#=GF ID   Med3
#=GF AC   PF11593.12
#=GF DE   Mediator complex subunit 3 fungal
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   manual
#=GF GA   29.30 29.30;
#=GF TC   29.30 29.30;
#=GF NC   29.00 28.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Mediator_(coactivator)
#=GF RN   [1]
#=GF RM   15175151
#=GF RT   A unified nomenclature for protein subunits of mediator
#=GF RT   complexes linking transcriptional regulators to RNA polymerase
#=GF RT   II. 
#=GF RA   Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ,
#=GF RA   Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M,
#=GF RA   Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP,
#=GF RA   Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch
#=GF RA   AG, Holmberg S, 
#=GF RL   Mol Cell. 2004;14:553-557.
#=GF RN   [2]
#=GF RM   10722672
#=GF RT   Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA
#=GF RT   polymerase II holoenzyme. 
#=GF RA   Papamichos-Chronakis M, Conlan RS, Gounalaki N, Copf T,
#=GF RA   Tzamarias D; 
#=GF RL   J Biol Chem. 2000;275:8397-8403.
#=GF DR   INTERPRO; IPR020998;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Mediator is a large complex of up to 33 proteins that is
#=GF CC   conserved from plants to fungi to humans - the number and
#=GF CC   representation of individual subunits varying with species. It
#=GF CC   is arranged into four different sections, a core, a head, a tail
#=GF CC   and a kinase-activity part, and the number of subunits within
#=GF CC   each of these is what varies with species. Overall, Mediator
#=GF CC   regulates the transcriptional activity of RNA polymerase II but
#=GF CC   it would appear that each of the four different sections has a
#=GF CC   slightly different function [1]. Mediator subunit Hrs1/Med3 is a
#=GF CC   physical target for Cyc8-Tup1, a yeast transcriptional
#=GF CC   co-repressor [2].
#=GF SQ   35
#=GS MED3_CANGA/13-481         AC Q6FXZ4.1
#=GS J8LNQ4_SACAR/3-398        AC J8LNQ4.1
#=GS MED3_YEAST/3-397          AC P40356.2
#=GS J6EII9_SACK1/3-412        AC J6EII9.1
#=GS A0A7H9B463_ZYGMR/8-279    AC A0A7H9B463.1
#=GS A0A1G4JCG7_9SACH/2-384    AC A0A1G4JCG7.1
#=GS G8ZWS1_TORDC/124-323      AC G8ZWS1.1
#=GS A0A0D2MAU2_9CHLO/466-686  AC A0A0D2MAU2.1
#=GS C5DHV2_LACTC/14-351       AC C5DHV2.1
#=GS A0A2N6NMW4_BEABA/656-813  AC A0A2N6NMW4.1
#=GS A0A1G4MBB3_LACFM/8-167    AC A0A1G4MBB3.1
#=GS J7S5W6_KAZNA/5-127        AC J7S5W6.1
#=GS A0A1X7R5Q2_9SACH/18-394   AC A0A1X7R5Q2.1
#=GS I2GX35_TETBL/12-175       AC I2GX35.1
#=GS MED3_ASHGO/7-199          AC Q752T7.2
#=GS G0WA71_NAUDC/11-385       AC G0WA71.1
#=GS A0A507AUA6_9PEZI/371-642  AC A0A507AUA6.1
#=GS A0A1E5RAI1_9ASCO/25-471   AC A0A1E5RAI1.1
#=GS A0A1E4T677_9ASCO/40-264   AC A0A1E4T677.1
#=GS G8JM86_ERECY/6-201        AC G8JM86.1
#=GS A0A7H9HR83_9SACH/6-314    AC A0A7H9HR83.1
#=GS A0A0A2VVG2_BEABA/145-309  AC A0A0A2VVG2.1
#=GS A0A1G4JS46_9SACH/11-346   AC A0A1G4JS46.1
#=GS A7TKX4_VANPO/10-364       AC A7TKX4.1
#=GS A0A1S7HVQ3_9SACH/8-139    AC A0A1S7HVQ3.1
#=GS H2AZT1_KAZAF/9-257        AC H2AZT1.1
#=GS A0A0C7N4X0_9SACH/16-361   AC A0A0C7N4X0.1
#=GS G8BZH5_TETPH/11-380       AC G8BZH5.1
#=GS MED3_KLULA/8-229          AC Q6CNQ9.1
#=GS G8ZWS1_TORDC/6-173        AC G8ZWS1.1
