#=GF ID MobC
#=GF AC PF05713.15
#=GF DE Bacterial mobilisation protein (MobC)
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_2832 (release 8.0)
#=GF GA 23.20 23.20;
#=GF TC 23.20 23.20;
#=GF NC 23.10 23.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF CL CL0057
#=GF RN [1]
#=GF RM 11976306
#=GF RT Characterization of two cryptic Helicobacter pylori plasmids: a
#=GF RT putative source for horizontal gene transfer and gene shuffling.
#=GF RA Hofreuter D, Haas R;
#=GF RL J Bacteriol 2002;184:2755-2766.
#=GF RN [2]
#=GF RM 9302013
#=GF RT The relaxosome protein MobC promotes conjugal plasmid
#=GF RT mobilization by extending DNA strand separation to the nick site
#=GF RT at the origin of transfer.
#=GF RA Zhang S, Meyer R;
#=GF RL Mol Microbiol 1997;25:509-516.
#=GF DR INTERPRO; IPR008687;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of several bacterial MobC-like,
#=GF CC mobilisation proteins. MobC proteins belong to the group of
#=GF CC relaxases. Together with MobA and MobB they bind to a single
#=GF CC cis-active site of a mobilising plasmid, the origin of transfer
#=GF CC (oriT) region [1]. The absence of MobC has several different
#=GF CC effects on oriT DNA. Site- and strand-specific nicking by MobA
#=GF CC protein is severely reduced, accounting for the lower frequency
#=GF CC of mobilisation. The localised DNA strand separation required
#=GF CC for this nicking is less affected, but becomes more sensitive to
#=GF CC the level of active DNA gyrase in the cell. In addition, strand
#=GF CC separation is not efficiently extended through the region
#=GF CC containing the nick site. These effects suggest a model in which
#=GF CC MobC acts as a molecular wedge for the relaxosome-induced
#=GF CC melting of oriT DNA. The effect of MobC on strand separation may
#=GF CC be partially complemented by the helical distortion induced by
#=GF CC supercoiling. However, MobC extends the melted region through
#=GF CC the nick site, thus providing the single-stranded substrate
