#=GF ID   NPH-II
#=GF AC   PF12011.12
#=GF DE   RNA helicase NPH-II 
#=GF PI   DUF3503;
#=GF AU   Assefa S;0000-0003-2178-533X
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   PFAM-B_2686 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   26.40 28.60;
#=GF NC   20.30 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8970979
#=GF RT   Vaccinia virions lacking the RNA helicase nucleoside
#=GF RT   triphosphate phosphohydrolase II are defective in early
#=GF RT   transcription.
#=GF RA   Gross CH, Shuman S;
#=GF RL   J Virol. 1996;70:8549-8557.
#=GF DR   INTERPRO; IPR021892;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   RNA helicase NPH-II or I8 is found in Poxviridae. It is 
#=GF CC   essential for viral replication and plays an important role
#=GF CC   during  transcription of early mRNAs, presumably by preventing 
#=GF CC   R-loop formation behind the elongating RNA polymerase.  It acts
#=GF CC   as NTP-dependent helicase that catalyzes unidirectional 
#=GF CC   unwinding of 3'tailed duplex RNAs. It might also play a role  in
#=GF CC   the export of newly synthesized mRNA chains out of the  core
#=GF CC   into the cytoplasm and is required for propagation of viral
#=GF CC   particles [1].
#=GF SQ   44
#=GS Q0NPD1_9POXV/1-165      AC Q0NPD1.1
#=GS NPH2_MCV1/1-177         AC Q98218.1
#=GS A0A1L3IZH2_9POXV/1-140  AC A0A1L3IZH2.1
#=GS A0A223FNB2_9POXV/1-164  AC A0A223FNB2.1
#=GS NPH2_MSEPV/25-182       AC Q9YW06.1
#=GS A0A3F2YKK9_SHEVT/1-168  AC A0A3F2YKK9.1
#=GS A0A1W6S9L2_LSDV/1-168   AC A0A1W6S9L2.1
#=GS NPH2_VACCW/1-165        AC P12927.2
#=GS A0A6B9R310_9POXV/1-173  AC A0A6B9R310.1
#=GS U3UBH1_9POXV/1-170      AC U3UBH1.1
#=GS Q6TUW4_YMTV5/1-169      AC Q6TUW4.1
#=GS Q0GP07_HSPV/1-165       AC Q0GP07.1
#=GS H6TA41_9POXV/1-169      AC H6TA41.1
#=GS W6JL25_9POXV/24-180     AC W6JL25.1
#=GS A0A385H9L6_FOWPV/2-174  AC A0A385H9L6.1
#=GS A0A481NJQ2_9POXV/1-168  AC A0A481NJQ2.1
#=GS NPH2_VACCC/1-165        AC P20502.1
#=GS A0A2U9QHL7_9POXV/1-174  AC A0A2U9QHL7.1
#=GS A0A097IVS2_9POXV/1-169  AC A0A097IVS2.1
#=GS Q08FC4_DPV84/1-172      AC Q08FC4.1
#=GS NPH2_FOWPN/2-174        AC O72904.1
#=GS A0A7R5WKA1_9POXV/6-180  AC A0A7R5WKA1.1
#=GS Q08FU4_DPV83/1-171      AC Q08FU4.1
#=GS A0A1B1MRC5_9POXV/1-174  AC A0A1B1MRC5.1
#=GS A0A223FMR1_9POXV/1-164  AC A0A223FMR1.1
#=GS Q9EMW8_AMEPV/22-185     AC Q9EMW8.1