#=GS J4WEV1_BEAB2/710-868      AC J4WEV1.1
#=GS A0A1S7HET9_9SACH/8-325    AC A0A1S7HET9.1
#=GS A0A1G4MBB3_LACFM/183-318  AC A0A1G4MBB3.1
#=GS A0A4C2EAK8_9SACH/9-128    AC A0A4C2EAK8.1
#=GS B4UMX1_CANGA/13-477       AC B4UMX1.1
MED3_CANGA/13-481                    .............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..........................ASYN...H.RG..KA---G..A.SI..SN....ST.PTPAAATPTTA..PTPGA..GTKK..A..A...KTAPTPTATA................................TIGTPS.--NNAPTP...ATT.ATTPG...TQAKKPR.KP..RQTKKqq.............qaaAAAAAVA.QAQ...AQAQAQAQNQnqnnmqnknisnpgmnsnmgtpvmgnpnmkQMQSP....IPANA.MNNMNvp....hngAMRPSVPngnmgNPSMGNLNMN.APN--MGN.PNMNnpnmnnpnaMMSPMAgQGQ..LN.QM.FPMQN.H..N.QNG.QFMGQQ....SPGPNigq...mqfPPNNGN.MNGMPGTSDmnlgmnpsmnmnmgMNLNQITPANILSMNTKGKDdqmQNIGMDQNQN..QNQSQ.......NQSQNQ..nQSMN......MNMN...ND.S.NNPKSaYDLVDFNSLDLSSLNMDFL.....................................................
J8LNQ4_SACAR/3-398                   .............................SIIPADTKLEDLEVKLAKNEN..........-ETRDNVCKQINEARNEILPLRLQFNEFIQSMANIDHDG.....TKQGDRMVKYLHIRDSILQLNDRFQSLSSHLETLQPLFNTVPEYLRTADNKDRSFQLLEPL..........................STYN...Q.NG..TVTGPA..A.AV..AN....TS.HSTAASTPTTT..--PHA..NSNA..H..T...HSLSNPNTTTammqqnpma..............gkrgpkgstTIGTPN.---SAAAA...ATA.A----...--AKKPR.KP..RQTKK..................AKAQAQA.QAQ...AQAQAQAQAQaqvy......................ahpsAVQTP....ITA--.-----.........SMTAALP.....NPTPNIINSV.SPTNVMGT.PLTN.........MMSPMT.---..--.NA.YSMVA.P..N.QGG.QPAMSQftnhSNGTN.........PNPTTN.ANNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQQQ..QQQQP.......QQPQQQ...Q---......YNMN...TM.N.NNGKE.LDSLDLNNLELGGLNMDFL.....................................................
MED3_YEAST/3-397                     .............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....SKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..........................STYN...K.NG..NAVCST..A.TV..VS....TN.HSAAASTPTTT..ATPHA..NPIT..H..A...HSLSNPNSTAtmqhnpla...............gkrgpksgsTMGTPT.VHNSTAAA...PIA.A----...--PKKPR.KP..RQTKK..................AKAQAQA.QAQ...AQAQVYAQQS..............................TVQTP....ITA--.-----.........SMAAALP.....NPTPSMINSV.SPTNVMGT.PLTN.........MMSPMG.---..--.NA.YSMGA.Q..N.QGG.QVSMSQfngsGNGSN.........PNTNTN.SNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQQQ..QQQQQ.......QQPQPQ...YNMN......MGMN...NM.N.NGGKE.LDSLDLNNLELGGLNMDFL.....................................................
J6EII9_SACK1/3-412                   .............................SIIAADVKLEDLEVALAKNEN..........-ETRDNVCKEISEARDEILPLRLQFNEFIQTMASIDKDG.....PKQGSRMARYLQVRDKILQLNGRFQSLSSHLEALQPLFSTVPEYLKTADNKDRSFQLLEPL..........................STYN...Q.NG..TVAGPA..A.AV..VN....TS.HSTAASTPTTT..-TPHA..NPIA..HahA...HSLSQPNSMAtmqqhsla...............gkrghkgssSIGTPN.APNSTVAA...ATA.A----...--TKKPR.KP..RQTKKaka............qaqAQAQAQA.QAQ...AQAQVYSQQS..............................AVQTP....ITA--.-----.........SMAAALP.....NPTPNMINSV.SPTNVMGT.PLTN.........MMSPMA.---..--.NG.YSWGG.Q..T.QGGgQPGMPQfnnnGNGTN.........PNPSTN.SNNTPLQSQ..............LNLNNLTPANILNMS-----...MNTDFQQQQQ..PQQPQqpqqqlpQQPQQQ...YNMN......MGMN...TM.N.NNGKE.LDSLDLNNLELGGLNMDFL.....................................................
