#=GF ID MtrD
#=GF AC PF04207.16
#=GF DE Tetrahydromethanopterin S-methyltransferase, subunit D
#=GF AU TIGRFAMs;
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE TIGRFAMs (release 2.0);
#=GF GA 25.00 25.00;
#=GF TC 185.50 68.50;
#=GF NC 23.50 20.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 9559648
#=GF RT Cloning, sequencing and expression of the genes encoding the
#=GF RT sodium translocating N5-methyltetrahydromethanopterin : coenzyme
#=GF RT M methyltransferase of the methylotrophic archaeon
#=GF RT Methanosarcina mazei Go1.
#=GF RA Lienard T, Gottschalk G;
#=GF RL FEBS Lett 1998;425:204-208.
#=GF DR INTERPRO; IPR005779;
#=GF DR TC; 3.C.1;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86)
#=GF CC of Methanosarcina mazei Go1 is a membrane-associated,
#=GF CC corrinoid-containing protein that uses a transmethylation
#=GF CC reaction to drive an energy-conserving sodium ion pump [1].
#=GF SQ 63
#=GS A0A166CF81_9EURY/6-227 AC A0A166CF81.1
#=GS A0A166A6W3_9EURY/3-224 AC A0A166A6W3.1
#=GS A0A0X3BNQ3_9EURY/25-252 AC A0A0X3BNQ3.1
#=GS F0T8R5_METLA/3-227 AC F0T8R5.1
#=GS F7XQ91_METZD/11-225 AC F7XQ91.1
#=GS I7J9J2_METBM/43-266 AC I7J9J2.1
#=GS MTRD_METAC/8-232 AC Q8TU00.1
#=GS D3E048_METRM/3-219 AC D3E048.1
#=GS A0A2V2MRP4_9EURY/40-265 AC A0A2V2MRP4.1
#=GS A0A2Z4L8I4_9EURY/1-216 AC A0A2Z4L8I4.1
#=GS A0A484F6M7_9EURY/5-226 AC A0A484F6M7.1
#=GS A0A328S6K3_9EURY/2-218 AC A0A328S6K3.1
#=GS A2STR7_METLZ/50-273 AC A2STR7.1
#=GS E3GZ49_METFV/12-227 AC E3GZ49.1
#=GS G7WPT4_METH6/1-207 AC G7WPT4.1
#=GS D5E7Y4_METMS/11-225 AC D5E7Y4.1
#=GS A0A1D3L4I0_9EURY/3-219 AC A0A1D3L4I0.1
#=GS MTRD_METTH/3-217 AC O27230.1
#=GS A0A0E3P014_9EURY/7-223 AC A0A0E3P014.1
#=GS A0A062V557_9EURY/3-225 AC A0A062V557.1
#=GS W9DW05_METTI/11-225 AC W9DW05.1
#=GS A0A483CUU7_9EURY/40-266 AC A0A483CUU7.1
#=GS Q0W337_METAR/6-77 AC Q0W337.1
#=GS MTRD_METMA/8-233 AC P80653.3
#=GS A0A498H1P5_9EURY/43-266 AC A0A498H1P5.1
#=GS Q0W337_METAR/77-243 AC Q0W337.1
#=GS A0A328SLL6_9EURY/1-213 AC A0A328SLL6.1
#=GS B8GE95_METPE/40-263 AC B8GE95.1
#=GS A0A166F2J2_9EURY/3-219 AC A0A166F2J2.1
#=GS A0A2V3JGQ1_9EURY/13-230 AC A0A2V3JGQ1.1
#=GS A0A366M812_9EURY/3-219 AC A0A366M812.1
#=GS A0A2U1S6Z4_9EURY/3-219 AC A0A2U1S6Z4.1
#=GS A0A4E0QCG8_9EURY/11-225 AC A0A4E0QCG8.1
#=GS D1YVZ0_METPS/71-254 AC D1YVZ0.1
#=GS F6BE99_METIK/12-227 AC F6BE99.1
#=GS L0KYT1_METHD/11-236 AC L0KYT1.1
#=GS A0A2V3JCI9_9EURY/5-220 AC A0A2V3JCI9.1
#=GS A0B8Y5_METTP/7-215 AC A0B8Y5.1
#=GS A0A1D2WB30_9EURY/3-225 AC A0A1D2WB30.1
#=GS D7DUH7_METV3/6-222 AC D7DUH7.1
#=GS A0A8J7URT8_9EURY/41-267 AC A0A8J7URT8.1
#=GS MTRD_METJA/6-218 AC Q58258.1
#=GS L0HFT9_METFS/40-265 AC L0HFT9.1
#=GS A0A2V3JGH2_9EURY/4-225 AC A0A2V3JGH2.1
#=GS A0A328PCL1_9EURY/3-216 AC A0A328PCL1.1
#=GS H1YXH7_9EURY/41-264 AC H1YXH7.1
#=GS MTRD_METKA/4-211 AC O32864.1
#=GS F4BZJ5_METSG/7-215 AC F4BZJ5.1
#=GS A0A8J7W7Z0_9EURY/46-269 AC A0A8J7W7Z0.1
#=GS Q2NI33_METST/2-218 AC Q2NI33.1
#=GS A0A1V6N4T2_METAZ/3-219 AC A0A1V6N4T2.1
#=GS D7EBK4_METEZ/11-225 AC D7EBK4.1
#=GS MTRD_METMP/6-221 AC Q6LWZ3.1
#=GS A7I5S9_METB6/41-264 AC A7I5S9.1
#=GS U6EC30_9EURY/3-225 AC U6EC30.1
#=GS Q2FRN5_METHJ/39-264 AC Q2FRN5.1
#=GS R9SP76_9EURY/2-219 AC R9SP76.1
#=GS D1YVZ0_METPS/6-84 AC D1YVZ0.1
#=GS E1RDX2_METP4/41-264 AC E1RDX2.1
#=GS A0A062VAC8_9EURY/10-228 AC A0A062VAC8.1
#=GS Q12VU5_METBU/11-225 AC Q12VU5.1
#=GS A6UWH4_META3/9-224 AC A6UWH4.1
#=GS A0A315XKX3_9EURY/3-216 AC A0A315XKX3.1
A0A166CF81_9EURY/6-227 ..................i-LTLIIAVAIGGILIGGGVHFIPVGGAPAAMATATGVGTGTAMLAAG....GGLTGLITAASMTGQ--.........PVYIVCIAGAVGGMLMIALTMLIANIIYVYGCGIVPSSA..........KVE.........KDIITGLDQEKYITPGTEGHGVPTGCFVSGVIGGLFGGVGGGLVYWAAYNALAEA.ITTP.I.LGves...nvvIAGLAAILGVAVFFINAVIASYNIGGTTEGVHDPKF.K.R.LPRGVLASGVAS..................
