#=GF ID MIC5
#=GF AC PF21496.1
#=GF DE Microneme protein MIC5
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE ECOD:EF15898
#=GF GA 27.00 27.00;
#=GF TC 31.40 29.80;
#=GF NC 24.80 22.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0570
#=GF RC Paper describing PDB structure 2lu2
#=GF RN [1]
#=GF RM 22896704
#=GF RT Microneme protein 5 regulates the activity of Toxoplasma
#=GF RT subtilisin 1 by mimicking a subtilisin prodomain.
#=GF RA Saouros S, Dou Z, Henry M, Marchant J, Carruthers VB, Matthews
#=GF RA S;
#=GF RL J Biol Chem. 2012;287:36029-36040.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Microneme protein MIC5 is found in Apicomplexa and expressed as
#=GF CC a preproprotein which is proteolytically processed to a
#=GF CC proprotein by the signal peptidase before being further
#=GF CC processed in a post-Golgi compartment to the mature protein [1].
#=GF CC The structure of MIC5 was determined in Toxoplasma gondii and it
#=GF CC revealed that it is a subtilisin propeptide mimic and a potent
#=GF CC inhibitor of TgSUB1 [1]. Tis protein adopts a subtilisin-like
#=GF CC prodomain structure, which consists of an open-sandwich
#=GF CC antiparallel-alpha/antiparallel-beta fold [1].
#=GF SQ 7
#=GS A0A125YHB4_TOXGV/101-173 AC A0A125YHB4.1
#=GS A0A2C6L7B3_9APIC/160-236 AC A0A2C6L7B3.1
#=GS F0VRT0_NEOCL/99-172 AC F0VRT0.1
#=GS F0VF24_NEOCL/120-198 AC F0VF24.1
#=GS A0A2C6L4S8_9APIC/113-187 AC A0A2C6L4S8.1
#=GS A0A2A9M6P0_9APIC/92-165 AC A0A2A9M6P0.1
#=GS V4YYL6_TOXGV/124-203 AC V4YYL6.1
A0A125YHB4_TOXGV/101-173 .................EMTRLMVTEK.....QE.SK.NFSKMAKSQSF-STRIEELGGSISFLTETGVTMIELPKTVSEHDMDQLLHDILAAGGVVG
A0A2C6L7B3_9APIC/160-236 lrllivdresdddspip----------.....--.--.SFVETAEESDVADHVGKELGGSLRTLNETGVVVIDLPSNTTDAELRNLIDDAKRRGGLVE
F0VRT0_NEOCL/99-172 .................NMVRLMVTDK.....AG.SK.RFSKTVETSALHSKIVDELGGTVSVLTETGVTLIDLPMTVSDIDMGKLISEIIAAGGIVE
F0VF24_NEOCL/120-198 ...............pv---RLLIVDKpagdeEEtRP.SFVQTALHSELAQRVVKELNGHVDVLDESGVVLVDLPANTTDKQLKEVIETAKAQGAIVE
A0A2C6L4S8_9APIC/113-187 ..............afl---TLMVTDD.....WGaSP.PFSQRFAELDLYHKVVDQLRGQVDVLRESGVTIIKLPVGVSDEDAEAVVEGVTAAGGVVE
A0A2A9M6P0_9APIC/92-165 ................k--MRFMVTDA....tQG.PQ.AFSQKVKDLPLHNKIVAELKGNVSVMSAMGITIIEVPSSVSDEDLKTLITALREAGGLVE
V4YYL6_TOXGV/124-203 .vrmlivdkrsddddde----------.....-E.TKtSFVETALHSDLAQRVVKELNGHVDVLRESGVVLVDLPAQTTDKQLQELIETARAQGTIVE
#=GC seq_cons ....................phhls-t......t.s..sFsppstcpsLtp+lVcELsGpVsVLsEoGVslI-LPsssoDc-hcpLIcshpAtGGlVE
//
