#=GF ID   MetOD2
#=GF AC   PF18548.5
#=GF DE   Metanogen output domain 2
#=GF AU   Galperin M;
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Galperin M
#=GF GA   30.60 30.60;
#=GF TC   34.00 33.10;
#=GF NC   29.20 28.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF DR   INTERPRO; IPR040541;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   MetOD2 (Metanogen output domain 2) is found in euryarchaeal
#=GF CC   class Methanomicrobia, usually in combination with the
#=GF CC   Response_reg Pfam:PF00072 domain (Galperin et al., 2018,
#=GF CC   Phyletic distribution and lineage-specific domain architectures
#=GF CC   of archaeal two-component signal transduction systems).
#=GF SQ   24
#=GS L0HG55_METFS/121-208      AC L0HG55.1
#=GS L0HHB8_METFS/349-436      AC L0HHB8.1
#=GS A7I9P1_METB6/121-207      AC A7I9P1.1
#=GS I7KAY7_METBM/121-207      AC I7KAY7.1
#=GS B8GDV3_METPE/121-208      AC B8GDV3.1
#=GS Q2FRF9_METHJ/121-208      AC Q2FRF9.1
#=GS A0A8J7RWX8_9EURY/121-206  AC A0A8J7RWX8.1
#=GS D1YVS5_METPS/127-213      AC D1YVS5.1
#=GS A0A483CPH5_9EURY/121-206  AC A0A483CPH5.1
#=GS A0A8J7W498_9EURY/122-209  AC A0A8J7W498.1
#=GS A7I6X2_METB6/321-404      AC A7I6X2.1
#=GS Q2FRE0_METHJ/124-211      AC Q2FRE0.1
#=GS A0A498H440_9EURY/121-208  AC A0A498H440.1
#=GS A0A2V2MUA6_9EURY/124-209  AC A0A2V2MUA6.1
#=GS L0HDI3_METFS/122-209      AC L0HDI3.1
#=GS H1YX59_9EURY/121-206      AC H1YX59.1
#=GS A7IAW8_METB6/124-211      AC A7IAW8.1
#=GS E1RHV4_METP4/121-205      AC E1RHV4.1
#=GS H1Z0S6_9EURY/122-202      AC H1Z0S6.1
#=GS A0A0X3BIM3_9EURY/121-207  AC A0A0X3BIM3.1
#=GS A7I8D5_METB6/337-424      AC A7I8D5.1
#=GS Q0W3H8_METAR/125-214      AC Q0W3H8.1
#=GS A7I9P0_METB6/122-209      AC A7I9P0.1
#=GS A0A2V2N5P1_9EURY/121-208  AC A0A2V2N5P1.1
L0HG55_METFS/121-208                 ..RRQAIKSDMDMARQSGFDTEIISE....YARLSKSIDVNKRLMKILETTYNFND.SKARVSDEIS.RAIKSMEMNIKFQESRLQQIKGELSGS-p...
L0HHB8_METFS/349-436                 ..RKQRFKDGLELAKKVGVDREKFCE....LAKLSRRISVNKKIIDILQAPAGTPAwGPDEMTPENK.EVIEQITMITRVNEKRAEQLKKEINT--v...
A7I9P1_METB6/121-207                 ..RRQTIRSDMDRARQSGVDFDVVNE....YALLSKSIDVNKRLMKILETTYNFND.SKVRISDDIS.RALKNMDTNIKFQEARLQQIKGELA---gr..
I7KAY7_METBM/121-207                 ..RRHSIAADIERAREAGVDHRIIDE....YERLSKSVDINKRLLKILETTYSIKD.TRAGMGENIM.RAIKSMATSIKLQEERLNQIRSQFS---dv..
B8GDV3_METPE/121-208                 ..RRTRIRLDVETAKAAGFDQRIIDE....YARLSKSIEVNNRLVNILESTYNISD.SKARVGDEIA.RAIKNMTMNISFQEERLGQIREELQLT-s...
Q2FRF9_METHJ/121-208                 ..RRKQIAEDMTRAKEGGFEDALINE....YGRLVKSTEITKRLLKLLSSTYDLSD.PSMKFSDDIN.IAIKSMETNMKFQEQRLIQIREIFSGA-a...
A0A8J7RWX8_9EURY/121-206             ..RREMIRSDVENAQQVGLDQHLVDE....YTRLAKGVDVNSRLLRILETTYNIHD.S--KASEKIS.LAIKNMENSIKFQENRLTQIKEQIKA--lq..
