#=GF ID   MTD
#=GF AC   PF01993.22
#=GF DE   methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase
#=GF AU   Enright A;0000-0002-6090-3100
#=GF AU   Ouzounis C;0000-0002-0086-8657
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Enright A
#=GF GA   25.00 25.00;
#=GF TC   314.60 314.50;
#=GF NC   24.60 23.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7852356
#=GF RT   Cloning, sequencing, and transcriptional analysis of the
#=GF RT   coenzyme F420- dependent
#=GF RT   methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase gene
#=GF RT   from Methanobacterium thermoautotrophicum strain Marburg and
#=GF RT   functional expression in Escherichia coli. 
#=GF RA   Mukhopadhyay B, Purwantini E, Pihl TD, Reeve JN, Daniels L; 
#=GF RL   J Biol Chem 1995;270:2827-2832.
#=GF DR   INTERPRO; IPR002844;
#=GF DR   SCOP; 1qv9; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This enzyme family is involved in formation of methane from
#=GF CC   carbon dioxide EC:1.5.99.9. The enzyme requires coenzyme F420
#=GF CC   [1].
#=GF SQ   75
#=GS MTD_METB6/3-279          AC A7I5N7.1
#=GS A0A0E3NUC0_9EURY/2-276   AC A0A0E3NUC0.1
#=GS D3RXG7_FERPA/2-272       AC D3RXG7.1
#=GS A0A1F2P8R9_9EURY/2-271   AC A0A1F2P8R9.1
#=GS A0A4E0R0I2_9EURY/2-273   AC A0A4E0R0I2.1
#=GS MTD_METPE/3-280          AC B8GJQ7.1
#=GS D7EB48_METEZ/2-277       AC D7EB48.1
#=GS MTD_METMA/5-279          AC Q8PXV8.1
#=GS MTD_METAC/5-279          AC Q8THT2.1
#=GS L0KTR5_METHD/2-274       AC L0KTR5.1
#=GS F4BZ98_METSG/2-272       AC F4BZ98.1
#=GS A0A2V3JBQ3_9EURY/2-274   AC A0A2V3JBQ3.1
#=GS A0A483CQ80_9EURY/3-280   AC A0A483CQ80.1
#=GS H1YWR8_9EURY/3-280       AC H1YWR8.1
#=GS A0A8J7W7W3_9EURY/3-280   AC A0A8J7W7W3.1
#=GS A0A133UKM3_9EURY/5-277   AC A0A133UKM3.1
#=GS A0A0F7DBG0_9EURY/2-272   AC A0A0F7DBG0.1
#=GS MTD_METKA/4-283          AC P94951.3
#=GS Q12XF4_METBU/2-273       AC Q12XF4.1
#=GS A0A166CUS3_9EURY/3-276   AC A0A166CUS3.1
#=GS Q0W2P5_METAR/3-274       AC Q0W2P5.1
#=GS A0A133V157_9EURY/4-276   AC A0A133V157.1
#=GS F2KNE0_ARCVS/1-272       AC F2KNE0.1
#=GS A0A8J7RXY8_9EURY/1-263   AC A0A8J7RXY8.1
#=GS N0BIS0_9EURY/2-272       AC N0BIS0.1
#=GS A0A133VB21_9EURY/4-276   AC A0A133VB21.1
#=GS A0A328SCW4_9EURY/3-276   AC A0A328SCW4.1
#=GS A0B7C4_METTP/2-273       AC A0B7C4.1
#=GS A0A133UGS7_9EURY/5-277   AC A0A133UGS7.1
#=GS A0A328S223_9EURY/3-275   AC A0A328S223.1
#=GS D3E118_METRM/3-276       AC D3E118.1
#=GS A0A2Z4L954_9EURY/2-275   AC A0A2Z4L954.1
#=GS A0A656YXJ9_9EURY/4-275   AC A0A656YXJ9.1
#=GS A0A133VI91_9EURY/4-277   AC A0A133VI91.1
#=GS D2RET8_ARCPA/1-253       AC D2RET8.1
#=GS A0A328P8W8_9EURY/3-276   AC A0A328P8W8.1
#=GS A0A166CNE9_9EURY/12-285  AC A0A166CNE9.1
#=GS A0A062V4F2_9EURY/3-276   AC A0A062V4F2.1
#=GS E1RKC0_METP4/3-280       AC E1RKC0.1
#=GS D7DR53_METV3/3-277       AC D7DR53.1
#=GS E3GZ78_METFV/3-276       AC E3GZ78.1
#=GS A0A366M9M5_9EURY/3-276   AC A0A366M9M5.1
#=GS A0A2V2MXR2_9EURY/3-280   AC A0A2V2MXR2.1
#=GS R9SJF9_9EURY/3-276       AC R9SJF9.1
#=GS A0A2V3JPM5_9EURY/4-279   AC A0A2V3JPM5.1
#=GS MTD_METST/3-276          AC Q2NHQ2.1
#=GS D1YY63_METPS/3-275       AC D1YY63.1
#=GS MTD_METTH/3-276          AC Q50501.3
#=GS A0A1V6N234_METAZ/3-276   AC A0A1V6N234.1
#=GS MTD_METMP/3-277          AC Q6M099.1
#=GS I7LMX2_METBM/3-280       AC I7LMX2.1
#=GS MTD_METLZ/3-280          AC A2SPK1.1
#=GS A0A1Q6DUD9_9EURY/1-268   AC A0A1Q6DUD9.1
#=GS A0A2U1S6A9_9EURY/3-275   AC A0A2U1S6A9.1
#=GS MTD_METJA/3-277          AC Q58441.1
#=GS A0A315XKK2_9EURY/3-276   AC A0A315XKK2.1
#=GS A0A498GYG8_9EURY/3-280   AC A0A498GYG8.1
#=GS A0A328SR55_9EURY/3-275   AC A0A328SR55.1
#=GS U6EAV6_9EURY/3-276       AC U6EAV6.1
#=GS MTD_ARCFU/3-273          AC O29544.3
#=GS L0HKS1_METFS/3-279       AC L0HKS1.1
#=GS A0A8J8C619_9EURY/3-277   AC A0A8J8C619.1
#=GS A0A166CS26_9EURY/3-276   AC A0A166CS26.1
#=GS A0A1Y3GBB2_9EURY/1-269   AC A0A1Y3GBB2.1
#=GS W9DRW4_METTI/2-273       AC W9DRW4.1
#=GS F0T7A4_METLA/3-276       AC F0T7A4.1
#=GS MTD_META3/3-277          AC A6UWS1.1
#=GS D5EAK3_METMS/2-276       AC D5EAK3.1
#=GS A0A2R6T814_9ARCH/1-271   AC A0A2R6T814.1
#=GS A0A0X3BMI1_9EURY/3-280   AC A0A0X3BMI1.1
#=GS G7WNZ3_METH6/2-272       AC G7WNZ3.1
#=GS MTD_METHJ/3-280          AC Q2FU89.1
#=GS A0A1D3KYY6_9EURY/3-276   AC A0A1D3KYY6.1
#=GS A0A1D2W4S5_9EURY/3-276   AC A0A1D2W4S5.1
#=GS F7XNL9_METZD/2-278       AC F7XNL9.1
MTD_METB6/3-279                     ..VKVGVAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVSN.M...KA..WKPDFAIVVSPNGVLPGPTGAREQLAAAGIP..VIIITDDVT.TKKE.wEEVKNSKFGYIIMKADSMIGARREFLDPIEMADFNGNLVKVLAITGAFRKLQLALDKVIDQVKAGKkgtEIELPKIVMTTDKAVD-GEFTNDYALAKARAAHEIAIAVAGQNVKGCFMTKEWEKYIPIVASAHEMMRIAAVLCDEAREIEKAGDGILRQPHKKD.GVLVRKTKLVAK--fe.