A0A7H9B463_ZYGMR/8-279               ............................e-MLTPNIKLEELESKLVAS-D..........GDCRDKVMGSIDNTQKAILPMRLLFNDFIQSMSNVDN--.....LGGENPKENFLLIRSKVLELSTRVQVVADDFNKLQPLFETISEYST--KHGDKKYQPLETL..........................KSFS...P.NG..GAITNN..V.LS..GA....NV.NGIAANINSTS..--VES..STKK..Y..N...RSNNG----T................................PINAST.PGSSTPTS...AVP.P----...--AKKPR.KP..RQSKK..................AIA-ANS.KN-...---------Q..............................THPSA....ISGTP.--AAN.........GM-GSTP.....NASM-PVISV.PPTNMMASpPLSA.........MMSPMA.PAN..FA.AT.PQSQA.Q..S.QPQ.QQPQQQ....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------p....................................................
A0A1G4JCG7_9SACH/2-384               .........................tdns--------VKEMETRFAQEDG..........-LQTE-LVREFQAPKGLIMPLRLQFNDLLNTMATIDQ--.....NKGKSAHENFQMVRAKVIALNSQIQEFSRQVKGLEPRFESLEKYAT--EMKTSKFAPLETL..........................SRSS...E.A-..AAV-QQ..S.KN..VS....GI.SG-LSGGPSVA..SGP--..SPAS..A..A...ARASY----S................................SANTPN.SSVSTPSG...AQ-.----G...AAARKPK.RS..RAKKNsvsgsmpgsmpsgmssgmPGSVPGT.QPL...QQMSLAPQQP..............................QQQQH....HQM--.--PMP.........S-----A.....NPGQ-ILANM.SPANMMSS.P-MN.........VISPMN.TGL..SG.VM.GSSF-.-..-.SSN.SMMTSA....NKPQT.........--APQQ.RQAVPTPQQ..............INMSNITPANILTMSMMDKN...MNNPAIRSQP..QQQPA.......QQPQPQ...QQQQptpqprTQTQ...QLpQ.VGSND.FTNLDLNNLDLSNLNMDF-f....................................................
G8ZWS1_TORDC/124-323                 ................pqsnsvsspqtqn---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--.-----------..-----..-NAI..V..G...ANLNKKANRS................................NDGTPV.SQTSTPMG...SAV.PTPYA...TTAKKPR.KP..RQPKKpq..............tpA----AA.AAA...AAVAANGHIK..............................SQASP....TPP--.----A.........HMVSSVPa...tNPVQ-MVNSV.PPTNMMGT.PMQN.........LMSPLG.-NT..PN.YG.FSQQQ.S..Q.QQ-.PTPQQQ....Q-RQQ.........YNSATK.NSTMPQSQP..............MNLNSITPANILSMSMTGDP...----LHQQQQ..QNK--.......------...----......----...--.-.-----.-------------------ke...................................................
A0A0D2MAU2_9CHLO/466-686             .edvgevlsllsevarqpafpearldvtr---------------------..........---------------------------------------.....------------------------------------------------------SQVLENL..........................SHRD...D.VG..SAVARRevR.KL..VL....GA.DSPWARTPTTK..GVASI..SRQD..L..QefwAAWERPDA-A................................VLGIVG.DFNPATLE...AQI.RGAFGdwaPAPGQPQ.AP..RTAPEgr.............alvSQAAGLA.EQQ...QQQQQQQQQQ..............................QQQDP....QGAGA.EAG--.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------lglrrvlgaassapppaakltrakqeklnsfvfnfatpsaqlqraaayellgi
C5DHV2_LACTC/14-351                  ......................kefdfgn-----------LHEKLESED-..........-GYKDSVKQEIQSVQDSIQPMRLRFNELLNMLAIIDQ--.....ETEVSNQEKFLSIRAKIVEFVSELQAFSSSYGRLQPLFDNIQQQPKGGKTSI-KFTPLERLr........................hLSDA...S.LG..NQAKS-..A.SG..GS....PP.AAAVASVPTTT..KQPKS..STNT..P..T...SNAATPSATF................................NA----.--------...---.-----...-AAKKSR.KS..RSKKNslptg.......lgghpvATAASPA.AVA...AAAAAVSTN-..............................-PGVA....MGSNP.GIQQQ.........-F---TPs...tNPTQ-ILSSM.SPMNMMSS.P-MN.........IMSPAN.--N..VN.MA.YTGPT.K..-.---.------....-----.........PP-VPS.HRHMPSSSQ.............qMNMNGITPANILNMS-----...MMEQANQPHL..TTAPA.......PQP---...-PNQ......LDMN...--.-.-N---.---LDLNNLDLSNLNMDFL.....................................................
