#=GF ID MOSP_C
#=GF AC PF02722.19
#=GF DE Major Outer Sheath Protein C-terminal domain
#=GF AU Bashton M;0000-0002-6847-1525
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_653 (release 5.5)
#=GF GA 25.00 25.00;
#=GF TC 37.50 36.30;
#=GF NC 23.20 23.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0193
#=GF RN [1]
#=GF RM 9023187
#=GF RT Conservation of msp, the gene encoding the major outer membrane
#=GF RT protein of oral Treponema spp.
#=GF RA Fenno JC, Wong GW, Hannam PM, Muller KH, Leung WK, McBride BC;
#=GF RL J Bacteriol 1997;179:1082-1089.
#=GF RN [2]
#=GF RM 23457251
#=GF RT The major outer sheath protein (Msp) of Treponema denticola has
#=GF RT a bipartite domain architecture and exists as periplasmic and
#=GF RT outer membrane-spanning conformers.
#=GF RA Anand A, Luthra A, Edmond ME, Ledoyt M, Caimano MJ, Radolf JD;
#=GF RL J Bacteriol. 2013;195:2060-2071.
#=GF DR INTERPRO; IPR003872;
#=GF DR TC; 1.B.38;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is a family of spirochete major outer sheath protein
#=GF CC C-terminal regions. These proteins are present on the bacterial
#=GF CC cell surface. In T. denticola the major outer sheath protein
#=GF CC (Msp) binds immobilised laminin and fibronectin supporting the
#=GF CC hypothesis that Msp mediates the extracellular matrix binding
#=GF CC activity of T. denticola [1]. This domain forms an amphipathic
#=GF CC beta rich structure with channel forming activity [2].
#=GF SQ 13
#=GS O83335_TREPA/559-762 AC O83335.1
#=GS E7NV53_TREPH/397-559 AC E7NV53.1
#=GS O83867_TREPA/319-505 AC O83867.3
#=GS O83619_TREPA/490-693 AC O83619.1
#=GS O83629_TREPA/411-609 AC O83629.1
#=GS O83994_TREPA/317-514 AC O83994.1
#=GS F7IWA5_TREPA/555-758 AC F7IWA5.1
#=GS O83337_TREPA/553-756 AC O83337.1
#=GS O83055_TREPA/436-660 AC O83055.1
#=GS O88138_TREPA/400-598 AC O88138.1
#=GS F7IWF6_TREDE/361-543 AC F7IWF6.1
#=GS S5ZXI9_9SPIR/424-525 AC S5ZXI9.1
#=GS A0A0A0X3G4_9SPIR/390-492 AC A0A0A0X3G4.1
O83335_TREPA/559-762 ..................DALFTAQWKWLSSGIYFATAPANVFGTRVLDNTIASCGDFAGFLKLETKSGDPYTHLLTGLDAGVETRVYIPLTYALYKNNG.............GTAVRG....IQEKEYIRPPVVGKAWCSYRIPVQDYGWVKPSVTVHASTNRAHLNAPAAGGAVGATY....LTKEYCAQLRAGISASLIEKTVFSLDWEQGMLSDVPY.L.LVSECLT....QG-.IGRIVCGVTLSW............
E7NV53_TREPH/397-559 ..................DMLFDTTYKWVGAGVYVGNENT-------FYKSNKDGVDMSIYAKFETKG-----DLVKNLNAGTA--LYV---HRLLS---.............------....-KPENEKTYPIGLKVYADYKYDINDSMWLKPYASFYGETNHA------EP-------....---KFGVYYNVGLTFSPLERLELTADWEQGKVVKNKHeG.FIEKSAG....KEH.NGRFKLSCKVS-f...........
O83867_TREPA/319-505 ..................DALLTLGYRWFSAGGYFASXASNVFGGVFLNMAMREH-DCAAYIKLETKGSDPDTSFLEGLDLGVDVRTYMPVHYKVLK---.............--ALPP....-----AIXFPVYGKVWGSYRHDMGEYGWVKVYANLYGGTNK-----KATPPAAPATK....WKAGYCGYYECGVVVSPLEKVEIRLSWEQGKLQENSN.V.VIEKNVT....ER-.-WQFVGACRLIW............
O83619_TREPA/490-693 ..................DALLTLQWRWFACGVYVATAPASVFGAMVFPTYGSTHTDGGGFLRVETKAGDAYTHLIDGLEAGMDVRCYIPLTHGLYIDNG............kGYYVSPmgvwKLPDTHINLPVMGKVWARYLIPLGETAWLKPSLAVYGTTNRFNYNLKTEN-------....LVHERCVQYQVGLTLSPIEKVTLHAQWEQGQLEPTPY.M.VITETVT....SRRyFGTFVCGMTINW............
