#=GF ID Med2
#=GF AC PF11214.12
#=GF DE Mediator complex subunit 2
#=GF AU Wood V;0000-0001-6330-7526
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE Wood V
#=GF GA 26.80 26.80;
#=GF TC 27.10 27.70;
#=GF NC 26.60 26.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF WK Mediator_(coactivator)
#=GF RN [1]
#=GF RM 15175151
#=GF RT A unified nomenclature for protein subunits of mediator
#=GF RT complexes linking transcriptional regulators to RNA polymerase
#=GF RT II.
#=GF RA Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ,
#=GF RA Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M,
#=GF RA Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP,
#=GF RA Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch
#=GF RA AG, Holmberg S,
#=GF RL Mol Cell. 2004;14:553-557.
#=GF RN [2]
#=GF RM 14988503
#=GF RT Site-specific Srb10-dependent phosphorylation of the yeast
#=GF RT Mediator subunit Med2 regulates gene expression from the
#=GF RT 2-microm plasmid.
#=GF RA Hallberg M, Polozkov GV, Hu GZ, Beve J, Gustafsson CM, Ronne H,
#=GF RA Bjorklund S;
#=GF RL Proc Natl Acad Sci U S A. 2004;101:3370-3375.
#=GF DR INTERPRO; IPR021017;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family of mediator complex subunit 2 proteins is conserved
#=GF CC in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with
#=GF CC and phosphorylates Med2. Post-translational modifications of
#=GF CC Mediator subunits are important for regulation of gene
#=GF CC expression [2].
#=GF SQ 94
#=GS A0A1E4RGJ9_9ASCO/2-106 AC A0A1E4RGJ9.1
#=GS A0A1G4J060_9SACH/12-119 AC A0A1G4J060.1
#=GS A0A1D8PMU7_CANAL/4-106 AC A0A1D8PMU7.1
#=GS A0A1L0C1S4_9ASCO/2-112 AC A0A1L0C1S4.1
#=GS A0A1D8PRM3_CANAL/4-106 AC A0A1D8PRM3.1
#=GS A0A8H7GNE6_9ASCO/2-164 AC A0A8H7GNE6.1
#=GS I2H5C7_TETBL/22-121 AC I2H5C7.1
#=GS A0A1E4SJ86_9ASCO/1-105 AC A0A1E4SJ86.1
#=GS G0V7X6_NAUCC/13-112 AC G0V7X6.1
#=GS A0A178ZSC4_9EURO/30-101 AC A0A178ZSC4.1
#=GS A0A8H6F3Q0_CANAX/4-106 AC A0A8H6F3Q0.1
#=GS A0A8H6BZB9_CANAX/4-106 AC A0A8H6BZB9.1
#=GS J8Q3R0_SACAR/27-125 AC J8Q3R0.1
#=GS G0W4Z7_NAUDC/46-199 AC G0W4Z7.1
#=GS G8XZW6_PICSO/2-112 AC G8XZW6.1
#=GS A0A8H6F2R2_CANAX/4-107 AC A0A8H6F2R2.1
#=GS A0A1E3NVK8_WICAA/3-104 AC A0A1E3NVK8.1
#=GS A0A8H6C2E9_CANAX/4-126 AC A0A8H6C2E9.1
#=GS A0A4C2E697_9SACH/19-120 AC A0A4C2E697.1
#=GS A0A0C7N1F3_9SACH/12-129 AC A0A0C7N1F3.1
#=GS J4TZU1_SACK1/27-124 AC J4TZU1.1
#=GS W9VSH8_9EURO/26-100 AC W9VSH8.1
#=GS W9XMT2_9EURO/13-83 AC W9XMT2.1
#=GS A5DR23_PICGU/2-106 AC A5DR23.2
#=GS G3AIB7_SPAPN/5-109 AC G3AIB7.1
#=GS A0A1C1C9J9_9EURO/26-102 AC A0A1C1C9J9.1
#=GS A0A8H6C157_CANAX/4-106 AC A0A8H6C157.1
#=GS MED2_CANGA/2-160 AC Q6FWM4.1
#=GS A0A8H6BZ97_CANAX/4-106 AC A0A8H6BZ97.1
#=GS A0A4P9ZH15_9ASCO/2-142 AC A0A4P9ZH15.1
#=GS Q59KS8_CANAL/4-106 AC Q59KS8.1
#=GS K0KU99_WICCF/3-101 AC K0KU99.1