A0A0E3NUC0_9EURY/2-276              ..VNIGFIKMGNLGMSQVINLIQDEIAAREGITVRVCGTGAKMGPDDAA-YTES.F...KQ..WDADFVIIISPNAAAPGPTAARELW--KDKP..CIVVSDGPT.KKDA.rQALEDEGFGYIILPVDPLIGAKREFLDPVEMASFNADAMKVLSLCGVVRLIQEEFDKVADQVNAGNsgkELELPHIFAKPEKCVEHGGFANPYAKAKALAALHMAEKVAQVNFPACFMLKDIEQVCLATATGHEIMGAAAVLATQAREIEKSNDTVLRQPHAKN.GTLLTKTKLYEKP-q..
D3RXG7_FERPA/2-272                  ..VKVGILKMGAIGTALLVEYLLDERADREDIEVRVVTSGAKMQPEEAK-IAEK.L...KE..FDPDLVLVVSPNAALPGPKAAREAF--EGKP..VIVISDAPA.KKAK..EEFEQKGFGYILVNADSMIGARREFLDPTEMALFNADVVKVLAATGAFRIVQEEIDKVIEALKKGE...KPELPKVVITAERAVEAAKFSNPYAKAKAMAAYFIAEKVADVDVRGCFIEKDPEKYIPLVAAAHEMMRIAAKLADEAREIEKSNDTVFRNPHARD.GKILSKTKLMEKP-q..
A0A1F2P8R9_9EURY/2-271              ..VKVGFIKLGNIGMSLIVNLLLDERADREDIDVRVAGTGAKMGKPEAQD-VLS.F...LK..WEPDLLIVTSPNAALPGPKIVREAF--EGKP..CIVISDGPA.KKAV..DSMKEKGFGYIILPGDPMIGARREFLDPTEMALFNTDVLKVLSACGASRLVQEEIDRVIEEIKAGK...EVTLPQIIATAEIVTERANFSNPYARAKAIAAYSMAEKVGELDSKACFMMKDPEAYTMMVAAAHELIREAALLADEAREIEKGQDTLSRAPHAKS.GELLSKQGLME---pl.
A0A4E0R0I2_9EURY/2-273              .a-KIGFIKLGNLGMSQVIDLVQDEIAAREGITVRVFGTGPKMGKDEAA-ATEE.L...KK..FDADFYVMISPNSSAPGPTAARELY--KDVP..CIVISDGPT.KKDD.rAALEEAGFGYIIMTVDPLIGAKTEFLDPVEMASFNSDAMKVLSTCGVVRLIQEELDKVTAMADEGK...ELELPHILAKPEKCIERAGFNNPYAKAKGLAALHMADMVAKINFPACFMMKELEQVALTTAAGHEMMRAAAQMAIEAREIEKANDSVFRQAHSKK.GNLMTKTRLYEKP-q..
MTD_METPE/3-280                     ..VKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVST.M...KA..WEPDFCIVVSPNGVLPGPVGARDELLKAGIP..CVVITDDIT.TKKEgwEALKASSFGYIIMKADAMIGARREFLDPVEMADFNGNLVKVLALTGAFRKLQTELDKVIDQVKEGKkgaDLVLPKVVMTSDKAVD-GEFSNPYALAKARAAYEIAQAVAGVNVKGCFMTKEWEKYIPIVASAHEMMRQAAALGDEAREIEKAGNGIIRKPHKKD.GTIVSKITLISKPE...
D7EB48_METEZ/2-277                  ..VKVGFIKLGNLGMSQVVDLLEDEIAAREGITTRVYGTGPKMSKEDAADTEAF.K...EE..FDPDFVIIISPNASTPGPTEARQLW--KDKP..CLIISDGPT.KKDD.rQAIEDEGFGYIILPVDPLIGAKTEFLDPEEMASFNSDVMKVLSTCGAVRLVQEELDKLTSQVDEGKsgdEIEMPHIYAKPQTCIERSGFSNPYAKAKALAALHMAEKVSQINLPACFMLKDLEEVAFTAATGHEMIRAAAELAVEAREIEKTNDTVLRKPHSKK.GKVLSKTKLYEKP-q..
MTD_METMA/5-279                     ..VNIGFIKMGNLGMSQVINLIQDEIAAREGITVRVFGTGAKMAPADAA-DTES.F...KQ..WNADFVVIISPNAAAPGPTAAREIW--KDVP..CIIVSDGPT.KKEA.rEAFEQEGFGYIILPVDPLIGAKREFLDSVEMASFNADAMKVLSICGVVRLIQEELDKVTEQVASGKsgkDLELPHIFAKPEKCVEHAGFANPYAKSKALAALHMAEKVAQVNFPACFMLKEIEQVCLTAAAGHEIMGAAAQLANQAREIEKSNDTVSRMPHAKN.GAVLKKVRLYEKPE...
MTD_METAC/5-279                     ..VNIGFIKMGNLGMSQVINLIQDEIAAREGITVRVFGTGAKMGPADAA-DTES.F...KQ..WNADFVVMISPNAAAPGPTAAREIW--KDVP..CIVVSDGPT.KKEA.rEALEQEGFGYIILPVDPLIGAKREFLDPVEMASFNSDAMKVLSSCGVVRLIQEELDRVTEQVASGKsgeDLELPHIFAKPEKCVEHAGFANPYAKAKALAALHMAEKVAQVNFPACFMLKEVEQVCLTAAAGHEIMGAAAILATQAREIEKSNDTVFRQPHAKN.GTLLKKVKLYEKPE...
L0KTR5_METHD/2-274                  .a-KIGIIKLGNLGMSQVVDLVQDEIAAREGITVRVFGTGPKMGKDEAA-ATAD.L...KK..MEADFYVMISPNSSAPGPTAARELY--KDVP..CIIISDGPT.KKED.rEALQQAGFGYIIMTVDPLIGAKTEFLDPVEMASFNSDAMKVLSTCGVVRLIQEELDKVAALVDAGE...PIQLPHILAKPEVCIERAHFNNPYAKAKGLAALHMADMVAKINFPACFMMKELEQVALTTAAGHEMMRAAAQLAIEAREIEKANDSVFRQPHSKKgGKQFQKTKLYEKP-q..
F4BZ98_METSG/2-272                  ..FKIGFVKLGNIATSTAIDLSLDEIAERTDIEFKIISFGPKMTEKEGK-GAEE.L...KA..WQPQLVVISSPNAATAGPTAAREAY--RGIP..TIIISDGPS.KKEA.rEALSAEGYGYIILPMDPLIGAKREFLDPAEMALFNSDALRVLAACGAIRLVEEELDRTIASIISGQ...-AKLPTILATPEKCAERMHFSNPYAQAKAMGALYMAQTVASIDAAACFRLKELKPIALTAAAGHEVMRAAARLADEARELEKSNDTVSRQPHART.GELMQKLSLLDKPE...
