#=GF ID Mvb12
#=GF AC PF09452.14
#=GF DE ESCRT-I subunit Mvb12
#=GF AU Wood V;0000-0001-6330-7526
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Wood V
#=GF GA 25.00 25.00;
#=GF TC 25.90 27.60;
#=GF NC 23.80 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 17145965
#=GF RT New component of ESCRT-I regulates endosomal sorting complex
#=GF RT assembly.
#=GF RA Chu T, Sun J, Saksena S, Emr SD;
#=GF RL J Cell Biol. 2006;175:815-823.
#=GF DR INTERPRO; IPR019014;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The endosomal sorting complex required for transport (ESCRT)
#=GF CC complexes play a critical role in receptor down-regulation and
#=GF CC retroviral budding. A new component of the ESCRT-I complex was
#=GF CC identified [1], multivesicular body sorting factor of 12 kD
#=GF CC (Mvb12), which binds to the coiled-coil domain of the ESCRT-I
#=GF CC subunit vacuolar protein sorting 23 (Vps23) [1].
#=GF SQ 28
#=GS G8ZVV1_TORDC/11-100 AC G8ZVV1.1
#=GS A0A1S7HFE2_9SACH/10-98 AC A0A1S7HFE2.1
#=GS A0A061AMV9_CYBFA/8-96 AC A0A061AMV9.1
#=GS G8BNT7_TETPH/7-98 AC G8BNT7.1
#=GS H2AQQ0_KAZAF/10-100 AC H2AQQ0.1
#=GS A0A1G4JL95_9SACH/9-97 AC A0A1G4JL95.1
#=GS J7S8V7_KAZNA/9-99 AC J7S8V7.1
#=GS A7TET9_VANPO/9-99 AC A7TET9.1
#=GS A0A1G4M756_LACFM/9-97 AC A0A1G4M756.1
#=GS J6EIQ9_SACK1/9-98 AC J6EIQ9.1
#=GS G8JWJ6_ERECY/2-90 AC G8JWJ6.1
#=GS MVB12_YEAST/9-98 AC P42939.1
#=GS C5DCA0_LACTC/9-97 AC C5DCA0.1
#=GS A0A1X7QW89_9SACH/7-94 AC A0A1X7QW89.1
#=GS A0A7H9HXL9_9SACH/43-132 AC A0A7H9HXL9.1
#=GS K0KSE9_WICCF/5-73 AC K0KSE9.1
#=GS Q6FND2_CANGA/13-106 AC Q6FND2.1
#=GS A0A1E5R2K9_9ASCO/14-109 AC A0A1E5R2K9.1
#=GS I2GZM2_TETBL/10-111 AC I2GZM2.1
#=GS G0W9T2_NAUDC/25-114 AC G0W9T2.1
#=GS Q6CN00_KLULA/5-92 AC Q6CN00.1
#=GS J8Q1Q5_SACAR/9-98 AC J8Q1Q5.1
#=GS A0A1E3P977_WICAA/10-103 AC A0A1E3P977.1
#=GS A0A1G4IRB5_9SACH/9-97 AC A0A1G4IRB5.1
#=GS Q75CP7_ASHGO/5-93 AC Q75CP7.1
#=GS A0A0C7NAZ6_9SACH/9-97 AC A0A0C7NAZ6.1
#=GS A0A7H9AXZ4_ZYGMR/12-101 AC A0A7H9AXZ4.1
#=GS G0V742_NAUCC/48-137 AC G0V742.1
G8ZVV1_TORDC/11-100 ...........................LRKHPLYNAHGSD..FPR.NVLKRT.........EVPQI..RLQPLQPS..PAMFAPWYQECDELVKAC.........EEH.DGRGEEFDQWYSQRYMSNKPPGMVGN....VVLSPSKR.......
A0A1S7HFE2_9SACH/10-98 ...........................LRSRPLVNSQGTR..FPH.DVPPRV.........HIPQI..KLTPMQSA..AEIFAPWYEECDQLVQLA.........DLH.DMRGRQFDRWYESQYLSNKPPGMAMG....-MLSPSRR.......
