#=GF ID   MU2_FHA
#=GF AC   PF18221.5
#=GF DE   Mutator 2 Fork head associated domain
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF05023
#=GF GA   29.20 29.20;
#=GF TC   31.80 33.00;
#=GF NC   29.10 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0357
#=GF RN   [1]
#=GF RM   22273583
#=GF RT   Dimerization, but not phosphothreonine binding, is conserved
#=GF RT   between the forkhead-associated domains of Drosophila MU2 and
#=GF RT   human MDC1.
#=GF RA   Luo S, Ye K;
#=GF RL   FEBS Lett. 2012;586:344-349.
#=GF DR   INTERPRO; IPR040513;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the N-terminal forkhead-associated (FHA) domain found in
#=GF CC   Drosophila mutator 2 (MU2) protein. FHA domains are generally
#=GF CC   phosphothreonine (pThr) specific-binding domains and are present
#=GF CC   in DNA repair and checkpoint proteins. However, phosphothreonine
#=GF CC   binding is not conserved in the MU2 active site pocket due to
#=GF CC   the absence of three key residues needed for pThr binding.
#=GF CC   Dimerization, is conserved between FHA domains of Drosophila MU2
#=GF CC   and human MDC1 albeit through different interfaces. The MU2 FHA
#=GF CC   domain dimerizes via the beta-sheet 2, the MDC1 FHA domain
#=GF CC   dimerizes via the opposite beta-sheet 1 [1].
#=GF SQ   38
#=GS B4M6W3_DROVI/3-101       AC B4M6W3.2
#=GS A0A6J2TTR4_DROLE/6-100   AC A0A6J2TTR4.1
#=GS A0A6P4IKQ2_DROKI/6-99    AC A0A6P4IKQ2.1
#=GS A0A0M4EYP6_DROBS/3-101   AC A0A0M4EYP6.1
#=GS B4KWX2_DROMO/5-100       AC B4KWX2.2
#=GS B4R3M4_DROSI/3-101       AC B4R3M4.1
#=GS A0A6J2U9H9_DROLE/3-97    AC A0A6J2U9H9.1
#=GS A0A484BVF3_DRONA/4-99    AC A0A484BVF3.1
#=GS B4LH00_DROVI/5-100       AC B4LH00.2
#=GS A0A6I8UXN7_DROPS/5-98    AC A0A6I8UXN7.1
#=GS Q9VYP9_DROME/3-101       AC Q9VYP9.2
#=GS A0A6J2U930_DROLE/3-97    AC A0A6J2U930.1
#=GS A0A6J2TSH3_DROLE/3-96    AC A0A6J2TSH3.1
#=GS B4IWQ9_DROGR/7-102       AC B4IWQ9.1
#=GS A0A6J2UD05_DROLE/3-97    AC A0A6J2UD05.1
#=GS A0A484AZG8_DRONA/3-101   AC A0A484AZG8.1
#=GS Q2M051_DROPS/5-98        AC Q2M051.3
#=GS B4L4Z1_DROMO/3-101       AC B4L4Z1.1
#=GS B4QN11_DROSI/5-98        AC B4QN11.1
#=GS B4GS41_DROPE/5-98        AC B4GS41.1
#=GS A0A3B0JWS1_DROGU/5-98    AC A0A3B0JWS1.1
#=GS A0A6J2UC47_DROLE/3-97    AC A0A6J2UC47.1
#=GS B4G9R6_DROPE/5-98        AC B4G9R6.1
#=GS B4N326_DROWI/7-100       AC B4N326.2
#=GS A0A0M4E8U8_DROBS/5-98    AC A0A0M4E8U8.1
#=GS Q9W061_DROME/5-98        AC Q9W061.1
#=GS A0A6J2TNZ6_DROLE/3-101   AC A0A6J2TNZ6.1
#=GS A0A6J2TY04_DROLE/3-97    AC A0A6J2TY04.1
#=GS A0A6P8X0Z8_DROAB/10-101  AC A0A6P8X0Z8.1
#=GS A2VEF9_DROME/5-98        AC A2VEF9.1
#=GS A0A6J2U5K9_DROLE/3-100   AC A0A6J2U5K9.1
#=GS B4HW32_DROSE/5-98        AC B4HW32.1
#=GS B3M778_DROAN/5-99        AC B3M778.2
#=GS B3MXS1_DROAN/3-101       AC B3MXS1.1
#=GS A0A6P4IHK6_DROKI/6-99    AC A0A6P4IHK6.1
#=GS A0A6P8WQL9_DROAB/10-101  AC A0A6P8WQL9.1
#=GS A0A3B0K4M4_DROGU/10-104  AC A0A3B0K4M4.1
#=GS Q95RC8_DROME/5-98        AC Q95RC8.1
B4M6W3_DROVI/3-101                  .....SITFKGRPTVVLRTYQVLRIGN...NvldN..KLDFCLDDKTVAKLHATLTRSEKG.L.FLVNeSR.NGTVSVNGQRFS.gPVLITYRDA.I.N.GI.VKLRFGRVEAFLR-v.