#=GS A0A0M3ZCP5_9POXV/1-172  AC A0A0M3ZCP5.1
#=GS NPH2_RFVKA/1-168        AC Q9Q927.1
#=GS Q6TVT4_ORFSA/1-171      AC Q6TVT4.1
#=GS A0A2C9DT24_9POXV/1-174  AC A0A2C9DT24.1
#=GS Q070I0_CPRVZ/1-162      AC Q070I0.1
#=GS A0A1V0S7V2_CNPV/2-173   AC A0A1V0S7V2.1
#=GS NPH2_MYXVL/1-168        AC Q9Q8Q2.1
#=GS Q775W7_CAMPS/1-165      AC Q775W7.1
#=GS Q9DHR3_YLDV/1-169       AC Q9DHR3.1
#=GS A0A220T6B4_9POXV/1-168  AC A0A220T6B4.1
#=GS D3IZI3_9POXV/1-172      AC D3IZI3.1
#=GS Q6VZN8_CNPV/2-173       AC Q6VZN8.1
#=GS F1AX03_ORFV/1-171       AC F1AX03.1
#=GS Q8V3P8_SWPV1/1-171      AC Q8V3P8.1
#=GS A0A7H0DN56_MONPV/1-165  AC A0A7H0DN56.1
#=GS NPH2_VACCT/1-165        AC Q9JFC3.1
#=GS NPH2_VAR67/1-165        AC P0DSU5.1
#=GS G3EID4_9POXV/1-164      AC G3EID4.1
Q0NPD1_9POXV/1-165                 .......MEKNLPDIFFFPNCVNVFSYKYSQDEFSNM....SKTERDSFSLAVFPVIKHRWHNAHVVK.HKGIYKVSTEARGK..--------KVSPP..S..LGKPTHIN.....LTAKQY.IYSE-HTISFECYSFLKCITN..A..EINSF..DEYILRGLLEAGNSLQI.FSNSVG...K..RTDTIGVLGNKYPFSKIPLASLTP..................
NPH2_MCV1/1-177                    ......m--KNLPGVFAFPDNETIFAHAYSQRELEAMlparAGAQPHAFAYAAWPLSKHRWRGAFVCR.QRGVLKLNLELDAG..AFERVPRSEA---..E..RFEPEQSD.....ARALMH.RGADGTVMSFECYSFLRCRPG..L..ELREA..GLALLRGLVVGGNRMRI.FSGVRRagaS..AATSAGMLGNESPFERAPFASLR-i.................
A0A1L3IZH2_9POXV/1-140             .......-----------------------------M....SIEEKGRFAFAIFPLIKHRWKNSFTVI.DKNIYRLNVELKAK..EYKRIKEPI----..I..TSLPNKID.....FKNNFY.VIDN-IKISFECYSFLKYSSF..I..DISLF..DEYLLRGLVDGGNKLNI.FTNNVG...N..IKNTIGIFGNKKHFSKITLKSL--ys................
A0A223FNB2_9POXV/1-164             ......m--NNLPDIFFFPNCVNIFSYNYSQDEFSKM....SDVEKKNFSLTVFPILKHRWNGAYVIK.HRNIYRVSSEAQGE..---KVKLESL---..-..-NHPEYVN.....IKTKQY.TVDG-IKISFECYSFIKCSMN..T..DIDSF..DEYVLRGLIEAGNKLKI.FSNSVG...N..QESSVGVFGNREPFSKVPLASLTP..................
NPH2_MSEPV/25-182                  kynymay--------LLFPNNATIFNSYITKKEVFEY....----PMQFAIALYPVYKLYWHNINICL.NNRFIYLSNEFKNN..----ISINTVYNL..L..YNNELKF-.....-EDDNIiINGKNLKISYSAYSYVTIISQ..ItiNISSL..NKYQIYGIIESANYLGI.LSSYKQ...N..K-----------------------yfdknlfsftkselr...
A0A3F2YKK9_SHEVT/1-168             ......m--DKLPNIYYFPNCVNLFPYQYSQNEFENM....SNEEKKNFSFAIFPLIKHRWNKSYVVK.DNKTYKLSNEVNKT..---LKKVTNVN-I..P..SIYPTKID.....SASKEY.TINN-IKISFECYSYLNYSKF..D..NIHSF..DDYILRGLLEGGNKLKI.FSNNIG...S..TNSTIGIFNNTEPFFKIKLASLQP..................