#=GF CC required for cleavage by MobA [2].
#=GF SQ 2845
#=GS A0A519W7I4_9SPHI/40-66 AC A0A519W7I4.1
#=GS A0A4R1RJP8_9FLAO/66-110 AC A0A4R1RJP8.1
#=GS A0A1G4VNW8_9FIRM/55-97 AC A0A1G4VNW8.1
#=GS B9Y5U0_9FIRM/147-191 AC B9Y5U0.1
#=GS A0A1G6EFU7_9FIRM/54-102 AC A0A1G6EFU7.1
#=GS A0A252F7L5_9CLOT/59-102 AC A0A252F7L5.1
#=GS A0A0V8QI46_9FIRM/48-88 AC A0A0V8QI46.1
#=GS A0A1G6SMZ3_9BURK/119-167 AC A0A1G6SMZ3.1
#=GS A0A430ATB3_9ENTE/60-104 AC A0A430ATB3.1
#=GS A0A1Y3TJ77_9FIRM/69-107 AC A0A1Y3TJ77.1
#=GS A0A1Y4EZQ5_9FIRM/61-106 AC A0A1Y4EZQ5.1
#=GS A0A3E2XNE4_9FIRM/61-113 AC A0A3E2XNE4.1
#=GS A0A3A9D0B5_9BACT/57-98 AC A0A3A9D0B5.1
#=GS A0A285T831_9RHOB/114-140 AC A0A285T831.1
#=GS A0A6I5CCZ1_9ACTN/151-186 AC A0A6I5CCZ1.1
#=GS A0A3A9A2T1_9BACT/56-108 AC A0A3A9A2T1.1
#=GS A0A143X6M4_9FIRM/61-113 AC A0A143X6M4.1
#=GS A0A3A9EE82_9FIRM/57-101 AC A0A3A9EE82.1
#=GS A0A2V1HLF1_9MICO/98-141 AC A0A2V1HLF1.1
#=GS A0A6L9HK08_9CLOT/47-102 AC A0A6L9HK08.1
#=GS A0A4R4RZI6_9ACTN/110-152 AC A0A4R4RZI6.1
#=GS L0NNK4_9HYPH/72-121 AC L0NNK4.1
#=GS A0A3A9EEA1_9FIRM/47-102 AC A0A3A9EEA1.1
#=GS A0A1T5MA15_9BACT/72-120 AC A0A1T5MA15.1
#=GS R5A5Y5_9CLOT/57-101 AC R5A5Y5.1
#=GS A0A0B8SYW3_9SPHI/76-124 AC A0A0B8SYW3.1
#=GS A0A133Q7I5_9BACT/121-164 AC A0A133Q7I5.1
#=GS A0A4R5M5R8_9BURK/82-127 AC A0A4R5M5R8.1
#=GS A0A174DUH0_9FIRM/60-107 AC A0A174DUH0.1
#=GS U6RCT3_9BACT/75-115 AC U6RCT3.1
#=GS D4JXU9_9FIRM/60-103 AC D4JXU9.1
#=GS A0A4Q5MF52_9GAMM/113-149 AC A0A4Q5MF52.1
#=GS A0A4R3EMZ0_9HYPH/64-113 AC A0A4R3EMZ0.1
#=GS A0A1H9Y848_9FIRM/117-160 AC A0A1H9Y848.1
#=GS A0A4Q6IP10_9ACTN/108-157 AC A0A4Q6IP10.1
#=GS A0A373B4G4_9FIRM/59-111 AC A0A373B4G4.1
#=GS A0A1B1S8U9_9BACT/66-95 AC A0A1B1S8U9.1
#=GS A0A345QU65_9RHOB/26-72 AC A0A345QU65.1
#=GS A0A225NBU0_9RHOB/114-143 AC A0A225NBU0.1
#=GS N2AI72_9FIRM/59-104 AC N2AI72.1
#=GS M4S8V6_9SPHN/69-109 AC M4S8V6.1
#=GS A0A239DKN7_9SPHN/2-46 AC A0A239DKN7.1
#=GS A0A7K0FSX5_9SPHI/75-109 AC A0A7K0FSX5.1
#=GS R9LZN4_9FIRM/54-101 AC R9LZN4.1
#=GS A0A0N9HSZ9_9PSEU/96-138 AC A0A0N9HSZ9.1