A0A6J2TTR4_DROLE/6-100              ...rf--SINGLPAVELQTYNKYYIGT...R...Q..HYEFCLQHESIEQDHAVIHCVRNG.E.VDVV.TL.MGRIFVNGREVR..VQELTQRDA.NeD.GV.VRLRIGDVEAEM--if
A0A6P4IKQ2_DROKI/6-99               ....v-LCVDGLPAIPLKPNEIYRIGK...Q...K..GLEICIAGESMELAHGIVSLLRSG.I.VRIA.SV.AGRIFVNEEEKQ..ISDIRKQDA.R.D.GK.VRLRFGNVEASLRF..
A0A0M4EYP6_DROBS/3-101              .....SITFKGRPTVVLRTYQVLRIGN...NlndK..QLDFCLDDKSVDKLHATLTRSERG.L.FLVNeSS.HGSVSVNGERFS.gPILITYRDA.I.N.GI.VSLRFGRTEATL--lv
B4KWX2_DROMO/5-100                  ....n-IEINNKEAVKLEPDIIYRVGR...R...P..GLEFSIDDESVELAHATIVLVAGG.I.VRLA.AV.NGDVFVNGLKTEleVKSISESDA.I.N.GL.VDLSFGNVTGKLR-f.
B4R3M4_DROSI/3-101                  .....SISFEGRPTQVLHTYQVWRIGSdenD...K..SLDYYSPDKSLHKLHASLTRGEKA.LyLENE.SR.TGCVAMNGIRFG.gPMIITYRDA.I.D.GI.VKLKFGNIEYMI--rv
A0A6J2U9H9_DROLE/3-97               ....r-LSVDGQKAMELQQCSPYRFGK...S...P..HAELCIDNEKLEHIHGFVLWSHTG.D.VHLL.SG.AGKIFFNGKEVF..GLKIDRSQA.N.EfGF.VELRFGEVEAKLHF..
A0A484BVF3_DRONA/4-99               iniei-----NKETVKLEPDIIYRVGS...R...P..GLEFSIDDESVELAHATIVLVAGG.I.VRLA.AV.NGDVFVNGHKTKleIKSISEADA.I.N.GF.IDLGFGNVTGKLR-f.
B4LH00_DROVI/5-100                  .....SIDGLNKVAVELEPDIIYRVGR...R...L..GLEFFIDDESIELAHATIVIIAGG.I.VRVS.AA.TGKVYVKGLETGleIKSISEADA.V.N.GL.VDLRFGNVAAKLQF..
A0A6I8UXN7_DROPS/5-98               .....SISFNGEPAVLLKLGNVYRIGR...K...K..SYEFCVDDESMELYHAVATVYLAG.V.LRVS.AL.QGKVFVNGLEKS..NADISQKDA.I.D.GK.VKLRFGNVEAEVQV..
Q9VYP9_DROME/3-101                  .....SISFKGRPTQVLHTYQVWRIGSdenD...K..SLDYYSPDKSLHKLHASLTRSENAlI.LDNE.SR.IGCVAVNGTRIG.gPMIITYRDA.I.N.GI.VKLRFGNIEGYLR-v.
A0A6J2U930_DROLE/3-97               ....r-LSVDGQKAMELQQCSPYRFGK...S...P..HAELCIDNEKLEHIHGFVLWSHTG.D.VHLL.SG.AGKIFFNGKEVF..GLKIDRSQA.N.EfGF.VELRFGEVEAKLHF..