A0A166A6W3_9EURY/3-224 ..................p-ITLLIFIIVGGVFIGGGVHFIPVGGAPAAMATATGVGTGTAMLAAG....AGLTGLITAASMSGQ--.........PWYLIALAGAIGAMMMMGITMFVANIIYVYGVGVVPSSA..........KTE.........VDPITGRNQEKYVTPGTEGHGVPTVCFVSGIIGGLLGGAGGGLVYYAIEESFKGT.ITAA.V.NGvpa...asiIAGLAAIIAVGVFFVNSVVASYNIGGTIEGFHDPKF.K.R.IGRGILACGIAS..................
A0A0X3BNQ3_9EURY/25-252 ..................g-LLALVGIIIGGVLIGFGVHFVPVGGAPAAMGQAPGIATGVAMRCGDarrrAGLAGLFGGAWAAPL--.........GFPLALAGGAIGGGLLMAITCTMVNVIYIFGMGIPAASG..........KVA.........KDPITGDTFPEYKSQGTEGHGLPFVSWVGGVVGGALGGLGGTLIYLELLDIYQAQ.MPAL.L.GAtveq.iapiAISLAGVFAVGMFLMNAVLAAYNITGTIEGPHDPKF.K.R.FPRAIIAAAAA-s.................
F0T8R5_METLA/3-227 .................pl--LLIGAISVGGLLIGGGVHFIPVGGAPAAIATATGVGTGTAMLAAG....GGMTGLIAAAAMTGQ--.........PLWLILASGAIGSMLMIGITMLVGNFIYVWGVGCVPASA..........KVE.........YDPITKYEQSKYVTSGTEGHGIPTVCFVSGIIGGALGGIGGGLIYWALYEGLSIL.PGYQ.L.SAllgggvsltAATVAAIFAIGVFFINAVVASYNIGGTIEGFHDPKF.K.R.IPRGALACLIVS..................
F7XQ91_METZD/11-225 ..................n-ILYLLLIIVGGLLVAIGVHFVPVGGAPAAMAQSTGVGTGTVQLAAG....AGLTGLVAAGAVMQVTD.........NLLLVIASGMVGAMIMIGSTMLVGNMIYIYGVGVPPASA..........KIK.........YDPITRDRQDLYISQGTEGHGVPTSCFISGIIGGGLGGLGGAMVYFALLSVTN--.-GTS.A.LN.........VIGLASIFSVAIFFINAVIASYNIGGTTEGFHDPKF.K.R.LPKAVVSSIIVT..................
I7J9J2_METBM/43-266 ..................g-LLALVGIIIGGVLIGFGVHFVPVGGAPAAMGQAPGIATGVAMLAAG....AGLAGLFGGAWAAPL--.........GFPLALAGGAIGGGLLMAITCTMVNVIYIFGMGIPAASG..........KVA.........KDPITGDTFPEYKSQGTEGHGLPFISWVGGVIGGALGGLGGTLIYLELLDIYQAQ.MPAL.L.GAtveq.iapiAISLAGVFAVGMFLMNAVLAAYNITGTIEGPHDPKF.K.R.FPRAIIAAAAA-s.................
MTRD_METAC/8-232 ..................n-ILWLVFIIIGGVLISWSVHFVPVGGAPAAMAQATGIGTGTVQLAAG....AGLTGLVSAGFMMNVTD.........NLPLILASGAVGAMIMISVTMIVGTWVYVYGVGCVPSSA..........KVK.........YDPITKYRQDLYVSQGTEGHGLPTVSFVSGVIGGLLGGIGGALVYYSLIEVGLTA.GLST.G.TSsgv..tgheLVGIAAMFAIGIFFVNAVIPSYNIGGTIEGFHDPKW.K.K.WPKAVISSFVAT..................
D3E048_METRM/3-219 ..................l-LIFIICVVIAGIIMGGGVHFIPVGGAPAAMATATGVGTGTAMLAAG....AGLTGLITAASMTGQ--.........PVWLIVLAGAVGSMLMMGITMLIGNFIYIFGVGVVPASG..........KAA.........VDPITGWNQEKYKTPGTEGHGIPTVCYISGIIGGLLGGAGGGLVYWAINEFATAN.LTGF.D.AT........vIAGLAAILSVGMFFINSVTASYNIGGTIEGFVDPKF.K.R.LPTGILACAVVS..................