#=GS A0A4U7J4D9_9FIRM/53-94 AC A0A4U7J4D9.1
#=GS A0A3R6KUG3_9FIRM/59-102 AC A0A3R6KUG3.1
#=GS A0A1I5JBP2_9BACT/72-115 AC A0A1I5JBP2.1
#=GS A0A519QAL2_9BACT/65-106 AC A0A519QAL2.1
#=GS A0A4Y8PZW4_9BACL/56-104 AC A0A4Y8PZW4.1
#=GS A0A1Y4BZA7_9FIRM/45-97 AC A0A1Y4BZA7.1
#=GS A0A5C4MHZ5_9RHOB/54-96 AC A0A5C4MHZ5.1
#=GS C6RGU8_9PROT/2-47 AC C6RGU8.1
#=GS A0A3M2SSY8_9EURO/119-172 AC A0A3M2SSY8.1
#=GS A0A1Y4UB28_9FIRM/64-110 AC A0A1Y4UB28.1
#=GS A0A7K0G504_9SPHI/68-106 AC A0A7K0G504.1
#=GS A0A1Y4ELR0_9FIRM/61-113 AC A0A1Y4ELR0.1
#=GS A0A2N4YB48_9RHOB/114-153 AC A0A2N4YB48.1
#=GS A0A124H5T9_9ACTN/133-176 AC A0A124H5T9.1
#=GS C6LDB3_9FIRM/61-106 AC C6LDB3.1
#=GS A0A1I2HG66_9RHOB/72-106 AC A0A1I2HG66.1
#=GS A0A7D4TMQ7_9SPHI/82-123 AC A0A7D4TMQ7.1
#=GS A0A3A9HRB5_9FIRM/60-105 AC A0A3A9HRB5.1
#=GS A0A7K1XSM3_9SPHI/77-118 AC A0A7K1XSM3.1
#=GS A0A1Y4C9X6_9FIRM/56-100 AC A0A1Y4C9X6.1
#=GS A0A127VF08_9SPHI/73-130 AC A0A127VF08.1
#=GS A0A368YJ37_9RHOB/113-155 AC A0A368YJ37.1
#=GS A0A285PED4_9HYPH/94-129 AC A0A285PED4.1
#=GS A0A1Y4SB05_9FIRM/51-104 AC A0A1Y4SB05.1
#=GS A0A2U2C920_9RHOB/41-90 AC A0A2U2C920.1
#=GS A0A1Y4EQF2_9FIRM/50-107 AC A0A1Y4EQF2.1
#=GS A0A0P1F850_9RHOB/99-147 AC A0A0P1F850.1
#=GS A0A1Q4ZF02_9ACTN/168-212 AC A0A1Q4ZF02.1
#=GS N9WB11_CLOIN/59-102 AC N9WB11.1
#=GS A0A255Z946_9PROT/59-103 AC A0A255Z946.1
#=GS A0A1I0M976_9FIRM/59-103 AC A0A1I0M976.1
#=GS I4EAW3_METSZ/68-115 AC I4EAW3.1
#=GS N1ZNV5_9FIRM/61-100 AC N1ZNV5.1
#=GS A0A2K4ZL75_9FIRM/56-99 AC A0A2K4ZL75.1
#=GS C5ETF0_9FIRM/60-104 AC C5ETF0.1
#=GS A0A0S2W774_9FIRM/59-102 AC A0A0S2W774.1
#=GS A0A495PTI8_9FLAO/108-150 AC A0A495PTI8.1
#=GS A0A6L9LY23_9DELT/62-105 AC A0A6L9LY23.1
#=GS G1WED3_9BACT/72-115 AC G1WED3.1
#=GS A0A223V3A6_9FLAO/66-109 AC A0A223V3A6.1
#=GS A0A391PB88_9FIRM/56-101 AC A0A391PB88.1
#=GS L0G3Z2_ECHVK/66-106 AC L0G3Z2.1
#=GS A0A1X7F701_CELCE/45-87 AC A0A1X7F701.1
#=GS A0A839QRV0_9MICC/110-151 AC A0A839QRV0.1
#=GS A0A1M6GUB0_9ACTO/60-103 AC A0A1M6GUB0.1
#=GS A0A364XZD7_9BACT/66-107 AC A0A364XZD7.1
#=GS A0A7W6GDL0_9HYPH/59-105 AC A0A7W6GDL0.1
