#=GF ID Ncstrn_small
#=GF AC PF18266.5
#=GF DE Nicastrin small lobe
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF05192
#=GF GA 25.90 25.90;
#=GF TC 26.50 25.90;
#=GF NC 25.40 25.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0105
#=GF RN [1]
#=GF RM 26280335
#=GF RT An atomic structure of human gamma-secretase.
#=GF RA Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SHW,
#=GF RA Shi Y;
#=GF RL Nature. 2015;525:212-217.
#=GF RN [2]
#=GF RM 25197054
#=GF RT Crystal structure of the gamma-secretase component nicastrin.
#=GF RA Xie T, Yan C, Zhou R, Zhao Y, Sun L, Yang G, Lu P, Ma D, Shi Y;
#=GF RL Proc Natl Acad Sci U S A. 2014;111:13349-13354.
#=GF DR INTERPRO; IPR041084;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is part of the protein Nicastrin, a component of
#=GF CC gamma secretase present in Homo sapiens. Gamma-secretase is
#=GF CC thought to contribute to Alzheimer's disease development by
#=GF CC generating beta-amyloid peptides. This domain is the known as
#=GF CC the small lobe which forms the 'lid'. The lid is an extended
#=GF CC surface loop that covers the hydrophilic pocket that is thought
#=GF CC to be responsible for substrate recruitment. On substrate
#=GF CC binding, the large lobe is thought to rotate relative to the
#=GF CC small lobe [1].
#=GF SQ 1725
#=GS A0A1U8JBC2_GOSHI/47-204 AC A0A1U8JBC2.1
#=GS A0A672IMJ2_SALFA/39-213 AC A0A672IMJ2.1
#=GS A0A8B8D9W0_CRAVI/40-216 AC A0A8B8D9W0.1
#=GS A0A4D9CV36_9STRA/45-220 AC A0A4D9CV36.1
#=GS A0A8C4E017_DICLA/26-200 AC A0A8C4E017.2
#=GS A0A673WSP0_SALTR/21-193 AC A0A673WSP0.1
#=GS A0A8J5DYU2_9DIPT/35-205 AC A0A8J5DYU2.1
#=GS A0A3Q0DYR6_CARSF/48-222 AC A0A3Q0DYR6.1
#=GS A0A1S3HK06_LINUN/31-206 AC A0A1S3HK06.1
#=GS A0A6A3KSM1_9STRA/38-201 AC A0A6A3KSM1.1
#=GS A0A093PSY9_9PASS/8-181 AC A0A093PSY9.1
#=GS A0A7M4F515_CROPO/196-369 AC A0A7M4F515.1
#=GS A0A8C5ACG5_GADMO/38-212 AC A0A8C5ACG5.1
#=GS A0A672RGH7_SINGR/46-219 AC A0A672RGH7.1
#=GS A0A8C0IXL7_CHEAB/53-226 AC A0A8C0IXL7.1
#=GS A0A6F9A1E2_9TELE/39-212 AC A0A6F9A1E2.1
#=GS A0A8C7K2J8_ONCKI/29-201 AC A0A8C7K2J8.1
#=GS A0A3Q7ISI7_SOLLC/48-205 AC A0A3Q7ISI7.1
#=GS A0A4U5NNS5_POPAL/47-204 AC A0A4U5NNS5.1
#=GS A0A8C8I2N6_ONCTS/25-197 AC A0A8C8I2N6.1
#=GS A0A3Q2LJE9_HORSE/49-223 AC A0A3Q2LJE9.1
#=GS A0A078GF29_BRANA/53-111 AC A0A078GF29.1
#=GS A0A835F651_9POAL/9-166 AC A0A835F651.1
#=GS A0A8C4D1S3_9TELE/22-196 AC A0A8C4D1S3.1
#=GS A0A498MXV1_LABRO/1-134 AC A0A498MXV1.1