A0A1W6S9L2_LSDV/1-168              ......m--DKLPNIYYFPNCVNLFPYQYSQNEFENM....SNDEKKNFSFAIFPLIKHRWKKSYVVK.DNKTYKLSNEVNKT..---LKKVTNVN-I..P..SIYPTKID.....GASKEY.TINN-IKISFECYSYLNYSKF..D..NIHSF..DEYILRGLLEGGNKLKI.FSNNIG...S..ANSTIGIFNNTEPFFKIKLASLQP..................
NPH2_VACCW/1-165                   .......MEKNLPDIFFFPNCVNVFSYKYSQDEFSNM....SKTERDSFSLAVFPVIKHRWHNAHVVK.HKGIYKVSTEARGK..--------KVSPP..S..LGKPAHIN.....LTAKQY.IYSE-HTISFECYSFLKCITN..T..EINSF..DEYILRGLLEAGNSLQI.FSNSVG...K..RTDTIGVLGNKYPFSKIPLASLTP..................
A0A6B9R310_9POXV/1-173             ......m--DNLPNIYYFPNNVTIFAYYYSQDEFDNM....NQTERFNFSFSVFSIIKHRWYNAYIIE.DKNTLKLNIELKTI.sKKNNKKIDAI--D..I..IRSPNKIN.....KRTKEY.TLDNDKKISFECYSFVKCFNK..T.iKLLSF..DDYILRGLLEAGNCLKI.FSNNTG...N..ASSSVSIFNNELPFSKVTLITLT-s.................
U3UBH1_9POXV/1-170                 ......m--EKLPDMYLFPNGVSVFTHEYSHSEFDTM....SARDRAGFSLAVFPLTKHRWRGAYATL.HEGVFRVSAELDTA..--ERPARASARAA..R..AVHPREVE.....VSNGTF.FDGQ-NRISFECYSFLRCAKH..T..SLAAM..DEHVLRGLMQGGNRMRI.FSRRRG...G..PRASVGVLGNRKPFQPVGLASMLP..................
Q6TUW4_YMTV5/1-169                 .......MDNHLPEIFYFPNCVDVFSHQYSQSEFDKM....EKDFKKGFSLSVFPIIKHRWKKSFVVM.DDGVLKLNLESSVN.gNKIKKKII-----..I..TRYPESVN.....FKLKTY.TIGN-LKITFECYSYLMCRQV..T..DTNLF..DEYILRGLVEGGNALKI.FSKKTG...H..VKSTIGIFGNDTPFLKVPLMSLKP..................
Q0GP07_HSPV/1-165                  .......MEKNLPDIFFFPNCVNVFSYKYSQDEFSNM....SKTERDSFSLAVFPVIKHRWHNAHVVK.HKGIYKVSTEARGK..--------KVSPP..S..LGKPAHIN.....LTTKQY.IYSE-HTISFECYSFLKCITN..T..EINSF..DEYILRGLLEAGNSLQI.FSNSVG...K..RTDTIGVLGNKYPFSKIPLASLTP..................
H6TA41_9POXV/1-169                 .......MYNKLPNIFYFPNCYTIFPYKYAQSEFSKM....SIEEKRRFAFAIFPLIKHRWKNSFTVI.DKNIYKLNVELKSK..EYKRIKEPI----..I..TSLPNKID.....FKNNFY.VIDN-LKISFECYSFLKYSSF..I..DISLF..DDYLLRGLVDGGNKLNI.FTNNVG...N..INNTIGIFGNKKHFSKITLKSL--ys................
W6JL25_9POXV/24-180                .nyithl---------LYPNNTIIFQTEIERT----Y....VNKYPDNFIILVFPVFKLYWSNVFLCLnNNKIY-LDKDNTKL.lTLYEMNTI-LTNS..K..LIFNNDI-.....IIIEPY.----NLYLTYSAYAYSTVLNN..NkfKLATL..NIHQLYGIVDDANKLGI.LSNSSV...K..SINS--------------------nylftfeksdlrs.....