#=GS A0A8H6BRA0_CANAX/4-107 AC A0A8H6BRA0.1
#=GS A0A1G4M9X5_LACFM/6-106 AC A0A1G4M9X5.1
#=GS MED2_KLULA/10-117 AC Q6CJZ6.1
#=GS A0A1S7HXA9_9SACH/19-119 AC A0A1S7HXA9.1
#=GS J7S3C1_KAZNA/2-101 AC J7S3C1.1
#=GS A0A8H6C575_CANAX/4-106 AC A0A8H6C575.1
#=GS W9WEP5_9EURO/27-100 AC W9WEP5.1
#=GS A0A1D8PDT5_CANAL/78-180 AC A0A1D8PDT5.1
#=GS A3GIB2_PICST/2-106 AC A3GIB2.2
#=GS A0A512UIX7_9ASCO/81-191 AC A0A512UIX7.1
#=GS A0A8J5QX47_9ASCO/2-107 AC A0A8J5QX47.1
#=GS A0A1D8PMT1_CANAL/4-106 AC A0A1D8PMT1.1
#=GS A0A0D2CTY0_9EURO/28-101 AC A0A0D2CTY0.1
#=GS A0A421JBI1_9ASCO/2-105 AC A0A421JBI1.1
#=GS A0A8H6BWC5_CANAX/4-106 AC A0A8H6BWC5.1
#=GS MED2_ASHGO/20-119 AC Q757M0.1
#=GS A0A1D8PC38_CANAL/4-106 AC A0A1D8PC38.1
#=GS C5MIA5_CANTT/4-106 AC C5MIA5.1
#=GS A0A7H9HRJ2_9SACH/22-123 AC A0A7H9HRJ2.1
#=GS A0A8H6F4J0_CANAX/4-106 AC A0A8H6F4J0.1
#=GS A0A4P6XTH4_9ASCO/2-164 AC A0A4P6XTH4.1
#=GS C5DNG0_LACTC/36-139 AC C5DNG0.1
#=GS A0A421JI76_9ASCO/69-168 AC A0A421JI76.1
#=GS A0A1D8PIT9_CANAL/4-113 AC A0A1D8PIT9.1
#=GS G8BNM5_TETPH/27-128 AC G8BNM5.1
#=GS A0A1D8PKY5_CANAL/4-111 AC A0A1D8PKY5.1
#=GS A0A7D9H260_DEKBR/1-105 AC A0A7D9H260.1
#=GS A0A8H6BYB1_CANAX/4-107 AC A0A8H6BYB1.1
#=GS A0A0D2HQH0_9EURO/30-102 AC A0A0D2HQH0.1
#=GS A7TIL6_VANPO/13-117 AC A7TIL6.1
#=GS A0A8H6BU89_CANAX/4-106 AC A0A8H6BU89.1
#=GS G8ZTP8_TORDC/21-121 AC G8ZTP8.1
#=GS A5E6L9_LODEL/4-107 AC A5E6L9.1
#=GS A0A1A0HAS5_9ASCO/2-111 AC A0A1A0HAS5.1
#=GS A0A1G4JJU7_9SACH/6-125 AC A0A1G4JJU7.1
#=GS A0A1D8PRK6_CANAL/4-106 AC A0A1D8PRK6.1
#=GS G8Y2V7_PICSO/2-167 AC G8Y2V7.1
#=GS A0A2V1AZS4_9ASCO/2-105 AC A0A2V1AZS4.1
#=GS W9Y4X5_9EURO/30-104 AC W9Y4X5.1
#=GS I2JYQ1_DEKBR/1-104 AC I2JYQ1.2
#=GS A0A1D8PUC0_CANAL/4-106 AC A0A1D8PUC0.1
#=GS M3K369_CANMX/4-106 AC M3K369.1
#=GS A0A1X7R3Y0_9SACH/19-123 AC A0A1X7R3Y0.1
#=GS A0A1D8PFZ1_CANAL/4-111 AC A0A1D8PFZ1.1
#=GS A0A2H1A110_CANAR/2-105 AC A0A2H1A110.1
#=GS A0A1D8PP87_CANAL/4-106 AC A0A1D8PP87.1
#=GS A0A7H9B274_ZYGMR/24-125 AC A0A7H9B274.1
#=GS A0A642UQF1_DIURU/2-133 AC A0A642UQF1.1
#=GS H2AWU3_KAZAF/30-133 AC H2AWU3.1
#=GS A0A1S7HSY8_9SACH/19-119 AC A0A1S7HSY8.1
#=GS A0A2P7YRL3_9ASCO/2-172 AC A0A2P7YRL3.1
#=GS I6NDA8_ERECY/11-110 AC I6NDA8.1
#=GS A0A1E5R1Y3_9ASCO/12-144 AC A0A1E5R1Y3.1
#=GS MED2_YEAST/27-157 AC Q12124.1
#=GS A0A1D8PPA9_CANAL/4-111 AC A0A1D8PPA9.1
#=GS A0A0D2FI38_9EURO/29-101 AC A0A0D2FI38.1
#=GS C4Y5P3_CLAL4/2-104 AC C4Y5P3.1
#=GS G8BEJ8_CANPC/4-106 AC G8BEJ8.1
#=GS H6BL10_EXODN/27-103 AC H6BL10.1
#=GS A0A367YJS9_9ASCO/4-106 AC A0A367YJS9.1
#=GS A0A8H6F194_CANAX/4-107 AC A0A8H6F194.1
#=GS Q6BXX9_DEBHA/2-140 AC Q6BXX9.2
A0A1E4RGJ9_9ASCO/2-106 .............NLESKLNESLNDVLKSSGYIF--EIIN...NNRKQSNLITGSNNQLispaiSLQLSNSINKFDEILDETVSKFNDAKWCVEQILENKQKQ..EELKLKE......EIERQKR..KAEEer...................................................................