#=GS A0A7J7UTS8_PIPKU/49-223 AC A0A7J7UTS8.1
#=GS A0A7E5VCS3_TRINI/37-209 AC A0A7E5VCS3.1
#=GS A0A8B7AEK2_ORYAF/49-223 AC A0A8B7AEK2.1
#=GS A0A8C4N2J2_EPTBU/45-214 AC A0A8C4N2J2.1
#=GS A0A8C6JHS5_MELUD/61-234 AC A0A8C6JHS5.1
#=GS A0A093FZN4_TYTAL/21-194 AC A0A093FZN4.1
#=GS A0A4W4GC36_ELEEL/54-227 AC A0A4W4GC36.1
#=GS A0A2G8KKF0_STIJA/41-163 AC A0A2G8KKF0.1
#=GS A0A7I4CSP8_PHYPA/44-194 AC A0A7I4CSP8.1
#=GS A0A8C7GVT0_ONCKI/39-212 AC A0A8C7GVT0.1
#=GS A0A507DV76_9FUNG/5-169 AC A0A507DV76.1
#=GS A0A0Q9WXI5_DROMO/39-216 AC A0A0Q9WXI5.1
#=GS A0A7L1YBE2_9PASS/22-195 AC A0A7L1YBE2.1
#=GS A0A672T9W8_SINGR/53-226 AC A0A672T9W8.1
#=GS A0A8C5HU84_9TELE/49-223 AC A0A8C5HU84.1
#=GS A0A8R2JSW3_ACYPI/38-197 AC A0A8R2JSW3.1
#=GS A0A8K0IGY3_COCNU/100-202 AC A0A8K0IGY3.1
#=GS A0A6I8VPK0_DROPS/35-206 AC A0A6I8VPK0.1
#=GS A0A8H7R2Y7_9FUNG/43-212 AC A0A8H7R2Y7.1
#=GS A0A8K0JZJ6_LADFU/40-209 AC A0A8K0JZJ6.1
#=GS U3J556_ANAPP/62-235 AC U3J556.1
#=GS A0A8J2WD92_9CRUS/42-221 AC A0A8J2WD92.1
#=GS A0A671W029_SPAAU/12-163 AC A0A671W029.1
#=GS A0A8C3LNJ2_CHRPC/30-203 AC A0A8C3LNJ2.1
#=GS A0A653BVE2_CALMS/295-457 AC A0A653BVE2.1
#=GS A0A0R3X6P0_HYDTA/16-189 AC A0A0R3X6P0.1
#=GS A0A452GAX8_CAPHI/49-223 AC A0A452GAX8.1
#=GS A0A093IJ51_EURHL/21-194 AC A0A093IJ51.1
#=GS A0A836FBU4_9HYME/11-177 AC A0A836FBU4.1
#=GS A0A6P8I7D1_ACTTE/4-167 AC A0A6P8I7D1.1
#=GS A0A6D2HX61_9BRAS/75-232 AC A0A6D2HX61.1
#=GS A0A8C7JUD6_ONCKI/27-158 AC A0A8C7JUD6.1
#=GS A0A8C9F752_PAVCR/62-235 AC A0A8C9F752.1
#=GS A0A8C4E269_DICLA/39-213 AC A0A8C4E269.2
#=GS A0A5B8MSI5_9CHLO/49-205 AC A0A5B8MSI5.1
#=GS A0A0R0EVX5_SOYBN/40-197 AC A0A0R0EVX5.1
#=GS A0A7L4EDY4_HIRRU/19-189 AC A0A7L4EDY4.1
#=GS A0A7L0NWZ4_9PASS/1-158 AC A0A7L0NWZ4.1
#=GS A0A2K6DXE0_MACNE/49-223 AC A0A2K6DXE0.1
#=GS A0A5E4BUQ0_MARMO/49-223 AC A0A5E4BUQ0.1
#=GS M4EX82_BRARP/53-214 AC M4EX82.1
#=GS A0A6G0URL6_9BILA/38-207 AC A0A6G0URL6.1
#=GS A0A1U8B9M7_NELNU/45-202 AC A0A1U8B9M7.1
#=GS A0A091REI3_9GRUI/21-194 AC A0A091REI3.1
#=GS A0A200QTS2_9MAGN/90-247 AC A0A200QTS2.1
#=GS A0A4E0QYE1_FASHE/43-212 AC A0A4E0QYE1.1
#=GS A0A225VLQ2_9STRA/41-201 AC A0A225VLQ2.1
#=GS NICA_CAEEL/34-219 AC Q23316.3
#=GS A0A1V9XJ20_9ACAR/49-218 AC A0A1V9XJ20.1
#=GS A0A670JUE9_PODMU/56-229 AC A0A670JUE9.1
#=GS A0A833R9M0_9POAL/49-202 AC A0A833R9M0.1
#=GS A0A6Q2YMN5_ESOLU/33-200 AC A0A6Q2YMN5.1
#=GS A0A7L3C2S1_PELUR/21-194 AC A0A7L3C2S1.1
#=GS A0A814T452_ADIRI/9-167 AC A0A814T452.1
#=GS A0A199VEX0_ANACO/48-109 AC A0A199VEX0.1