A0A2V3JBQ3_9EURY/2-274              .l-KVGFVKLGNIGTSRIVDLLLDERADREDIDVRVLGTGAKMTPEVAA-DTAR.L...LD..WDPDMVVVISPNAALPGPKRAREMVKERGKP..CIVISDGPA.KKAV..NELKENGFGYLIIPGDPMIGARREFLDPVEMSIFNSDVLSVLSVTGAMRLVQEEIDSVIEALKAGK...EAKLPQMIVTAEEAVERAKFSNPYAKAKAIAAYNMLERVAEMDARGCFMMKDPADYIPMVAAAHELLREASKLAFEAREMEKQADRLVREPHARS.GELRSKEKLLEKP-g..
A0A483CQ80_9EURY/3-280              ..VKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVTN.M...KA..WGPDFCIVVSPNGVLPGPKGAREALAEAGIP..CVVITDDIT.TKKDdfAALKESAFGYIIMKADSMIGARREFLDPIEMADYNGNLVKVLALTGAFRKLQLELDKVVDQVKEGKkgaDLVLPKVVMTSDKAVD-GEFTNPYALAKARAAYEVASAVAGVNVKGCFMTKEWEKYIPIVTSAHEMMRQAAVLCDEAREIEKAGDGVIRMPHKKD.GVIVSKTALISKPE...
H1YWR8_9EURY/3-280                  ..VKVGIAKLGNIGSGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVDN.M...KA..WGPDFCIVVSPNGVLPGPKGAREALAAAGIP..CVVITDDIT.SKKDdfAALKESNFGYIIMKADSMIGARREFLDPVEMSDYNGNLIKVLTITGAFRKLQLALDAVIDQVKAGKkgaELELPKIVMTSDKAVA-DEFTNPYAYAKARAAYEIAQAVAGVNVKGCFMTKGHENYTPIVASAHEMMRSATLLCDEAREIEKGCDGVIRMPHKND.GEIVKKTALISKP-w..
A0A8J7W7W3_9EURY/3-280              ..VKVGIAKLGNIASGVMAELLLDERADREDMESFMATSGTKMQTEDIERVVSN.M...KA..WGPDFCIVVSPNGILPGPTSAREDLAKAGIP..VVVITDDITsKKDK.fDELKASNFGYIIMKADSMIGARREFLDPVEMADFNGNLIKVLALTGAFTKLQVALDEVIDQVKAGKkgaDLVLPKIVMTADKAVD-GEFVNPYSLAKARAAYEIAQGVAAVTVKGCFMTKEWEKYIPIITSAHEMMRHAALLCEEARELEKAGDSVLRKPHKKD.GVLVSKTKLISKPE...
A0A133UKM3_9EURY/5-277              ..IRVGFVKLGNIGTSTMLDLMLDERAEREDVDFRVVTSGPQMTEENGREVSKK.V...LD..FDPNLILTASPNPTTPGPSAAREVLEDVDVP..CIVIGDAPG.AKIS..EELEEKGFGYIFINADAMIGARREFLDPVEMALFNSYLIKTLAVTGALSAVQEEVDLTISKIKEDE...-RYLPQLIVDRDKSIDVAEFENPYAKTKAMAAFEIASKVADLTFEGCFKIQESEKYIPIVGSAHEMMRVAAKLSDEAREIEKGENSVLRKPHYDD.GSILRKRKFLASPE...
A0A0F7DBG0_9EURY/2-272              ..VKVGVLKMGAIGTALLVEYLLDERADRGDIEVRVVTSGAKMQPEEAV-VAEK.L...KE..FDPDVVIVISPNAALPGPKAAREAF--EGKP..VIVISDAPA.KKAK..DELAEKGFGYILINADSMIGARREFLDPTEMALFNADVVRVLAATGAFRIVQEEIDKVIEAVKKGE...TPELPKIVITAEKAVKAGNFQNPYAKAKAMAAFYIAEKVADIDVKGCFIEKDPEKYIPLVASAHEMMRIAAQLADEAREIEKSNDTVYRTPHSKD.GEILKKFKLMEKPE...
MTD_METKA/4-283                     .a-KAIFIKCGNLGTSMMMDMLLDERADREDVEFRVVGTSVKMDPECVEAAVEMaLdiaED..FEPDFIVYGGPNPAAPGPSKAREMLADSEYP..AVIIGDAPG.LKVK..DEMEEQGLGYILVKPDAMLGARREFLDPVEMAIYNADLMKVLAATGVFRVVQEAFDELIEKAKEDEi.sENDLPKLVIDRNTLLEREEFENPYAMVKAMAALEIAENVADVSVEGCFVEQDKERYVPIVASAHEMMRKAAELADEARELEKSNDAVLRTPHAPD.GKVLSKRKFMEDPE...
Q12XF4_METBU/2-273                  .a-KIGFIKLGNLGMSQVIDLVQDEIAAREGISVRVFGTGPKMGKDEAA-ETAA.L...KE..WDADFYVMISPNSSAPGPTAAREIY--KDVP..CIVISDGPT.KKDD.rQALEDAGFGYIIMTVDPLIGAKREFLDSVEMASFNSDAMKVLSTCGVVRLIQEELDIVTAQVDEGK...EIVLPHILAKPEKCIERAGFSNPYAKAKALAALHMADKVAQINFPACFMMKEIEQVTLTTATAHEMMRAAAQLAIDAREIEKSNDTVLRQPHAKK.GNILSKTALYEK--qq.
A0A166CUS3_9EURY/3-276              ..VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVIGSGAKMNPEQVEEVVPK.V...KE..FNPDFAIFISPNPGAPGPAKARELLSGYDIP..AVIIGDAPG.ASKK..DEMNEQGLGYIIVKGDPMIGARRELLDPTEMASFNADVIKVLSLTGAYRLVQTAIDGLIADVEAGK...DLELPKIILTAEKAAEAAGFANPYAKAKAIAAYEAASTVANIDTKGCFMVRDAEQYIPLVAAAHELIGVAAKLATEARDIEKSNDTVLRTPHNKD.GAIVTKTALLDKP-a..
Q0W2P5_METAR/3-274                  ..VRVGIVKLGNIGTSRFIDLVLDERADR-DIYVRTVGAGAKMGEAEAE-EMKK.I...ID..FKPQFCIVISPNATVPGPTKAREMLKEAGIP..TIVISDSPV.LKIK..DDLKAKGFGYFVVKCDPMIGARRQFLDPTEMVLFNADVLKVLANTGVVRLIQKELDAVIEGFAAGQ...TPALPQIVISADKAVAAAGYKNPYAKAKAMAAFVAAEKVADIDLQGCFMQKEMEQYIPTVASAHELLREAAKLSDEARELEKATDAILRTPHAAD.GKVLSKTQLMLKPE...
A0A133V157_9EURY/4-276              ..VRVGLVKLGNIGTSPMLDLMLDERAEREDIEFRSVSSGPRMGKEDSKDVAEK.I...LE..FNPDLITIISPNPTTPGPSSARDALSETGVP..CTVVGDAPG.TQIT..DDLEEAGFGYIFVIADSMIGARKEFLDPTEMALFNADLIKVLSITGALRAVRQEMDKAIESIKSSE...-LYLPRIIVDRDTAAEAAGFENPYAKVKAMSAFEIASKVAELSVEGCFKVQDKEKYIPIVGSAHEMMRTAAQLADEARELEKSKDSVLRKPHADD.GKTLSKRKFMETP-k..