A0A2V2MRP4_9EURY/40-265 ..................l-VIPLIGIIVGGALIAFGVHFVPVGGAPAAMGQAPGIATGVAMLAAG....AGLAGLFGGAWAFETTG.........DFLISIIGGAVGGGLMMAITCLMVNATYVFAMGIPAASG..........KIA.........KDPITGDTFPEYKSQGTEGHGLPFISFVGGVIGGLIAGLGGTIIYIELLDAYSTG.LATL.M.QAkpea.iaplAISLAGIFAIGFFLVNAVLAAYNITGTIEGPHDPKF.K.R.VPRAIIGCAVAS..................
A0A2Z4L8I4_9EURY/1-216 ..................m-LSMLILIIIASTLIGVGVLFIPVGGAPAALSTTAGIPTGAPMITIG....MGVTGILVTSSVIGK--.........SLPVVLLSGMSASMLMMAITMLFSNLVHVYGVGVNIASS..........TFE.........KDPITSFNQGEYVSPGTTGHGIPTVSFISGLIGSLLGGLGGSLLYSAIYEALIVN.NSFV.M.Q-.........AGVISAILTLLVFFVIAVMSSYNIGGTIQGFYDKKFnM.K.IKSAFIASILT-a.................
A0A484F6M7_9EURY/5-226 ..............ilfli---ASLLITLGGVLITISVHLIPVGGAPAAMAQATGVGTGTTQLAAG....AGLTGLLVAVSVHLLSG.........DVLLSIILGGIGSAIMISIVMLISNIGYIYGIGIPLASG..........KAV.........RDPMTKDRQDIYVSKGTEGHGIPTAAFLSGIVGGIIGGIGGSLIYSVIYTVLHSQ.TDFV.F.STp.......aALTISILLSISIYFINAVIASYNIGGTIEGYYDPKF.K.K.LPKAIIVSAVM-t.................
A0A328S6K3_9EURY/2-218 ................lfe---LLISLIIGATLIGVGVHFIPVGGAPAALSTSAGIPTGAPMITMG....MGITGVLSAAMMLDQ--.........PYYVMIVSGAVGSMIMISVTMLFSNLVHIYGVGVPPSSS..........NFE.........KDPITGFEQEDYVSPGTKGHGIPTISFISGLIGSFLGGIGGSIAFTSIYSILSTN.LHNS.M.IT.........NGTIATIFSLLLFFIVAVMASYNIRGTIQGFHDEKF.KqK.ILPGTISCLLI-a.................
A2STR7_METLZ/50-273 ..................v-LQTLCLIILGAALIAFGVHFVPVGGAPAAMGQAPGIATGVAMLATG....AGLAGLFGGAWAAEL--.........GIGVALASGAIGGALMMAITCLMVNISYVFGMGIPAASG..........KVE.........KDPITGDLQAAYKSQGTEGHGLPFISYVGGVIGGLFGGLGGTLIYIELLDFYNAG.LPAL.G.FVgaad.inmlSVGLAGIFAIGMFLVIAVLSAYNITGTIEGPHDPKF.K.R.FPRAIVAAILAS..................
E3GZ49_METFV/12-227 ..................p-ITLVAALTLGGMSVFAGVHLVPVGGASGAMATSSGIPTGTTQLAAG....ASMTGLIVAGMALKK--.........PLWMILLAGGIGASVMITLTGLFTNICLVYGIGSVPTIA..........KRK.........KDPITGWNQEKYVTPGTEGHGAPTSAYISGAMGAFLGGVGGALVYWALYHALVTI.PYFG.D.LG.........AKAIAVAYALGMFFVNAVLASYNIGGTTEGLWDPKI.H.R.LPRGIVGSLIVS..................
G7WPT4_METH6/1-207 ..................m---HIIEIVIGGLLVGIGVHFVPVGGAPAAMAQATGVGTGTVQLAAG....SGLTGLLSAGLMLNYTD.........SILLVVISGAVGAMIMIDATMIVGNWVYIYGVGTPLASA..........KAN.........YDPITKDSQAPYVAPGTVGQGIPTVCFVSGTIGGLLGGAGGSLIYYVLYQINR--.----.-.--.........DPGLSAFFAIGIFVVNAVIASYNIQGTIEGFHDPKF.K.R.VPRAFQVCLVAS..................
D5E7Y4_METMS/11-225 ..................n-FLYVILITLGGVLVSGSVHFVPVGGAPAAMAQATGIGTGTVQLAAG....AGLTGLVTAGAMLNVTD.........SIALILAAGMVGAMIMIGVTMMVGNLVYVYGVGVPPASA..........KVD.........YDPITKDRQDIYVSQGTEGHGLPTVSFVSGIIGGGLGGIGGALVYYSLMSIAN--.-GMA.S.AD.........FIGLAAIFAVGIFFVNAVIPSYNIGGTIEGFHDPKF.K.K.WPKAVVTSLIVT..................
A0A1D3L4I0_9EURY/3-219 .................pl--LLIGAMTVGGVLIGGGVHFIPVGGAPAAIATATGVGTGTAMLAAG....SGMTGLIAAAAMTGQ--.........PLWLILASGAVGSMLMIGITMLIGNLIYVWGVGCVPTSA..........KVE.........IDPITKYEQEKYITPGTEGHGVPTVCFVSGIIGGALGGIGGGLVYWALNSALTAAgLSYS.S.LG.........AATVAGIFAVGTFFVNAVVASYNIGGTIEGFHDPKF.K.R.LPRGVLACLLAS..................
