSLRLDEDGLMFDALQRYVFDKETGHVVYVKDQVGVELDEPIDVGEPLPEDELKKITTIYR.SDNVSL........RD..DEEVIKVVEAIHFARTDGGY-g.
D7E8X8_METEZ/6-247 ...KQYHPGKTSVAKNRSKHM--SNDLEKLREISDEDLTLILGHRSPGSDYPSTHPPLEEMGEPECSIREIVEPTEGAKAGDRIRYAQWVDSMYNAPATPYFRTYHAAINFRAVDPGTLSGRQLVEARERDMEKMTKV.Q.LETEMTCPGLAGLRGATVHGHSLRLQEDGVMFDMLDRRRLE--NGTIVMDKDQQARPIDKKVDLGKPMSEDEAAKRTTIYR.ADNVPF........RD..DDEVVEWVHRIWEQRTEYGFQ..
E1RJD6_METP4/4-249 ...PQYGPGTSVVAQNRRNQMNPEYELSKIRSVTDEDIILILGHRAPGQAYPSAHPPLAEQQEPDDPMRKLVKPTEGAKAGDRVRYIQFADSMFNAPCQPYQRTYMEMYRFRAIDPGTLSGRQIVECRERDLEQYSKI.L.IETEVFDPATVSCRGATVHGHSLRLAEDGLMFDALQRCILA-EDGNVCYVKDQIGIPLDRPVYVGKPMDEEWLREKSTIFHsLVGTAL........RD..DKEYVKYIQRIHSLRTKYGFM..
#=GC seq_cons ...sQaYPGsopVAcNRR+aMsPshcLEKLR-IoDEDlVhlLGHRAPGpsY.SsHPPLsEhsEP-ssIR-lVEPs-GAKAGDRVRYIQFsDSMY.APupPY.RuhhhhhRaRGlDsGTLSGRQIlEsRERDLEchoKp.L.lETEhFDPApsGlRGATVHGHSLRLDEsGlMFDhLpRtlhs.csGpVpYVKDQlGhPLDcsVslG+PhsEcpLKc+TTIYR.hDGsua........RD..DpEslEhlpRIHphRTphGF...
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