#=GF ID   Msap1
#=GF AC   PF17077.9
#=GF DE   Mitotic spindle associated protein SHE1
#=GF AU   Llagostera M;0000-0001-8177-8321
#=GF AU   Mitchell A;0000-0001-8655-7966
#=GF SE   Manual
#=GF GA   27.00 27.00;
#=GF TC   31.30 31.30;
#=GF NC   25.50 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   23142046
#=GF RT   She1-mediated inhibition of dynein motility along astral
#=GF RT   microtubules promotes polarized spindle movements.
#=GF RA   Markus SM, Kalutkiewicz KA, Lee WL;
#=GF RL   Curr Biol. 2012;22:2221-2230.
#=GF DR   INTERPRO; IPR031401;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   She1 seems to be related to the spindle integrity function of
#=GF CC   the Dam1 complex. She1 is a dynein regulator and limits dynein
#=GF CC   offloading by gating the recruitment of dynactin to the astral
#=GF CC   microtubule plus end. Aurora B phosphorylates She1, modulating
#=GF CC   its potency against dynein [1].
#=GF SQ   21
#=GS C5DIR1_LACTC/10-357      AC C5DIR1.1
#=GS J4U2I2_SACK1/29-332      AC J4U2I2.1
#=GS A0A4C2E2W5_9SACH/2-271   AC A0A4C2E2W5.1
#=GS G0W4F8_NAUDC/40-355      AC G0W4F8.1
#=GS SHE1_CANGA/102-282       AC Q6FUD9.1
#=GS SHE1_YEAST/30-334        AC P38200.1
#=GS SHE1_KLULA/1-331         AC Q6CNI5.1
#=GS J7RPB1_KAZNA/18-313      AC J7RPB1.1
#=GS SHE1_CANGA/1-103         AC Q6FUD9.1
#=GS H2AYX1_KAZAF/24-316      AC H2AYX1.1
#=GS Q756R9_ASHGO/17-402      AC Q756R9.2
#=GS A0A1S7HYI5_9SACH/2-289   AC A0A1S7HYI5.1
#=GS A0A0C7NDQ1_9SACH/1-300   AC A0A0C7NDQ1.1
#=GS A0A1G4J466_9SACH/2-297   AC A0A1G4J466.1
#=GS G0V849_NAUCC/25-353      AC G0V849.1
#=GS J8PRA3_SACAR/29-339      AC J8PRA3.1
#=GS A0A1S7HLD2_9SACH/2-200   AC A0A1S7HLD2.1
#=GS G8BNH7_TETPH/84-323      AC G8BNH7.1
#=GS A0A1G4MIU1_LACFM/1-342   AC A0A1G4MIU1.1
#=GS A0A0H5C3X0_CYBJN/45-157  AC A0A0H5C3X0.1
#=GS G8JWP7_ERECY/25-331      AC G8JWP7.1
C5DIR1_LACTC/10-357                 ....................................sdagmeyh------------DQVIDNLGVSKRLGNSVLSELDLRATDKAS-------SLGPRF.EDAQPH---------TA.ACDR..FEIMHQTEFGAMQSI.GSH..YAAH...........KYPVAE-.-.--.T.....SGISQGATDEGGS...AGEDEIpgtpkrAP...EQN..LQS.......SN...KrlrdrN...GKSRESD..S......FVF.....S...PVSDITRRIRRLRVRNQTPRENRSN.VNRVRNTP....L......SG--..----VPPP-.-........KISF.........D..RQ.QATFAKPTFTSINRETRPGAiF....SKLKK...P..DSKPN..KFAPPstPS..PAPPLP---.---QLSSRSA.ELLRAKDST....KIKDKA...........TKNSP.....ST.AHNSVFQRLYEQTT....ISRSNSSNTI...ATQKKTIR..KS.......QT.MK.NLR--------------------------------------qesrqdtsptptpvtssvtrskssytlstrdksnekiprststs.............................................................................