D1YVS5_METPS/127-213                 ..AKTDVERIMGMAGKSGVQKEMLTElkdrYLRKFTQYRSLKKKYSLYSQMYGEN-.----GGEQST.AMLSSLKKGLEQQAEDLSHIEKMLMATQ....
A0A483CPH5_9EURY/121-206             ..RRETIIRDVERAKEAGLDKNLVDE....YARLAKGVDVNNRLLRILETTYNIND.S--RASEKIS.LAIRNMENSIRFQQSRLAQIKEDIEG--lq..
A0A8J7W498_9EURY/122-209             ..RRREIAEAIRLAEERGTNIALVSE....YARLVKSVDVNRRLIRILENTYSLKD.LQTGSVDKIE.IAMRNMKNGLSIQEARLEELRDQI----gvek
A7I6X2_METB6/321-404                 ..RRRLIREAVRAAMRAGYEKETVCA....YARLRRRVEVDKKLLGIISTASPGAE.S---GRDASF.KDIAAVNRELQSDQETLRQLQRKLE---pv..
Q2FRE0_METHJ/124-211                 ..RNAEINREKERALQNGGSPADVDE....YGELLKRVQVEQRLIEILGRIYPIQR.D-GTIETDLEiPELHEFVHRFETHKARCEELKNKLFSGS....
A0A498H440_9EURY/121-208             ..RRHSITADIERARQAGVDQRIIDE....YERLSKSVDINKRLLKILETTYSIKD.AKVGMGENIT.RAIKSMATSIKLQEERLHQIRGEFT---vfa.
A0A2V2MUA6_9EURY/124-209             ..RKEMISREMDQATAKGGDSNLIVE....YSNVRHRTLIGKRLITILGRIYPIRT.D-GTIETDFDmPELHDIINRFEEERKRCRELHKIL----le..
L0HDI3_METFS/122-209                 ..RRSDVKAETKGAEAAGVESGIIDE....YAALRKSIEVDRNLLCVLKKACDMSN.VGREAPAEDL.AAIKNLEEKILADEIRLKELSGKIPNS-p...
H1YX59_9EURY/121-206                 ..RREKISFGVEMAKKAGIEDQIIDE....FERLSRSVDVSKRLLRILESTYSLDD.DDVRVGENIE.RAIKSMEMSIKLQEERLEQINKLF----gv..
A7IAW8_METB6/124-211                 ..RRQAILSDVERARRCGIDGEVISE....YARLAKSIEVNRRFLTILENTYKPDK.PPVPVSDNIL.QALKNLEGHLKTQEARHRQIKEEIKKAS....
E1RHV4_METP4/121-205                 ..RKDEISQKIEEAKEAGIEDRIIEE....YERLSKSVDVSRRLLKILESTYNISN.DELKVGENIA.QAIKSMEMSINLQEERLKQIKKT-----fi..
H1Z0S6_9EURY/122-202                 dd---NIAAFCEKALDSGADEEAVSE....YAALRNNVRVLGEMFTYLEKIIISN-.--PKPGDEQN.PEVLKVRELLEEKEKRLHELGNILK---....
A0A0X3BIM3_9EURY/121-207             ..RRHSIAADIERAREAGVDHRIIDE....YERLSKSVDINKRLLKILETTYSIKD.TRAGMGENIM.RAIKSMATSIKLQDERLNQIRSQFS---dv..
A7I8D5_METB6/337-424                 ..RRQMIEEKIAAAKRAGIDRDKLCE....HARLTRVVDVNKRLWDLLVRTYHLDT.DTPEPESEIG.IAIKNAERKIRDQEHRLKQIERSLGSG-a...
Q0W3H8_METAR/125-214                 ..ARTRIERTLEMARKSGVAAEIINAyrdrYEKLHTQAQRNKKLLTLMSQLYPED-.-KLKASPASR.NMLMSLKKGLESQEEELRRLEKILTTP-a...
A7I9P0_METB6/122-209                 ..RRNDVLLARLAAQDKGMDTTIIDE....YALLRKNVEVNRNLLSVLRAASGIDL.PGREVSREDR.DAIRNLEDKVYAEERRLREIHDLVEKVQ....
A0A2V2N5P1_9EURY/121-208             ..RRQRIQDDMKKAKEGGFDELLINE....YGRLVKSVEITKRLLKLLSATYDLSD.PSMKLSDDIN.IAIRSMETNLKFQEIRVSEIREEFSG--kp..
#=GC seq_cons                        ..RRppIppch-tA+cuGhDpcllsE....YuRLsKul-Vs+RLlcILcsTYslsc.sthcsu-cIp.tAI+shcpslchQEpRLpQI+cplp.......
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