A0A1G4J060_9SACH/12-119 ............r-QQNKLTACFDEIMKLSAEMLVQQQMK...TIQLSSDMIKGFSHNQ.....QKLLGEKIHMFHTILDDVDLTLSSSQDFVNRIAGEAVKK..KQDKIKE......EERLRLK..DEEEarkreemn.............................................................
A0A1D8PMU7_CANAL/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKR..EEE-a....................................................................
A0A1L0C1S4_9ASCO/2-112 .............NLETRLTDTLNDVLRTSGYIF--EMIN...NNKRQSNLITGPNNQLippqvTNQLTLSIAQFDQILDETVSKFNDARWCIEQMVESKQKQ..EELRIQE......ELERQKK..AEAErkrkeeea.............................................................
A0A1D8PRM3_CANAL/4-106 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKE..E---gak..................................................................
A0A8H7GNE6_9ASCO/2-164 .............NLEERLNKSLNDILRTSGYVF--EIIN...NNRRQSNLITGPNNQLipppmMEQLAQKIAGFELILDDTVTKFNDVPWCVEQIVQNKKKQ..EEQKQQE......ELEKQQR..EAE-kkrqeeekkrqeeqrekeraekeereqkereereklakraqnqdqnqnqnqnqsqldqnqn........
I2H5C7_TETBL/22-121 ............v-YKNQLTDCFDDILRLSAEMMVKQQMK...SIQLDASIVNGFNKNQ.....QNILNEKINLFHTILDDLALTIDNSKSYINEIYQIGKEK..KIQKEKE......EELRRIQ..EQEE.....................................................................
A0A1E4SJ86_9ASCO/1-105 .............NLQAKLDNSLNDILKTSGYIF--EIIN...NNKKQSNLITGSNNQLitptiTSQLASNISKFDEILDDTLSKFNDARWCIEMMLENKQRQ..EELKLKE......ELEKQKKlkEE--ee...................................................................
G0V7X6_NAUCC/13-112 ...........qp--KNKLTQCFDDILKISSEMLLQQQLK...TIQLDSKVSNGFNASQ.....QRSLKEKINLFHGILDDLEISIAKSFDYVDTIVEISNEK..LIKK---......-KELQRK..EEE-aaaaa................................................................
A0A178ZSC4_9EURO/30-101 .......kdplny---------------------------...------------AQST.....KAVLAETAKKFQDALDDCEVQILDAKWYLERQLALNKAR..REAKAREdg..aaS-AKRKR..EE--skea.................................................................
A0A8H6F3Q0_CANAX/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EEARKKR..EEE-a....................................................................
A0A8H6BZB9_CANAX/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKH..DELKVKE......EAARKKR..EEE-a....................................................................
J8Q3R0_SACAR/27-125 ............t-YKNKLTVCFDDILKVGAEMMMQQQLK...NVQLDSYLVNGFSQPQ.....QRLLKEKVKLFHGILDDLETSLSQSSSYVETLTVLGEER..E--KERQ......EAERKKA..EEE-nl...................................................................