J4U2I2_SACK1/29-332                 ......................................dfhsnn-----------NSNIIETIGVSKRLGNSVLSELDSRATSKFEFLQGQ---NQQQH.NSSESG---ELNSDSYD.INEF..FQTEHDSQFSQMESL.DAH..YTLL...........----HTP.K.RK.S.....QHATQQ-------...----DR......SE...SLK..RS-.......--...-.....-...-RPSRSI..S......YTT.....P...AVNDITRRIRRLKLRNSLVNGNDIV.ARARFMQA....N......SNVN..-SIKNTPLS.K........PKPF.........M..-Q.KPNFLTPTTNSLNKVN---S.T....HRN-A...S..SSSSV..PVIPK..PK..V--PKST-S.IR-DLHTRIK.PTERTPLAP....-----G...........TNSQL.....KK.SVS-VFDRLYKQTT....FSRSTSMKNL...SSGVSAKS..KE......hTN.TKtRMVKSKTSGSLSSHLKQ------------------------nadantkn.................................................................................................................
A0A4C2E2W5_9SACH/2-271              .......................................qndid--------------AIGKFGVTKRIGSSVLDELDERAGEKFSELKPGDV----NG.SDTNNE--R-----YRE.LSRH..FQNVHESQFNRMPSL.ESH..YVNA...........-------.-.--.-.....-SLPQTP-KRHVE...NNDNG-......--...---..---.......-F...S.....N...PKKLKIP..V......PSS.....P...PVHDITKRIRRLRIRNSLTGGNSNQ.SRTPSQAA....-......----..--LKSTPLT.K........QRPM.........-..-E.PPRFLRPTVNSLNKNV--DT.P....-SIVG...N..RE-SR..DDVKR..TT..KAIPKSH--.----------.-LNQPQPTP....----QR...........EKKQM.....PR.SQS-VFERLYSQTT....VARSCSMGNV...S-------..--.......--.--.-----------------------------------------vkshahdvpsrsrerdnsagnnnnnnnssgyt.........................................................................................
G0W4F8_NAUDC/40-355                 .....................................qqaqhhq-----------NSNIIDTIGVSKTLGNKVFDELDSRTTLKFQ-------QLREQH.NDNNNN-DDSNDLTSSN.FEEF..FKSKHNIQFNNMQSLqDYKylYNIN...........INEQRQQ.A.EQ.Q.....QVLPRTPKKQSIDtiiSHNDEN......N-...NNN..LESlkrfktnDS...T.....F...RTKRRSI..V......PTA.....T...PVSDITRRIRRLRLRTSIANKKDVS.NNDALYSImntpL......SNAKplQMSSSIPQPpP........NVNV.........P..QH.EPTFLKPTINFLNKMKRSEP.I....FKNLN...T..H----..-----..--..---------.----------.---------....------...........-----.....--.--------------....----------...--------..--.......--.--.-----------------------------------------iksknpsinsgfsnvrfssapivasssstssssnsrpavpdnthtsrtsfrppklkqlqrtvphsasnsilrtk...............................................
SHE1_CANGA/102-282                  ...........................................p-------------------------------------------------------.-----------------.----..---------------.---..----...........-------.-.--.-.....-------------...------......--...---..---.......--...-.....-...-------..-......---.....-...EVNEITKKIRRLKLRSSSNLSSSGG.SPEKRTTN....A......SNVE..QKTELAPL-.-........----.........-..-K.TPNFLRPTFNSMNRAK--DT.S....HKVES...S..RRTYG..NLLPP..TS..RAIPAVKEA.VRQDYTKRSI.SIQLPRKSP....APPKIP...........EQRSI.....SD.SSSNVFERLYKQTT....MSRSNSMA--...FDQQ----..--.......-N.RK.QLPKSRT---------------ITGLSSVVGDKHRTFPSKH.........................................................................................................................