#=GS R9JGV7_9FIRM/59-102 AC R9JGV7.1
#=GS A0A3A9EY67_9BACT/72-111 AC A0A3A9EY67.1
#=GS A0A3N2LW56_9BACT/73-114 AC A0A3N2LW56.1
#=GS A0A0B7H3E8_9FLAO/89-134 AC A0A0B7H3E8.1
#=GS A0A223V6C1_9FLAO/66-110 AC A0A223V6C1.1
#=GS A0A3A9CYY5_9BACT/60-100 AC A0A3A9CYY5.1
#=GS A0A7K3NHH4_9DELT/58-101 AC A0A7K3NHH4.1
#=GS A0A0K0Y141_9RHOB/90-135 AC A0A0K0Y141.1
#=GS A0A3E1NH41_9BACT/78-121 AC A0A3E1NH41.1
#=GS A0A256FR20_9HYPH/72-121 AC A0A256FR20.1
#=GS A0A345HRC2_9ACTN/153-200 AC A0A345HRC2.1
#=GS A0A7M2CBW6_9MICC/52-95 AC A0A7M2CBW6.1
#=GS G2H041_9ENTR/64-107 AC G2H041.1
#=GS A0A810Q2Z9_9FIRM/59-103 AC A0A810Q2Z9.1
#=GS A0A563W3G7_9CYAN/60-103 AC A0A563W3G7.1
#=GS A0A4Y7R9I2_9FIRM/61-111 AC A0A4Y7R9I2.1
#=GS A0A365ZU67_9ACTN/150-194 AC A0A365ZU67.1
#=GS A0A4D7C802_9SPHN/34-78 AC A0A4D7C802.1
#=GS A0A391PCU1_9FIRM/56-101 AC A0A391PCU1.1
#=GS L2F4Z0_9GAMM/66-115 AC L2F4Z0.1
#=GS U2RWZ6_LEIAQ/87-129 AC U2RWZ6.1
#=GS R5AAA0_9CLOT/60-104 AC R5AAA0.1
#=GS A0A4Q9HSM6_STRKA/130-176 AC A0A4Q9HSM6.1
#=GS C7H6Y5_FAEPA/54-95 AC C7H6Y5.1
#=GS A0A1I3SUH8_9HYPH/68-110 AC A0A1I3SUH8.1
#=GS A0A1H4HLC4_9SPHI/78-120 AC A0A1H4HLC4.1
#=GS A0A6H0CP03_9ACTN/115-161 AC A0A6H0CP03.1
#=GS A0A2K8P8J7_STRLA/100-149 AC A0A2K8P8J7.1
#=GS G2SYF6_ROSHA/64-104 AC G2SYF6.1
#=GS A0A1H6UZC0_9LACT/65-109 AC A0A1H6UZC0.1
#=GS A0A7H8J1G3_9ACTN/135-184 AC A0A7H8J1G3.1
#=GS A0A3A5MY28_9MICO/80-123 AC A0A3A5MY28.1
#=GS A0A2H5F5F3_9RHOB/113-160 AC A0A2H5F5F3.1
#=GS A0A1M7JDX2_9BACT/23-52 AC A0A1M7JDX2.1
#=GS A0A173XRH4_9FIRM/85-123 AC A0A173XRH4.1
#=GS R6RGE7_9FIRM/48-92 AC R6RGE7.1
#=GS A0A0M2NES9_9FIRM/71-112 AC A0A0M2NES9.1
#=GS A0A1Y4WH26_9FIRM/56-100 AC A0A1Y4WH26.1
#=GS A0A3L8PZ14_9GAMM/111-151 AC A0A3L8PZ14.1
#=GS A0A3A9F641_9BACT/60-105 AC A0A3A9F641.1
#=GS V2YAL0_9FIRM/61-106 AC V2YAL0.1
#=GS A0A2T1LR70_9CHRO/58-101 AC A0A2T1LR70.1
#=GS D4M0A7_9FIRM/56-90 AC D4M0A7.1
#=GS A0A372STB2_9FIRM/57-99 AC A0A372STB2.1
#=GS A0A7X3MFE1_9FIRM/61-113 AC A0A7X3MFE1.1
#=GS A0A7W7Z5T1_9BRAD/71-112 AC A0A7W7Z5T1.1