A0A061AMV9_CYBFA/8-96 ..lsqipltstlfpprpvrlsynytpl-------------..---.------.........---PA..TIPQTQVT..EDNLKAWVKECDHLKSCL.........YEYgSRETAEYKKW-EESMLK-LAPGYMDH....GLLTPHKR.......
G8BNT7_TETPH/7-98 ...........................LKGIPLYNAFGES..FPSqKNLNRL.........TVPNI..NVPASQQQ.pSEMFKPWYKLCNDLIEGC.........NNH.DKSSEDFEKWYEDRYLKNKPHGMRES....IVLSPSKK.......
H2AQQ0_KAZAF/10-100 ...........................LRKIPLYNKYGDD..YPD.KMLPKL.........DVPEI..KIQPLPPI..NKTIEAWITELDKAVDYW.........SKYsDNNIKEFNDWYNKKYLSNKPPGLVNS....SVLSPVHK.......
A0A1G4JL95_9SACH/9-97 ..........................l-LQVPLRNGMEQD..LFQ.-PVRKL.........EFSPV..TLPAGAPA..QQHLKAWIFECEQLQQAI.........DER.RKRTEKFDVWFAETCLSKRPPGMTSG....GVLSPARR.......
J7S8V7_KAZNA/9-99 ...........................LRRVPLYNKRGVAggGPP.---APL.........EVPTL..QPPQRHPGgsESLVSPWIHECESLEAQL.........QGY.IGQGALFDQWYASTYLAHKPAGLLSH....KVLSPTR-p......
A7TET9_VANPO/9-99 ...........................IRGIPLYNAYGVM..FPNvNKLRKF.........TSDVI..DVPVVRGT..DEMFNPWYKECEHILNDC.........NGH.DSSFKTFDDWYKEKYLSSKPHGITDN....ITLTPVKR.......
A0A1G4M756_LACFM/9-97 ...........................IRSIPLQNLHSGL..FPH.-SRPKL.........QLPSL..FLPETTPA..EQHLHAWVEECDRVTQAV.........EER.DTETKKFDDWYRENYLRRQPPGMMES....TLLSPSKR.......
J6EIQ9_SACK1/9-98 ...........................LRRIPLYNKYGKG..FPQ.ETVTRL.........QMPEF..RLPPLQPT..KDLLNPWFEECDNVTKVC.........QLH.DSSSKKFDQWYKEHYMSKKPPGMAGN....MLLSPSRK.......
G8JWJ6_ERECY/2-90 ...........................LRNIPLYNTLGYE..MPK.-KRPEL.........KLPNL..GLPRSTTT..AEHLQAWSDECDQIIGSM.........ESL.EEQSKEWDLWYDQMFLQKQPPGISDA....GILSPKKK.......
MVB12_YEAST/9-98 ...........................LRRIPLYNKYGKD..FPQ.ETVTRF.........QMPEF..KLPALQPT..RDLLCPWYEECDNITKVC.........QLH.DSSNKKFDQWYKEQYLSKKPPGIVGN....TLLSPSRK.......
C5DCA0_LACTC/9-97 ...........................LHQIPLRNAHADL..LPQ.-AQRKL.........DLPPL..ALPETTPA..KQHLEAWIEECSQISQAI.........KQR.KDRGKRFDTWYAENCLSKQPPGITDC....AVLSPSRR.......
A0A1X7QW89_9SACH/7-94 ...........................LRRVPLSNKIGVT..YPD.QMPALA.........VIPEL..RVPPIPPV..EEMFQAWFDELDQALEGV.........KQR.LDRSKLWDQWYSETYLSKKPMGIQST....--LLPSKR.......
A0A7H9HXL9_9SACH/43-132 ...........................LRKYPLYNSHGDE..FPR.NVLKRV.........PVPHI..KLQPLQPS..AEMFAPWYQECDSLVKSC.........QVH.DKAGELFDQWYSQRYMSNKPPGMVGN....VILSPSRR.......
K0KSE9_WICCF/5-73 .......................plpt-------------..---.------.........-----..QLPGTNVT..QDNLEAWITECGNVKEEI.........KNYgAKEKEAYQTWHES-VVRKLAPGYIGGs..nTLLTPQKK.......