#=GS A0A815GLY3_9BILA/404-572 AC A0A815GLY3.1
#=GS A0A7K8UGP7_OCEOC/59-232 AC A0A7K8UGP7.1
#=GS A0A3Q1EQ29_9TELE/39-213 AC A0A3Q1EQ29.1
#=GS A0A5N6MMN4_9ASTR/49-205 AC A0A5N6MMN4.1
#=GS H0Y3Z4_HUMAN/4-71 AC H0Y3Z4.9
#=GS A0A8C3LML1_CHRPC/59-232 AC A0A8C3LML1.1
#=GS A0A8C8I8E0_ONCTS/19-191 AC A0A8C8I8E0.1
#=GS H0Z1S0_TAEGU/65-239 AC H0Z1S0.2
#=GS A0A7I8XR46_BURXY/24-130 AC A0A7I8XR46.1
#=GS S8EAN5_9LAMI/86-200 AC S8EAN5.1
#=GS A0A2G5F728_AQUCA/45-202 AC A0A2G5F728.1
#=GS A0A819S8R7_9BILA/9-169 AC A0A819S8R7.1
#=GS A0A0K9QW20_SPIOL/46-202 AC A0A0K9QW20.1
#=GS A0A2R6W1V6_MARPO/60-218 AC A0A2R6W1V6.1
#=GS A0A1U8J773_GOSHI/1-47 AC A0A1U8J773.1
#=GS A0A7J8CSC6_MOLMO/49-223 AC A0A7J8CSC6.1
#=GS A0A2K5QQF9_CEBIM/29-203 AC A0A2K5QQF9.1
#=GS A0A8B9BSG9_9AVES/37-210 AC A0A8B9BSG9.1
#=GS A0A7K9ESB2_BARMA/22-195 AC A0A7K9ESB2.1
#=GS A0A663M2Q2_ATHCN/40-213 AC A0A663M2Q2.1
#=GS A0A443PYZ6_9MAGN/45-203 AC A0A443PYZ6.1
#=GS A0A8B9U1L3_9AVES/6-179 AC A0A8B9U1L3.1
#=GS A0A6P8UAK1_GYMAC/1-121 AC A0A6P8UAK1.1
#=GS A0A251S3Y9_HELAN/49-205 AC A0A251S3Y9.1
#=GS A0A8H7UL25_MORIS/1-120 AC A0A8H7UL25.1
#=GS A0A8D2HN61_UROPR/49-223 AC A0A8D2HN61.1
#=GS A0A484CTR3_PERFV/39-213 AC A0A484CTR3.1
#=GS A0A1J1J526_9DIPT/37-208 AC A0A1J1J526.1
#=GS A0A2I0VYT6_9ASPA/51-216 AC A0A2I0VYT6.1
#=GS A0A8C0HRL5_9AVES/50-223 AC A0A8C0HRL5.1
#=GS A0A016WXK1_9BILA/36-177 AC A0A016WXK1.1
#=GS A0A015M1P5_RHIIW/1-168 AC A0A015M1P5.1
#=GS A0A0N4UT91_ENTVE/9-174 AC A0A0N4UT91.1
#=GS A0A7J7SSV9_MYOMY/49-223 AC A0A7J7SSV9.1
#=GS A0A8I3Q3T8_CANLF/78-151 AC A0A8I3Q3T8.1
#=GS A0A7J7PF53_9CHLO/10-171 AC A0A7J7PF53.1
#=GS A0A7L2YWZ8_JACJC/4-78 AC A0A7L2YWZ8.1
#=GS A0A8J4THT0_9TREM/44-217 AC A0A8J4THT0.1
#=GS A0A2K5K0J8_COLAP/29-203 AC A0A2K5K0J8.1
#=GS A0A2P4QM78_RHIID/39-217 AC A0A2P4QM78.1
#=GS A0A7K8WFP4_9FURN/22-195 AC A0A7K8WFP4.1
#=GS A0A6J8C594_MYTCO/38-218 AC A0A6J8C594.1
#=GS A0A6V7TQX1_9BILA/35-206 AC A0A6V7TQX1.1
#=GS A0A6A6L653_HEVBR/48-205 AC A0A6A6L653.1
#=GS A0A8B8A4M5_ACAPL/40-218 AC A0A8B8A4M5.1
#=GS A0A673AAM8_9TELE/39-213 AC A0A673AAM8.1
#=GS A0A8C4XYZ7_9SAUR/54-227 AC A0A8C4XYZ7.1
#=GS A0A6P4J836_DROKI/39-212 AC A0A6P4J836.1
#=GS A0A1S4F865_AEDAE/41-215 AC A0A1S4F865.1
#=GS A0A834IS34_RHYFE/39-205 AC A0A834IS34.1
#=GS A0A8C3LN27_CHRPC/30-203 AC A0A8C3LN27.1
#=GS A0A7L2B5X5_9GRUI/21-194 AC A0A7L2B5X5.1
#=GS H3AMW0_LATCH/21-194 AC H3AMW0.1
#=GS A0A6I9V3X3_BACDO/40-217 AC A0A6I9V3X3.1
#=GS A0A6J3LFF5_9HYME/37-202 AC A0A6J3LFF5.1
#=GS A0A7L4CKU1_9AVES/59-232 AC A0A7L4CKU1.1