MTRD_METTH/3-217 .................pl--LLIGAITAGGVLIGGGVHFVPVGGAPAAMATATGVGTGTAMLAAG....AGLTGLITAAAMTGQ--.........SPLMIMAAGAVGSMLMIGITMLVGNLIYVYGVGTVPVSA..........KVA.........VDPLTGMEQEKYVTPGTEGHGLPTVCFVSGIIGGALGGIGGGLIYWALNEALK-T.LSYG.A.IG.........AAGVAAIFAVGIFFINAVIASYNIGGTIEGFHDPKF.K.R.IGRGIVACLIAS..................
A0A0E3P014_9EURY/7-223 ..................n-FLWMFLVVIGGVLISWSVHFVPVGGAPAAMAQATGIGTGTVQLAAG....AGLTGLISAGYMMQVVD.........NLPLILASGTVGAMIMISVTMIVGTWVYVYGVGCVPSSA..........KVK.........VDPITHDRQDLYVSQGTEGHGLPTVSFVSGVIGGALGGFGGSLVYYALLKVGM-G.VAEV.D.AN.........MIGLVAIFAVGIFFVNAVIPSYNIGGTIEGFHDPKW.K.K.WPKAVISSFVAT..................
A0A062V557_9EURY/3-225 .................pv--TAFFAIILGGVLVGICVHFIPA-SATGAMSAATGIATGPSMLSAG....AGMAGLLSASYSIDS--.........GLSVVLASGATASALMVALTILSGNIANAFGTGVPPASGqtasgqsitgKST.........KDAISGWDQKPYISPGTDGHGMPVQTNFSGLIGAFIGGTGGALVLFAVYTLLV--.PILR.Q.DA.........AFTISGFIAGGVFLINCVLPAYTLVGKTEGMFDQKI.R.K.TPKTLVSCFIVS..................
W9DW05_METTI/11-225 ..................n-ITYVILITLGGALISWSVHFVPVGGAPAAMAQATGIGTGTVQLAAG....AGLTGLVTAGAMMQVSN.........SPALVIASGAVGAMIMISATMIVGTWVYVYGVGCPPASA..........KVK.........YDPITKDRQDLYVSQGTEGHGLPTVSFVSGVIGGALGGVGGSVVYYALMSVQN--.-GLP.L.AD.........LVGMASVFAVGIFFVNAVIPSYNIGGTIEGFHDPKF.K.R.FPKAVLASLIAT..................
A0A483CUU7_9EURY/40-266 ................alg---AIIGVIIGGLLIGFGVHFVPVGGAPAAMGQAPGIATGVAMLAAG....AGLAGLFGGAWAAANPA........fGIAIVIAAGAVGGGLMMAITCLMVNIIYVFGMGIPSASG..........KVD.........KDPITGDSQPEYKSQGTEGHGLPFISYVGGVIGGLLGGAGGTLIYYELLQVYSAA.LPAL.F.NAeaae.vlpvAVSLAGIFAIGMFLVNAVLAAYNITGTIEGPHDPKF.K.R.FPRAIIGCAVAS..................
Q0W337_METAR/6-77 ..................l-VIIVACIGLGGLLVGLGVHFVPVGGAPAAMAQATGIGTGTTMLAAS....SGFLGLISAGLVTEE--.........---------------------------------------..........---.........-------------------------------------------------------.----.-.--.........------------------------------------.-.-.------------ilinkiqypg........
MTRD_METMA/8-233 ..................n-ILWMVFIIIGGVLISWGVHFVPVGGAPAAMAQATGVGTGTVQLATG....AGLTGLVSAGFMMNVTD.........NFPLIVASGAVGAMIMIAVTMIVGTWIYVYGVGCVPSSA..........KVK.........VDPITKYRQDLYVSQGTEGHGIPTVSFVSGVIGAALGGIGGSLIYYSLIEVGVSV.GLER.V.GVtsav.tgnsLVAVAAIFAIGIFLVNAVIPSYNIGGTIEGFHDPKF.K.K.WPKAVISSVVAS..................
A0A498H1P5_9EURY/43-266 ..................g-LIALIGIIIGGILIAFGVHFVPVGGAPAAMGQAPGIATGVAMLAAG....AGLAGLFGGAWAAEF--.........GLAVALAGGAVGGGLMMAITCLMVNVTYIFGMGIPAASG..........KVD.........KDPITGDTFPAYKSQGTEGHGLPFISYVGGVIGGTLGGLGGTLIYLMLLGVYEEV.LPVA.M.NAsvee.iapvAISLAGIFAVGMFLVNAVLAAYNITGTIEGPHDPKF.K.R.FPRAVIAAAVAS..................
Q0W337_METAR/77-243 .........gfaealangt-----------------------------------------------....-----LFSIAGITANIG.........AIAIIIVAGIIGAMLMIAILCVVPNVLYIFGLGVPLASA..........KVK.........FDPVTGDRQDIYVTKGTEGHGTPTVAVVSSLIGGFLAGIGGALTYLALLAGGF--.----.-.--.........SIAAAAFVAIGIFFVNSVLASYNIAGTIEGFHDPKF.K.R.WPRAFIGCLIAS..................
A0A328SLL6_9EURY/1-213 ...................----MICLVIASMLIGVGVHFVPVGGAPAALSTSAGIPTGAPMITIG....MGITGLLSAVSFIGQ--.........PEYMILLAGAIGSMIMISVTIFFSNIIHVYGVGVPIATN..........KFK.........KDPFTSFEQEDYVSPGTNGHGIPTVSFISGMIGAFLSGLGGSLAFNSLYSTVMLN.AQNT.E.VA.........GATIATIMSLVLFFIVAVIASYNIGGTIQGFYDDKF.KeK.ILYGILSSFIVS..................