F2KNE0_ARCVS/1-272                  ..MRIGIIKLGAIATALLIDYMLDERADREDIDVRTITSGSKLRERDAE-IVDK.M...RE..FNPDLVIVASPNAALPAAKLARDALKAEGKP..VIVISDAPA.KKVK..DELEAEGFGYILVNADSMIGARREFLDPTEMCLYNSDVIKVLAATGAFRAVQLAVDEAIESAKAGK...-PKLPRLIIDAEAAVNAGNFSNPYARAKAMAAYTIAEKVAAVTTKACFVEKDAEKYIPMVAAAHEMMRYAAKLAEEAREIEKSSDAVYRTPHAKD.GRVLSKWGLMEKP-s..
A0A8J7RXY8_9EURY/1-263              .m----------------AELLLDERADREDMQTFMATSGTKLQPEDIDRVVTT.M...KE..WVPDFCIVVSPNGILPGPTGAREQLAEAGIP..CIVITDDITgKKDQ.fAALKESQFGYIIMKADSMIGARREFLDPVEMADFNGNLVKVLALTGAFRKLQLELDKVIDQVKEGKkgaDLVLPKLVMNSDKAV-AGEFSNPYALAKARAAYEIAQAVAGVNVKGCFMTKGFENYVPIVASAHEMMREAAYLCDEAREIEKAGDGIIRKPHKKD.GVIVSKTALISKPE...
N0BIS0_9EURY/2-272                  ..VKVGVVKMGAIGTALLVEYLLDERADREDITVRVVTSGAKMQPEEAE-IVEK.M...KE..FDPDLVIVVSPNAALPGPKAAREAF--EGKP..VIVISDAPA.KKAK..EEFEEKGFGYILVNADSMIGARREFLDPTEMALFNSDVVKVLAATGAFRLVQEEIDKVIEALKEGK...TPELPKIVVTAEKAVKAGNFKNPYAKAKAMAAYYIAEKVADIDVKGCFIERDPEKYIPLVAAAHEMMRVAAIEADRAREIEKGGDSVYRNPHAKD.GKILSKTSLMEKP-q..
A0A133VB21_9EURY/4-276              ..VRVGLVKLGNIGTSPMLDLMLDERAEREDIEFRSVSSGPRMGKEDSKDVAEK.I...LE..FNPDLITIISPNPTTPGPSSARDALSETGVP..CTVVGDAPG.TQIT..DDLEEAGFGYIFVIADSMIGARKEFLDPTEMALFNADLIKVLSITGALRAVRQEMDKAIESIKSSE...-LYLPRIIVDRDTAAEAAGFENPYAKVKAMSAFEIASKVAELSVEGCFKVQDKEKYIPIVGSAHEMMRTAAQLADEARELEKSKDSVLRKPHADD.GKTLSKRKFMETP-k..
A0A328SCW4_9EURY/3-276              ..VKIAIVKIGNIGTSPVIDLVLDERADRNDVEVRTISSGSKMGSKQVEDLLPN.I...HK..LNPDIIIFISPNPNAKHPKRAREILSEIDIP..TIIIGDKPG.EKAI..GQMKEQNLGYILIRADPMIGARREFLDPTEMALFNSDVLKVLSITGAFRLVHETMDELINKLNNNE...EIELPEIVVKAEVAIQYAGFKNPYAMSKALAAYHIASRVSDMDIKACFKTDEPDIYIPLVTAAHEMMSAAAKLADEARDIEKGNDTVLRTPHRRD.GTVLRKTSLMDN--fd.
A0B7C4_METTP/2-273                  ..FKIGFIKLGNIASSLVVDLALDEIAERTEIESKVVSHGPKMSRGEGERLAEE.M...RA..WGPQMVVVVSPNAATPGPTAARSML--KGIP..LIVISDGPT.KKEA.rDAMETEGFGYIILPMDPLIGAKREFLDPAEMAIFNADALKVLSICGAVRLVQEEIDRAIASVAAGS...-PQLPHILATPELCAERMDFANPYARAKAIAALYMAQTAASIDAQACFRLKELEAIALAAAAGHEVIRAAARLADEARELEKSGDTVSRKPHARS.GDLLVKRKLLEKP-a..
A0A133UGS7_9EURY/5-277              ..IRVGFVKLGNIGTSTMLDLMLDERAEREDVDFRVVTSGPQMTEENGREVSKK.V...LD..FDPNLILTASPNPTTPGPSAAREVLEDVDVP..CIVIGDAPG.AKIS..EELEEKGFGYIFINADAMIGARREFLDPVEMALFNSYLIKTLAVTGALSAVQEEVDLTISKIKEDE...-RYLPQLIVDRDKSIDVAEFENPYAKTKAMAAFEIASKVADLTFEGCFKIQESEKYIPIVGSAHEMMRVAAKLSDEAREIEKGENSVLRKPHYDD.GSILRKRKFLASPE...
A0A328S223_9EURY/3-275              ..IKIGIIKIGNLGTSTIIDLILDERADREDIDVRTISSGSKMEKEQVEDIMPR.I...SE..YNPDLIIFISPNPNSKQPGVIRNYLSKTGIP..TIVVGDQPG.EKAI..NKMKEQKLGYILIRADAMIGARREFLDPTEMALFNADVLKVLSITGTLRLVNHKIDEVINSIKEEE...PIELPELVVTAELAVFNAGFKNPYAMGKAIAAYNMATLVSEMNITACFKIDEPDMYIPIVTASHELMLAAAKLADEAREIEKSNDTVLRTSHAKD.GSVWVRQSLID---ty.
D3E118_METRM/3-276                  ..VKIGIVKSGNIGTSPVLDLLLDERADRPNIDVRVFGSGAKMNPEQVEDVVPK.L...DQ..FDPDFCIFISPNPGAPGPARARELLSEKDLP..AIIIGDAPG.KGKK..DEMDEQGLGYIIVMSDPMIGAKREWLDPTEMAIFNADILKVLAETGALRLVQKTLDAVIAAADAGE...EIELPKLIVTAEKAVEAAGFANPYAKAKAIAAYEMAGAVAGLDMKGCFMTKGFENFIPLVAAAHEIASAAAKLAQEAREIEKSNDTVLRTPHMKE.GNLGCKVDLISKP-v..
A0A2Z4L954_9EURY/2-275              ..IKVGVVKVGNIGISTIIDLILDERADRDDFHIRTISTGSKMGQNEVNDIIRR.V...KN..IDVDLLVFISPNPGARQIKHAIEEITKLNLP..LVIIGDKPG.ERAI..PFMKEHHLGYILIRADAMIGARREFLDSTEMALFNSYVLNVLSITGVIRLIHEEIDKVLYSVKDDA...PIEFPEIIVTAQKAVSYARFNNPYAEAKAMAAYQIATQVSEMDVTACFRVNDPEEYIPLVVAAHEMMKAASILAEEARELEKSNDTVTRTPHKRD.GSIVFKSKLLHN--ye.
