#=GF ID   MGMT_N
#=GF AC   PF09153.14
#=GF DE   Methylated DNA-protein cysteine methyltransferase, N-terminal
#=GF PI   DUF1938;
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1mgt
#=GF GA   22.10 22.10;
#=GF TC   23.80 72.40;
#=GF NC   22.00 19.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0219
#=GF RN   [1]
#=GF RM   10497033
#=GF RT   Hyperthermostable protein structure maintained by intra and
#=GF RT   inter-helix ion-pairs in archaeal O6-methylguanine-DNA
#=GF RT   methyltransferase. 
#=GF RA   Hashimoto H, Inoue T, Nishioka M, Fujiwara S, Takagi M, Imanaka
#=GF RA   T, Kai Y; 
#=GF RL   J Mol Biol. 1999;292:707-716.
#=GF DR   INTERPRO; IPR015236;
#=GF DR   SCOP; 1mgt; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in the archaeal protein O6-alkylguanine-DNA
#=GF CC   alkyltransferase (also known as Methylated DNA-protein cysteine
#=GF CC   methyltransferase MGMT), adopt a secondary structure consisting
#=GF CC   of a three stranded antiparallel beta-sheet and three alpha
#=GF CC   helices. This entry represents the N-terminal ribonuclease
#=GF CC   H-like domain, associated with 6-O-methylguanine DNA
#=GF CC   methyltransferase activity. The exact function has not, as yet,
#=GF CC   been defined, though it has been postulated that they confer
#=GF CC   thermostability to the archaeal protein [1].
#=GF SQ   4
#=GS OGT_THEBM/1-88  AC F0LIT8.1
#=GS OGT_THESM/1-88  AC C6A382.1
#=GS OGT_THEKO/1-85  AC O74023.1
#=GS OGT_PYRFU/2-90  AC Q8TZV2.1
OGT_THEBM/1-88             MISIEKFEIFGREIWIAVFFEEKIDGVTFSLDGCEYLMERINSLKALLERR--NVSVNLAEEKSDYPKIVYNVLVGDIENQDALRFL---sfr
OGT_THESM/1-88             MISIKSFQIGEKEIVIAILFDKKIQGITFSFDGEQFLQERVNALVEHLTNRGVKVNLEERD--SELPALVYKILIGEIRNQDGLEYL---sfe
OGT_THEKO/1-85             MLSVEKFRVGERVVWIGVIFSGRVQGIAFAFDRGTLMK-RIHDLAEHLGKRGVSISLDVQP--SDYPEKVFKVLIGELDNASFLR--ELS...
OGT_PYRFU/2-90             ILEVRKFQVKNKAVYIGTLSEDKIFGIIFSIDEPEVIRHRIPTLINFLEKR-LNKKLEIKEGNSGFSDVVFKTLIGKISNEEAAEFIEVS...
#=GC seq_cons              MlSlcKFpltp+tlaIullF-cKIpGIsFShDtsphlpcRIssLhpaLp+R.lslsL-lp-..S-aPclVaKlLIG-IcNp-uLcal......
//