B8GE95_METPE/40-263 .................af--YALIGIVVGGVLIGFGVHFVPVGGAPAAMGQAPGIATGVAMLAAG....AGLAGLFGGAWAAEQG-.........-TTIAVITGGVGGALMMAITCLMVNAIYVYGMGIPAASG..........KVA.........KDPLTGDTQAAYKSQGTEGHGLPFISYVGGVIGGFFGGAGGTLIYLELLGVYEQA.LPTL.F.NAkleq.implAVSLAGIFAVGMFLVNSVLAAYNITGTIEGPHDPKF.K.R.FPRAIVASMIAS..................
A0A166F2J2_9EURY/3-219 ..................p-ITLLILIILGGVLIGGGVHFIPVGGAPAAMATATGVGTGTAMLAAG....AGLTGLITAAAMTGE--.........PWYIIALAGAVGAMLMMGITMFIANIIYVYGVGVVPSSA..........KVE.........VDPITGRNQEKYVTQGTEGHGLPTVCYVSGIIGGLLGGAGGGLVYYGINVAMLES.SFVTdP.AI.........TAGLGAILAVGIFFINSVVASYNIGGTIEGFHDPKF.K.R.IGTGVLSCALVS..................
A0A2V3JGQ1_9EURY/13-230 .................hw--ISIIGIIIGGICIAVGVHFVPVGGAPAAMAQATGIGTGTVQLAAG....SGLTGLLAAGYMYMVLSadgayvgtsQIALICATGAVGAMIMISVTMLVGNWVYIYGVGVPPASA..........KRD.........YDPITGDSQAPYVAAGTVGQGLPTVCFVSGTIGGLLGGLGGSLVYCMLMWVNG--.----.-.--.........DPAISSIFAIGVFLVNAVLPSYNIQGTIEGFHDPKF.K.R.VPKAILACFIAS..................
A0A366M812_9EURY/3-219 ..................p-ITLVLFITFGGILIGGGVHFIPVGGAPAAMATATGVGTGTAMLAAG....AGLTGLITAAAMTGQ--.........PWYIIAIAGAVGAMMMMGITMLVANIIYVYGVGVVPSSA..........KVE.........VDPITGRNQEKYVTSGTEGHGIPTVCYISGIIGGLLGGAGGGLVYYGVNIAVTEG.SFVS.DpTI.........TVGLAAILAVAVFFINSVIASYNIGGTIEGFHDPKF.K.R.IGTGILACAVAS..................
A0A2U1S6Z4_9EURY/3-219 ..................p-ITLILFIAIGGVLIGAGVHFIPVGGAPAAMATATGVGTGTAMLAAG....AGLTGLITAASMTGE--.........PWYIIGIGGAIGAMIMMGITMYIADLIYVYGVGVVPAAS..........KVE.........VDPITGRNQEKYKTPGTEGHGVPTSSFISGIIGALCGGFGGGMVYYAINLAATEG.SFVT.DpTM.........TIGLAAILGTGVFFVNAVIASYNIGGTIEGFTDPKF.K.R.IGTGAVACLIAS..................
A0A4E0QCG8_9EURY/11-225 .................df--LNILLITLGGMLIALGVHLVPVGGAPAAMAQATGVGTGTVQLAAG....AGLTGLVTAGFMMNVTE.........SMALIIASGTIGAMIMISVTMIVGQWMYVYGVGCPPASA..........KVK.........YDPITKDRQDLYVSQGTEGHGIPTASFISGVIGAGLGGLGGSLIYYSLLSIEN--.-GLP.E.AN.........FIGIASIFAIGLFFVNAVIPSYNIGGTIEGFHDPKF.K.K.FPKAVLASFVAT..................
D1YVZ0_METPS/71-254 gslktaypgfatamndgtl-----------------------------------------------....------LSISGISSNLM.........AILLVFVAGIVGAMIMMVILGVTANILYSFAIGVPLVSA..........KVK.........YDPITGDRQDLWVTRGTEGHGTPTVAIISSLIGGLLGGLGGAMLYLAFMAGGLGN.FDKL.G.VA.........GIAAAAFLTVGIFFVNSVLASYNITGTIEGFHDPKF.K.R.VPRAIIACTVAS..................
F6BE99_METIK/12-227 ..................l-LIPLAEITIAGAIINASVHFVPVGGAPAAMATSTGVGTGTTQLAAG....AGFTGLMAAAAMAAQAGvdv..fnpaHLALIALSGAVGSMIMLGITMLIGQLIYVFGVGVVPAAD..........KCE.........KDPITGDEQRPYITPGTTGHAVPTVCFVSGLIGAGLGGIGGALAYIALKQLGF--.----.-.--.........DTAIAGILAVGFFFINAVLASYNIGGTIEGFHDPKF.K.K.MPNGVIASFVAS..................
L0KYT1_METHD/11-236 ...................NIMYMLLITLGGVLVSVSVHFVPVGGAPAAMAQATGIGTGTVQLAAG....AGLTGLVTAGSMMGVTD.........NIGLVLASGAVGGMIMIAVTMIVGQWVYFYGVGCPAASA..........KVK.........YDPITKDRQDLYISQGTEGHAIPTVSFVSGVIGAGLGGLGGGTVYYALLKMGEVA.AGLT.I.KDimsa.tghqLVGLASIFAVGIFFMNAVIPSYNIGGTIEGFHDPKF.K.K.WPKAAITSLVVT..................