#=GS A0A1R4F6M7_9MICO/65-109 AC A0A1R4F6M7.1
#=GS A0A1Y4HBZ0_9FIRM/52-104 AC A0A1Y4HBZ0.1
#=GS G5GKM9_9FIRM/61-104 AC G5GKM9.1
#=GS R5VCH3_9FIRM/56-100 AC R5VCH3.1
#=GS H8XSU6_FLAIG/65-106 AC H8XSU6.1
#=GS R9LU97_9FIRM/54-105 AC R9LU97.1
#=GS A0A1D9MFK8_9RHOB/114-143 AC A0A1D9MFK8.1
#=GS A0A1T4K3E2_9FIRM/53-96 AC A0A1T4K3E2.1
#=GS D9W1D3_9ACTN/185-231 AC D9W1D3.1
#=GS E0R995_9ENTR/172-212 AC E0R995.1
#=GS A0A1B1BQM9_9MICO/80-124 AC A0A1B1BQM9.1
#=GS A0A231GUG0_9NOCA/109-152 AC A0A231GUG0.1
#=GS A0A059W9L2_STRA9/147-191 AC A0A059W9L2.1
#=GS J6HFI4_9FIRM/63-104 AC J6HFI4.1
#=GS A0A2G8T9C0_9BURK/70-114 AC A0A2G8T9C0.1
#=GS K9VBA9_9CYAN/68-115 AC K9VBA9.1
#=GS A0A367GGB5_9FIRM/59-104 AC A0A367GGB5.1
#=GS D4M3I9_9FIRM/54-106 AC D4M3I9.1
#=GS A0A2A2GW64_9GAMM/64-105 AC A0A2A2GW64.1
#=GS A0A7W9FGE7_9CAUL/111-151 AC A0A7W9FGE7.1
#=GS A0A5R9LW09_9ACTN/154-197 AC A0A5R9LW09.1
#=GS A0A511B562_9PROT/69-114 AC A0A511B562.1
#=GS A0A1Y3U8Y4_9ACTN/62-110 AC A0A1Y3U8Y4.1
#=GS A0A0D1LW28_9LACO/64-105 AC A0A0D1LW28.1
#=GS A0A3L8A283_9BACT/73-114 AC A0A3L8A283.1
#=GS A0A2A4FQM7_9SPHN/116-154 AC A0A2A4FQM7.1
#=GS A0A3A5MIP5_9MICO/96-140 AC A0A3A5MIP5.1
#=GS A0A7M2T561_STRCW/160-206 AC A0A7M2T561.1
#=GS A0A3A9BZY5_9BACT/61-113 AC A0A3A9BZY5.1
#=GS A0A1I0MYI1_9FIRM/58-101 AC A0A1I0MYI1.1
#=GS R9IFY7_9FIRM/61-100 AC R9IFY7.1
#=GS A0A5N7MLB7_9HYPH/31-72 AC A0A5N7MLB7.1
#=GS G8T8Y3_NIAKG/69-122 AC G8T8Y3.1
#=GS A0A1S2PCY7_9ACTN/115-157 AC A0A1S2PCY7.1
#=GS A0A7W5VKM0_9ACTN/76-122 AC A0A7W5VKM0.1
#=GS S0IPR1_9FIRM/60-100 AC S0IPR1.1
#=GS A0A416EMR0_9FIRM/59-102 AC A0A416EMR0.1
#=GS A0A1V4ACE6_9ACTN/93-142 AC A0A1V4ACE6.1
#=GS C4Z3W3_LACE2/66-108 AC C4Z3W3.1
#=GS C7H1E4_FAEPA/47-102 AC C7H1E4.1
#=GS F9MMX2_9FIRM/35-78 AC F9MMX2.1
#=GS A0A4D7AM48_9FIRM/58-102 AC A0A4D7AM48.1
#=GS A0A2T7QBI4_9BACT/72-104 AC A0A2T7QBI4.1
#=GS A0A417N855_9FIRM/55-104 AC A0A417N855.1
#=GS A0A0F5R9H8_9BACL/56-104 AC A0A0F5R9H8.1
#=GS A0A4Y9HEU4_9BACL/60-103 AC A0A4Y9HEU4.1
#=GS A0A1Y4S2H2_9FIRM/59-99 AC A0A1Y4S2H2.1
#=GS A0A4R1YWC5_9RHOB/114-141 AC A0A4R1YWC5.1