#=GS A0A6P3I0M7_BISBI/49-223 AC A0A6P3I0M7.1
#=GS A0A453PIQ8_AEGTS/1-47 AC A0A453PIQ8.1
#=GS A0A498SH56_ACAVI/99-272 AC A0A498SH56.1
#=GS A0A6J0WVP7_ODOVR/1-116 AC A0A6J0WVP7.1
#=GS K3XAK7_GLOUD/44-205 AC K3XAK7.1
#=GS A0A448X7N7_9PLAT/36-188 AC A0A448X7N7.1
#=GS A0A6J1MJ39_BICAN/41-212 AC A0A6J1MJ39.1
#=GS D7FSD7_ECTSI/219-296 AC D7FSD7.1
#=GS A0A8C7Z5D7_9TELE/41-215 AC A0A8C7Z5D7.1
#=GS A0A8C2ZKV7_CYCLU/43-217 AC A0A8C2ZKV7.1
#=GS A9V5M6_MONBE/730-889 AC A9V5M6.1
#=GS K0TI67_THAOC/24-228 AC K0TI67.1
#=GS A0A507FPH1_9FUNG/37-211 AC A0A507FPH1.1
#=GS A0A6P5YTI4_DURZI/45-202 AC A0A6P5YTI4.1
#=GS A0A8C0FR50_BUBBB/52-225 AC A0A8C0FR50.1
#=GS A0A2Y9FSD2_PHYMC/49-223 AC A0A2Y9FSD2.1
#=GS A0A7K7TG43_9TYRA/37-210 AC A0A7K7TG43.1
#=GS A0A7J8NJD3_9ROSI/19-194 AC A0A7J8NJD3.1
#=GS A0A6J0NJP5_RAPSA/53-210 AC A0A6J0NJP5.1
#=GS A0A4Z2C2U4_9TELE/39-213 AC A0A4Z2C2U4.1
#=GS S9XLP1_CAMFR/49-223 AC S9XLP1.1
#=GS D8RHJ7_SELML/20-183 AC D8RHJ7.1
#=GS A0A8C6PQA5_NOTFU/37-211 AC A0A8C6PQA5.1
#=GS A0A672T6G6_SINGR/60-189 AC A0A672T6G6.1
#=GS A0A2Z6RZ24_9GLOM/39-217 AC A0A2Z6RZ24.1
#=GS A0A8D0KWK5_STROC/78-251 AC A0A8D0KWK5.1
#=GS A0A1S3LZ30_SALSA/38-210 AC A0A1S3LZ30.1
#=GS A0A2K6DXF0_MACNE/29-203 AC A0A2K6DXF0.1
#=GS A0A087Y2U1_POEFO/39-213 AC A0A087Y2U1.1
#=GS A0A8K1CTA1_PYTOL/43-198 AC A0A8K1CTA1.1
#=GS A0A6I9TJD2_SESIN/49-206 AC A0A6I9TJD2.1
#=GS A0A7R8UP54_HERIL/33-205 AC A0A7R8UP54.1
#=GS A0A4W4GCA3_ELEEL/39-212 AC A0A4W4GCA3.1
#=GS A0A0D3BYG4_BRAOL/21-129 AC A0A0D3BYG4.1
#=GS A0A3B0JCQ0_DROGU/39-211 AC A0A3B0JCQ0.1
#=GS A0A6P7K972_9TELE/54-228 AC A0A6P7K972.1
#=GS A0A8C2ZLK0_CYCLU/28-202 AC A0A8C2ZLK0.1
#=GS A0A0V0RXK9_9BILA/34-209 AC A0A0V0RXK9.1
#=GS A0A8C6YJ16_NAJNA/38-197 AC A0A8C6YJ16.1
#=GS A0A7L3PTG7_9DEND/1-159 AC A0A7L3PTG7.1
#=GS F6YW17_HORSE/49-223 AC F6YW17.2
#=GS A0A2Y9IDT5_ENHLU/49-223 AC A0A2Y9IDT5.1
#=GS A0A7M4F4S1_CROPO/196-369 AC A0A7M4F4S1.1
#=GS A0A8B8VMQ2_BALMU/28-158 AC A0A8B8VMQ2.1
#=GS A0A673H713_9TELE/48-221 AC A0A673H713.1
#=GS A0A1I7SK11_BURXY/4-125 AC A0A1I7SK11.1
#=GS A0A8C5GK34_9TELE/23-197 AC A0A8C5GK34.1
#=GS A0A1S3E882_CICAR/43-200 AC A0A1S3E882.1
#=GS H2XT29_CIOIN/5-75 AC H2XT29.1
#=GS A0A8C4DWV5_DICLA/24-198 AC A0A8C4DWV5.2
#=GS D8S4R7_SELML/20-177 AC D8S4R7.1
#=GS A0A2C9WBY5_MANES/40-197 AC A0A2C9WBY5.1
#=GS A0A7L4BJB9_9CHAR/59-232 AC A0A7L4BJB9.1
#=GS A0A673ABX6_9TELE/36-210 AC A0A673ABX6.1
#=GS A0A091R7I9_MERNU/21-194 AC A0A091R7I9.1
#=GS A0A8C2ZL09_CYCLU/11-170 AC A0A8C2ZL09.1