G0W4Z7_NAUDC/46-199 ............r-KTNKLTQCFDDILKLSTEMMVQQQLK...TIQLDSNLINGFNENQ.....QNSLKEKINSFHGILDDLEISINKSLTYLDTISKISIEK..RKENIKTki..lkEQEEKEK..E---kqlellkqkqkqeqeeaeaqalklkqeeeelerkrkqrkeeqeqqmlltnkks................
G8XZW6_PICSO/2-112 .............NLEEKLNDTLNEILKTSGYVF--EIIS...SNKRQSNIITGTNNQLispaiISQLSNSIARFDDILDDTTSKFNDAKWCIESILETRQK-..EELKIRM......EEEKQKKirEQE-ekrrqdee.............................................................
A0A8H6F2R2_CANAX/4-107 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITGPNNELiqksiTQSLNGEIQNFNAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKR..EEE-ak...................................................................
A0A1E3NVK8_WICAA/3-104 ..........tqi---DNLSLSFNEILYNIGDLF--DDLY...TDKTANLVLPNNNNKA.....AENLNKAIKTFDKNLDDILIQLNDISLFDKKLKQRAIER..EQQKNTI......-------..----pakqeptpanetkqp......................................................
A0A8H6C2E9_CANAX/4-126 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKH..DELKVKE......EAARKKR..----rggkkaeeakkaeeakkaetapqk.............................................
A0A4C2E697_9SACH/19-120 ............q-HENKLTQCFNDIMRVAVEMMLHQQLK...TVQLDSSVVNGFSYNQ.....QRILSEKIHVFHAILDDMETTLGKSKNFVETIYELGREK..ELQKERE......RKELKKR..EEEEer...................................................................
A0A0C7N1F3_9SACH/12-129 ............r-HQNKLTKCFDDIMKTAAEMLVQQQMK...SIQLSSDIAAGFTQSQ.....HKLLGEKVHTFHSILDDLDLTLTTAKNCVDKFAAEAAAR..REKLLEEqrvqqiEQEKLKR..EQE-dqkrlieaqkase........................................................
J4TZU1_SACK1/27-124 ............t-YKNKLTVCFDDILKVGAEMMMQQQSK...NVQLDSYLVNGFSHSQ.....QRLLKEKVKLFHGILDDLETSLNQSSSYVNTLTMLGKEK..E--KERE......EAERRRA..EEE-n....................................................................
W9VSH8_9EURO/26-100 ayvmkdpvnfapa---------------------------...---------------T.....KAVLAETAKKFHDALDDCEIQILNAKWYLERQLAANRAR..REAKARDd...saS-SAKRK..R---devqd................................................................
W9XMT2_9EURO/13-83 ......ikdplny---------------------------...------------AQST.....KAVLAETAKKFQDALDDCEIQILEAKWYLEHQLALNKAR..REAEAREe....sAAHAKRK..HE--eik..................................................................
A5DR23_PICGU/2-106 .............NLEEKLRSSLDDVLCTSGYIF--EIIG...NNRKQSNLLTGTNNSLitpavTNSLARSLAKFDEVLDDTISKFNDTRWCVEQIVENKQRQ..KEQKARE......EEERKRL..DDE-krk..................................................................
G3AIB7_SPAPN/5-109 .............NLQTKLDASLNDILKTSGYIF--EVLN...NNKKQSNLLTGPNNQLitpqiIAQLSHQMLKFDDILDETITKFNDARWCIDQMVENKQRQ..EEMKIRE......EQERARRlkEE--ee...................................................................
A0A1C1C9J9_9EURO/26-102 ayvmkdpvnfapa---------------------------...---------------T.....KAVLAETAKKFHDALDDCEIQILNAKWYLERQLAANRAR..REAKARDd...saS-SAKRK..----rddvqevq.............................................................
A0A8H6C157_CANAX/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLDDAEWCLGVMVEKKKKL..DELKVKE......EAARKKE..EEA-k....................................................................
MED2_CANGA/2-160 ............s-YKNRLTACFDDILKVSAEMMMQQQLK...NVQLDPYMVNGFSAQQ.....QNTLKEKIHMFHGILDDLENMLSKSTYYVDTLANLGKES..KRQKELE......-LEKQRE..QEEEekkqkllelerkkkeqeeeeekkkkqkeeeekrkkeleeqerkkkeqeeeekrrrqqeqd.........
A0A8H6BZ97_CANAX/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKR..EEE-a....................................................................
A0A4P9ZH15_9ASCO/2-142 .............NLEERLTSTFNDVLRSAGYIF--EIIT...NNKRQSNIITGPNNQLipsavANQLAQSIALFDEILDDIASKFDDARWCMEQIADTRRKQ..EQLRAQD......ELERQKK..AE--verkrkeedatrkkkeeddrllqesrakeekdfrekerla.............................