A0A2V3JCI9_9EURY/5-220 .................il-VLILVSAIIGGILASLGVHLLPVGGAPAAMATATGVATGCVMLMTG....SAVTGLFTASAVASFWEfe.....haNIALVALSGGVGAMLMIGWTMLIANLLYVFGAGIVPVSG..........RVA.........VDPITKESQTEYKTPRTDGHGMPNVSYISGMIGGFVGGFGGALIYVTLENFAH--.----.-.-F.........SPATAGIVAIGIFIANAILAAYNIGGTIEGFHDPKF.KeR.IAVGLFAAFVVS..................
A0B8Y5_METTP/7-215 ..................t-IVYILEIIVGGLLVGVGVHFVPVGGAPAAMAQATGVGTGTVQLAAG....SGLTGLLAAGLMMSVTD.........NIWPILASGAVGAMIMIDATMMVGGWIYAYAVGAPFASA..........KVN.........YDPITGYSQPPYVAPGTVGQGIPTVSFVSGTIGGFMGGLGGALIYYPLMMINH--.----.-.--.........NPSLSALFAIGIFLVNAVLASWNIQGTIEGFHDPKF.K.R.WTKAFRSCLVAT..................
A0A1D2WB30_9EURY/3-225 .................pl--FLIGAVTAGGLLIGGGVHFIPVGGAPAAMATATGVGTGTAMLAAG....GGMTGLITAAAMTGQ--.........SLPLILAAGAIGSGLMLGITMLAGNFIYVWGVGCVPSSA..........KVD.........VDPITKMEQSKYVTPGTEGHGIPTVCFVSGIIGGLLGGIGGGLIYYALYNALTAT.TAYA.V.PAgst..fslaAATLAGIFALGTFFINAVVASYNIGGTIEGFHDPKF.K.R.LPRGALACIIVS..................
D7DUH7_METV3/6-222 ..................i-ILPLVEITLAGAIINASVHFVPVGGAPAAMATSTGVGTGTTQLAAG....AGFTGLLAAAGMAAQPGiia..snplHALLIMLSGAVGAMIMLGLTMLIGQLIYVYGVGIVPAAD..........KCD.........IDPITKDPQSAFITPGTTGHGIPTVCFVSGLIGAALGGIGGGMAYVGLLGLGF--.----.-.-T.........IPAIAGVLAVGFFFMNAVLASYNIGGTIEGFHDPKF.K.K.MPNGVIASTVSS..................
A0A8J7URT8_9EURY/41-267 ..................a-LAALIGVIVGGLLIGFGVHFVPVGGAPAAMGQSPGIATGVAMLAAG....AGLAGLFGGAWAAANPE........fGFAIVIASGAIGGGLLMAITCLMVNIVYIFGMGIPAASG..........KVA.........KDPITGDTQEAYKSQGTEGHGLPFISYVGGVIGGLLGGAGGTLIYYELLKLYSAL.LPDI.L.TAdvaq.impiAVSLAGIFAIGMFLVNAVLAAYNITGTIEGPHDPKF.K.R.FPRAIIGCATAS..................
MTRD_METJA/6-218 ..................a-IVPLIEMTIAGAIINASVHFIPVGGAPAAMATSTGVGTGTTQLAAG....AGFTGLMGAAVMASNVGls.....piGMALIMISGAVSSMIMLGVTMLIGQLIYVFGVGVVPAAD..........KCE.........IDPITKDPQKPYVTPGTTGHGVPTVCFVSGLIGAALGGIGGALAYIALRKLGL--.----.-.--.........DPGVAGMLAVGFFFINAVLASYNIGGTIEGFHDPKF.K.K.MPNGVIASTVAS..................
L0HFT9_METFS/40-265 ..................g-LMPLLLIVVGGVMIGFGVHFVPVGGAPAAMGQAPGIATGVAMLAAG....GGLAGLFGGAWAAAAGQ.........DALVVVITGGIGGGLMMAITCMMVNFVYVFGMGIPAASG..........KVA.........NDPITGDSQAEYKSQGTEGHGLPFVSFVGGVIGGLFAGAGGTLIYLELLEVYKAA.LPGV.M.QItaaq.vlpiAVSAAGMFAVGMFLVNAVLTAYNITGTIEGPHDPKF.K.R.WPRSVVASAVAS..................
A0A2V3JGH2_9EURY/4-225 .................pl--IATIMIIAGGVLVGVCVHFIPA-SATGAMAAATGIATGPSMLSAG....AGLTGIYAAAYSIDS--.........GLALVIVSGAVGSALMLLITILCGNIMLAFGIGAPPVSG..........QTAsgkstfggtKDIITGFEQEGYASPGTDGHGMPFQTAVSGGFGALMGGAGGALVFYAVYSMTL--.PAIS.T.EN.........VVTLAGIVAAGVFLINSVLPAYVLVGKTEGMFDMKI.R.S.MHRTFISCLVTS..................
A0A328PCL1_9EURY/3-216 .................pl--TLIGAITVGGILVGGGVHFVPVGGAPAAMATATGVGTGTAMLAAG....AGMTGLITAAAMTGQ--.........NPILILAAGAVGAMLMLGITMLFGNLIYVFGVGTIPVSA..........KVD.........RDPITRLEQKDYVTPGTEGHGLPTVCFVSGLIGAALGGIGGGLVYWALQQALL--.ASYG.M.LG.........AATIAGIFAVGVFFINAVIASYNIGGTIEGFHDPKF.K.R.IGRGILACLVAS..................