A0A2N6NMW4_BEABA/656-813             ............endqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--.-----------..----A..NTKN..L.dT...SEVPIPTTIE................................ELSPPVrTHRSSSWG...PVA.ATSPS...EEQRSPR.NG..NPNND..................AQSQAQQ.QQQ...QQQQQQQQQQy...........................qqQQQQH....VAQNGdFDSFD.........GM-SSFP....gDPSAMV----.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------mdppfpqpllpqdlftlpmtldwnwaemsggayp...................
A0A1G4MBB3_LACFM/8-167               ..........................qav-----RLKMEEMEDKLGSD--..........SMYKDSVLQDIRKAKDSILPMRLRFNDLINTIASIDK--.....TQGKSSQEKFTMIRAKVLELSTEIQSFCGEYHKLQPVFEAMQQYSKEGK-TSKKFTPLETLrh.....................vneVTIN...T.QS..K-----..-.--..--....--.-PPNATSPSNA..RLNKS..NVNT..P..A...SNVPTPSA--................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------ggnv.................................................
J7S5W6_KAZNA/5-127                   ............................e-LVPNGTKLADLEKRMVEDTM..........--VRDGLVVGLRQVREEILPIRLKFNAFLNKMSHLDSEP.....QGAKTNEERFKEVRDNLLDLYKSIQTLSARFHEIQPLFSVIEQFGA--VDGEKQFCPLETL..........................G---...-.--..------..-.--..--....--.-----------..-----..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------ngptv................................................
A0A1X7R5Q2_9SACH/18-394              .............................SILTLHMKLEELERRLAQNPQ..........--GKEQLALTLSTTRESILPIRLELNNFIHMVSNIAD-D.....KNGITNQEKFHNVRTMLLKLHTSIQSLSQRFQELSPLFGTVPEYTTEYKSKE--YQPLETLtptnipq............tpavndpSNKA...T.SG..NTATSN..T.TA..TN....TN.NITSTGAPATT..TTTTA..TKKGrgS..A...ASLKSPPTAA................................--NTPT.TGTATPAT...TST.N-AST...TTAKKPR.KP..RQKKS..................VSSAKNT.PAA...THATTTNTNS..............................VVATP....LSATT.MN---.........---PTLS.....VPP-QLMTGM.IPGNIVGM.SPTN.........TMMNMA.---..-P.QM.QPQMQ.F..N.SNN.-----M....NNRQT.........----GN.TPGPQGQLS..............PQNNTITPANILSMG-----...SNNNITNNSN..LVSNN.......S-----...NNNN......NNNN...NQ.GpNAMND.FGNLDLNNIDLSSLNMDFL.....................................................
I2GX35_TETBL/12-175                  ............................a-LLPKDCNISKLESSLAANPA..........--SHEALQRQLSQMQQQVLPLRLLFNNLLSILSGTND--.....-TIADNEIYYSTVREMVVEISQQLQNISGNMAQLEPILSTVRSYNQ-EPNRSSFSQLLQNL..........................SETKslsQ.KF..PQPIMT..T.AS..SN....KR.SKSQAATPISS..-----..-TSN..Q..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------nvnlssvapap..........................................
MED3_ASHGO/7-199                     ............................g-ILRENLTLEELQEWLTSSEG..........--NKLAIDDHIKATQGRVLPLRLLFNEFLRTISHIEQ--.....LSDKTPQEKFQLIRSKLQELYGKLHALVRDFQRLQPLFDTMVPFSET---SERKFYPKETL..........................GTAV...E.PV..RPLASP..S.YR..RP....SN.RSSADTPSSNA..PTPSA..AVVS..G..A...ALVA-PQ---................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------vkhqrrprtntakrqpsvsasvvpsanssgp......................