#=GS G7J8R1_MEDTR/43-200 AC G7J8R1.1
#=GS A0A7J5ZC58_DISMA/1185-1359 AC A0A7J5ZC58.1
#=GS A0A2Y9FUB6_PHYMC/28-158 AC A0A2Y9FUB6.1
#=GS A0A8J4ZWE0_9CHEL/36-215 AC A0A8J4ZWE0.1
#=GS A0A3Q1NB59_BOVIN/105-279 AC A0A3Q1NB59.1
#=GS V4AJE4_LOTGI/13-192 AC V4AJE4.1
#=GS A0A814RKK1_9BILA/38-206 AC A0A814RKK1.1
#=GS A0A2K5K0I3_COLAP/49-223 AC A0A2K5K0I3.1
#=GS A0A6A3BCU7_HIBSY/45-202 AC A0A6A3BCU7.1
#=GS A0A8J5NAM4_HOMAM/43-220 AC A0A8J5NAM4.1
#=GS A0A5F8GRR2_MONDO/65-238 AC A0A5F8GRR2.1
#=GS A0A2I4BL42_9TELE/39-213 AC A0A2I4BL42.1
#=GS A0A8J5M565_9STRA/36-196 AC A0A8J5M565.1
#=GS A0A8C9ZYF1_SANLU/39-213 AC A0A8C9ZYF1.1
#=GS A0A2C9WBZ8_MANES/48-205 AC A0A2C9WBZ8.1
#=GS A0A663M2T1_ATHCN/39-212 AC A0A663M2T1.1
#=GS A0A830HD34_9CHLO/64-236 AC A0A830HD34.1
#=GS A0A8D0D8K0_SANLU/65-239 AC A0A8D0D8K0.1
#=GS A0A6P5YTQ0_DURZI/45-202 AC A0A6P5YTQ0.1
#=GS A0A7L4GN99_PODST/59-232 AC A0A7L4GN99.1
#=GS A0A8C3TF37_CHESE/58-231 AC A0A8C3TF37.1
#=GS A0A8C9ZZ82_SANLU/45-219 AC A0A8C9ZZ82.1
#=GS A0A8C4CZ51_9TELE/46-220 AC A0A8C4CZ51.1
#=GS A0A2A2JNF3_9BILA/47-115 AC A0A2A2JNF3.1
#=GS A0A1S4BIG9_TOBAC/48-205 AC A0A1S4BIG9.1
#=GS A0A267EPH2_9PLAT/41-137 AC A0A267EPH2.1
#=GS A0A2K5YH34_MANLE/49-223 AC A0A2K5YH34.1
#=GS A0A653BV97_CALMS/295-457 AC A0A653BV97.1
#=GS A0A8C5BWS9_GADMO/36-210 AC A0A8C5BWS9.1
#=GS A0A843VXN0_COLES/133-285 AC A0A843VXN0.1
#=GS A0A814GRA7_9BILA/10-178 AC A0A814GRA7.1
#=GS F6WKT8_MACMU/49-223 AC F6WKT8.3
#=GS A0A6P5DZV7_BOSIN/49-223 AC A0A6P5DZV7.1
#=GS A0A016VLH9_9BILA/10-90 AC A0A016VLH9.1
#=GS A0A6P5YSV1_DURZI/2-106 AC A0A6P5YSV1.1
#=GS A0A8B8PVV1_9MYRT/1-148 AC A0A8B8PVV1.1
#=GS A0A6P3HRE8_BISBI/49-223 AC A0A6P3HRE8.1
#=GS A0A1R3H963_COCAP/45-202 AC A0A1R3H963.1
#=GS A0A0P1B109_PLAHL/38-196 AC A0A0P1B109.1
#=GS A0A8B9DPR2_ANSCY/49-222 AC A0A8B9DPR2.1
#=GS F7F9Y3_MONDO/65-238 AC F7F9Y3.2
#=GS A0A6P6T8X3_COFAR/47-204 AC A0A6P6T8X3.1
#=GS A0A6J2TKE4_DROLE/37-215 AC A0A6J2TKE4.1
#=GS A0A6H5IZE1_9HYME/43-206 AC A0A6H5IZE1.1
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A0A8C5HT36_9TELE/39-213 ......................................................PCVRLLNATHQIGC.......Q............S..S...........L.......S.G..N...V...G....V.LH.EL.ES.......EE...NL.D...WV.......LT........SGPN....PPYMVILE...SRL...F........T....R......S.....I.M.MK......LKE.gSG......................RVAGVVVVAP-............NTNPPEG.......F.S...PHTACPN.D.NSGVyten...................ydptLAHCNA.....T-VWN..P....LGN...............GLAY...E.EF.DFPIFSVKD..DN...D..T.....RV......IR...Q.-...C.........Y...........QDHN......RRVNGS...N.PQFPLCAMQLRSSMSA........................................