A0A385H9L6_FOWPV/2-174             ......t-TNDLFSIYAFSNMYDIFPRKYSQKELEEY....HRKNPLFFSYTIFPVIKHRWSKAYICF.QNNVYMLNIELDTS.kPYDRVPIQHL---..I..DIRPISTD.....IKKEIY.KISDKTFITFECYSYLKCKGY..N..SIYDI..TLDDKRGLLSAGNILSI.FSSNKQ..mP..EKSSIGILKNPKPFTVIKFKSLS-l.................
A0A481NJQ2_9POXV/1-168             .......MENHLPNIFYFPNCVTAFPYRYTQKELDDM....KPVDRERFKYAVFPLIKHRWCRAYVVR.DNHTFKLNVETS--..----KRLRRVAYP..T..LVPLVGVN.....AALREY.VMEDGTKISFECYSYLICKRT..T..SLHDV..DDSTIRGLVEGGNQLNI.FTNSVG...S..VTNTVGIFGNPNPFAKVPLKSLHP..................
NPH2_VACCC/1-165                   .......MEKNLPDIFFFPNCVNVFSYKYSQDEFSNM....SKTERDSFSLAVFPVIKHRWHNAHVVK.HKGIYKVSTEARGK..--------KVSPP..S..LGKPAHIN.....LTTKQY.IYSE-HTISFECYSFLKCITN..T..EINSF..DEYILRGLLEAGNSLQI.FSNSVG...K..RTDTIGVLGNKYPFSKIPLASLTP..................
A0A2U9QHL7_9POXV/1-174             .....ml---NLPNIYLFPNRVNTFTHAFTHSEFNDM....SQKEKFNFSMAVFPLMKHRWNDAYVVK.HDNKLKLNIEINEE..PYDNYKWKKASSHsiN..SFVPTKTS.....LLSEEY.IHGN-TSMSFECYAFIKCIHG..I..SLSSL..DTTVLRGLMVGGNRLKI.FSSNRD...N..ESSTIGVLGNAREFSMITLASLNP..................
A0A097IVS2_9POXV/1-169             .......MYNKLPNIFYFPNCYTIFPYKYAQSEFSKM....SIEEKRRFAFAIFPLIKHRWKNSFTVI.DKNIYKLNVELKSK..EYKRIKEPI----..I..TSLPNKID.....FKNNFY.VIDN-LKISFECYSFLKYSSF..I..DISLF..DDYLLRGLVDGGNKLNI.FTNNVG...N..INNTIGIFGNKKHFSKITLKSL--ys................
Q08FC4_DPV84/1-172                 .......MLNPLPNIFYFPNCVNIFSYHYSQVEFDIM....NNMDKKRFSMAVYPLIKHRWKNCSIVY.NNRTYKLTCEHKQY.nTVENKNVNHL--L..D..ISIPSKIN.....IKKKEY.TIGN-IKMSFECYSYIKSFSI..T..DITLF..DEYVLRGLLEGGNKLNI.FSNVIG...N..QNDTINIFGNPKPFSKIPLKSLQP..................
NPH2_FOWPN/2-174                   ......t-TNDLFSIYAFSNMYDIFPRKYSQKELEEY....HRKNPLFFSYTIFPVIKHRWSKAYICF.QNNVYMLNIELDTS.kPYDRVPIQHL---..I..DIRPISTD.....IKKEIY.KISDKTFITFECYSYLKCKGY..N..SIYDI..TLDDKRGLLSAGNILSI.FSSNKQ..mP..EKSSIGILKNPKPFTVIKFKSLS-l.................