G0WA71_NAUDC/11-385                  .............................KLLTPKLTLDQLEDRLAGDIDnldttdlsddSLPKQVIANSLIETEKSILPLRLVFNKLIQTMATLDT--.....MPEKSQQEMFLSIRNQLLDLYTKIQEISTDFQHLQPLFGTIEEYSE--KNNTKKFHMLETLkpiv.................epapaTAKA...T.KG..DASHSK..K.KS..VA....GT.PGSVGNTPVGT..-TPGS..STGT..V..A...ANVPA-----................................NINANT.TNTSTTSA...AST.TQTTS...STAKKPR.KP..RQNKK..................--AAAKA.QQQ...QQQQLLQQQQ..............................QQQIPkqqgIATNP.MMNMN.........AM-----.....NATP-MMNSV.SPSNVMGT.PLNN.........GISPMG.AVM..AG.GF.YSQPP.G..S.QSQ.QFDQQM....NNGDH.........---NTN.NNNF-----..............QNMNNITPANILSMNTVGDP...------QSRM..ASSSQ.......QYP---...----......--TN...NN.N.NN---.--TLDLNNLDLSSLNMDFL.....................................................
A0A507AUA6_9PEZI/371-642             .....................vliddlka---------------------..........---------------------------------------.....---------------------------------DDDVVKKIEEYQK-EKEEARKAEQEKPK..........................SPVA...D.KA..SPVAET..D.TK..SN....GQ.QEKRESAKSSK..-SPTP..PPAS..A..A...ASAKSPSAEP................................S-AKPA.ANNATGTP...AAT.DGDSQ...SSKKRPAeEP..AENPK..................VPKAPKA.MQQ...QQQE-AQQQQ..............................MMQHM....MNS-M.MPGMNgmggmpgmpGM-PMMP.....FGGMPMMNNF.PP---MGM.PNMNmn.....mgMMNPMM.NPM..MGmPN.FGNNG.M..N.GGG.GFGPGN....NNGMGggwgmsgggPPMNGGpMNGG-YNQQ..............FNNNN---------------...----------..-----.......------...----......----...--.-.-----.-------------------ggggnkmmggnfgqq......................................
A0A1E5RAI1_9ASCO/25-471              dlqslqkylleqvpqsepnnksasasial---------------------..........-------NGYMAKVQNEILPLRLEFNALLKQMAHLDN--.....-PQESGKQKYLALKARLVTVTTKINDLSQEFKKLQPLLYILKNNQKILETPN-SYYILETLdqlpqpeikvplpkqfqpkiintlpnAVSN...S.TGvnTAVSSA..Q.KAtkSP....VN.SVNSPSTPATA..KTPGSvaASNT..V..K...HSLQGNLASA................................STFSG-.IRKNAKGS...GAN.AHASS...GSVKKPA.TNskRGTPQ..................AFSPLSA.NTP...VTNVSASNNStnlsnigavy.........nsggrsknhdqVTSAP...lSKANS.ANESP.........SMYMNTS.....NITPANILQN.LNS-SMGN.N--S.........QSSNMG.ALS..SR.VG.M----.N..G.PSG.NIGQQR....VN--N.........PNSNSN.SNNINNNSMn...........ygNNMNNRVPSTDNSMGGYGYN...GNFSMSPSSI..LQNMN.......NLPNNNssvASGN......MSPNgslNT.N.NN--S.AGMLDLNTLDLSNLD-DFL.....................................................
A0A1E4T677_9ASCO/40-264              ....................etgkldias---------------------..........------VIVEVQELKSKISGLRYEMCQYIRLLSSIEETS.....----VPLLVFQEVSNQISVLKSQIDSYYTSYRRLLPVIRYTK--LKIGLNPDDQIKILVHDvkves................klildTSIK...S.DG.lNVGMSN..S.GS..GI....GS.GTNSVSTKFVA..STPQS..SVPP..A..-...SSASS-----................................MITTPG.IANTPGSL...APArKNTAT...KKVVKPR.AP..TKKQQ..................-AAAAAA.AAA...AQKQATQQQG..............................KQQ--....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------pqkngqgsltqp.........................................