A0A090L452_STRRB/33-206 ......................................................PCYTLINGTHRIGC.......R............T..G...........K.......D.G..N...N...G....V.IL.FF.ND.......EK...EI.N...KL.......EKls...ynkKVTS....ESYIPVID...MKY...L........T....K......S.....F.V.QK......LIS..SD......................VITGVVFYSK-............-NIQDFS.......F.S...EDSECPN.K.EFSY...........................--YQSDi..ehGCHWN..S....NSAlh...........pdGLRF...L.DW.KKPVFFLTN..QT...E..L.....DI......LY...K.-...I.........Y...........KKFN......NPIL--...-.----------------nleqvwkplafmnlglp.......................
A0A663M249_ATHCN/40-213 ......................................................PCVRLLNATHQIGC.......Q............S..S...........I.......S.G..D...T...G....V.IH.VV.EK.......EE...DL.N...WV.......LA........DGPH....PPYMILLD...GNL...F........N....R......R.....V.M.LQ......LKG..TS......................RVSGLAVAIA-............KPSPPQG.......F.S...PGLKCPN.D.GFGVyskd...................ygpqFAHCNN.....T-VWN..P....LGS...............GLSY...E.DF.DFPIFLLED..AN...E..T.....QV......IK...Q.-...C.........Y...........QDHN......VPRDGS...G.PEYPLCAMQLFSHMHA........................................
A0A3B6NS09_WHEAT/50-205 ......................................................PCVRLLNLSGEIGC.......S............N..-...........-.......P.G..H...G...L....V.IA.PI.VR.......FK...NS.D...DQ.......LA........----....QPSAVLLP...LDQ...M........-....P......A.....F.F.LR......VSN.ePEl...................yhKVAGVLVESN-............-GDKLLE.......L.S...PDRKFPQ.E.DFAP...........................--YSNV.....SHDWN..P....AGS...............GIMW...N.RY.DFPVFLLSE..ES...-..T.....QT......LR...K.I...A.........D...........KN--......---EKS...N.NGYQANVAEFDLVMQT........................................
A0A6A1VEP7_9ROSI/33-190 ......................................................PCVRLLNLSGVIGC.......S............N..-...........-.......P.G..R...E...M....V.VA.PI.VS.......YR...SD.K...EL.......S-........-QS-....--SAVLVS...LDE...I........-....E......S.....F.F.TK......IRN.dSSf...................arNIAGVIVESGI...........eIQKNLKG.......F.S...PTQKFPQ.A.EFAP...........................--YQTT.....NYEWN..P....IGS...............GIMW...N.EY.NFPVFLLSE..SG...-..T.....VT......LL...E.A...A.........T...........KN--......---EKS...N.KAYIADVAEFDLVMQT........................................