A0A7R5WKA1_9POXV/6-180             ...ryer--------LFIPNGVDLFTIFHVDQDIKAY....IRENYKDFFLLFFPVYKHIWYNKFCVR.DRQTGKIYLQSKNE.hITINQEIFDIDQH..R..KALLRDLQldpifLEKENN.IQCGDFLIDLTAYAFLYIRIF..D..NITQQ..NMSFLLALSLLRNSLPYgFCNSPI...K..QKRTIR--KPVFNFDKIPLKSLQ-l.................
Q08FU4_DPV83/1-171                 .......MLNPLPNIFYFPNCVNIFSYHYSQVEFDSM....NITDKKRFSMAVYPLIKHRWKNCSIIY.NNRTYKLTCENKQY.nNIENKNVNHL---..D..INIPSKIN.....IKKKEY.TIGN-IKMSFECYSYIKSFSI..T..DITLF..DEYILRGLLEGGNKLNI.FSNIMG...N..QNDTINIFGNPKPFSKIPLKSLQP..................
A0A1B1MRC5_9POXV/1-174             ......m--QNIPNLYLFPNCVDIFTHEYSDEDFDKM....SKSEKDMFKFAVFPLLKHRWKSAYVVK.HNNVIKLNKENVTK..TSKDTIWKKVNRS..TlkTIHVTSVD.....KK-KRM.FKSGKSLITYECYAFLKCDIN..K..DLNSF..DEYTLRGLMDAGNKLKI.FSNSVG...N..AKNTINVLGNNKPFSVVPLASLKP..................
A0A223FMR1_9POXV/1-164             ......m--NNLPDIFFFPNCVNIFSYNYSQDEFSKM....SDVEKKNFSLTVFPILKHRWNGAYVTK.HRNIYRVSSESQGE..---KVKLESL---..-..-NHPESVN.....IKTKQY.TVDG-IKISFECYSFIKCSMN..T..DIDSF..DEYVLRGLIEAGNKLKI.FSNSVG...N..QESSVGVLGNREPFSKVPLASLTP..................
Q9EMW8_AMEPV/22-185                kynyish--------LLFPNNTNIFQ---SYIDFDYV....-KKYKYNFLILLYPVYKLYWKNMYICY.NQNSNKIYLDNKEI..--YNTSIELI---..N..DFLIDGID.....INNNIItIRSNGSTITYSAYAYATILYD..LpyRLGNL..DINQIFGIVESSNILGI.LSTNEE...Q..KKK---------------------fpkyinnieleknilfkf
A0A0M3ZCP5_9POXV/1-172             ....mpl---NVFSIYAFPNMYDIFPKKYTQKELEDY....HTKNNLFFSYTIFPVIKYRWNDVFVCL.SNDTYMLNIENNNI..NCRKVSIKKL---..I..GITPISID.....YEGNKY.KISDDKFITFECYSYVKCIAY..T..RITDI..SLNDKRGLVIAGNKLSI.FSSNRK..tS..NKESIGILKNKNPFSIITFKSLS-l.................
NPH2_RFVKA/1-168                   .......MENHLPNIFYFPNCVTTFPYRYTQKELDDM....KPDERERFKYATFPIIKHRWSHAYVVK.DNHVFKLNVETS--..----KRLRRATPP..T..LSVPVSMN.....TMLREY.ITQDGTKISFECYSYLTCKKA..T..SLHDL..DDNAIRGLVEGGNRLQL.FTNSVG...S..VKDTVGIFGNPNPFMKVPLKSLHP..................
Q6TVT4_ORFSA/1-171                 .......MENHLPDMLMFPNCVSVFPFEYSLEDVFRL....PEERRRAFAMAVFPLSKHRWRGARLQRdERSVW-LSVEEDRG.rALGERNCSWLSDV..-..--------.....--AARM.VDDEGRAVTPEAYAFMRAAPG..A..RVAELaaDAGVLAGLVAGGNALRV.FSSESTqarEgwKARSVGVLGNAAPLAPVPLASLRP..................