G8JM86_ERECY/6-201                   .............................EILSAKLTLEELKEKLANNDE..........--SKSAISGQIQLVKHNVLPLRLSFNDFLKTMSQIEH--.....LNDKSPQEKFLLIRAKVLELYGKLKELVRDFQKLMPLLDTMAVFSE--SNE-QKFYPLETLn........................lLPDP...I.KS..TASPSY..K.KA..VNksnaET.PSSNAATPSAA..-----..-LSS..N..N...VVLVGPQAKNqrr.........................prtnNKRQPS.---GTASA...APS.A----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------gsagsapi.............................................
A0A7H9HR83_9SACH/6-314               .............................DLLTPDLKLDDLEASLAGGTK..........-EPQEKVMNAIDKAQGSILPMRLQFNDFLQTMSSLDD--.....LQDQTPLEKFTMIRNKVLDLTNRLQMISEDVGKLQPLFDTIPEYSERY--GTKKFQPLETL..........................KLTS...Q.NS..------..-.--..--....--.---TISTPQTQ..NSGGS..NPLT..S..R...K-ISK----S................................SGGTPV.SHTSTPLG...STA.PSTFP...AAGKKPR.KP..RQSKK..................AQATAVA.---...-ADTVKSQPS..............................TVLSP....TPPAH.MIN--.........SA---PP....aNP-MQMMNGV.VPNTMMGS.PMQS.........LMSPVG.--N..TP.NG.YGIPQqQ..M.QSQ.QPPQQF....-----.........-NQPAV.GNSVPPVQP..............LNMNSITPANILNMSMGADP...QQQPIQ----..-----.......------...----......----...--.-.-----.-------------------rkn..................................................
A0A0A2VVG2_BEABA/145-309             .........ekaendqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--.-----------..----A..NTKN..L.dT...SEVPIPTTIE................................ELSPPVrTHRSSSWG...PVA.ATSPS...EEQRSPR.NG..NPNHD..................AQSQAQQ.QQQ...QQQHQHQQQQqy..........................qqQQQQQ....IAQNGdFDSFD.........SM-SSFP....gDPSAMVM---.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------dppfpqpllpqdlfalpmtldwnwaemsggaypsve.................
A0A1G4JS46_9SACH/11-346              ........................nearp--------LENLFERLGSDHE..........--FKNSIKQELQNVQNSILPMRLHFNELLNAMASIDA--.....KQESSALERFTYVRTKLLEFMKDVDTLSSDYVRLQPLFDGLQQASK-DDNISVKFSPLERL..........................SNIN...D.AA..LA---T..A.GR..PQ....SG.KRSNVNSPSAL..--AAA..STTK..S..A...VSSGN-----................................---TPS.--SNLPTP...STT.A---S...AAAKKPR.KP..RTKKNs...............gpSPSSMPS.QPQ...PPSQALQQAI..............................HQQQP....AQS--.MQHQK.........QFTPS-T.....NPSQ-LLSGM.SPMNIMSS.PL-N.........TMSPVN.---..-G.SN.MSFPP.G..G.KPS.NMHSVQ....-----.........------.RHVQPSQPS..............FNSNSITPANILSMSM--S-...-----DQSNP..A---A.......AYT---...----......-QMN...PQ.G.SVNQD.LGSLDLNNIDLSNLNMDFL.....................................................
A7TKX4_VANPO/10-364                  ............................t-ILSGKVKLEQLEDTLGLDDN..........--SRNTVVTAISQAHDSILPLRLQFNDLIRLLSHIEE--.....QPTQTSEEKYLLIRSKLLDLYKNIENLSIDVKQLQPLFQTVSEYSTKYKNKK--YQPLETLyqss..................tgatTTIT...S.SA..NTSNGP..S.VT..GS....TS.AGSAANTPNVS..ASAST..TTKR..A..K...SNAATPSSATntpnasgasvgtpnsasagitsgsgitpipttGVSAAS.GSAATTAAsisATT.PTTTT...TTVKKPR.KP..RQPKK..................TAAANKK.QPVpspLNSQIPLNTA..............................SINNN....NTSSA.YNNMKann...tnmKMA---PnagpmNNQAQMMGNP.SPKNMVNT.PLNN.........MMGSLG.G--..VS.QD.YGMQL.QtpN.QPT.PLQMQM....G----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------qqgi.................................................
