#=GF ID   Metal_CEHH
#=GF AC   PF14455.10
#=GF DE   Predicted metal binding domain
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   26.40 25.30;
#=GF NC   22.80 24.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR025873;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A predicted metal-binding domain that is found in
#=GF CC   gene-neighborhood associations with genes encoding components of
#=GF CC   the bacterial homologs of the ubiquitin modification pathway
#=GF CC   including the E1, E2, JAB  metallopeptidase and ubiquitin
#=GF CC   proteins. The domain is characterised  by a conserved motif with
#=GF CC   a CxxxxxEYHxxxxH signature.
#=GF SQ   25
#=GS A0A1M5L8M7_9HYPH/90-144   AC A0A1M5L8M7.1
#=GS A0A7W9HFD7_9PSEU/10-180   AC A0A7W9HFD7.1
#=GS A0A7R7CP84_9HYPH/7-182    AC A0A7R7CP84.1
#=GS K0Q1I0_9HYPH/7-174        AC K0Q1I0.1
#=GS A0A1I0VFD0_9ACTN/25-136   AC A0A1I0VFD0.1
#=GS A0A4Y9NLP0_9BACI/167-233  AC A0A4Y9NLP0.1
#=GS A0A139BPI4_9PROT/3-170    AC A0A139BPI4.1
#=GS A0A5N1IZU8_9BACT/118-278  AC A0A5N1IZU8.1
#=GS A0A271K9G5_9HYPH/7-182    AC A0A271K9G5.1
#=GS A0A1M5BBT2_9BACT/7-166    AC A0A1M5BBT2.1
#=GS A0A495XKJ0_9PSEU/10-180   AC A0A495XKJ0.1
#=GS A0A6G8QDR6_9ACTN/7-178    AC A0A6G8QDR6.1
#=GS A0A1B9YGK3_9BRAD/7-182    AC A0A1B9YGK3.1
#=GS A0A1I0VFD0_9ACTN/120-186  AC A0A1I0VFD0.1
#=GS Y4JH_SINFN/7-182          AC P55508.1
#=GS A0A2A3C9X8_9HYPH/7-182    AC A0A2A3C9X8.1
#=GS Q2K2A7_RHIEC/7-182        AC Q2K2A7.1
#=GS A0A849HL00_9MICO/127-180  AC A0A849HL00.1
#=GS A0A4Y9NLP0_9BACI/72-164   AC A0A4Y9NLP0.1
#=GS A0A439EZZ3_9BURK/7-183    AC A0A439EZZ3.1
#=GS A0A509EJX5_9HYPH/89-143   AC A0A509EJX5.1
#=GS A0A102DAQ9_9SPHN/5-177    AC A0A102DAQ9.1
#=GS A0A514WR66_9SPHN/4-180    AC A0A514WR66.1
#=GS A0A5C4NAM8_9RHOB/6-164    AC A0A5C4NAM8.1
#=GS K0Q5H1_9HYPH/7-182        AC K0Q5H1.1
A0A1M5L8M7_9HYPH/90-144              ...........phpvt-----------------------------------..-------------.....--..-------------------------------------.--.----.....-.-..----------------------.-----..----GRLFVCMRGVREYHTHESHLTEAWSNYRG.TSGNDLIGIVTQIYRS-----wkktv....................
A0A7W9HFD7_9PSEU/10-180              ................VDPEVSRRKFDRQVADYRALERDYQAKGWFLVDAT..FPEVFVVMAARQI.....SP..PALVTGVLIDYTNYDVRPPSVRLADPFTREPYRTGQL.PT.TLMQstgkiH.S..PSPGGPPVM----------EVQ.ELMQG..YSPDSLPFLCLPGVREYHDHPGHSGNAWELHRA.TGAGALVRLLDVIHTYGVAPL.........................
A0A7R7CP84_9HYPH/7-182               ................VDPAVSRAKFDRQIGWFQTQAGAYRAQGCFLIEAR..FPTAFFIFAPPKI.....RP..QIIGAAVEIDFSNYDLRPPSVVFVDPFTRRPVARKDL.LL.SMLR.....R.P..HLPGTPPDMISVLMQQKALSLA.DFLQA..NSAEHTPFLCMAGVREYHDNPAHSGDSWLLHRG.SGEGCLAFILDKIIKYGTGPV.........................
K0Q1I0_9HYPH/7-174                   ................VEPEVSRAKFDREIGRFRPYADAYRTQGCFLVEAS..FPIAFFIFASPKL.....KP..RVIGAAIEIDFTNFDLRPLSVVFVDPFTRQPIARKDL.PL.NMLR.....R.-..-LPGTPPD----LIQPNTV--T.DFIQA..NSLEDEPFLCMAGVREYHDNPAHSGDPWLLHRG.SGEGRLAFILDKIIKYGTGPV.........................