A0A656YXJ9_9EURY/4-275              ..VRVGLAKLGNIGTSSMLDLMLDERAEREDIDFRVLCSGPKMRKEDGKELADK.L...QG..FDPDLIIISSPNPSTPGPTAARETVSDLDIP..RVIIGDAPG.TRIK..DDLEKAGFGYLFILADAMIGARREFLDPIEMSLFNADLIKVLSVTGAFRVVQEEIDKIISAEKTGN...-SYIPQLVVDRDTAISAADFENPYARAKAMAAYEMASKVADLDVEGCFQVHEESKYVPIVASAHEMMRSAANLADEARELEKSEDSVLRKPHADD.GDILSKNKLME---sl.
A0A133VI91_9EURY/4-277              ..IRVGLAKLGNIGTSSMLDLMLDERAEREDVDFRVVSSGPKMGDEDGEDIVDK.L...LD..FNPDLIIISSPNPATPGPTAAREAVKDIDIP..RIVIGDAPG.TKIQ..EDLENIGYGYIFVLADAMIGARREFLDPIEMAIFNADLIKVLSVTGAFRVVQEEIDNTISSLKSGS...SSYVPEKIVDRNTAVAAADFENPYARAKAMAAYEMASKVADLDVEGCFRVHEEKEYVPIVASAHEMMNTAASLAEEARKLEKGEDSVLRTPHADN.GDMLKKRKLMKSPE...
D2RET8_ARCPA/1-253                  ..MRIGIAKLGAIGSAVLLEYCLDELAMRGDIETFVVSSGSKIKVEVLEEL---.-...EK..RDFDLKIVTCPN--------AEKFLKDVNLSdrVIVITDRAS.K---..DWLDSLNWGYIVVKADAMIGARREFLDPTEMVLYNSDLLKVLAVTGIIRLLQYEINRALK------...EDYLPKVVVDYNTAVKFAGFCNPYARAKAIASYIIAENISKITHKACFVEKDAENYITLCATAHEMMRIAGKLADEAREIEKSNDSVLRTPHSKS.GEILKKVGLYD---v..
A0A328P8W8_9EURY/3-276              .a-KIGVLKCGNLGTSPVIDLVLDERADRPNVEIRVMGSGTKMNPDDIEFVVPK.M...LE..LDRDFVIFISPNPGAPGPARARELLSEADVP..AMIVGDAPG.LRVK..DEIEEQGLGYIIVKADSMIGARREFLDPTEMAAFNADLMKVLALTGAYRVVHNTIDAMIADVEAGK...EIELPQLVITRDVAVEAADFKNPYAKAKAMAAYEIASKVADIDVEGCFMVQDPEKYIPIVASAHEMMSTAARLAEEAREIEKSNDTVKRTPHGKE.GETLSKEKLLEKP-s..
A0A166CNE9_9EURY/12-285             ..VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVIGSGAKMNPEQVEEVTPK.V...KE..FNPDFAIFISPNPGAPGPAKARELLSSYDIP..AVIIGDAPG.AGKK..DELNEQGLGYIIVKGDPMIGARRELLDPTEMASFNADVIKVLALTGAYRIVQDAIDDLVDAADAGK...ELELPKIIITAEKAAEAAGFTNTYAKAKAIAAYTAAEKVADLDLKGCFMVKESDKYIPLVAAAHELIGVAAKLATEARDIEKSNDTVLRTPHGAN.GSTVKKTVLLEKP-v..
A0A062V4F2_9EURY/3-276              ..VKIGFVKLGNLGTSLVIDLLLDEIAAREGIAVRVFGTGAKMGKDDAA-DTAS.F...MS..WKPDFVIITSPNASAPGPTGAREIW--RDIP..TIIVSDGPT.KKDD.rEKLEQAGFGYIILPVDPLIGAKREFLDPVEMASFNSDALKVLSVCGAIRLVQAELDTVVDQVAVGAe.rPLTLPHILAKPERCVESAGFSNPYAKAKALAALHIATKVADIDFQACFVLKELEQIAVAAAAGHEAMRTAARLADEAREIEKSNDSVLRKPHAKD.GRLLSKTKLLEKP-q..
E1RKC0_METP4/3-280                  ..VKVGIAKLGNIASGVMAELLLDERADREDMETFMATSGTKLQEKDIDRVVEN.M...KA..YGPDFCIVVSPNGVLPGPKGAREALAAAGIP..CVVITDDIT.TKKDefAALKETSFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLAVTGAFRKLQIALDEVIDQVKEGKkgaDLVLPKIVMSSDKAVE-GEFTNPYAYAKARAAYEMAQSVAGINVKGCFMTKGHENYTPIVASAHEVMRQAMLLCEEAREIEKSCDGVIRKPHKSD.GTRVEKVKLIDKP-w..
D7DR53_METV3/3-277                  ..VKVGIIKCGNIGMSPLVDLSLDERADRNDIDVRVVGSGAKMGPEQVEEVTKKmI...ED..IKPDFVLYIGPNPAAPGPKVARELLSAADIP..AVIIGDAPG.IKDK..DAMAEQGLGYILIKCDPMIGARRQFLDPVEMSMFNADVVRVLAGTGAVRVVQNAIDAMIYAVEEGK...EIELPKIIVTDAKAVAAAEFSNPYAKAKAMAAFVMAEKVADIDVKGCFMTKEMDKYIPIVASAHEMIRYAAKLVDEARELEKATDGVSRKPHAGP.GAILNKSKLMEKPE...
E3GZ78_METFV/3-276                  ..VKIGVIKCGNIGTSPVIDLLLDERADRPNIDVRVIGSSAKMNPEQVEDVVPK.M...LD..MDRDLVIFISPNPGAPGPAKARELLSESDVP..SIIIGDAPG.KRVK..DEIEKQGLGYIIVEADPMIGARREFLDPTEMASFNADVIKVLACTGAYRLIHKTLDDLISDLEAGK...EIELPKLIIDSEKAVEAGEFENPYAKAKAMAAYEIAAKAADLDVKGCFMVQDPEKYIPIVASAHEMVSIAAKLASEAREIEKSNDTVKRTPHGKK.GELLEKVELMAKP-k..
A0A366M9M5_9EURY/3-276              ..VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVIGCGAKMNPNQIEEVTPK.V...KD..FDPDFAIFISPNPGAPGPAKARELLSGYDIP..VVIIGDGPG.VGKK..DEMKEQGLGYIIVKGDPMIGARRELLDPTEMASFNADVIKVLALTGAYRVVQNAIDDLIEAADAGK...ELELPEIILTAEKAVEAAGFTNPYAKAKAYAAYETAAKVADIDTKGCFMVQDATQYITIVAAAHELIATAAKLATEARELEKANDAVLRTPHGGD.GSVVSKTKLMDKP-s..
A0A2V2MXR2_9EURY/3-280              ..VKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVSN.M...KA..WGPDFCVVVSPNGVLPGPKGAREALAAAGIP..CVVITDDIT.SKKEewEALKASEFGYIIMKGDSMIGARREFLDPIEMADFNGNLVKVLALTGAFRKLQVALDEVIDQVKAGKkgkDLALPKIVMTSDKAVE-GEFSNPYAYAKARAAYEISSAVAGVNVKGCFMTKGFENYTPIVASAHEMMRQAAFLCDEAREMEKATDAVIRKPHKND.GTRVAKKTLISKPE...