SHE1_YEAST/30-334                   .......................................fhsnn-----------NSNIIETIGVSKRLGNSVLSELDSRASSKFEFLKDQSE--QQYN.GDKNNE----PKSGSYN.INEF..FQAKHDSQFGQMESL.DTH..YTLL...........HTPKRKS.-.--.-.....--QHAIPQ---DR...SDSMKR......S-...---..---.......--...-.....-...-RPSRSI..P......YTT.....P...VVNDITRRIRRLKLRNSLVNGNDIV.ARARSMQA....N......SNI-..NSIKNTPLS.K........PKPF.........M..-H.KPNFLMPTTNSLNKIN---S.A....HRNTS...S..SST-A..SSIPR..SK..V----HRSIsIR-DLHAKTK.PVER---TP....--VAQG...........TNSQL.....KN.SVS-VFDRLYKQTT....FSRSTSMNNL...SSGTSAKS..KE......hTNvKT.RLVKSKTSGSLSSNLKQSTAT--------------------gtksdr...................................................................................................................
SHE1_KLULA/1-331                    ............................................MDKENMPPLLDGHQMIEYIGVSKRLGNNVLQELEQRASNLLPNVSPEKTRLMHLG.HDSEMK---------NS.ISMK..FQDKHEKRFQVMDSI.DTH..YSLA...........-------.-.-K.Y.....SGMPQTPGKRKNG...SDADET......SV...AVN..LGS.......PG...S.....V...KKKQKSV..G......NVF.....S...PVTDITHRIRRLRVRITTPNERERT.ERDRRRNI....I......SN--..-----TPLS.R........QRQL.........H..ES.IPTFAQPTATSLKRKQMNNP.L....HKLVA...S..DNNNV..ESQPK..PK..PAKPRHGDI.FR-NLNQSEK.QASHPRSAP....----VP...........KQQRI.....PQ.SKS-VFERLYEQST....ISRSNSSKNL...LKQEKTTS..SD.......GN.TS.QIPRSKTQHDLHGGMKNARLTKSTTLQNVALDR----PQWR.........................................................................................................................
J7RPB1_KAZNA/18-313                 ........................................revn---------ADGTTLIEHTGASRKLGSSVLNELDSRTNAKFQ--------QLRTQ.S-TPLE----SGEGP-T.FSSY..FNIQHNAQFEKMDSV.NSH..YSIH...........---QFTK.E.NL.P.....TRAPKTP-KTKNI...KTEQLT......SD...SI-..---.......--...-.....-...-KRLKSN..P......NVY.....GtppPISEITRRIRRLRIRNSLTGTPESS.RRNSSPKK....T......SD--..--VKRTPIT.K........Q--E.........P..MK.PPSFLQPTKNSLNKIK---R.S....PQVSS...G..LNNR-..--LNP..TT..NVPPLGKPA.FASKLSKPPT.TASSRLPGP....-----S...........KSATL.....AT.SPDSVFDRLYKTST....MSRSNSMNNV...NGNTKTK-..--.......--.--.-----------------------------------------ihfsrsktssslakngeqsnvptk.................................................................................................
SHE1_CANGA/1-103                    ............................................MN-EN-----DSNEIIEQLGISKRLGNSILDELNQRASETNP--------LLRKH.EDTDNEEERPAESTPTA.HNLV..FNKVHNLNFENLTDK.DPD..FTIH...........NDPLHKK.K.YK.Y.....SPIKRVP------...------......--...---..---.......--...-.....-...-------..-......---.....-...-------------------------.--------....-......----..---------.-........----.........-..--.--------------------.-....-----...-..-----..-----..--..---------.----------.---------....------...........-----.....--.--------------....----------...--------..--.......--.--.-----------------------------------------e........................................................................................................................