#=GS A0A347UG29_9RHOB/96-140 AC A0A347UG29.1
#=GS A0A7X3MFZ3_9FIRM/61-106 AC A0A7X3MFZ3.1
#=GS A0A2A2S8Q3_9SPHI/74-113 AC A0A2A2S8Q3.1
#=GS W0EV40_9BACT/73-113 AC W0EV40.1
#=GS A0A5D6UQ49_9BACT/113-156 AC A0A5D6UQ49.1
#=GS A0A1Y4H316_9FIRM/47-97 AC A0A1Y4H316.1
#=GS E6JZP9_PARDN/66-110 AC E6JZP9.1
#=GS A0A1G6E8Z2_9FIRM/54-101 AC A0A1G6E8Z2.1
#=GS A0A8J6MFL7_9FIRM/76-120 AC A0A8J6MFL7.1
#=GS A0A4Y8S400_9SPHI/78-120 AC A0A4Y8S400.1
#=GS A0A2K4ZR31_9FIRM/61-113 AC A0A2K4ZR31.1
#=GS A0A4D7B1P9_9FIRM/60-103 AC A0A4D7B1P9.1
#=GS A0A3A9CA02_9BACT/59-102 AC A0A3A9CA02.1
#=GS A0A2W7NHT6_9BACT/42-83 AC A0A2W7NHT6.1
#=GS A0A1D7XNX2_9CLOT/55-100 AC A0A1D7XNX2.2
#=GS A0A6N8I386_9FIRM/53-90 AC A0A6N8I386.1
#=GS A0A139NGJ7_9STRE/58-105 AC A0A139NGJ7.1
#=GS A0A416BPP8_9FIRM/60-103 AC A0A416BPP8.1
#=GS A0A1Y3Y174_9FIRM/69-117 AC A0A1Y3Y174.1
#=GS A0A3E2N6I7_9CLOT/69-104 AC A0A3E2N6I7.1
#=GS D1VV32_9FIRM/61-104 AC D1VV32.1
#=GS A0A6S6R1M5_9FIRM/66-111 AC A0A6S6R1M5.1
#=GS A0A4U8UIR4_9HELI/68-112 AC A0A4U8UIR4.1
#=GS A0A140L9B3_9CLOT/56-100 AC A0A140L9B3.1
#=GS A0A7X4K9J5_9SPHN/64-106 AC A0A7X4K9J5.1
#=GS A0A3A8ZXU4_9BACT/59-102 AC A0A3A8ZXU4.1
#=GS A0A1Y5KAQ0_9BACL/56-104 AC A0A1Y5KAQ0.1
#=GS E3GME8_9FIRM/65-109 AC E3GME8.1
#=GS F0YZ59_9CLOT/54-110 AC F0YZ59.1
#=GS C4ZEP1_AGARV/59-112 AC C4ZEP1.1
#=GS A0A495IV44_9SPHI/72-114 AC A0A495IV44.1
#=GS A0A4Y8WNS2_9PORP/76-126 AC A0A4Y8WNS2.1
#=GS A0A6I0FEJ8_9CLOT/56-100 AC A0A6I0FEJ8.1
#=GS H0I178_9HYPH/56-97 AC H0I178.1
#=GS A0A1M6WMD9_9FIRM/59-102 AC A0A1M6WMD9.1
#=GS N2AU80_9FIRM/69-102 AC N2AU80.1
#=GS R6M7A1_9FIRM/55-99 AC R6M7A1.1
#=GS A0A2M9HQA8_9BIFI/72-116 AC A0A2M9HQA8.1
#=GS A0A1M4X8C7_9CLOT/54-104 AC A0A1M4X8C7.1
#=GS F7K2F9_9FIRM/61-106 AC F7K2F9.1
#=GS A0A413FVN3_9FIRM/61-113 AC A0A413FVN3.1
#=GS A0A6N4TI26_9FIRM/56-100 AC A0A6N4TI26.1
#=GS A0A6G8BTS3_9BURK/86-130 AC A0A6G8BTS3.1
#=GS D4MPJ5_9FIRM/57-102 AC D4MPJ5.1
#=GS A0A495J490_9SPHI/81-123 AC A0A495J490.1
#=GS S0JGK8_9FIRM/59-102 AC S0JGK8.1
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