R9SJF9_9EURY/3-276                  ..VKIGIVKSGNIGASPVLELLLDERADRPNIDVRVFTSGAKMNPEQVEDVVPK.V...KD..FNPDFVMFSSPNPTAPGPAKARELLSEMDVP..AFIIGDAPG.KRAK..DEMDEQGIGYIIVEADSMIGARREWLDPTEMSVFNSDLIKVLACTGAYRLIQNTIDGVIAQADAGE...EIELPKLVINAQKAVDAAGFTSPYAKAKAYAAYEMCAKVADLDMKGCFMMKNYEEFLPVVAAAHEMASAAAQLATEAREIEKANDTVLRTPHMSD.GSTGKKVNLISKPE...
A0A2V3JPM5_9EURY/4-279              ..VKIGFVKLGNLGMSQVIDLILDEIAARQGIAVRTLGTGAKMGADEAADTKAL.I...EH..WDPDFVVMISPNAGAPGPTAAREIY--KDTP..TIIVSDGPD.KKDA.rQALKEAGFGSIILKVDPLIGAKREFLDPTEMASFNSDAMKVLSACGPVRLIQEEFDKVIDQVAAGKsgkDLELPYILGSPDKCVERGCFENPYAKAKALAALHMANTVAAINFPACFMLKEVEKVSLVAAAGHELMGAAAVLAREAREIEKSNDTLFRQPHAKM.GELLSKTKLYDKP-t..
MTD_METST/3-276                     ..VKIGIVKVGNIGTSVLIDMILDERADREDIDVRTISSGAKMGKNQMDDVLPK.I...DE..YNPDVIIFISPDPGAKSPSSARETLSKKNIP..TIVIGDGPG.ERAI..GSMKEQGLGYIIVKADSMIGARREFLDATEMAVFNSDVLMVLSTTGVFRLIHKTLDKVIRDIDEDK...LYSLPELVITAENAVDAADFKNPYAKSKAIAAYSIACQVSSMNVRACFKTKDYHVYIPLVSAAHEMMSAASKLAYEAREIEKSNDTVVRTAHRRN.GSILYGTSLND---nke
D1YY63_METPS/3-275                  .a-RVGIVKLGNLGTSRYIDLILDERADR-DIYVRTVGTGAKLGEAEADEAVAK.I...LE..FKPQLCIVISPNGALPGPTKAREAIKAAGVP..TIAISDVPM.MKVK..DDLKAKGLGYFIVKCDSMIGARRQFLDPTEMVLFNADMTKVLAETGVVRLIQTELDKCIDMINAGQ...PVTVPQIVIDAAKAVPMAGYTNPYAQAKAFAAFAAAEKVGDLDLLGCFMQKEMEQYIITVASAHELLRTAALLCDQARELEKGGNSIKRTPHAAD.GKVLSKTTLVSKPE...
MTD_METTH/3-276                     ..VKIGIIRCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIERAVPT.M...LE..MDRDFVIFISPNPGAPGPAKARELLSEADVP..AMIIGDAPG.LRVK..DEIEEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMIADVEAGK...APELPQVVIDTDVAVEAAGYENPYAKAKAMAAYEIATKVADIDVKGCFMVQDPDKYIPIVASAHEMLAAAAKLAVEAREIEKANDTVLRTPHGKE.GETLSKTDLLAKPE...
A0A1V6N234_METAZ/3-276              ..VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRIIGSGAKMNPEQVEEVTPK.V...KD..FDPDFAIFISPNPGAPGPAKARELLSGYDIP..AVIIGDAPG.AGKK..DEMDEQGLGYIIVKGDPMIGARRELLDPTEMASFNADVIKVLALTGAYRVVQNAIDALIEAAEAGK...ELELPKIILTAEKAVESAGFTNPYAKAKAIAAYEAAGKVADIDTKGCFMVRDANQYIPLVAAAHELIGTAAKLATEAREIEKANDSVLRTPHAGD.GSIVSKTKLLDKP-s..
MTD_METMP/3-277                     ..VKIGILKCGNIGMSPVVDLCLDERADRNDIDVRVLGSGAKMGPEQVEEVAKKmV...EE..IKPDFIVYIGPNPAAPGPKKAREILSAGGIP..AVIIGDAPG.IKDK..DAMAEEGLGYVLIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGALRVVQNAIDDMVFAVEEGK...EIPLPKIVITEQKAVEAMDFANPYAKAKAMAAFVMAEKVADIDVKGCFMTKEMEKYIPIVASAHETIRYAAKLVDEARELEKATDAVSRKPHAGA.GKILNKCKLMEKPE...
I7LMX2_METBM/3-280                  ..VKVGIAKLGNIASGVMAELLLDERADREDMITFMATSGTKLQPEDIDRVVSN.M...KA..WAPDFCIVVSPNGVLPGPTQAREDLAAAGIP..CIVITDDVT.TKKDqfAALKESDFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLAITGAYRKMQLELDKVIDQVKAGKkgkDLVLPKVVMTSDKAVD-GEFSNPYALAKARAAYEIAQQVAAVNVKGCFMTKEWEKYIPIVASAHEMMRQAMILCEEARDLEKGMDAVIRKPHKKT.GEIVSKTKLISKPE...
MTD_METLZ/3-280                     ..VKVGVAKLGNIAAGVMAELLLDERADREDMMTFMATSGTKLQKEDVDRVVSN.L...KA..WQPDFAIVVSPNGVLEGPVGAREDLKAAGIP..TIVITDDVT.TKKEgwEALKASGFGYIIVKADAMIGARREFLDPVEMADYNGNLVKVLALTGAFRKLQLELDKVIDQVKAGKkgaELELPKLVLNSDNST-KGEFTNPYALAKARAAYEIAQAVAGVNVKGCFMTKEWTDYVPIVASAHEMMRAAANLCDQARELEKGCDGVIRKPHKKT.GEIVSKVALISKPE...
A0A1Q6DUD9_9EURY/1-268              .m-NVGVAKFGNIGSS-FIDLLLDERATRKNLEIKVAGSGSKLDKKSCLSALDS.L...LN..FDLDLVLIISPNPKLKGPKAARKKTKKQDIP..VIVIGDVVD.KDLK..NELEENKFGYILLKNDPLIGARREFLDPIEMADFNSNILKILALSGVFRKIQSELDQVINQPQENK...-NKLPNIVIDEFNATK-NEFDNPYARYKAIGALKIAKSVDKTNLKGCYKYEDPDKYIPTVASTHEMLKAAKDLVEEAREIEKSNDTVKRTPHKKN.GNIIEKRKI-----qk.
A0A2U1S6A9_9EURY/3-275              ..VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRIVGSGAKMNPEQTEEVVPK.I...KD..FDPDFCIFISPNPGAPGPAKARELLSEMDVP..AIIIGDAPG.AGKK..DEMDEQGLGYIIVKADPMIGARRELLDPTEMACFNSDIIKVLAATGAYRLVQNTIDEVIASCEAGD...-IELPKLIITAEKAVDAANFANPYAKAKAIAAYEMAAAVADLDLKGCFMLKDHNQYIPIVAAAHEMAAAAAKLAVEARDIEKSNDTVTRTPHMGD.GSTGSKSVLLEKP-q..
MTD_METJA/3-277                     ..VKIGIIKCGNIGMSPVVDLALDERADRKDIAVRVLGSGAKMDPESVEEVTKKmV...EE..VKPDFIIYIGPNPAAPGPKKAREILSQSGIP..AVIIGDAPG.LRVK..DEMEQQGLGYIIIKCDPMIGARREFLDPVEMALFNADVIRVLAGTGALRIVQEAIDKMIDAVKEGK...EIELPKIVITEQKAVEAMEFTNPYAKAKAMAAFTIAEKVGDVDVKGCFMTKEAEKYIPIVASAHEMIRYAAKLVDEARELEKAMDAVSRKPHHPE.GKRLSKKALMEKPE...