A0A1I0VFD0_9ACTN/25-136              ..............vp--HEVSRAKFHQQLERFETNRNAFARRGWLLLDHGdlWVEVGFLHQVPMAs...lSV..PVMTACVRIDYWNFDLWPPSVMFVDPLTREPAP----.--.----.....-.-..----------------------.-----..---------------------------------.---------------------plvrapdkvsdtevrdalidghpet
A0A4Y9NLP0_9BACI/167-233             ...ngehgvrdalven-----------------------------------..-------------.....--..-------------------------------------.--.----.....-.-..----------------------.-----..HPVTGLPFLCLPGIREYHSHPQHSGDDWLLHRR.SGAGRIAVICERIWQRMV---vnv......................
A0A139BPI4_9PROT/3-170               ...............a-DPSVSRRKFEREVAAALAH-KPFHEQGVWILRAE..YPTVFAVLITTLN.....VPiwRGILCGVHINFTNFDVRPPSLKFVDPFNERPLNYNECwKFtRLNL.....K.S..PLPGDT----AGPQQYEAVPLL.QAFDT..N----KPFLCLPGVREYHDSSAHTGDSWFLHRR.K--NMLIYILTILQQFG----sss......................
A0A5N1IZU8_9BACT/118-278             ................VDSEVTQQKFSEELAVFVQLKEEYRKKGILLLEQR..YPDLFFAFVAPSL.....FP..MPIAFAVRINFINYDVQPLSVKFVHPLTLEPVTNDQI.PS.R-LR.....R.-..KLEG-------------STQSQ.DLLQA..DS-DQIPFFCIPGVREYHEHPYHNGDSWFLYRKkGGEGSLCFILDNLHLYGT---shl......................
A0A271K9G5_9HYPH/7-182               ................VDPEVSRAKFDREIGRFRPYADVYRAQGCFLIEAT..FPRAFFIFASPKL.....KP..RVVSAASEVDFTDYDLRPPSVVFVDPFTRDPIARKDL.YL.KMLR.....R.P..PLPGTPPEMIGALIQQNAVPLT.DFIQA..NSPEDEPFLCMAGVREYHDNPAHSGDPWLLHRG.SGEGCLAFILDKIIKYGIVPI.........................
A0A1M5BBT2_9BACT/7-166               ................VDPVVTQQKFTEELERFRQLKEEYRSKGVLLLEEA..YPNLYFAFTAPSL.....NP..VPIVFAVCINFINYDVEPLSVRFVHPVTLQHVLFTQM.QT.RFFR.....N.-..-INGPAPQAL------------.--LQA..QS-DQVPFFCIPGVREYHKHTFHNGDSWFLYRKnGGEGSLCFLLDNLQLYGTS--ai.......................
A0A495XKJ0_9PSEU/10-180              ................VDPEVSRRKFDRQVADFRALERDYQAKGWFLVDAT..FPDVFVVMAARQV.....SP..PALVTGVLIDYTNYDVRPPSVRLADPFTREPYRTGQL.PT.TL-R.....R.StgKIHSITPDG------RPVMEAE.TLMQG..YSPDSLPFLCLPGVREYHDHPGHSGDAWELHRA.AGAGTLVRLLEVIHTYGVAPV.........................
A0A6G8QDR6_9ACTN/7-178               ................VDPAVSRAKFDREVAQYREREDEYVRRGWFLVKAE..YPEVFVVFGAPQL.....SP..PALVFGALLDFTDYDLWPPSVKLVNPFTKEPYKNKDL.PR.RLPR.....Q.P..TVPADQ--ALA--GQVQFIQPQ.DLMVA..HDPEDVPFLCIPGVREYHEHPAHSGDSWLLHKD.SGEGTLYFLLDQIHRYGVQPI.........................
A0A1B9YGK3_9BRAD/7-182               ................VDPEVSRVKFERELANYRSMESVYRKRGWILLEAE..FPEIFVVFAATKP.....RP..PPIVAGIALNFTDYDLRPPSVRFVDPFTREPIPAKLL.QV.QMLR.....R.A..AIPGATPETILALAQQGGVQMT.NMIQY..NSPDDRPFICLPGIREYHDNPAHTGDSWLMHRG.SGEGSLAFILEKIWHHGVKPI.........................
A0A1I0VFD0_9ACTN/120-186             vsdtevrdalidghpe-----------------------------------..-------------.....--..-------------------------------------.--.----.....-.-..----------------------.-----..---TGMAFLCIPGIREYHSHPQHNGDDWLLHRG.LHEGDLAVLCDRIWRR-----marnv....................
Y4JH_SINFN/7-182                     ................VDPKVSRAKFDREISRFRAYADAYRMQGCFLIEES..FPSAFFIFASPKV.....KP..RVIGAAIEIDFTNYDLRPLSVVFVDPFTRQPIARKDL.PL.NMLR.....R.P..QLPGTPTEMISNLIQQNAVSLT.DFIQA..NSLEDQPFLCMAGVREYHDNPAHSGDPWLLHRG.SGEGCLAFILDKIIKYGTGP-a........................