A0A2I3SBE3_PANTR/29-203 ......................................................PCVRLLNATHQIGC.......Q............S..S...........I.......S.G..D...T...G....V.IH.VV.EK.......EE...DL.Q...WV.......LT........DGPN....PPYMVLLE...SKH...F........T....R......D.....L.M.EK......LKG.rTS......................RIAGLAVSLT-............KPSPASG.......F.S...PSVQCPN.D.GFGVysns...................ygpeFAHCRE.....-IQWN..S....LGN...............GLAY...E.DF.SFPIFLLED..EN...E..T.....KV......IK...Q.-...C.........Y...........QDHN......LSQNGS...A.PTFPLCAMQLFSHMHA........................................
A0A851QBC6_ANHAN/21-194 ......................................................PCVRLLNATHQIGC.......Q............S..S...........I.......S.G..D...T...G....V.IH.VV.EK.......ED...DL.K...WV.......LV........DGPH....PPYMILLD...GNL...F........N....R......S.....V.M.LQ......LKG..TS......................RVSGLAVAIA-............KPSPPQG.......F.S...PGLKCPN.D.GFGVyskd...................ygpqFAHCNK.....T-VWN..P....VGS...............GLSY...E.DF.DFPIFLLED..AN...E..T.....QV......IK...Q.-...C.........Y...........QDHN......VPHDGS...G.PEYPLCAMQLFSHMHA........................................
A0A7J8VB06_9ROSI/19-194 ......................................................PCVRLVNLSGEIGC.......S............N..-...........-.......P.G..R...D...K....V.VA.PI.IK.......YK...NN.K...ELglpsailLSmd...dvqGFFS....SNTELVLR...KHL...N........V....K......D.....H.I.QR......ISN.dSSf...................asNVAGVLVESRV...........eIQHELKG.......F.S...PARKFPQ.A.EFAP...........................--YHNT.....TYEWN..P....IGS...............GIMW...K.SY.NFPVFLLSE..SS...-..T.....ST......LQ...E.I...A.........M...........KN--......---EKT...E.KAYTTNVAEFDVVMQT........................................
A0A1L8F4M3_XENLA/51-224 ......................................................PCVRLLNATHQVGC.......Q............S..S...........K.......N.G..D...T...G....V.IH.VV.EQ.......EE...DL.Q...WV.......LE........SGPH....PPYIVVLE...AHL...F........T....R......D.....T.M.QK......LKG..SR......................RVSGIAVTFS-............KTSPAAG.......F.S...PDPPCPN.D.GFGLytsd...................hgsqYAHCNN.....-ITWN..P....LGT...............GLSY...E.EF.QFPIFLLRD..EN...E..T.....EV......IK...Q.-...C.........Y...........RDHN......VPQNGS...A.PQHPLCAMQLSSFMNA........................................
A0A183KTB8_9TREM/41-198 .....................................................f-CTRKLNLTGQVGC.......S............S..D...........I.......N.G..N...S...G....V.AL.FM.NE.......SQ...DI.I...QT.......LS........SDIS....TSFVVVVN...VGQ...F........V...nT......S.....L.M.RY......FRS..TT......................NIKGLIVFSNE...........gENYDSYA.......F.S...ESSKCPN.S.DYSAy........................nfTDQCDL.....DAQWN..P....AGT...............EYSY...I.SW.PFPVVLVAD.vNN...T..I.....WV......FR...D.-...-.........-...........----......------...-.----------------lisdlfldfhsse...........................
A0A6J2VH76_CHACN/42-215 ......................................................PCVRLLNATHQIGC.......Q............S..L...........K.......S.G..S...T...G....V.LH.VL.QS.......EA...DL.D...WV.......LS........TGPH....PPYMVFME...ASF...F........N....N......V.....T.M.MR......LKN..ST......................RVAGVAVVIP-............NTGPAQG.......Y.S...PHTGCPN.Q.NTGVysek...................ygplLANCNN.....T-VWN..P....LGN...............GLSY...E.DF.RFPIFSLKD..DN...E..T.....EV......IR...K.-...C.........F...........EDHN......VAANGS...A.PQYPLCAMQLFSHMSA........................................
T1GH01_MEGSC/99-256 ...................................................lqr--------------.......-............-..-...........-.......G.R..Q...H...G....V.LY.VI.EK.......QQ...DF.E...YL.......LN........SPTS....PPYAPVVP...PEL...F........T....R......E.....N.L.IK......LKS.aAK......................NISVVVLINK-............-FDKLSS.......F.S...HELACPN.Q.YSGIn........................gtQGSCDLs..rpETLWN..P....QGT...............GLMH...E.DF.PFPIHYVAD..PS...E..I.....EK......IV...K.-...C.........F...........KKFN......DFEYEN...H.PMRSLCSIEVKSFMSA........................................