A0A315XKK2_9EURY/3-276              ..VKIAIIKSGNIGTSPVIDLLLDERADRPNIDVRTFGSGAKMNPEQVEDVVPK.I...DA..FEPDFAIFISPNPGAPGPAKARELLSEKDVP..AIIIGDAPG.KGKK..DEMDEQGLGYIIVMSDPMIGAKREWLDPTEMAIFNSDILKVLAETGALRLVQKTIDAVIAQADAGE...AIELPKLIITAEKAAEAGGFANPYAKAKAIAAYEMAGSVANLDMKGCFMTKGFENFIPLVAAAHEIAACAAKLAQEAREIEKANDTVLRTPHMKE.GNPGCKTDLISKP-q..
A0A498GYG8_9EURY/3-280              ..VKVGIAKLGNIASGVMAELLLDERADREDMITFMATSGTKLQPEDIDRVVNN.M...KA..WGPDFCIVVSPNGILPGPTGAREALAAAGIP..CVVITDDIT.TKKEqfEALKASNFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLSVTGAFRKMQFELDKVIDQVKAGKkgaDLALPKVVMTSDKAVD-GEFSNPYALAKARAAYEIAQSVAGVNVKGCFMTKEWEKYIPIVSSAHEMMRQAMLLCEEAREIEKSTDAVIRKPHKKT.GEIVAKTALISKPE...
A0A328SR55_9EURY/3-275              ..VKIGIIKVGNIGTSTVIDLILDERADREDIDVRTFGTGSKMGKKQVEDVFPE.I...LD..YNPDLIIFISPNPNAKQPSKVRSKLSKLDIP..SIVIGDKPG.EKVT..KQMRDEGLGYILIRADAMIGARREFLDPTEMALFNADVLKVLSITGTLRLVTNIIDTLLHNMMEKE...YVELPEVIVTAELAVFNAGFKNPYAMGKAIAAYNMAAMVSEMNIEACFKIDEPDMYIPIVTASHELMSAAAKLSDEARELEKSNDSVLRTPHAKD.GSVWVRQSLVD---ay.
U6EAV6_9EURY/3-276                  ..VKIGVIKSGNIGTSPVLDLVLDERADRPNIDVRGVGSGAKMNPEQVEEVVPK.I...MD..FDPDFVIFISPNPGAPGPAKARELLSEMDIP..ALIIGDAPG.MGKR..EEMDEQGLGYIVVLGDPMIGARREFLDPTEMASFNADVIKVLAATGAYRVVQETIDEMIAACEAGK...DIELPKVVIDAATATEAAGFANPYAKAKAMAAYEMAAKVGDIDLKGCFMVKDMEKYIPIVASAHELIAAAAQLATEAREIEKANDTVLRKPHGSK.GQTMSKTVLVSKPE...
MTD_ARCFU/3-273                     ..VKVGVLKMGAIGTALLVEYLLDERADREDIEVRVVTSGAKMQPEEAV-VAEK.L...KE..FDPDVVIVVSPNAALPGPKAAREAF--EGKP..VIVISDAPA.KKAK..DELKEKGFGYILINADSMIGARREFLDPTEMALFNADVVKVLAATGAFRLVQEAIDKVIEDIKAGK...QPELPQIVVTAEKAVEAGKFSNPYAKAKAMAAFYIAEKVADIDVKGCFIEKDPEKYIPLVASAHEMMRIAAILADQAREIEKSNDTVFRNPHAKD.GKILGKTQLMAKPE...
L0HKS1_METFS/3-279                  ..VKVGVAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVSN.M...KA..WKPDFCIVVSPNGVLPGPTGAREELAKSGIP..CIVITDDVT.TKKE.wEGIKTSSFGYIIMKADSMIGARREFLDPIEMADFNGNLVKVLAGTGAFRKLQVAIDQVIDQVKAGKkgaELVLPKIVMTTDKAVD-GEFTNNYALAKARAAHEIAMAVAGQNVKGCFMTKEWEKYIPIVASAHEMMKVAAALCDEAREIEKAGDTVLRQAHKKD.GVLVRKNKLVAK--fd.
A0A8J8C619_9EURY/3-277              ..VKIGIINCGNIGTSPLIDLILDERADRKDIDVRVLGSGAKMGVEQVEEVTKKmI...ED..IKPDLIIYIGPNPAAPGPKKARELLGNCDIP..GVIIGDAPG.LRVK..DEIAKEGLGYIIIKCDPMIGARREFLDPTEMALFNSDVLKVLAGTGALRVVQNAIDSIIDALKEGK...EVQLPNIVINETKALEAMEYNNPYAKAKAMAAFKIAEMVGDINVKGCFMVKEMEKYIPVVASAHEMIRYAAKLVDEAREMEKSQDAVSRKPHASD.GRILCKNKLIEKP-q..
A0A166CS26_9EURY/3-276              ..VKIGIIKSGNIGTSPVLDLLLDERADRPNIDVRVIGSGAKMNPEQVEEVTPK.I...KE..FNPDFAIFISPNPGAPGPAKARELLSSYDIP..ALIIGDGPG.MGKR..EEMDEQGLGYIIVKADPMIGARRELLDPTEMASFNSDVIKVLALTGAYRTVQNAIDGMIADVEAGK...DVELPKIVLSRDVAVKAADFKNPYAKAKAMAAYEIATKVADIDTEGCFMVQDAEKYIPLVASAHEMIAVAAKLAEEAREIEKSNDTVVRTPHSGK.GTTVSKTKLLDKP-a..
A0A1Y3GBB2_9EURY/1-269              ml--VGIGKFGFIGSS-FVDALFDERADREDVDVRVVGSGSKMGVDDCMSVMKC.L...LE..FDLDCLILVSPNPSMPGPAKARELAVESGLP..CIVVSDYFG.VGSK..GDVEDSGLGYIYVKGDPLIGARREFLDFVEMADFNSNVLKVLSLCGSFRKLQLEIDRFVGS--DLD...DPYLPRCVITPEKAVED-EFSNPYAESKAIAALEIANRVAEINHKVCFKINDRERYVRLASSSHEMLKKAAVLAEEAREIEKKNDSVRRTPHKKD.GGCLEKKRLHE---di.
W9DRW4_METTI/2-273                  .a-KIGFIKLGNLGMSQVIDLVQDEIAAREGITVRVFGTGPKMGKDEAA-ATEE.L...KK..FDADFYVMISPNSSAPGPTAAREIY--KDVP..CVVISDGPT.KKDD.rAALEEAGFGYIIMTVDPLIGAKTEFLDPVEMASFNSDAMKVLSTCGVVRLIQEELDKLAAMADEGK...ELELPHILAKPEKCIERAGFNNPYAKAKGLAALHMADMVAKINFPACFMMKEIEQVTLTTAAGHEMMRAAAQLAIEAREIEKANDSVFRQPHSKK.GNLMTKTALYEKP-q..