Q59KS8_CANAL/4-106 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKR..EEE-a....................................................................
K0KU99_WICCF/3-101 ..........nqi---DNLSLSFNEILLNVGTLF--DELV...SD-KTTNLVLPNNNKK.....SNKLNDSIKQFDKNLDDILIQLNDISLFDRKLKQTKLEK..EQAKLNN......NNTTDTQ..E---kqiep................................................................
A0A8H6BRA0_CANAX/4-107 .............NLQTRLHNSLDEILKSSGYIL--EVID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFNAILDQTVSKLNDAEWCLGVMVEKKKKH..DELKVKE......EAARKKC..EEE-ak...................................................................
A0A1G4M9X5_LACFM/6-106 ............r-QQNRLTQCFEDIMRAGAEMLVQQQMK...TIQLGSDVATGFTKSQ.....HRSLGEKVHLFHTILDDLDLTLTASTKYLEAVATEAAER..KRQKEKE......EQQKQQQ..QQQ-qq...................................................................
MED2_KLULA/10-117 ............r-QENKLTQYFDDILRLSADLLTQQQLK...TIKLDPKVTTGFSKAQ.....QKGLGDRITQFYSLLDTLDVSLQTTADYVGAVKDSALQL..KKQREEE......QIKKQEQ..E---klerqlleqqk..........................................................
A0A1S7HXA9_9SACH/19-119 ............v-HKNKLTQCFDDIMRVAAEMMLHQQLK...TVQLDCSVVNGFSYNQ.....QRVLGEKIHVFHAILDDMETTLDKSKSYVEAVYEIGREK..EIKKERE......REELRRR..QEEEe....................................................................
J7S3C1_KAZNA/2-101 ............t-EQNKLTRCFDDILRLSSEMLVQQQLK...TIQLDT--VNGFTQDH.....QKVLSEKIHSFHGILDEVDVTLLNAVRFVEKFDAVSKEK..ELERVKQ.....rEREAQIT..AEEEa....................................................................
A0A8H6C575_CANAX/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKF..DELKVKE......EEARKKR..EEE-a....................................................................
W9WEP5_9EURO/27-100 ....yamkdplny---------------------------...------------AQST.....KAVLAETAKKFQDALDDCEVQILDAKWYLERQLALNKAR..REAKAREd...saA-SAKRK..RE--epkd.................................................................
A0A1D8PDT5_CANAL/78-180 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKH..DELKVKE......EAARKKR..EEE-a....................................................................
A3GIB2_PICST/2-106 .............NLQTKLDNSLNDILKTSGYIF--EIIN...NNRKQSNLITGTNNQLitpaiTSQLASNITRFDDILDETLSKLNDTRWCLDQIMENKQKQ..EEMKLKE......ELERQKKlkEE--ee...................................................................
A0A512UIX7_9ASCO/81-191 .............NLEERLNKSVNDILRTSGYVF--EIIN...NNKRQSNLITGPNNQLipppmMEQLAQKIAGFESILDETVSKFNDAPWCIDQIIQNKKKQ..EEQKMQE......ELERQHR..AEAErkrkqqee.............................................................
A0A8J5QX47_9ASCO/2-107 .............NLQTKLDNSLLDILKTSGIIF--EILN...NNKSQSNLLTGPNNQLitptiTNQLQSQISKFDEILDETLSKFNDAKWCIEQMLENKQRQ..EELKLKE......EMEKQRRlkEE--eer..................................................................
A0A1D8PMT1_CANAL/4-106 .............NLQTRLHNSLDEILKSSGYIF--EXID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKX..DELKVKE......EAARKKR..EEE-a....................................................................
A0A0D2CTY0_9EURO/28-101 .....avkdplny---------------------------...------------AQST.....KAVLAETAKKFQDALDDCEVQILEAKWYLERQLALNKTR..RETKAREds..aaSAKRKRD..E---skea.................................................................
A0A421JBI1_9ASCO/2-105 .............NLEEKLRQSLDDVLCASGYIF--EIIG...NNRKQSNLLTGTNNSLitpavTNSLARSLAKFDEVLDETISKFNDTRWCVEQIVENKQRQ..KEQKARE......EEERKRL..DDE-kr...................................................................
A0A8H6BWC5_CANAX/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKF..EELKVIE......AAARKKR..EEE-a....................................................................