A0A2C9DT24_9POXV/1-174             ......m--KNIFSVYAFPNNRTLFPCEYSQAELDRA....HGADAAAFAHAAFPLCKHRWRNAVVCL.RDGTYMLSVELDTG.tVCDRVRLSEA---..A..AFEPVSED.....ARAMVF.ADVHGRRMSFECYSFVRLHTDppT..RVEEL..SLRVKRGLVAGGNRMRI.FSSGTR..tR..ARTSVGVLGNAAAFSEVSFRSLE-l.................
Q070I0_CPRVZ/1-162                 ......m-----LDLFAFPNNVDVFPHEYSQERLEEL....NAADPSAFSLAVFPVHKHRWADAYVVR.ARGVYRLSAEVRTA..----LPEADAAPL..E..DFVPVRT-.....--YADH.HEAGGVKVSLECYSMLQCRRG..L..RLADL..GLAVKRGLVAAGNRLGI.FSAPVR...T..EATSVGRLGNARDFDRVPFRSL--g.................
A0A1V0S7V2_CNPV/2-173              ......t-ANDLFSVYAFPNMYDIFPYKYTQKDLEEY....HKKNVLFFSHSIFPVIKHRWNKVFTCL.KNDTYMLNIESDDY..SFIKIPVRKL---..L..DVTPINTD.....YGKQVY.YIGDDRFITFECYSYIKCIGY..N..NVSDI..TLNDKRGLLIAGNHLSI.FSSNKK..vH..ANNSIGILNNPKPFSVISFKSLS-l.................
NPH2_MYXVL/1-168                   .......MENHLPNIFYFPNCVTAFPYRYTQKELDDM....KPVDRERFKYAVFPLIKHRWCRAYVVR.DNHTFKLNVETS--..----KRLRRVAYP..T..LVPLVGVN.....AALREY.VMEDGTKISFECYSYLICKRT..T..SLHDV..DDSTIRGLVEGGNQLNI.FTNSVG...S..VTNTVGIFGNPNPFAKVPLKSLHP..................
Q775W7_CAMPS/1-165                 .......MEKNLPDIFFFPNCVNVFSYRYSQDEFSNM....SKTERDSFSLAVFPVIKHRWHNAHVVK.HKGIYKVSTEARGK..--------KVSPP..S..LGKPTHIN.....LTAKQY.IYSE-HTISFECYSFLKCITN..A..EINSF..DEYILRGLLEAGNSLQI.FSNSVG...K..RTDTIGVLGNKYPFSKIPLASLTP..................
Q9DHR3_YLDV/1-169                  .......MDNHLPEIFYFPNCVDIFSHQYSQIEFNKM....EKTTKKNFSLAVFPIIKHRWKKSFIVI.DNGIFKLNLESENN..NNKIKKNIK----..I..DTYPESID.....IQLKIY.TVGN-LKITFECYSYLMCKQI..K..DINLF..NEYILRGLIEGGNALKI.FSKKTG...Y..VNSSIGIFGNESSFLKIPLTSLKP..................
A0A220T6B4_9POXV/1-168             .......MDNNLPNIFFFPNNVTVYSYNYTQDEFDSM....NKLEKQRFKLTVFPLLKHRWKFAYVVQ.KGNIIKLNKETNSK..SFKKIELNS----..-..INLPIYVD.....NKNKQF.KIDN-KLISFECYSFIKCKQG..V..NVDTF..DDYILKGLIEGGNAMKI.FSNSVG...N..IESSKEIFGNTLPFAKIPLASLLP..................
D3IZI3_9POXV/1-172                 .......MENHLPDMLMFPNCVSVFPFEYSLEDVFRL....PEERRGAFAMAVFPLLKHRWRGARLENdQRAVW-LSVEREDRgrALAA---------..-..RDCPWLAD.....A-AARM.VDDEGRAATPEAYAFMRAAPG..V..RVADLaaDAGALAGLVFGGNALRV.FSSEASqarEgwKARSVGVLGNAAPLAPVPLASLRP..................