H2AYX1_KAZAF/24-316                 ....................................lneesvts----------TSETLIDNLGVSKKLGNSVLNELDSRTTEKLDELKETHTTLAP-K.EDTNE----------TS.FEQY..FGIKHNLQFNRMDSI.GHH..YMNN...........-------.-.--.-.....--IPKTP-TKKNL...TDQQLQ......SE...SIK..R--.......--...-.....Q...RVEQNSM..V......-KN.....T...PVTEITRRIRRLRIRNSIANNNNS-.NGNSNINS....V......RN--..-----TPLS.K........PKPM.........-..-Q.PPSFLRPTLNSLNKIK----.-....---ES...S..RSTST..FDLSR..--..-QKSTTTKT.LNTNSKSKPA.TTTTYRSTS....---GLP...........KS---.....--.SSVAVFDRLYKQST....VSRLTSMNNL...NDNIKTNA..KSvipppttRS.KI.QFGRSKTSSSLSSNLKD------------------------sssssr...................................................................................................................
Q756R9_ASHGO/17-402                 ........................................rsrd--------LEDTEQLIDDIGVSKRLGNSVLSELDHRATNLLANLTTSTLSAASTL.TDPELC----DEAAHKG.VS-R..FETVHGELIESMDSI.DTH..YAVK...........------R.N.RH.G.....LNVPATP-KRYSI...QDAMSS......VS...AAR..ETD.......RA...E.....LlyhKRARDAM..G......NIVerlttS...PVTDITRRIRRLRMNMSTPREHHREqERQRRRSS....IirqsltGN-S..DKENHVPRS.KgfanlygeMRAVsssaisvaaH..ESgAPTFAKPTITSRQKTV--NT.LlrnpHDATSffaSfrRRSPI..SSSPT..PSfqHRQPSPIPT.PRQQLSVPD-.RASPARTSP....TVASVPtsskfrplltlNSQNI.....STtSSSTSPDCEAHKPR....VVASKSVFDR...LYHQPTTA..AQ.......QK.TL.GIRKSKTQGDLHYI---------------------------skppkssyass..............................................................................................................
A0A1S7HYI5_9SACH/2-289              ........................................hqdm-------------DVLGRVGTSKRIGSSVLHELDSRAGEKLG--------ELK--.------TNQGSLPTPTAtLAQQ..FQDAHTSQFNKMDSL.DSH..YA--...........-------.-.--.-.....-CIPHTP-KRHSE...TEAGRL......DS...YHN..NNI.......NG...N.....T...NKKLKI-..-......PLS.....P...PVNEITRRIRRLRLRGSLTGG-NGN.SNQSRTPS....Q......AAV-..---KNTTLT.K........QRPM.........-..-D.PPRFLRPTINSLNKHK----.-....-EVKD...H..DKPRT..NLHSG..--..----ASAS-.------ASGN.SCSGTAATP....APSK-P...........K-SSI.....PR.SQS-VFQRLYTQTT....ISRSCSMGNV...SVKGH-PA..SQ.......PV.AS.Q----------------------------------------hlaskssastgqrglsnghaqhttasnhghiqr........................................................................................
A0A0C7NDQ1_9SACH/1-300              .....................................mnaemgy-----------HNQVISDLGVSQRLGNSVLSELDYRANFKACN------SISKIH.NSGEHDEHRGR------.--DR..FQSTHRINFDTMDSI.DDH..YAAKkastndttlqpNDPNSTDlN.FKeN.....VAVPATP---KRE...SDGVTQ......NS...SKR..MRD.......L-...-.....D...GRRRDSD..V......FVH.....S...PVSDITRRIRRLRVRNNSQTPRN--.-NQAKINS....V......RN--..--TPLNPI-.-........NRPS.........F..ES.HATFAKPTFTSISRET--KP.G....-----...-..--AIF..SKLKK..PD..NANKSV-SS.FRKGATTNQP.TLSQPHPSP....--PVV-...........-----.....-A.PSS-VFRRLYEQST....VSRSNSSQTL...SNAGA---..--.......--.--.-----------------------------------------tkgpavppkktstirasqtmrnlr.................................................................................................