MED2_ASHGO/20-119 ...........mr--GDRLTQCLDDIMRASTEMMVQQQLK...TIQLNSDVAAGFRKAL.....SKSLGDRVRAFHSILDGVETTLTTASQYLDAVEEAAVKM..KQWKQQQ......EEEQRRK..HQAE.....................................................................
A0A1D8PC38_CANAL/4-106 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKH..DELKVKE......EAARKKR..EEE-a....................................................................
C5MIA5_CANTT/4-106 .............NLQTRLDASLNEILKTSGYIF--EIIN...NNKKQSNLITGPNNQLiqpfvIQQLNNQIGKFDEILDETVSKFNDAKWCVATMVENKQKQ..EELKLKE......EMERQKR..EAE-a....................................................................
A0A7H9HRJ2_9SACH/22-123 ............p-HNNKLTQCFDDIMKVAAEMMVQQQLK...TVQLDTSVINGFSEAQ.....QRVLSDKIHLFHSILDDLETTLSKSKSYVKAIHQIAVEK..EKEKERQ......RIDQRRK..QEEEeq...................................................................
A0A8H6F4J0_CANAX/4-106 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKE..EEA-k....................................................................
A0A4P6XTH4_9ASCO/2-164 .............NLEERLNKSLNDILRTSGYVF--EIIN...NNRRQSNLITGPNNQLipppmMEQLAQKIAGFELILDDTVTKFNDVPWCVEQIVQNKKKQ..EEQKQQE......ELEKQQR..EAE-kkrqeeekkrqeeqrekeraekeereqkereereklakqaqnqdqnqnqnqnqshldqnqn........
C5DNG0_LACTC/36-139 ............v-HQSRLTQCFDEIMKTAAEMLVQQQIK...SIQLSSDIAPGYTQKQ.....YKSLGDKVHAFHSVLDDLDLTLSASKSCVDKLALEAQER..KQEAEKQri..keEEEARKK..----lsev.................................................................
A0A421JI76_9ASCO/69-168 ............y-------TSLNDILKTSGYIF--EILN...NNKKQSNLLTGPNNQLitpqiITQLSNQMVKFDDILDETITKFNDARWCVDQMVENKQRQ..EEMKIKE......EMERARR..LKEEqee..................................................................
A0A1D8PIT9_CANAL/4-113 .............NLQTRLHNSLDEILKSSGYIF--EXID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EEAKKKE..EEA-kkkeeeak.............................................................
G8BNM5_TETPH/27-128 ............k-YRNKVTQCFDDILDVSTQMLVQQQLK...TIQLDINVTNGFNLSQ.....QKILHEKVNLFHSLLDDLECTLETSKTFTEHIAKLGKQR..EEEKLKK......DKEREEE..L---ertrk................................................................
A0A1D8PKY5_CANAL/4-111 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKE..E---gakkkaee.............................................................
A0A7D9H260_DEKBR/1-105 ...........mt---NLLKDSMDNIFISSADIL--DKLTyklSSATTSTVIPHNNDSLlk.plTDVLKGDFEAYNRVLDNYNLELLGAESMLTYMKVKMKKE..AELQQKM......ETERVKK..EKEEa....................................................................
A0A8H6BYB1_CANAX/4-107 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITGPNNELiqksiTQSLNGEIQNFNAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKR..EEE-ak...................................................................
A0A0D2HQH0_9EURO/30-102 .......kdplny---------------------------...------------AQST.....KAVLAETAKKFQDALDDCEVQILDAKWYLERQLALNKAR..REAKAREds..aaS-AKRKR..EE--skeaq................................................................
A7TIL6_VANPO/13-117 ...........gg--KNKLVECFEDILEVSSQMLVQQQLK...SIQLDNSVISGFNQGQ.....QKVLLEKVTLFHSILDDLEITLNKGKNYVDELTKIGKDK..EEERERVr...raEEEKKRL.lEEE-ek...................................................................
A0A8H6BU89_CANAX/4-106 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKE..E---gak..................................................................
G8ZTP8_TORDC/21-121 ............a-HRNRLTECFDDIMKVAAEMMVQQQLK...TVQLDSAVVNGFSQAQ.....QRVLSEKIHMFHAILDDLQTTLTKSKSYVGTIHEIALEK..QKVKEKE......RADLRKR..QEEEe....................................................................
A5E6L9_LODEL/4-107 .............NLQTKLDSAFNDILRTAGFIF--EIIN...NNEKQNRLITGPNNQLiqptiIQQLTNHINKFDDILDETVFKFNDAKWCIDTMIENKQKQ..QEMKIKE......ELERQRR..EAEEa....................................................................