A0A6J2TSH3_DROLE/3-96               ....r-VSINGQPPVELVPYVRYRIGS...R...S..YMEFYIDHESIEGYHGVFDCE-PD.C.VYVI.KL.LGQTFVNGKEVE..VQKLTSESAgE.D.GL.VKLRFGEVEAEM--yf
B4IWQ9_DROGR/7-102                  ..idd---NNNRSAVQLEPDIIYRIGR...R...L..GLELHSDDETMELAHATIALLADG.N.VRLS.AV.AGKVFVNGLETGeeIKNISKIDA.V.D.GI.VNLSFGKVAAKLHF..
A0A6J2UD05_DROLE/3-97               ....r-LSVDGQKAMELQQCSPYRFGK...S...P..HAELCIDNEKLEHIHGFVLWSHTG.D.VHLL.SG.AGKIFFNGKEVF..GLKIDRSQA.N.EfGF.VELRFGEVEAKLHF..
A0A484AZG8_DRONA/3-101              .....SITFKGHPTVVLRTYQVVRIGN...NeldK..TLDFCLNDKSVAKLHATLTRSERG.L.FLVNeSS.YGIVSMNGQRFS.gPILITFRDA.I.N.GI.VYLRFGRVEAFLR-v.
Q2M051_DROPS/5-98                   .....SLSINGEPAVLLQPDTVYRIGR...N...E..AYEFCVADESMELFHAMAIVYRAG.V.LRVN.AL.MGKVFVNGLENG..NVDISRKDA.I.D.GK.VKLRFGNVAAEAQI..
B4L4Z1_DROMO/3-101                  .....SITFKGRPTVVLRTYQVVRIGN...NaqdK..SLDFCLEDKSVAKLHATLTRSERG.L.FLVNeSS.YGTVSMNGQRFS.gPILITFRDA.I.N.GI.VYLRFGRVEAFLR-v.
B4QN11_DROSI/5-98                   ....s-LFFGGLPAILLKPDTIYRIGR...Q...K..GLEISIADESMELAHATACILRRG.V.VRLA.AL.VGKIFVNDQEET..VVDIGMEDA.S.A.GK.VKLRFGNVEARLEF..
B4GS41_DROPE/5-98                   .....SLSINGEPAVLLQPDTVYRIGR...N...E..AYEFCVADESMELFHALAIVYRAG.V.LRVT.AL.MGKVFVNGLENG..NVDISRKDA.I.D.GK.VKLRFGNVAAEAQM..
A0A3B0JWS1_DROGU/5-98               .....SLSINGDPAVLLEPGTVYRIGS...K...E..EYEFCVADESMELYHALATVYRAG.I.LRVN.AL.LGKVFVNDVENG..NADISHKDA.I.E.GK.VKLRFGNVNAEVQL..
A0A6J2UC47_DROLE/3-97               ....r-LSVDGQKAMELQQCSPYRFGK...S...P..HAELCIDNEKLEHIHGFVLWSHTG.D.VHLL.SG.AGKIFFNGKEVF..GLKIDRSQA.N.EfGF.VELRFGEVEAKLHF..
B4G9R6_DROPE/5-98                   .....SISFNGEPAVLLKLGNVYRIGR...K...K..SYEFCVDDESMELFHAVATVYLAG.V.LRVN.AL.QGKVFVNGLEKI..NADISQKDA.I.D.GK.VKLRFGNVEAEVQV..
B4N326_DROWI/7-100                  .....SLSVAGKKAV-LEPDVIYRIGR...K...P..GLEFFIPDESMELAHATISLLRSG.I.VRFA.AV.VGKIWVNEQEQT..FVDLSSKDT.T.D.GQnVKLRFGNVEAQLEI..
A0A0M4E8U8_DROBS/5-98               .rfta----SEKPMLFLEPDIIYRIGS...R...S..GLELHSDDESMELAHATITLLSDD.T.VKLC.AV.GGRIYVNGSETE..VRRITRTDA.N.N.GQ.VELRFGNAAAKLHF..