A0A1G4J466_9SACH/2-297              .........................................ayh------------DQVIDELGVSKILGHSVLTELDLRATNKAT----------NLG.VDASPK----VGGFSGL.EANR..YESTHTNDFQRMESI.QSH..YAAQ...........KTPVAYP.QpGK.P.....AAGTSV--GEPTM...VDTLET......PK...RVH..EGS.......SK...S.....T...SKRRRDLngGardndsAVY.....S...PVSDVTRRIRRLRVRSQQQTPREN-.--QAKINA....V......RN--..-----TPLS.Gp.....ppSQLV.........FdgKP.QATFAKPTFTSINRES--KP.G....--AIF...S..RLKKT..EESDK..TR..--------A.FR-RGTARNQ.LLQNAASAT....------...........-QSTT.....NM.APSSVFQRLYTQST....ISRSNSSNTIshtLDSQKLIP..--.......NS.KA.TLPKKRT----------------------------------syrn.....................................................................................................................
G0V849_NAUCC/25-353                 ..............................tnnnnmtfhnfnst-----------PNEIINTLGVSKRMGNKVLNELDSRTHQKFE--------QLKDN.DDTNATHE---SSSSSS.FQQL..FNTKHNVQFNHMQSI.GNQ..PTTP...........------K.K.NI.H.....SY---TP---DNG...NIHDNTv....sES...MKR..MKT.......ND...S....qS...RIKRRSI..T......P-A.....T...PVSEITRRIRRLRLRASIAPKVDDS.I--TSSTS....I......RN--..-----TPLT.G........GNPI........tM..MN.PPTFLKPTINSLNKRTI-KR.S....EPIHS...N..LNR--..--NVT..TS..DASNIRQER.TRRDNSKQET.TVVVNSNVK....--PRT-...........SQLKK.....ST.TMS-VFDRLYSTATpktsISRSTSMNTI...QSGE-PSS..SN.......VH.-S.RRVHSD-----------------------------------tantitdksmshnastskikfgrsktsgsls..........................................................................................
J8PRA3_SACAR/29-339                 ......................................dfhsnn-----------NSNIIETIGVSKRLGNSVLSELDSRATSKFE--------FLQDQ.TQQQHNGTRNSESGPDS.YNINefFQAQHDSQFGQMESL.DTH..FTLL...........HTP----.-.-K.R.....RSQRVVPQDRSE-...------......--...SLK..RS-.......--...-.....-...-RPSRSI..P......YTT.....P...VVNDITRRIRRLKLRNSLVNGNDIA.ARARSMQA....N......SNVN..-SIKNTPLS.K........PKPF.........M..P-.KPNFLMPTTNSLNKIN---S.A....HRNAS...S..SS---..-SASA..TS..RSKLPKSTP.IR-DLHARTKpPERTPRTSL....APG---...........TNTQL.....KN.SVS-VFDRLYKQKT....FSRSTSMNNL...SSDAAAKSkeSI.......NA.KT.RMVKSKTSGSLSSHLKQNSATNNT-----------------kndrp....................................................................................................................
A0A1S7HLD2_9SACH/2-200              ........................................hqdm-------------DVLGRVGTSKRIGSSVLHELDSRAGEKLG--------ELK--.------TNQGSLPTPTAtLAQQ..FQDAHMSQFNKMDSL.DSH..YACV...........-------.-.--.-.....---PHTP-KRHSE...MEAERL......EA...SHN..NNI.......NS...N.....T...NKKLKI-..-......PLS.....P...PVNEITRRIRRLRLRGSLTGG-NGN.SNQSRTPS....Q......AAV-..---KNTTLT.K........QRPM.........-..-D.PPRFLRPTINSLNKHKEV--.-....-----...-..-----..-----..--..---------.----------.---------....------...........-----.....--.--------------....----------...--------..--.......--.--.-----------------------------------------kdhdkpranlhssasasasans...................................................................................................