H1YXH7_9EURY/41-264 ..................a-LMSLIGVIIGGLLIGFGVHFVPVGGAPAAMGQSPGIATGVTMLAAG....AGLAGLFGGAWAAEL--.........GLGVALAGGAIGGGLMMAITCLMVNVVYVYAMGIPAASG..........KVA.........KDPITGDTFEAYKSQGTEGHGLPFISYVGGVIGGALGGLGGTLIYLELLAVYEEF.LPTA.L.NApaeq.ilplAVSMAGVFAIGMFLVNAVIAAYNITGTIEGPHDPKF.K.R.FPRAVIGCAVAS..................
MTRD_METKA/4-211 ..................l-IAVLVLITLGSIMVNVGVHYVPVGGAPAAMATATGVGTGTTQLAAG....SGLTGLITAAAMSQK--.........PFLVILWNGALGAATMMAITMLVGNFIYVYGVGCPPCSA..........KVD.........KDPITGWDQEAYVTPGTEGHGIPTVSFVSGILGGLLGGSGGAMVYYALYKVLG--.----.-.-M.........SAALAGILAMGFFYANAVLASYNIGGTIEGYHDPKF.T.R.LPKAVVCSLVF-g.................
F4BZJ5_METSG/7-215 ..................t-IVYILEIVVGGLLVGVGVHFVPVGGAPAAMAQATGIGTGTVQLAAG....SGLTGLLAAGLMMSVTD.........NIWLVLASGAVGAGIMVGSTMLTGSWIYAYAVGVPFVSA..........KVT.........YDPITGFSQPPYIAPGTVGHGIPTVCFVSGLIGGMMGGLGGAMIYYALYLING--.----.-.--.........NAALSAMFAIGIFMVNAVIASWNIQGTIEGFHDPKF.K.K.WPFAFRACLIAS..................
A0A8J7W7Z0_9EURY/46-269 .................af--YSLIGIIIGGMLVTFSVHLVPVGGAPAAMGQAPGIATGVTMLAAG....AGLAGLFKGAWAAQF--.........SYPVALGTGAIGGALLMAITCMLVNVTYVFAMGIPAASG..........KVN.........KDPLTGDTQPEYKSQGTEGHGLPFISYVGGVLGGLIGGFGGTLIYLSLYDAYLTG.IPAL.M.GTdves.vmplIVSIAGIFAIGMFLVNAVLTAYNITGTIEGPHDPKF.K.R.FPRAIVASAVAS..................
Q2NI33_METST/2-218 ................ife---LLISIIIGSTLIGFGVHFIPVGGAPAALSTTAGVPTGAPMITIG....MGITGILSALSMTGQ--.........SEIVIILSGAIGSMLMMAVTMFFSNMIHVYGVGVPLASS..........NFE.........RDPITGFKQEEYVSPGTTGHGIPTVSFISGVIGALFGGIGGSLAFWAIYNYILGN.CHLS.S.IY.........TNSISAILAVMLFFIIAVVASYNIGGTIQGFYDKKFrK.K.IVSGTFSCFLIS..................
A0A1V6N4T2_METAZ/3-219 ..................p-ISLILFITVGGILIGGGVHFIPVGGAPAAMATATGVGTGTAMLAAG....AGLTGLITAAAMTGQ--.........PWYIIAIAGAVGAMMMIGITMLIANIIYIFGVGVVPSSA..........KVE.........VDPITGRNQEKYVTSGTEGHGIPTVCFVSGIIGGLLGGAGGGLVYYGINIAMTEG.SFVT.DpAI.........TAGLAAILAVGVFFINSVIASYNIGGTIEGFHDPKF.K.R.IGTGILACAIAS..................
D7EBK4_METEZ/11-225 ..................n-LLYVLLITIGGTLVSFSVHFVPVGGAPAAMAQAPGIGTGTVQLAAG....AGLTGLITAGTVLGLTN.........SIAIVLASGAVGAMLMIGSTMIIGQMVYVFGVGVPPAGG..........KSK.........YDPITKDKQDIYSSQGTEGHGLPTASYISGIIGGGLGGLGGSLVYYSLVNVTN--.-NIG.M.TD.........LAGLAGIFAVGIFFINAVIPSYNIGGTTEGFHDPKF.K.R.WYRAVISSIIAT..................
MTRD_METMP/6-221 ..................f-ILPLAEITIAGAIINASVHFVPVGGAPAAMATSTGVGTGTTQLAAG....AGFTGLLAAAAMASQAGvsl..snpvHMLLIMLSGAVGAMIMLGLTMLIGQIIYVYGIGIVPAAD..........KCE.........KDPITGDIQKPYITPGTTGHGIPTVCFVSGTIGAALGGLGGALAYIALQQLGF--.----.-.--.........AAAIAGVLAVGFFFMNAVLASYNIGGTIEGFHDPKF.K.K.MPNGVIASFVSS..................
A7I5S9_METB6/41-264 ..................g-LMALIGVVIGGVLIGFGVHFVPVGGAPAAMGQAPGIATGVAMLAAG....AGLAGLFGGAWAADQ--.........GFVIAIITGGVGGGMMMAITCMMVNFVYIFGMGIPAASG..........KVL.........KDPITGDSQPEYKSQGTEGHGLPFVSFVGGVLGGVLGGAGGTLIYLELLSLYKAT.LPNI.M.SIsaaq.alpiAVATAGIFAIGMFLVNSVLTAYNITGTIEGPHDPKF.K.R.WPRSVVASAVAS..................