O83629_TREPA/411-609 ..................DALLTAQWTYVSAGLYGATAGTNVFGKRVLPALRSWHFDFAGFLKLETKSGDPYTHLLTGLNAGVEARVYIPLTYIRYRNNG.............GYELNG....AVPPGTINMPILGKAWCSYRIPLGSHAWLTPHTSVLGTTNRFNVINPAYT-------....LLNERALQYQVGLTFSPFEKVELSAQWEQGVLADAPY.M.GIAESMW....SERyFGTFICGVKVVW............
O83994_TREPA/317-514 ..................DALLSMQWKWLSSGAYFATAGANMFGKRVFSRQLTDYLDCAAFLKLETKSGDPYTHLLTGLNAGVEARLYIPFTYTSYVNNG.............GIDYKK....TTMRGPINLPVVGKTWLSYQIALGSHAWLKPYAVVYGTTNRFN-TDKANN-------....LLREKAMQYHVGFTVSPIEKVEFDARWEQGRLATAPY.M.LITEDIS....SDKhFGTFVCGLKIAW............
F7IWA5_TREPA/555-758 ..................DALFTAQWKWLSSGIYFATAPANVFGTRVLDNTIASCGDFAGFLKLETKSGDPYTHLLTGLDAGVETRVYIPLTHDLYKNNN.............GNPLPS....GGSSGHIGLPVVGKAWCSYRIPVQDYGWVKPSVTVHASTNRAHLNAPAAGGAVGATY....LTKEYCAQLRAGISASLIEKTVFSLDWEQGMLSDVPY.L.LVSECLT....QG-.IGRIVCGVTLSW............
O83337_TREPA/553-756 ..................DALFTAQWKWLSSGIYFATAPANVFGTRVLDNTIASCGDFAGFLKLETKSGDPYTHLLTGLDAGVETRVYIPLTYALYKNNG.............GTAVRG....IQEKEYIRPPVVGKAWCSYRIPVQDYGWVKPSVTVHASTNRAHLNAPAAGGAVGATY....LTKEYCAQLRAGISASLIEKTVFSLDWEQGMLSDVPY.L.LVSECLT....QG-.IGRIVCGVTLSW............
O83055_TREPA/436-660 ..................DALLIVQWRWISLGAYVASAPTNVFGSMLFPRGSSDHFDCAAFVRVESKWYDSLSKLVSGLSGGVEARLYIPFTHGLYLEPGsctpnstrgkkpqAFVLPPp.gvVHPGAHSALPVVGKLWLNYRITLAAHAWIRPMVSLYGATYGAQGFSYGPGGAAGTVKrnrtFRAGKNLYYQVGVAVSPFERCELLIEWSQGMLARRPY.I.SLEHGSW....PDK.RSELVCSCKVLW............
O88138_TREPA/400-598 ..................DALLRMQWKWLSSGIYFATAGTNIFGKRVFATTRAHYFDFAGFLKLETKSGDPYTHLLTGLNAGVEARVYIPLTYIRYRNNG.............GYELNG....AVPPGTINMPILGKAWCSYRIPLGSHAWLAPHTSVLGTTNRFNIINPAGN-------....LLNERALQYQVGLTFSPFEKVELSAQWEQGVLADAPY.M.GIAESIW....SERhFGTLVCGMKVTW............
F7IWF6_TREDE/361-543 ...............dlr---FDASYKWVALGAYFGNDLSAYAGKD---KNNKAIGDMAAMIAFKSAAS-GDTNFVEGLAFGVDFRL----NHLLSA---.............---VP-....--TGDKSTLPMGISAWVNYKYALTDSMWVKPYANFWGETNRKSI---------DASK....TDKFFGVAYKVGATFSPAEKIEIDTYWSQGKLSWNKY.E.GTEGMISapafDAH.NGTFVIGVKVI-y...........
S5ZXI9_9SPIR/424-525 lskiskeeramgeliplg----------------------------------------------------------------------------------.............------....------------LNVGAGYKAMLTDSIWIKPYADLWGETNSDIYSDDTPK-----SK....QKLYFGLAYKVGLSVSPMERLTIDLNWSHGKA-----.-.-------....---.------------fnpdvlmgtgsm
A0A0A0X3G4_9SPIR/390-492 ..............yqll----------------------------------------------------------------------------------.............------....----GASKFPLFAKVWGAYKININDSMWLKPFADVWLETNHG---SSAV--------....-----GLAYDLGVKFSPVEKVEVQAKWNHGSITKNKY.LgVINKSVI....DGQhYGAFVLSLKVA-y...........
#=GC seq_cons ..................DALhshQW+WlSuGhYhAoAssNlFGphlhspshssthDhAuFlKlETKuuDshT+LlsGLsAGV-sRlYIPhTatlYtpss.............u..l.s....h..tstIshPlhGKsWsuY+Isls-auWlKPassVaGsTNRtph.s.Ass...........hhpchsltYcVGlohSPlEKlElshpWEQGhLucsPY.h.hlscsls....ptp.hGphVCGs+lsW............
//