G8BNH7_TETPH/84-323                 smefpvtpkklrlspikdldltikrlkandsasvpmpapptssp-------------------------------------------------------.-----------------.----..---------------.---..----...........-------.-.--.-.....-------------...------......--...---..---.......--...-.....-...-------..-......---.....-...AVNDITRRIRRLRLKAAMVNTSSHN.TNIKNLNN....S......ESVI..NK----KLS.N........QQPL.........-..-K.TPNFLKSTINSSNKRIM-NT.V....KQNTS...S..NRTPTlfNSNNT..NE..FGRSSSRMD.VR--VNNTSK.VIPTPSKPSnnahSVNNTN...........KSASIksqvtRS.SSTQVFDRLYHQSS....VSRSISMNNV...AVENGNCK..PP.......GT.KR.SMTRSKTSNMLS-----------------------------shisestnk................................................................................................................
A0A1G4MIU1_LACFM/1-342              ........................................mahn------------DRLIDTLGVSRRLGRSVLSELDSRANEKAA-------QLDTVL.DDVDQL--------TEN.TSHR..FNSLHQTRFNAMDSI.ESH..YAAK...........-KSFHFE.N.DG.FndgstSRSSRTS-QQSDS...NSNDEP......STpkrHANedITSst..kryKD...S.....Q...RRARKSD..A......FLY.....S...PVTDITKKIRRLRMISQAPRENQSK.MNAIRNTP....L......TRHD..PSYLSATGY.I........PSDF.........N..KS.QPTFAKPTFTSIKRES--KP.G....--AIF...S..NLKKK..GSIPR..TH..IKSVGTKPP.APLKTTSTIS.KVEGPSSD-....------...........-RPAL.....TS.STS-VFERLYQQST....ISRSNSSNKL...PPV-----..--.......--.KR.SLPKSQT-------MKNVR----------------------ssaimeatpaatsslprskssanlslqsqsdtlsaks....................................................................................
A0A0H5C3X0_CYBJN/45-157             ................................dqlmpqvssslq-------------EQCSQLGYSKKLSNNVLQELDQRAATMHP-------RRSHIG.K---GN----GGSTLSP.RNSR..FTSLHRQKFNKLESI.SSH..YSTM...........-------.-.--.-.....-------------...------......--...---..---.......--...-.....-...-------..-......---.....-...-------------------------.--------....-......----..---------.-........----.........-..--.--------------------.-....-----...-..-----..-----..--..---------.----------.---------....------...........-----.....--.--------------....----------...--------..--.......--.--.-----------------------------------------rtreeielekenvpsydpfskrtgsstles...........................................................................................
G8JWP7_ERECY/25-331                 .......................................lqqqn--------LDEKQQLIDNIGVSRRLGNSVLNELDHRATNLLANLTSSTVSTVSTAsTLTDPEQEQDN-ETQKN.HASR..FESVHGELIQNMDSI.DTH..YAVK...........------R.N.RQ.G.....LNVPATP-KRYSI...QDAMTA......VP...LTR..ETD.......RGellY.....N...KRARDAM..G......NIVerlttS...PVTDITRRIRRLRMNMSTPREHHRErERQRRRSS....I......I---..---------.-........----.........-..--.--------------------.-....-----...-..-----..-----..--..---------.----------.---------....------...........-----.....--.--------------....----------...--------..--.......--.--.-----------------------------------------rqsltggsdkenllprkkgfanlygelravsssaitssiqgpggpafakptitsrqktvnpllrsqhdaasifpqirkkasplaasssssslsfqhhrqsspiptpkqqftvfthrspvtg
#=GC seq_cons                       ........................................pptp............pplI-plGVSKRLGNSVLsELDpRAspKhs..........p.t.pssp.p.........ps.hsph..FpshHpppFspM-Sl.-oH..Yshh................................hstsP.tp.s....tpt.p.......s.....hp...t........................+tpcu...s.......hh.....s...PVsDITRRIRRLRlRsShsstpptt.tpppphss...........ps.........sPlo.t.........psh.............p..PsFh+PThsSlN+hp...s..........s...s..ppt.......st..sp...............t.ptp....hptst.ss.....................pp.ph......p.o.o.VFcRLYpQoT....hSRSsS.tsl....st......................t........................................pptpt.t..................................................................................................................
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