U6EC30_9EURY/3-225 ..................p-LLMIGAVTAAGILIGGGVHFLPVGGAPAAIATATGVGTGTAMLAAG....SAMTGLITAAAMTGS--.........PLWLILASGAVGSMLMIGITMLVGNWVYVWGVGTVPASA..........KVE.........IDPITKYNQEKYVTPGTEGHGIPTVCYISGIIGGLLGGIGGGLAYWAIYESLVTL.PAYA.P.LVsgq..tsitAAMVAGMFALGLFFVNSVIASYNIGGTIEGFHDPKF.K.R.IPRGIVACLLAS..................
Q2FRN5_METHJ/39-264 ..................s-IVPLIGIIIGGALIGFGVHFVPVGGAPAAMGQAPGIATGVAMLAAG....AGLAGLFGGAWAYEATG.........DFAVAVAGGAVGGGLMMAITCLMVNATYVFAMGIPAASG..........KIA.........KDPITGDTFPEYKSQGTEGHGLPFISFFGGVVGGFIAGLGGTLIYIELLDVYHTG.LPAI.M.QAnpea.ieplAVSLAGIFAIGFFLVNAVLAAYNITGTIEGPHDPKF.K.R.VPRAIIGCAVAS..................
R9SP76_9EURY/2-219 ..................d-LIMMLLIIIAGVCMGAGVHFIPVGGAPAAMSTATGVGTGTAMLAAG....AGMTGLITAASLEGA--.........GLGLILLAGAIGSMMMMGITMLFGNFIYVFGVGVVPSSG..........KVE.........KDPITGLPQAAYKTPGTEGHGVPTVSFVSGIIGSALGGIGGGMAFYAVQEMAKNS.TLFA.G.NMp.......vIIGVAAICSIGLFFVNSVVASYNIGGTIEGFHDPKF.K.R.IGNGALASIIAS..................
D1YVZ0_METPS/6-84 ..................l-IIVLLAITIGGLLIGLGVHFVPVGGAPAAMAQATGIGTGTTMLAFS....SGALGLISAGFTVN---.........---------------------------------------..........---.........-------------------------------------------------------.----.-.--.........------------------------------------.-.-.------------diyrgslktaypgfatam
E1RDX2_METP4/41-264 .................af--TSLILVIVGGLLIGFGVHFVPVGGAPAAMGQSPGIATGVTMLAAG....AGLAGLFGGAWAAEL--.........GFGVALAGGAIGGGLMMAVTCLMVNVVYVWGMGVPAASG..........KVA.........KDPITGDTFEAYKSQGTEGHGLPFVSYVGGVIGGCLGGLGGTLIYVELLGVYEEF.LPAS.M.GAsaea.vlpiAVGIAGIIAVGMFLVNAVIAAYNITGTIEGPHDPKF.K.R.FPRAIMGCAVAS..................
A0A062VAC8_9EURY/10-228 ..................t-LTSILLIAISGTLICIAVHFVPVGGAPAAMAQATGIGTGTVELAAG....SGLVGLITASYMNANVPd.......aPMALILGAGAMGSMIMISSAMFVGGLIYAYGVGVPFASA..........QIK.........RDPFTGTRQDIYMSKGTQGQGLPTICFVSGVIGAGLGGIGGALIYYVLYGIYE--.PLIS.P.TS.........AAAVAGVFTVGVFYVNAVIPSYGVGGTIEGFHDPKF.R.RvLPKDTVTSFVVS..................
Q12VU5_METBU/11-225 ..................n-ILYIAMVTLGGMLISWSVHFVPVGGAPAAMAQATGIGTGTVQLAAG....AGLTGLVTAGAVMAVSD.........SLLLVVASGGVGAMIMIAVTMIVGTWVYVYGVGVPPASA..........KVD.........YDPITKDRQDIYVSQGTEGHGLPTVSYVSGVIGGALGGIGGSAIYFALMST---S.TTLI.Q.SD.........LVALASIFAVGIFFVNAVIPSYNIGGTIEGFHDPKF.K.K.WPKAVLASFVAT..................
A6UWH4_META3/9-224 .................la--IPLAEITIAGAIINASVHFVPVGGAPAAMATSTGVGTGTTQLAAG....AGFTGLMAAAALAAQSGisl..tnplHLALIMASGAVGSMIMLGLTMLIGQMIYVYGIGVVPAAD..........KVD.........KDPFTGDYQKSYITPGTTGHAIPTVCFISGLIGAALGGIGGGLAYIAFKLLGF--.----.-.--.........SSEVSGVIAVGFFFLNAVLASYNIGGTTEGFHDPKF.K.K.IHFGIVASFVAS..................
A0A315XKX3_9EURY/3-216 ..................p-ITLILFIAIGGIMIGAGVHFIPVGGAPAAMATATGVGTGTAMLAAG....AGLTGLITAATMTGE--.........PFYIVGIGGAIGAMIMMGITMLIANLIYIFGVGIVPAAS..........KVP.........VDWITKRNQEIYKTPGTEGHGVPLTSFVSGLIGGLLGGFGGGLVYYGIYDTVQ--.ASFE.P.AI.........AIGLAAILGVGVFFINSVIASYNIGGTIEGMHDPKF.K.R.IGTGAIACAIAS..................
#=GC seq_cons ..................h.lhhllhIhlGGlLIuhGVHFVPVGGAPAAMApATGlGTGTsMLAAG....AGLTGLlsAAhhsst...........shhlllhuGAlGuMlMhulTMlhuNhlYVaGlGlssASu..........KVc.........hDPITGcpQctYlo.GTEGHGlPTVsFVSGlIGGhLGGlGGuLlYhuLhphht.....h.....s.........ssulAuIhAlGhFalNAVlASYNIGGTIEGFHDPKF.K.R.hP+ullushlAS..................
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