A0A2A3C9X8_9HYPH/7-182               ................VDPEVSRAKFDREMGRFRPYADAYRAQGCFLIEAS..FPSAFFIFAPPKI.....KP..QMIGAAVEIDFSNFDLRPPSVVFVDPFTRQPVARKDL.ML.RMLR.....R.P..ALPGTPPGMIPALIQQNAVALT.DFIQA..NGPEDPPFLCMAGIREYHDNPAHSGDPWLLHRG.SGEGCLAFILDKIIKYGINPV.........................
Q2K2A7_RHIEC/7-182                   ................VDEAVSRRKFEREVAQYRELEDSYRRRGWFLLDAT..FPTVLVLFVALKV.....TP..RSLVCAVRLDFTNYDLEPPSVTFVDPSTGTALPAKSL.GF.KMLR.....L.N..GLKEASPETVTTLAQQQRLSVQ.ELLQA..HSPDETPFLCLPGVREYHDHPAHTGDLWLLHRR.SGEGSLHFILEQIWASGINPI.........................
A0A849HL00_9MICO/127-180             ...........rgiir-----------------------------------..-------------.....--..-------------------------------------.--.----.....-.-..----------------------.----N..HPDYQRPFFCRRGLREYHSHPQHQDDPWDKHRE.---------------------elrldalvlellvdl..........
A0A4Y9NLP0_9BACI/72-164              .............vpe---QVTAAKLQAELCDWQANAEIYQRRGWVMLEHT..EQQVDIAFVASVPlvgvlAA..PVITACVRIDYTNYDLWPPSVTFIDPRTRQPAP----.--.----.....-.-..----------------------.-----..---------------------------------.---------------------pvvra....................
A0A439EZZ3_9BURK/7-183               ...............a-DPQVSRAKFDREIAEFRALGEHHRTRGWLLVHAE..YPTALVVLATPKT.....SP..STIVTGVSFDYSNYDSAPPSVRLVHPFSGEPYTLAQL.PT.QLNR.....AmP..TQPFAIPGQAAGQPQLLFQAQQ.PLMQA..HAPEDIPFLCLAGVREYHDHPAHSGDLWELHRA.SGAGRLVRLLEIISRYGVEPI.........................
A0A509EJX5_9HYPH/89-143              ..........sphpvt-----------------------------------..-------------.....--..-------------------------------------.--.----.....-.-..----------------------.-----..----GRMFVCMRGTREYHTHFSHVGERWDGYRG.QSGLDLLGILDQIWR------cwkra....................
A0A102DAQ9_9SPHN/5-177               ...............a-DPAVSRRKFDAEVGNLRANQAMMIDRGIWIMNAT..FPYVKVAFATVNM.....KP..RMIATTIKVDFTDYDARPLSVKFVDAFEDRELMFGEL.LT.NLPK.....R.A..PSP--MPQII-GPDGQPQIQLT.TLCQA..YGPDKPAFLCLPGVREYHDHPGHSGDAWELHRA.SGEGSLFSIIDVVWRYGSSPI.........................
A0A514WR66_9SPHN/4-180               ...............a-DPAVSRRKFDREVAQLHDLGSTLVARGMWVMQAE..FPVVKVAFATVNC.....RP..WTIPFAVRIDFTDYDVQPLAITFVEPFTDRELMPAEM.PT.K-LR.....R.-..AVPGGAMQQIEMNGQPVLMQMAmELYQHypQMPHVPGFLCLPGTRAYHAHPAHTGDPWEIHRA.VGEGKLFNLLETVWRYGTAPI.........................
A0A5C4NAM8_9RHOB/6-164               ................VDPAVSRTKFERELEQFRRLEAMHRQRGWWVMSAE..FPVVQIAFATPHC.....RP..VSIAVCARIDFTNYDLWAPSVMFVDPFTGQPLTLEQV.GV.PFGR.....-.-..ALPDG------------TVQ--.QMIQG..-HPGRPAFLCLPGVREYHEHPAHSGDSWLLHRG.KGEGGLYFLVDKISTYGSE--si.......................
K0Q5H1_9HYPH/7-182                   ................VDPEVSRVKFDREVARFRAYADAYWTQGCFLVEAS..FPSAFFIFASPKV.....KP..RAICAATNIDFTNYDLRPPSVVFVDPFTRQPVARKDL.QL.NMLR.....R.P..PLPGTPPEMIANLIQQNAVQLT.DFIQA..NSLQDPPFLCMAGVREYHDNPAHSGDPWLLHRG.SGEGCLAFILDKIIKYGIKPI.........................
#=GC seq_cons                        .................DPtVSRtKF-RElupa+shtp.aptpGhhLlcAp..aPpshhhFsssph.....pP...slssulplDFoNYDlpP.SVhFVDPFTcpPhhhtpl..h.ph.R.....p.....lsss.............h..t.phhQu..ps.cshPFLChsGVREYH-HPuHoGDsWhLHRu.uGEGsLhhlL-pIhpYGht...........................
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