Q9W061_DROME/5-98                   ....s-LFFGGLPAILLKADTIYRIGR...Q...K..GLEISIADESMELAHATACILRRG.V.VRLA.AL.VGKIFVNDQEET..VVDIGMENA.V.A.GK.VKLRFGNVEARLEF..
A0A6J2TNZ6_DROLE/3-101              .....SITFAGRPALELREYKAYRIGS...DitaK..DLDFCIVDKSVAKFHATLTRAGPR.L.YLVNeSR.VGNVFVNGMGIG.sVTLISIRNV.I.N.GV.VRLRFGNVEAELRV..
A0A6J2TY04_DROLE/3-97               ....r-LRISGQPTVQLQPYHSYRFGS...S...P..IVELQIEHESVEQFHGALGVSPDF.V.VRLV.AW.SGKVYVNGEDVA..AKDIGFEIA.D.DrGF.VELRFGDVPAELY-f.
A0A6P8X0Z8_DROAB/10-101             ..dgt-----NPEAVQLQPDTIYRIGR...K...R..ELEFHSDDESLELAHATIALIAGG.I.VRIA.AV.AGKVIVNGSETE..IQSISNSDI.V.N.CL.VDLKFGNVKAKLSF..
A2VEF9_DROME/5-98                   ....s-LFFGGLPAILLKADTIYRIGR...Q...K..GLEISIADESMELAHATACILRRG.V.VRLA.AL.VGKIFVNDQEET..VVDIGMENA.V.A.GK.VKLRFGNVEARLEF..
A0A6J2U5K9_DROLE/3-100              ....c-IHFEGHPTISMEKLQVIRIGS...N...KltNLDVCLDDESVAQFHATITYTYKT.V.YLVN.ETdDGKVLVNDQPVE.sVTTVTYKDA.I.D.GS.VKLQFGNVEAKL--cf
B4HW32_DROSE/5-98                   ....s-LFFGGLPAILLKPDTIYRIGR...Q...K..GLEISIADESMELAHATACILRRG.V.VRLA.AL.VGKIFVNDQEET..VVDIGMEDA.L.A.SK.VKLRFGNVEARLEF..
B3M778_DROAN/5-99                   .....TLIVNGSKPIHLEPDTIYRIGR...K...A..GVEIHIADQSMELAHATACILRRG.V.VRFA.AA.LGRVFVNGEERN..VADVGKEDA.F.N.GKdVKLRFGNVEAILEF..
B3MXS1_DROAN/3-101                  ....s-LTIKGLPTQVMHTYQVLRIGSdvnD...K..TLTFCLNDKSIDKLHATLTRYEKG.L.FLVNeSR.HGSVSVNGKKVG.gPVHITYRDT.Y.R.GC.VRLRFGHTEALLR-v.
A0A6P4IHK6_DROKI/6-99               ....v-LCVDGLPAIPLKPNEIYRIGK...Q...K..GLEICIAGESMELAHGIVSLLRSG.I.VRIA.SV.AGRIFVNEEEKQ..ISDIRKQDA.R.D.GK.VRLRFGNVEASLRF..
A0A6P8WQL9_DROAB/10-101             ..dgt-----NPEAVQLQPDTIYRIGR...K...R..ELEFHSDDESLELAHATIALIAGG.I.VRIA.AV.AGKVIVNGSETE..IQSISNSDI.V.N.CL.VDLKFGNVKAKLSF..
A0A3B0K4M4_DROGU/10-104             ...kl--SVNVGPVRTLESFIMYRIGN...S...K..ENEFFVDHQNMAALHAYAYKMQNG.V.TRMV.AI.HGLIKVNGMNVF..QMNIGPEDAdV.N.GY.VVLQIGKVFALMQI..
Q95RC8_DROME/5-98                   ....s-LFFGGLPAILLKADTIYRIGR...Q...K..GLEISIADESMELAHATACILRRG.V.VRLA.AL.VGKIFVNDQEET..VVDIGMENA.V.A.GK.VKLRFGNVEARLEF..
#=GC seq_cons                       ......lshsGpPAl.LcssplYRIGp...p...c..sLEhslsDEShEhhHAolshhcsG.l.V+ls.uh.sG+lFVNGpEht..shcIohcDA.l.s.Gh.VcLRFGNVEAcLch..
//