A0A1A0HAS5_9ASCO/2-111 .............NLEEKLTKSLSDILRTSGYVF--EIIN...NNKRQSNLIAGPNNQLipppmMEQLAQKIASFELILDDTVAKFNDAPWCVDQIVQNKKKQ..DEQKIRE......DRERQQR..EEAErkrkiee..............................................................
A0A1G4JJU7_9SACH/6-125 ............r-HHNKLSKCFDDIMTAAAEMMVQQQIK...SIQLSSDIAPGFTQSQ.....HKLLGEKVHAFHSVLDDLDLTLTAARNSVDSLAAEALER..EQ-KLREqqrlqeKEDQKMK..EQE-eerkrleearksseqa.....................................................
A0A1D8PRK6_CANAL/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKF..DELKVKE......EEARKKR..EEE-a....................................................................
G8Y2V7_PICSO/2-167 .............NLEEKLNDTLNDILKTSGYVF--EIIN...SNKRQSNIITGTNNQLispaiISQLSNSIARFDDILDDTTSKFNDAKWCIESILETRQK-..EELKIRM......EEEKQKKirEQE-ekkrqdeelarkrreqeeernrierekdekmkeeamkrekeleqkrkaeqerelerqreqkaa......
A0A2V1AZS4_9ASCO/2-105 ............n-LEARLTGTLNDVLRTSGYIF--EIIN...NNKRQSNLITGPNNQLipppiTAQLAASIAQFDSILDDTVSKFNDARWCVEQIVENKQKQ..EELRLQE......EIERKKR..LEE-qk...................................................................
W9Y4X5_9EURO/30-104 .......kdplny---------------------------...------------AQST.....KAVLAETAKKFQDALDDCEIQILEAKWYLEHQLALNKAR..REAKAREd....sAAHAKRK..HEE-ikdeqek..............................................................
I2JYQ1_DEKBR/1-104 ...........mt---NLLKDSMDNIFISSADIL--DKLTyklSSATTSTVIPHNNDSLlk.plTDVLKXDFEAYNRVLDNYNLELLGAESMLTYMKVKMKKE..AELQQKM......ETERVKK..EKEE.....................................................................
A0A1D8PUC0_CANAL/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKF..EELKVIE......AAARKKR..EEE-a....................................................................
M3K369_CANMX/4-106 .............NLQTKLDDTLNEILKTSGYIF--EIVN...NNKRQSNLITGPNNQPippyvIQKLNGQISKFDEILDETVSKFNDAKWCVATMVENKQKQ..EELKARE......ELERQRR..EAE-a....................................................................
A0A1X7R3Y0_9SACH/19-123 ............l-HKNKLTQCFDDMMRMSSEMLVQEQLK...TIQLDNGITNGFSATH.....QKNLKEKFHVFHGILDDLDITLDKCATYVETLNKIGIEK..EELRKKEe...elEAERQKK..LEEEke...................................................................
A0A1D8PFZ1_CANAL/4-111 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKL..DELKVKE......EAARKKE..EEA-kkkeee...............................................................
A0A2H1A110_CANAR/2-105 .............NLETRLTGTLNDVLRTSGYIF--EIIN...NNKRQSNLITGPNNQLipppiTAQLAASVAQFDSILDDTVSKFNDARWCVEQIVENKQKQ..EELRIQE......EIERKKR..LEE-qr...................................................................
A0A1D8PP87_CANAL/4-106 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKH..DELKVKE......EAARKKR..EEE-a....................................................................
A0A7H9B274_ZYGMR/24-125 ............v-HRNKLTKCFDDIMKIASEMMVQQQLK...TVQLDALVVNGFSQSQ.....QRQLAEKIHSFHAILDDLETTLSKSKSYVQTVHDIGLEK..ERQKQKE......MEEIRIK..QEKEee...................................................................
A0A642UQF1_DIURU/2-133 ...........sl--EARLNDSLNDILKTSGYIF--EIIN...NNKKQSNLITGTNNQLisqpiVQQLARNLAKFDEILDETVSKLNDVKWCVEETVGRQQRE..AESKIKE......QLEQQRL..QEE-akrqeeqrreeegqrqreeeerrkrleqer.......................................
H2AWU3_KAZAF/30-133 ............y-ERNRLTSCLDDILKLSSEMIVQEQLK...TIQLSNSIVSGFNINQ.....QRQLKDKIHTFHSILDDIDITLANTSNYIVQLTEIGTER..QIQIKQE......EEVLRRK..KQ--lqqeee...............................................................