F0T7A4_METLA/3-276                  ..VKIGIIKCGNIGTSPVIDLLLDERADRPNIDTCVVGSGAKMNPEEIEKAVPL.M...LE..MDRDFVIFISPNPGAPGPAKARELLSAADVP..AIIIGDAPG.LRSK..DEMDEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLALTGAYRVVQNTIDAAVTAVESGE...TLELPKVVITRDKAVEAAAFGSPYAKAKAMAAYEIATKVADIDVEGCFMVRDAEKYIPLVASAHEMLGVAAKLASEARDIEKANDTVVRTPHGGK.GQTLSKVALADKPE...
MTD_META3/3-277                     ..VKIGIIKCGNIGMSPLIDLALDERADRTNIDVISIGSGAKMGPNQVVEVTTKmV...ED..IKPDFIIYVGPNPAAPGPAKAREILSASDIP..SVIIGDAPG.IKAK..DKMAEEGLGYILIKCDPMIGARRQFLDPVEMAMFNADVIRVLAGTGAARVVQNAIDDIVEAIEAGN...EIELPKIVVTDAKSVAAAEFSNPYAKAKAMAAFAMAEQVANIDVKGCFMTKEMEKYIPIVASAHEMIRTAAKLVDEARELEKATDSVSRKPHGAD.GKRLNKTKLMEKPE...
D5EAK3_METMS/2-276                  ..VKVGFIKLGNLGMSQVIDLVQDEIAAREGITTRVFGTGPKMDKETAA-STEE.L...KA..WDPDFVVMISPNASAPGPKSARELW--KDYP..CIVVSDGPT.KKDD.rQALEDAGFGYIIMTVDPLIGAKTEFLDAVEMASFNSDAMKVLSTCGVVRLLQEELDAVTAQVDEGKsgaDLELPHILAKPQKCIERAGFNNPYAKAKGLAALHMASKVAEVNMPACFILKEIEDVTLTAATGHELMRAASQLAIEAREIEKANDSVFRQPHSKK.GFQLQKTKLYEKP-q..
A0A2R6T814_9ARCH/1-271              .m-KLGIAKLGHIGSS-FVDKLLDERAEREDLDVFCIGSGSKMDPCSSKEVIKK.L...FE..TNCDAYIVVSPNPSTPGSREALEKIEEIEEP..IVIIGDVAG.KEVR..EDLEKWGFGYIFVYGDALIGARKEFLDPVEMADFNSNVLKVLSLTGVFRKIVSETDRLIDSVKKDS...-NYLPKDILEPNKIVS-EEFENPYARAKARASLEISQNVAILNQKACFKLDNRDEYLPLVVATHEMMEKASELAKEAREIEKTNDNVLRKPHDYD.GGFLEKRELFEE--fk.
A0A0X3BMI1_9EURY/3-280              ..VKVGIAKLGNIASGVMAELLLDERADREDMITFMATSGTKLQPEDIDRVVSN.M...KA..WAPDFCIVVSPNGVLPGPTQAREDLAAAGIP..CIVITDDVT.TKKDqfAALKESDFGYIIMKADAMIGARREFLDPIEMADYNGNLVKVLAITGAYRKMQLELDKVIDQVKAGKkgkDLVLPKVVMTSDKAVD-GEFSNPYALAKARAAYEIAQQVAAVNVKGCFMTKEWEKYIPIVASAHEMMRQAMILCEEARDLEKGMDAVIRKPHKKT.GEIVSKTKLISKPE...
G7WNZ3_METH6/2-272                  ..FKIGFIKLGNVASSLVADLALDEIAERTDVEVRSLSFGAKMTVKEAE-MSAE.L...KG..WGPQLVVIVGPNAATPGPTAARALY--RDVP..TIVISDGPS.KKEA.rEALEAEGFGYIILPFDPLIGAKREFLDPAEMALFNSDALKVLSICGSVRLVQEELDGAMASIISGA...-PRLPTILSSPEGCTDRMAFRNPYARAKAIGALHMAQTVAGIDAAACFRLKELDRIALTAAAGHEVMRAAARLADEARELEKSTDSVSRRPHARS.GAILAKTGLLDKPE...
MTD_METHJ/3-280                     ..VKVGIAKLGNIASGVMAELLLDERADREDMQTFMATSGTKLQPEDIDRVVTN.M...KA..WGPDFCIVVSPNGVLPGPKGAREALAAAGIP..CVVITDDIT.TKKEewEALKASEFGYVIMKGDSMIGARREFLDPIEMADYNGNLIKVLSITGAFRKLQVALDEVIDQVKAGKkgkDLALPKLVMTSDKAVE-GEFSNPYAYAKARAAYEIAQAVAGVNVKGCFMTKGFENYTPIVASAHEMMRQAMLLCEEAREMEKATDAVIRKPHKND.GTRVAKKTLISKPE...
A0A1D3KYY6_9EURY/3-276              ..VKIGVIKCGNIGTSPVIDLVLDERADRPNIDVRTVGSGAKMNPEQIEDAVPK.I...AD..FDPEFVVFISPNPGAPGPAKARELLSAMDIP..AIIVGDAPG.IRAK..DEMDEQGLGYILVKADPMIGARRELLDPTEMASFNSDVLKVLAATGAYRVVQSTLDAVIAAAEAGN...DIELPKVVISAEKAVDAAGFANPYAKAKALAAYTIAEKVADVDVKGCFMTKEAEKYIPIVASAHEMLSAAAKLAVEAREIEKANDTVLRTPHGAQ.GQTVSKTALMDKP-q..
A0A1D2W4S5_9EURY/3-276              ..VKIGIIKCGNIGTSPVLDLLLDERADRPNIDTCVVGSGAKMNPDEIEKAVPL.M...LE..MERDFVIFISPNPGAPGPAKARELLSAADVP..AIIIGDAPG.LRAK..DEMNEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLALTGAYRVVQNTIDEVVATVEAGN...EIELPKVVITRDKAVEAAAFASPYAKAKAMAAYEIATKVADIDVEGCFMTKGAENYIPIVASAHEMLKVAADLATQAREIEKANDTVVRTPHGGK.GETLAKCCLMEKPE...
F7XNL9_METZD/2-278                  .a-KIGFIKLGNLGISQVIELVQDEIAAREGISIRVFGTGPKMGKDEAA-STEQ.F...KDmsWDADFYVIISPNASAPGPTAAREIW--KDVP..CIIVSDGPT.KKDD.rQALEEAGFGYIILKVDPLIGAKTEFLDSVEMASFNSDAMKVLSTCGVVRLIQEELDKVVEQVDAGKsgsDIELPHILAKPEVCVERAGFENPYAKAKALASLFMAEKVAQINFPACFMMKELEDVALTTATGHEMMRAAAELAVQAREIEKINDTVSRHPHSKK.GKVLSKTRLFEKP-a..
#=GC seq_cons                       ..VKlGllKhGNIGoSsllDLlLDERADRc-I-lRshuSGsKMssE-s-clssp.l...cc..acPDFsIhlSPNsusPGPstAREhLtttslP..sIlIuDuPu.pKtc..-plc-pGaGYIIlcuDsMIGARREFLDPsEMA.FNuDllKVLuhTGAhRllQpplDclIsplcuGc...-lcLP+lllss-KAV-tutFsNPYA+AKAhAAachAppVAslslcGCFMhK-hEcYIPlVAoAHEMMRsAApLA-EAREIEKusDoVlRpPHu+c.GpllsKspLh-KP....
//