Q6FND2_CANGA/13-106 ...........................LNNIPLRNKFGDN..YPR.ERLSKV.........EVPLY..KIENIADS..KKMFEPWYKECDEIIAAC.........EVH.DQLGRNFEQWYNEKYISTKPPGMVQGngeiSVLSPSKK.......
A0A1E5R2K9_9ASCO/14-109 kdmvtmpplipslyeleeqqtkqdqqs-------------..---.------.........-----..--LDKENT..LSVLKLWIKECDKFKKQLxxggvsdpsKNV.SESQSSFQEWYNQEFIKKQPPGLTMS....--------lldlqkk
I2GZM2_TETBL/10-111 ...........................LRQLPLINSKGVG..FPQeSVVSKLnegqtqtqgQIQTL..NLNRSVNT..KEMFEPWYKECDELKNRL.........EKD.IREGETFHDWYKEKYLNKIPPGLLDGq..mNVLSPSKK.......
G0W9T2_NAUDC/25-114 ...........................LRKIPLYNKYGED..FPK.ETLQLM.........KVPEF..KYNELQPT..ETMFKPWYEECDNLVKTC.........EQH.DKSNESFDNWLYDKYLKTKPPGMMGS....TLLSPSKR.......
Q6CN00_KLULA/5-92 ...........................LRKVVLYHGVESSekWPK.-GRKKL.........TLPSL..QLLPDTDT..AE-LQQVIQFNSDIEELI.........RQR.QESKETFDKWYQETYLASKPKGLLEH....--LAPKRR.......
J8Q1Q5_SACAR/9-98 ...........................LRRIPLYNKYGKD..FPQ.ETLNRF.........QIPEF..KLPVLKPI..NELLDPWYQECDNITKVC.........QMH.DSSSKKFDQWYKDQYMSKKPPGMVGN....ILLSPSKK.......
A0A1E3P977_WICAA/10-103 .........................la--QIPLIVSPFYN..PPK.AVTLPF.........NYKPLpsQLPETNVT..KDNLEAWIAECQHVKKEI.........KSYgTKQKEAYEEWHNNVVRRLAPGYLGGS...nTLLTPQRR.......
A0A1G4IRB5_9SACH/9-97 ...........................LRHAGVNNPRSEL..FPR.-ARQRL.........HVPEL..SLPQTTDA..TEHLRAWIEECDAVLVAI.........AAR.KEATAQFDEWYADKYLRRQPPGILES....GILAPAKR.......
Q75CP7_ASHGO/5-93 ...........................LRKIPLYNAFEGD..MPR.-RRAKL.........QLAAL..QIAPAAAT..GEHLAAWDEECRRVLESV.........QQA.RAQGGEWEAWYEQTYLRKQPPGLLES....GTLRPRRK.......
A0A0C7NAZ6_9SACH/9-97 ...........................LRQITLRNGHSSL..LPQ.-TVTKL.........NLSPI..NLPQPTPV..KQHLQAWINECKQIQQAI.........DLR.HRKTAEFDSWYSENCLSKRPPGMTTG....GVLSPARR.......
A0A7H9AXZ4_ZYGMR/12-101 .........................ll--KSPLYNAHGSA..FPH.MDLKKL.........EAPQI..RLQPLQPS..SQVFESWHKECENLINLC.........NVH.DQGPKQFDQWYTEKFMSSKPPGMIEN....VMLSPSRR.......
G0V742_NAUCC/48-137 ...........................LRKVPLYNKFGPD..FPR.EKLSRV.........RVPEF..RLEPLQSS..EEMFQSWHKECDNLTRSC.........QFH.DKGSQMFDKWYFDTYLKNKPPGMIEK....NVLSPSKR.......
#=GC seq_cons ...........................LRplPLhNthGts..aPp..shp+l.........plPpl..pLsshpso..p-hlpsWhcECDplhpsh.........pt+.cppscpFDpWYp-pYLsp+PPGhhss....slLSPu++.......
//