A0A1S7HVQ3_9SACH/8-139               .............................DILSTNIKLDELELKLASTGG..........--VKESVIGTITEAQKSILPIRLKFNDFLQTMSSIDK--.....VDSVTPEEKFKMIRSKLLELTNSMQDVSEEFTKLQPLFDTVPEYAERYGNKR--YIPLETL..........................KSST...N.LG..NGLPSQ..-.--..--....--.-----------..-----..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------tqlq.................................................
H2AZT1_KAZAF/9-257                   .............................EVLTLTVKLEELETKFATNEN..........--SKQSVLDLVNETRSLILPIRLQLNEFISLMANIDK--.....MTETSNIDKYNHIRKSLLTLQNNIQTLSQNFVKLNPLFNTIPEYST--KHNSREFKPLESL..........................SNDP..fA.KG..SP--RT..T.SS..GS....AN.NTITSATSITT..---NA..NNKI..S..A...ATPS-----S................................NINTPA.----SSSQ...NIT.NTTPS...--IKKPR.KP..RQPRK..................SITQTNT.ANK...AS---KTTTP..............................SAPTP....VAA-P.MQTPG.........TMNPALPv...qN-----FNTK.TPIN-LGS.PNGP.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------qfspp................................................
A0A0C7N4X0_9SACH/16-361              ...............skshsvdkvferlg-----------------SD--..........DSYKDSVKQELQHVQDSILPMRLKFNELLSTLAAIDR--.....KGESSSAETFNQIRTKLLEFISGVQQFSSDYGKLQPLFERLQEVSKSEDTI-VNFVPLERL..........................SRLN...D.AS..TT-ASG..G.KI..SN....GN.SPSANFVSTGK..QAP-S..NAQT..P..L...SNVPT-----................................----PS.--------...-SV.D---N...APAKKPR.KP..RAKKT..................AGPSPSSiAPQ...QQQQQKQQPQ..............................QHQQP....QPPQ-.----Q.........HFT-PAT.....NPSQ-ILQSM.SPMNMMSS.P-MN.........TISPMNnAAP..IS.QIpFSAPS.K..P.P--.--MQQQ....QRH--.........------.VQQTP-QQQ..............FNLDSITPANILHMS-MSDH...GNTPHAQQTNsqQQQQQ.......QQPQPQ...QQ--......QQHL...QS.S.NQ--D.FSALDINNIDLSSLNMDFL.....................................................
G8BZH5_TETPH/11-380                  .......................ffntve-------SLENLEDKLVMNNF..........-ENKDILMEKISSTQKSILPIRLLFNEFIQTMALLNDGKghkteNNNEEALAKFYLVRDKLVRLSECLQNLSSDMSNLKPLFDLISEYSL--KNNSKQFDPLETLkqidndvfn........sqaalatnaADSQ...N.NG..KTKAKN..S.TS..TA....AT.PNSSVNTPITN..--LGS..QTIL..S..N...TNASVPALATtptt.......................vtkgaSVASAS.-SKSVTAN...LSS.VNVPA...ATTKKPR.KP..RQTKK..................STATSK-.KLQ...SNSAASPMNP..............................PTPSN....ITANK.RANKA.........SAQTA--.....QSTGNMLGMNgSQQNVAGN.MNNN.........NNNNMV.--Q..RN.NS.ISMNS.Q..DfMAM.QYKNGN....GNGNA.........PMNNQM.MNNQMINNQ..............MINNQMLNQQQMKMNNMGNM...-N--------..-----.......------...----......----...--.-.-----.-------------------mgnmg................................................
MED3_KLULA/8-229                     ......................qifkdnl-------TFDTFRELIIEKE-..........-STADEVADKVLEAKKALLPIRTLMTEFVGMIANLES--.....MGNKTSQEKFLAIRMKLIELQNNIQKFSKDFQQLQPVMRTMDKFNEEVNAGEKKFFVQETLg........................yTQLA...S.NG..SAAGIT..K.TS..SG....ND.GNTTGSTANTM..-AMAK..GLKK..N..A...AGKPN-TGTGvqsgpgrrn..............stkktghtgPATAPT.TSNSAASA...AAA.AANTP...SL-----.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------kqipntqpmql..........................................
G8ZWS1_TORDC/6-173                   .............................DLLVPDMKLEELETSLATGGD..........-DPKDRVDKAITDAQNSILPMRLQFNDFMHTMSNIDD--.....LQNSTPMEKFNLIRSKVLDLSDKLQTMSEDVGKLHPLFDTIPEYSE--KYGTKKFQPLETLripqsn..............svsspqTQNN...AiVG..ANLNKK..AnRS..ND....GT.PVSQTSTPMGS..AVP--..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------tpya.................................................