Q6VZN8_CNPV/2-173                  .....at--NELFSIYAFPNMYDIFPHSYTYKELEEY....HNKDTLFFSHSVFPIIKHRWNKVFICL.KDDTYMLNIETTNS..ISAKIPVSKL---..I..DVIPVSIN.....YSKQVY.YIGNDRFITFECYSYVKCIGY..N..HVSDI..TLDDKRGLLVAGNHLSI.FSSNKK..vP..VKNSIGILNNPNPFAIISFKSLS-l.................
F1AX03_ORFV/1-171                  .......MENHLPDMLMFPNCVSVFPFEYSLEDVFRL....PEERRRAFAMAVFPLSKHRWRGARLQRdERSVW-LSVEEDRG.rALGERNCSWLSDV..-..--------.....--AARM.VDDEGRAVTPEAYAFMRAAPG..A..RVAELaaDAGVLAGLVAGGNALRV.FSSESTqarEgwKARSVGVLGNAAPLAPVPLASLRP..................
Q8V3P8_SWPV1/1-171                 .......MDNHLPNIFYFPNCINTFPYKYSQIEFDKM....DKKEKMRFAYAVFPLIKHRWKYAYIIKdNNNVYKLNCESKQF..----YKEIILDNS..L..ISPPTKIY.....IKTKEY.LMDN-IRISFECYSYIKIKQD..T.iDIHNM..DDFLLRGLLEGGNNLNI.FTNCIG...H..RDNTIGIFGNIKPFSKIPFVSLQP..................
A0A7H0DN56_MONPV/1-165             .......MEKNLPDIFFFPNCVNVFSYKYSQDEFSNM....SKTERDNFSLAVFPVIKHRWHNAHVVK.HKGIYKVSTEARGK..--------KVSPP..S..LGKPAHIN.....LMSKQY.IYSE-YAISFECYSFLKCITN..T..EINSF..DEYILRGLLEAGNSLQI.FSNSVG...K..RIDTIGVLGNKYPFSKIPLASLTP..................
NPH2_VACCT/1-165                   .......MEKNLPDIFFFPNCVNVFSYKYSQDEFSNM....SKTERDSFSLAVFPVIKHRWHNAHVVK.HKGIYKVSTEARGK..--------KVSPP..S..LGKPAHIN.....LTAKQY.IYSE-HTISFECYSFLKCITN..T..EINSF..DEYILRGLLEAGNSLQI.FSNSVG...K..RTDTIGVLGNKYPFSKIPLASLTP..................
NPH2_VAR67/1-165                   .......MEKNLPDIFFFPNCVNVFSYKYSQDEFSNM....SNMERDSFSLAVFPVIKHRWHNAHVVK.HKGIYKVSTEAHGK..--------KVSPP..S..LGKPSHIN.....LTAKQY.IYSE-HTISFECYSFLKCITN..A..EINSF..DEYILRGLLEAGNSLQI.FSNSVG...K..RTDTIGVLGNKYPFSKIPLASLTP..................
G3EID4_9POXV/1-164                 ......m--NNLPDIFFFPNCVDIFTYTYSQDEFDKM....NNDERKKFSLAVFPLLKHRWNGAYITK.HRNIYRVSSEIKGE..-KTKLNI------..-..STVPKHID.....TKNKQY.SIDG-IKLSFECYSFIKCSIN..K..DINTF..DEYILRGIVDAGNKMNI.FSNSIG...N..QSSSIGVLGNKEPFSKIPLASLT-r.................
#=GC seq_cons                      .........ppLPsIahFPNCVslFsacYSQcEhspM....spp-+cpFuhAVFPlIKHRW+sAallp.cpslYKLssEscsp.....thph.pl........hshPspls.....hpscpY.hhss.hpISFECYSal+Chps..s..clssh..D-alLRGLl-uGNpLpI.FSNssG...p..ppsoIGlhGNttPFuKlPLtSLpP..................
//