A0A1S7HSY8_9SACH/19-119 ............v-HKNKLTQCFDDIMRVAAEMMLHQQLK...TVQLDCSVVNGFSYNQ.....QRVLGEKIHVFHAILDDMETTLDKSKSYVEAVYETGREK..EIKKERE......REELRRR..QEEEe....................................................................
A0A2P7YRL3_9ASCO/2-172 ............n-LEARLNGTLNDVLRTSGYIF--EIIN...NNKRQSNLITGPNNQLipppiTAQLAASIAQFDLILDDTVSKFNDARWCVEQIVENKQKQ..EELRLQE......EVERKKR..LEE-qkrreeeerqrkeqeevkrreeeerkkkeaqeqeekakqererlekerqaeqerqereeqerqekerrd
I6NDA8_ERECY/11-110 ............m-NTDRLTQCLDDIMRAATEMMVQQQLK...TIQLNSDVAAGFRKNF.....SKSLGDKVRLFHSILDGVDTTLTTASQYLETVDDVAHRM..KQWKLRQ......EEELRRK..QQEE.....................................................................
A0A1E5R1Y3_9ASCO/12-144 ...........yy--NNALKVSLNDLMKYSSDLLLQQQLK...TIRLDPNVMNVQDPNH.....MATINKCVSDFHSILDNMDITLSNSQKFLTTYQKQLVIKmeQERKERE......LQEKLKK..EQEElqkrqreeeeqrekerkkqeeekqlklqqen......................................
MED2_YEAST/27-157 ............t-YKNKLTVCFDDILKVGAEMMMQQQLK...NVQLDSYLVNGFSQSQ.....QKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGKEK..EKE--RE......EAEKKRA..EQE-nmrkvreqeelkkrqeleeasqqqqlqqnskekn...................................
A0A1D8PPA9_CANAL/4-111 .............NLQTRLHNSLDEILKSSGYIF--EIID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLDDAEWCLGVMVEKKKKL..DELKVKE......EAARKKE..EEA-kkeeex...............................................................
A0A0D2FI38_9EURO/29-101 ...mkdplnyaps---------------------------...---------------T.....KAVLAETAKKFQDALDDCEVQILDAKWYLERQLALNKAR..REAKAREds..aaSAKRKRD..E---tkea.................................................................
C4Y5P3_CLAL4/2-104 .............NLEAKLTSTLNDVLRSSGYIF--EIIN...NNKKQSNIVTGPNNQLipsqvTNQLAQSIAQFDQILDDTVSKFNDARWCIEQMVDSRQKQ..EEMKHQE......EIERQRR..EEA-d....................................................................
G8BEJ8_CANPC/4-106 .............NLQTKLENSLYEVLKTAGFIF--EVIN...NNKKQSALITGPNNQLiqptiIKQLTNHINEFDSILDETIFKFNDAKWCIDTMIENKQRQ..EEMKIKE......ELERQKR..EAE-a....................................................................
H6BL10_EXODN/27-103 ...ayaikdpany---------------------------...------------AQST.....KAVLAETAKKFQDALDDCEIQILEAKWYLEHQLAVNKAR..REEKARQes..aaA-HAKRK..RE--etted................................................................
A0A367YJS9_9ASCO/4-106 .............NLQTRLDASLNEILKTSGYIF--EIIN...NNKKQSNLITGPNNQLiqpfvIQQLNNQISRFDEILDETVSKFNDAKWCVATMVENKQKQ..EELKLKE......EMERQKR..EAE-a....................................................................
A0A8H6F194_CANAX/4-107 .............NLQTRLHNSLDEILKSSGYIF--EVID...QNRKQSNVITSPNNELiqksiTQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKH..DELKVKE......EAARKKR..EEE-ak...................................................................
Q6BXX9_DEBHA/2-140 .............NLEEKLNNSLNDILKSSGYIF--EIIH...SRKKQSNLITGTNNQLitpviTSQLTNSITKFEDILDDTICKFNDTKWCVEQMLQNRQKQ..EELKLKE......EEEKQRR..IKE-dderkrleeektkkrkkeeeearikkekedqqakeee................................
#=GC seq_cons ..............hps+Lpsohs-IL+sSu.lh..-.lp...sspppSsllsusNsph.....ppsLspcIppFcsILD-ssoplsDAcWhlpphl-ppp+p..-EhKh+E......Etc++++..E-E.tt...................................................................
//