J4WEV1_BEAB2/710-868                 ............endqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--.-----------..----A..NTKN..L.dT...SEVPIPTTIE................................ELSPPVrTHRSSSWG...PVA.ATSPS...EEQRSPR.NG..NSNHD..................AQSQAQQ.QQQ...QQQHQHQQQQqy..........................qqQQQQQ....IAQNGdFDSFD.........SM-SSFP....gDPSAMVM---.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------dppfpqpllpqdlfalpmtldwnwaemsggayp....................
A0A1S7HET9_9SACH/8-325               .............................DILSINMKLDELELKLASTNG..........--VKESVIGTITEAQKSILPIRLKFNDFLQTMSSIDK--.....VDSVTPEEKFKMIRSKLLELTSSMQNVSEEFTKLQPLFDTVPEYAERYGNKR--YIPLETL..........................KSST...N.LG..NGLASQ..T.QL..QQ....QQqQQSQAQAQVQSqqQSQSQ..QPQS..Q..P...QQLPNGNPVSssnsia...................srkpsksNAGTPG.SNMNTPSG...TTM.TN-MT...PSSKKQR.KP..RQPKKts.............sgiG--MGPA.STP...VMSASNFKAQ..............................TAQSP...qVGT--.-----.........KIAGA-P....lNNTTQTVSSV.PPTSTMNT.PMNN.........VMSPLG.GVApgFG.IS.QSQPP.Q..S.MPQ.QISQQF....S----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------qqlsqqr..............................................
A0A1G4MBB3_LACFM/183-318             ..................pgaasiplqas---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--.-----------..-----..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-----PP....tNPSQ-ILSNM.SPMNMMSS.PM-S.........TMSPVN.-GS..MN.LP.Y----.-..N.GSA.SISTAP....KPQSQ.........-----P.QRHIPSASQ.............qLNMNNITPANILNMS-----...---MMEQNPM..QAPSS.......QQSQLS...QP--......---Q...HQ.S.SNSLD.LNSLDLNNIDLASLNMDFL.....................................................
A0A4C2EAK8_9SACH/9-128               ............................e-ILSLNMKLDELESKLSSEGS..........--SKESVMGAIDEAQGSILPMRLKFNDFLQTMSSIDK--.....MQEVGPDEKFLLIRSKLLELTSSMQQVSEEFTKLQPLFDTVPEYAERYGNKR--YLPLETL..........................RS--...-.--..------..-.--..--....--.-----------..-----..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.---..--.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------asn..................................................
B4UMX1_CANGA/13-477                  .............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..........................ASYN...H.RG..KA---G..A.SI..SN....ST.PTPAAATPTTA..PTPGA..GTKK..A..A...KTAPTPTATA................................TIGTPS.--NNAPTP...ATT.ATTPG...TQAKKPR.KP..RQTKKqq.............qaaAAAAAVA.QAQ...AQAQAQAQNQnqnnmqnknisnpgmnsnmgtpvmgnpnmkQMQSP....IPANA.MNNMNvp....hngAMRPSVPngnmgNPSMGNLNMN.APN--MGN.PNMNnpnmnnpnaMMSPMAgQGQ..LN.QM.FPMQN.H..N.QNG.HFMGQQ....SPGPNigq...mqfPPNNGN.MNGMPGTSDmnlgmnpsmnmnmgMNMNQITPANILSMNTKGKDdqmQNIGMDQNQN..QNQNQ.......NQN---...QSMN......MNMN...ND.S.NNPKSaYDLVDFNSLDLSSLNMDFL.....................................................
#=GC seq_cons                        ....................................plppLc.phstp..............s+ptlhtplppspppILPhRLpFN-hlphhusl-p........tp.os.-+F.hlRs+llpL.splQplSpchppLpPLFpsl.pasc..pstp.papsLEsL..........................ss.s...p.tu..ss...t..t.t...ss....ss..ssssssssss....stu..ssts.....s...tshst....t.................................hssss....sss.s...sss.s..........++PR.ps..pttpp..................s.s.s.t.t......ttt...pt.................................tp......s..................th....s.....sss...h.........hs.....s............................................................................................................................................................................................................................................................
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