A0A5G2QCC7_PIG/49-223 ......................................................PCVRLLNATHQIGC.......Q............S..S...........V.......S.G..D...T...G....V.IH.VV.EK.......EE...DL.Q...WV.......LT........DGPN....PPYMVLLE...GTL...F........T....R......N.....L.M.EK......LKG.rTG......................RIAGLAVSLA-............KPSPTSG.......F.S...PSVQCPN.D.GFGIysds...................ygpeFAHCRE.....-ILWN..S....LGN...............GLAY...E.DF.SFPIFLLED..ED...E..T.....NI......IK...Q.-...C.........Y...........RDHN......LSQNGS...A.PAFPLCAMQLFSHMHA........................................
A0A673AAG6_9TELE/36-210 ......................................................PCVRLLNATHQIGC.......Q............S..S...........L.......S.G..N...V...G....V.LH.VL.ES.......ED...NL.D...WV.......LS........KGPN....PPYLVILE...AAL...F........T....R......S.....I.M.MK......LKN.gSN......................RVAGVAVVAP-............NTNPTEP.......F.S...PYTTCPN.E.NTGVytek...................ydpaYAHCNV.....T-VWN..P....LGN...............GLAY...E.EF.DFPIFSLKD..DN...D..T.....QV......IR...Q.-...C.........F...........LDHN......QVVNGS...A.PQYPLCAMQLYSHMSA........................................
M7B2R0_CHEMY/15-181 ...............................................gcraerv--------------.......S............S..S...........M.......N.G..D...T...G....V.IH.VV.EK.......DQ...DL.K...WV.......LT........DGPH....PPYMVLLE...GAL...F........T....R......E.....L.M.LQ......LKG..SS......................RVSGLAVAIS-............KPSPAQG.......F.S...PGLKCPN.D.GFGVysnn...................ygpqYAHCNW.....T-MWN..P....LGN...............GLAY...E.DF.NFPIFLLED..AN...E..T.....QV......IK...Q.-...C.........Y...........QDHN......LPQNGS...V.PEYPLCAMQLFAHMHA........................................
A0A5N5N0Q0_9ROSI/684-791 .............................................fcfrisnds--------------.......-............-..-...........-.......-.-..-...-...-....-.--.--.--.......--...--.-...--.......--........----....--------...---...-........-....-......-.....-.-.--......--N.fAK......................NIGGVLVEQGM...........dTQIKSKG.......F.S...PDQKFPG.A.EFAP...........................--YKTN.....NYEWN..P....IGA...............GMMW...R.AY.SFPVFLLTE..GG...-..T.....QL......VQ...E.V...A.........M...........NN--......---EKK...K.NDYTEDVVEFDLVMQ-v.......................................
A0A811JVL9_9BILA/37-205 ......................................................PCIRLLNGTKTFGC.......Q............S..E...........R.......G.G..N...V...G....V.VV.EV.VK.......PE...DI.E...SA.......VK........SLPWg..fNEIIALVA...VND...L........T....S......D.....L.L.SS......LVE..SE......................GVSGVLLVKD-............QSRAFEG.......F.S...EDGYTPN.K.EYSL...........................--YGED.....SQEWN..K....IGAls...........veGLLK...S.NI.PKPIFFIRN..ST...E..V.....QL......LY...K.N...C.........Y...........HAFN......---TKQ...S.LYRERCVARLQSFMQA........................................
A0A663M3X0_ATHCN/46-219 ......................................................PCVRLLNATHQIGC.......Q............S..S...........I.......S.G..D...T...G....V.IH.VV.EK.......EE...DL.N...WV.......LA........DGPH....PPYMILLD...GNL...F........N....R......R.....V.M.LQ......LKG..TS......................RVSGLAVAIA-............KPSPPQG.......F.S...PGLKCPN.D.GFGVyskd...................ygpqFAHCNN.....T-VWN..P....LGS...............GLSY...E.DF.DFPIFLLED..AN...E..T.....QV......IK...Q.-...C.........Y...........QDHN......VPRDGS...G.PEYPLCAMQLFSHMHA........................................
#=GC seq_cons ......................................................PCVRLLNuTHpIGC.......p............S..s...........h.......s.G..s...s...G....V.lH.sl.cp.......cc...-L.p...al.......Ls........pusp....sPYhllLp...ssL...F........s....+......s.....l.h..p......L+s..os......................+luGlhVhhs.............psssspu.......F.S...PshpCPN.c.saGlh.........................thuaCst.....s..WN..P....hGs...............GLta...E.-F.sFPIFhLc-..ps...-..T.....ps......I+...p.....C.........a...........pcaN.........pso...s.spaPLCAhpLhSaMpA........................................
//
